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array:24 [ "pii" => "S0325754122000189" "issn" => "03257541" "doi" => "10.1016/j.ram.2022.02.002" "estado" => "S300" "fechaPublicacion" => "2022-10-01" "aid" => "484" "copyright" => "Asociación Argentina de Microbiología" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2022;54:318-21" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0325754122000220" "issn" => "03257541" "doi" => "10.1016/j.ram.2022.02.004" "estado" => "S300" "fechaPublicacion" => "2022-10-01" "aid" => "488" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2022;54:322-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Molecular subtyping of <span class="elsevierStyleItalic">Salmonella</span> spp. strains in provincial abattoirs with no hazard analysis critical control point from Buenos Aires, Argentina" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "322" "paginaFinal" => "325" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Subtipificación molecular de <span class="elsevierStyleItalic">Salmonella</span> spp. en frigoríficos provinciales sin análisis de peligros y puntos críticos de control ubicados en Buenos Aires, Argentina" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1857 "Ancho" => 2917 "Tamanyo" => 429706 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">XbaI-PFGE dendrogram, strain number, sample type, serovar, abattoir, stage, sampling and sampling date of <span class="elsevierStyleItalic">Salmonella enterica</span> strain isolates (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>32) from three Argentine abattoirs.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Magdalena Costa, Victoria Brusa, Alejandra Londero, Lucía Galli, Gerardo A. Leotta" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Magdalena" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "Victoria" "apellidos" => "Brusa" ] 2 => array:2 [ "nombre" => "Alejandra" "apellidos" => "Londero" ] 3 => array:2 [ "nombre" => "Lucía" "apellidos" => "Galli" ] 4 => array:2 [ "nombre" => "Gerardo A." "apellidos" => "Leotta" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Salmonella enterica</span> was established in products and the environment.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">Cross-contamination in abattoirs was confirmed.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">The application of HACCP is necessary to meet the zero-tolerance criteria for <span class="elsevierStyleItalic">Salmonella</span> on beef.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754122000220?idApp=UINPBA00004N" "url" => "/03257541/0000005400000004/v1_202212150521/S0325754122000220/v1_202212150521/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0325754122000281" "issn" => "03257541" "doi" => "10.1016/j.ram.2022.05.002" "estado" => "S300" "fechaPublicacion" => "2022-10-01" "aid" => "494" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2022;54:314-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Informe breve</span>" "titulo" => "Descripción de un caso de sepsis abdominal por <span class="elsevierStyleItalic">Desulfovibrio desulfuricans</span>" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "314" "paginaFinal" => "317" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Description of a case of abdominal sepsis due to <span class="elsevierStyleItalic">Desulfovibrio desulfuricans</span>" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marianela Machaca, María Luz Bodean, Sabrina Montaña, Susana D. García, Daniel Stecher, Carlos A. Vay, Marisa N. Almuzara" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Marianela" "apellidos" => "Machaca" ] 1 => array:2 [ "nombre" => "María Luz" "apellidos" => "Bodean" ] 2 => array:2 [ "nombre" => "Sabrina" "apellidos" => "Montaña" ] 3 => array:2 [ "nombre" => "Susana D." "apellidos" => "García" ] 4 => array:2 [ "nombre" => "Daniel" "apellidos" => "Stecher" ] 5 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Vay" ] 6 => array:2 [ "nombre" => "Marisa N." "apellidos" => "Almuzara" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall">La identificación de <span class="elsevierStyleItalic">Desulfovibrio</span> spp. por pruebas bioquímicas no es dificultosa.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">La morfología celular, la movilidad y la producción de SH<span class="elsevierStyleInf">2</span> y de desulfoviridina lo caracterizan.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">La espectrometría de masas es un método fiable para su identificación.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Desulfovibrio</span> spp. podría estar subdiagnosticado por su lento crecimiento.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754122000281?idApp=UINPBA00004N" "url" => "/03257541/0000005400000004/v1_202212150521/S0325754122000281/v1_202212150521/es/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "<span class="elsevierStyleItalic">Scedosporium aurantiacum</span>: First isolation in Argentina from a previously healthy patient after traumatic inoculation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "318" "paginaFinal" => "321" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Susana Carnovale, Carolina Epelbaum, Ruben Abrantes, Susana Córdoba, Carla Cabrera, Beatriz Caracciolo" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Susana" "apellidos" => "Carnovale" "email" => array:1 [ 0 => "susacarnov@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Carolina" "apellidos" => "Epelbaum" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ruben" "apellidos" => "Abrantes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Susana" "apellidos" => "Córdoba" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Carla" "apellidos" => "Cabrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Beatriz" "apellidos" => "Caracciolo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital de Pediatría S.A.M.I.C. “Prof. Dr. Juan P. Garrahan” Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Infectología, Hospital de Pediatría S.A.M.I.C. “Prof. Dr. Juan P. Garrahan” Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Micología, INEI-ANLIS Dr. C.G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Scedosporium aurantiacum</span>: primer aislamiento en Argentina de un paciente previamente sano después de una inoculación por un traumatismo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1035 "Ancho" => 2333 "Tamanyo" => 204322 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Scedosporium aurantiacum</span>. Sabouraud glucose agar. A. Front view. B. Reverse view.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0015" class="elsevierStylePara elsevierViewall">Species of <span class="elsevierStyleItalic">Scedosporium/Lomentospora</span> (<span class="elsevierStyleItalic">Lomentospora prolificans</span> formerly <span class="elsevierStyleItalic">Scedosporium prolificans</span>) are widely distributed in nature. They can be found in soils, sewers, standing waters, streams, especially in areas where human activity takes place.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In general they are saprophytes but they can cause opportunistic infections in immunocompromised and occasionally in immunocompetent patients, which are difficult to treat due to high levels of resistance to antifungals<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a>.</p><p id="par0025" class="elsevierStylePara elsevierViewall">It is known that they cause trauma-associated infections in healthy individuals. In immunocompromised patients, the clinical manifestations range from local infection to lung colonization and severe invasive disease with mortality rates that may exceed 80%<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a>.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Currently 11 species are acknowledged within the genus <span class="elsevierStyleItalic">Scedosporium</span>: <span class="elsevierStyleItalic">Scedosporium aurantiacum</span>, <span class="elsevierStyleItalic">Scedosporium americanum</span>, <span class="elsevierStyleItalic">Scedosporium minutisporum</span>, <span class="elsevierStyleItalic">Scedosporium desertorum</span>, <span class="elsevierStyleItalic">Scedosporium cereisporum</span>, and <span class="elsevierStyleItalic">Scedosporium dehoogii</span>, besides the <span class="elsevierStyleItalic">S. apiospermum</span> complex which comprizes <span class="elsevierStyleItalic">Scedosporium angustum</span>, <span class="elsevierStyleItalic">Scedosporium apiospermum</span>, <span class="elsevierStyleItalic">Scedosporium boydii</span>, <span class="elsevierStyleItalic">Scedosporium ellipsoideum</span> and <span class="elsevierStyleItalic">Scedosporium fusoideum</span><a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,10,14</span></a>.</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Scedosporium boydii</span> and <span class="elsevierStyleItalic">S. apiospermum</span> are the most frequently isolated species in our environment. They are among the most commonly recovered fungi from the respiratory secretions of patients with chronic lung diseases such as cystic fibrosis (CF). Lung colonization of patients with cystic fibrosis by <span class="elsevierStyleItalic">Scedosporium</span> spp. is well established and the rate ranges between 0 and 21%, being the most frequent genus after <span class="elsevierStyleItalic">Aspergillus</span> spp<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7,8</span></a>.</p><p id="par0040" class="elsevierStylePara elsevierViewall">It has been reported that the lungs, ears, and sinuses are the main sites of <span class="elsevierStyleItalic">S. aurantiacum</span> infection<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a>. In Argentina, South America, two <span class="elsevierStyleItalic">S. aurantiacum</span> isolates recovered from the sputum of patients with CF have been reported. One isolate belonged to a patient from the city of Buenos Aires who had traveled to Egypt and Europe and the other one belonged to a patient from the province of Santa Fe, Argentina<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a>. Moreover, in the United States of America, a single clinical case of <span class="elsevierStyleItalic">S. aurantiacum</span> infection in a patient with lung cancer, which was recovered from bronchoalveolar lavage fluid and lung biopsy has been reported<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a>.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Below we present the isolation and identification of <span class="elsevierStyleItalic">Scedosporium aurantiacum</span> from a 4-year-old previously healthy female patient from San Antonio de Areco (Province of Buenos Aires, Argentina), who exhibited a penetrating trauma in her left eye caused by a kitchen utensil while she was playing with a friend. After being assessed by an ophthalmologist, the patient was referred to our institution. A surgery procedure was performed on the left eye for corneal trauma. The postoperative treatment included antibacterial eyedrops, intravenous treatment and prednisolone.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ten days after the procedure, an ultrasound study was performed, confirming the presence of images compatible with inflammatory membranes and probable retinal detachment. Infectious endophthalmitis was taken into consideration.</p><p id="par0055" class="elsevierStylePara elsevierViewall">As a result of the poor evolution of the clinical picture with a marked lack of improvement in the local and systemic treatments applied, endophthalmitis of probable mycotic origin was suspected. Vitrectomy of the left eye and intravitreal injections of amphotericin and vancomycin were the treatments performed.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The vitreous humor was sent to our laboratory for mycological analysis. The fresh microscopic examination with potassium hydroxide (KOH) 40% was negative. The material was cultured in Sabouraud glucose agar (Britania S.A.) and incubated at 28<span class="elsevierStyleHsp" style=""></span>°C. The development of a filamentous fungus that was subcultivated was obtained 48<span class="elsevierStyleHsp" style=""></span>h later. After 15 days of incubation a cotton-like colony with a brown center developed. It was whitish towards the edges on the obverse and greyish brown on the reverse with a striking diffusible light yellow pigment (<a class="elsevierStyleCrossRef" href="#fig0005">Figs. 1A and B</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">With regard to micromorphology, conidiogenic cells (annelids) emerge from undifferentiated hyphae, cylindrical to slightly flask-shaped, with single-celled conidia heads, smooth-walled, sub-hyaline, ovoids or sub-cylinders compatible in shape and size with the genus <span class="elsevierStyleItalic">Scedosporium</span><a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), although these characteristics were not sufficient for identification at species level.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The isolates were sent to the Department of Mycology of INEI-ANLIS “Carlos G. Malbrán” to perform susceptibility tests and a molecular study. It was based on the sequence of the partial portion of the β-tubulin gene (<span class="elsevierStyleItalic">BT2</span>)<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4,5</span></a>. The similarity of the sequence obtained was searched in the NCBI GenBank database using the BLAST algorithm [National Center for Biotechnology Information (NCBI) Internet homepage, [<a href="http://blast.ncbi.nlm.nih.gov/Blast.cgi">http://blast.ncbi.nlm.nih.gov/Blast.cgi</a>] with automatically adjusted parameters.</p><p id="par0075" class="elsevierStylePara elsevierViewall">A BLAST search using the <span class="elsevierStyleItalic">BT2</span> sequence (584<span class="elsevierStyleHsp" style=""></span>bp) identified our strain DMic 216397 (GenBank Accession Number OK258096) as <span class="elsevierStyleItalic">Scedosporium aurantiacum</span>, showing 100% similarity, 97% coverage and an E-value of 0.0 with the <span class="elsevierStyleItalic">Scedosporium aurantiacum</span> strain CBS 101725 (GenBank Accession Number GU126389<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a>).</p><p id="par0080" class="elsevierStylePara elsevierViewall">Susceptibility tests were performed using the Reference Method M38-3er Ed. of the Clinical and Laboratory Standards Institute (CLSI)<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a>. The results of the minimum inhibitory concentrations (CIM) were the following: 8<span class="elsevierStyleHsp" style=""></span>mg/l for amphotericin B, 0.5<span class="elsevierStyleHsp" style=""></span>mg/l for itraconazole, 0.25<span class="elsevierStyleHsp" style=""></span>mg/l for voriconazole, 0.5<span class="elsevierStyleHsp" style=""></span>mg/l for posaconazole, and 2<span class="elsevierStyleHsp" style=""></span>mg/l for isavuconazole.</p><p id="par0085" class="elsevierStylePara elsevierViewall">To date, the CLSI has not yet established clinical or epidemiological cut-off points for the genus. The results obtained coincide with the data published by Heath et al.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a>, who studied 27 isolates of <span class="elsevierStyleItalic">S. aurantiacum</span> and obtained a MIC range of 2–16<span class="elsevierStyleHsp" style=""></span>mg/l for amphotericin, 0.25–2<span class="elsevierStyleHsp" style=""></span>mg/l for itraconazole, 0.03–0.5 for voriconazole and 0.125–1 for posaconazole.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Systemic antibiotic therapy with amphotericin B was initiated and after the confirmation of the etiological agent, it was decided to change to voriconazole, which led to a favorable clinical outcome<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a>.</p><p id="par0095" class="elsevierStylePara elsevierViewall">The geographical distribution of the species of the <span class="elsevierStyleItalic">Scedosporium apiospermum</span> complex is universal. <span class="elsevierStyleItalic">S. aurantiacum</span> was only reported in Australia and some European regions<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a>. It has been reported that it colonizes the airways of patients mainly in these countries where there is a large number of patients with CF<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a>. Another report describes the isolation of <span class="elsevierStyleItalic">S. aurantiacum</span> from a brain abscess in a 2011 tsunami survivor in Japan<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a>.</p><p id="par0100" class="elsevierStylePara elsevierViewall">In Australia, <span class="elsevierStyleItalic">S. aurantiacum</span> was recovered from more than 50% of the environmental isolates studied, while <span class="elsevierStyleItalic">S. apiospermum</span> and <span class="elsevierStyleItalic">S. dehoogii</span> are predominant in Austria and France, respectively.</p><p id="par0105" class="elsevierStylePara elsevierViewall">In addition, <span class="elsevierStyleItalic">S. aurantiacum</span> is characteristic of agricultural areas in western France. <span class="elsevierStyleItalic">S. boydii</span> is the most frequent species (62%) in a French cohort, followed by <span class="elsevierStyleItalic">S. apiospermum</span> (24%), <span class="elsevierStyleItalic">S. aurantiacum</span> (10%), and <span class="elsevierStyleItalic">S. minutisporum</span> (4%).</p><p id="par0110" class="elsevierStylePara elsevierViewall">In a study carried out in Germany in patients with CF, <span class="elsevierStyleItalic">S. apiospermum</span> was the most frequent species (49%) followed by <span class="elsevierStyleItalic">S. boydii</span> (29%), <span class="elsevierStyleItalic">L. prolificans</span> (12%), <span class="elsevierStyleItalic">S. aurantiacum</span> (5%) and <span class="elsevierStyleItalic">S. minutisporum</span> (5%).</p><p id="par0115" class="elsevierStylePara elsevierViewall">Conversely, <span class="elsevierStyleItalic">L. prolificans</span> was the most frequent species isolated in patients with CF in northern Spain. In Australia, the most frequent species appears to be <span class="elsevierStyleItalic">S. aurantiacum</span> followed by <span class="elsevierStyleItalic">L. prolificans</span> and <span class="elsevierStyleItalic">S. apiospermum</span>.</p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Scedosporium</span> species can cause keratitis in immunocompetent hosts usually after corneal trauma with a clinical presentation similar to other types of keratitis.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Endophthalmitis has also been described in immunocompetent individuals secondary to surgery, traumatic inoculation, intravenous drug addiction and contiguous extension from an adjacent site<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a>.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Mycological diagnosis in these cases is classically based on direct microscopic examination with KOH from clinical samples and culture in appropriate media. On microscopic examination, however, the hyaline and branched hyphae are similar to those of the genera <span class="elsevierStyleItalic">Aspergillus</span> or <span class="elsevierStyleItalic">Fusarium</span>.</p><p id="par0135" class="elsevierStylePara elsevierViewall">The identification of species of the genus <span class="elsevierStyleItalic">Scedosporium</span> is often difficult to carry out due to the similarity of their morphological characteristics. Currently, molecular or matrix-assisted laser identification by desorption/ionization time of flight mass spectrometry (MALDI-TOF/MS) is mandatory for reliable identification.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Nucleotide sequence-based analysis is the gold standard for the identification of these fungi. Sequencing of rDNA ITS regions allows the proper identification of the main species of <span class="elsevierStyleItalic">Scedosporium/Lomentospora</span> while the β-tubulin partial gene (<span class="elsevierStyleItalic">BT2</span>) is necessary to differentiate closely related species<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a>.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Isolates of <span class="elsevierStyleItalic">Scedosporium/Lomentospora</span> present limited susceptibility to all current antifungal drugs. Species of <span class="elsevierStyleItalic">Scedosporium</span> are resistant to 5-flucytosine and amphotericin B, as well as to first-generation triazoles, fluconazole and itraconazole.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In addition, they have reduced susceptibility to equinocandins, in particular to caspofungin and anidulafungin. Voriconazole proved to be the most effective antifungal in the treatment against <span class="elsevierStyleItalic">Scedosporium</span> spp<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9,11</span></a> and the European guidelines recommend it as a first-line drug for treatment along with surgery, when it is possible to perform it<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a>.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Although several cases of traumatic <span class="elsevierStyleItalic">Scedosporium</span> spp. infections have been documented in our region, no cases of <span class="elsevierStyleItalic">S.aurantiacum</span> have been reported so far<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a>.</p><p id="par0160" class="elsevierStylePara elsevierViewall">This is the first report in Argentina and the Americas of an isolation of <span class="elsevierStyleItalic">S. aurantiacumin</span> from a previously healthy patient with a traumatic infection without a history of previous trips abroad.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conflict of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:3 [ "identificador" => "xres1819645" "titulo" => "Highlights" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:3 [ "identificador" => "xres1819646" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1588119" "titulo" => "Keywords" ] 3 => array:3 [ "identificador" => "xres1819647" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0015" ] ] ] 4 => array:2 [ "identificador" => "xpalclavsec1588120" "titulo" => "Palabras clave" ] 5 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 6 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-05-25" "fechaAceptado" => "2022-02-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1588119" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Scedosporium aurantiacum</span>" 1 => "Argentina" 2 => "Endophthalmitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1588120" "palabras" => array:3 [ 0 => "<span class="elsevierStyleItalic">Scedosporium aurantiacum</span>" 1 => "Argentina" 2 => "Endoftalmitis" ] ] ] ] "tieneResumen" => true "highlights" => array:2 [ "titulo" => "Highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall">First case of <span class="elsevierStyleItalic">S. aurantiacum</span> in our country from a pediatric patient.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">Improved methods are necessary for the identification of species of this genus.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0170" class="elsevierStylePara elsevierViewall">Voriconazole proved to be most effective antifungal in the treatment and led to a favorable clinical outcome.</p></li></ul></p></span>" ] "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Scedosporium/Lomentospora</span> species are widely distributed in nature. They are generally saprophytes, but can cause opportunistic infections in immunocompromised patients and occasionally in immunocompetent patients that are difficult to treat due to high levels of antifungal resistance. The distribution of <span class="elsevierStyleItalic">Scedosporium/Lomentospora</span> species shows regional differences. <span class="elsevierStyleItalic">Scedosporium boydii and Scedosporium apiospermum</span> are the most frequently isolated species in our region, whereas <span class="elsevierStyleItalic">Scedosporium aurantiacum</span> is more common in other regions. We describe the first isolation in Argentina of <span class="elsevierStyleItalic">S. aurantiacum</span> in a vitreous humor infection from a previously healthy patient after traumatic injury in her left eye. Due to the suspicion of fungal endophthalmitis, a mycological study of the vitreous humor was performed. The culture allowed the isolation of <span class="elsevierStyleItalic">S</span>. <span class="elsevierStyleItalic">aurantiacum</span>. The patient was treated with voriconazole with favorable clinic evolution<span class="elsevierStyleBold">.</span></p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las especies de <span class="elsevierStyleItalic">Scedosporium/Lamentospora</span> se encuentran ampliamente distribuidas en la naturaleza. En general son saprófitas, pero pueden causar infecciones oportunistas de difícil tratamiento debido a sus altos niveles de resistencia a los antifúngicos en individuos inmunocomprometidos y, ocasionalmente, en personas inmunocompetentes. La distribución de las especies de <span class="elsevierStyleItalic">Scedosporium/Lamentospora</span> muestra diferencias regionales. <span class="elsevierStyleItalic">Scedosporium boydii</span> y <span class="elsevierStyleItalic">S. apiospermum</span> son las especies más frecuentemente aisladas en nuestra región, mientras que en otras <span class="elsevierStyleItalic">S. aurantiacum</span> es más común. Presentamos el primer aislamiento en Argentina de <span class="elsevierStyleItalic">S. aurantiacum</span> de una infección de humor vítreo de un paciente previamente sano que sufrió una lesión traumática. El paciente fue tratado con voriconazol y tuvo una evolución clínica favorable.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Co-author.</p>" "identificador" => "fn0005" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1035 "Ancho" => 2333 "Tamanyo" => 204322 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Scedosporium aurantiacum</span>. Sabouraud glucose agar. A. Front view. B. Reverse view.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1084 "Ancho" => 1084 "Tamanyo" => 104225 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lactophenol cotton blue stain of <span class="elsevierStyleItalic">Scedosporium aurantiacum</span>. Conidiogenous cells, producing ovoid-shaped conidia, either individually or in small groups.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Scedosporium</span> spp. from clinical setting in Argentina with proposal of the new pathogenic species <span class="elsevierStyleItalic">Scedosporium americanum</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "R. Abrantes" 1 => "N. Refojo" 2 => "A. Hevia" 3 => "J. Fernandez" 4 => "G. Isla" 5 => "S. Cordoba" 6 => "M.F. Davalos" 7 => "S. Lubovich" 8 => "I. Maldonado" 9 => "G. Davel" 10 => "A. 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Year/Month | Html | Total | |
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2024 November | 1 | 0 | 1 |
2024 October | 57 | 9 | 66 |
2024 September | 70 | 6 | 76 |
2024 August | 53 | 3 | 56 |
2024 July | 54 | 7 | 61 |
2024 June | 55 | 15 | 70 |
2024 May | 20 | 9 | 29 |
2024 April | 34 | 9 | 43 |
2024 March | 47 | 8 | 55 |
2024 February | 57 | 5 | 62 |
2024 January | 56 | 12 | 68 |
2023 December | 55 | 16 | 71 |
2023 November | 68 | 13 | 81 |
2023 October | 79 | 17 | 96 |
2023 September | 86 | 8 | 94 |
2023 August | 48 | 12 | 60 |
2023 July | 65 | 14 | 79 |
2023 June | 57 | 14 | 71 |
2023 May | 59 | 19 | 78 |
2023 April | 46 | 6 | 52 |
2023 March | 49 | 15 | 64 |
2023 February | 40 | 14 | 54 |
2023 January | 33 | 15 | 48 |
2022 December | 46 | 17 | 63 |
2022 November | 38 | 22 | 60 |
2022 October | 14 | 18 | 32 |
2022 September | 12 | 23 | 35 |
2022 August | 13 | 18 | 31 |
2022 July | 12 | 7 | 19 |
2022 June | 21 | 16 | 37 |
2022 May | 3 | 0 | 3 |