was read the article
array:23 [ "pii" => "S0325754123000251" "issn" => "03257541" "doi" => "10.1016/j.ram.2023.02.003" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "539" "copyright" => "Asociación Argentina de Microbiología" "copyrightAnyo" => "2023" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2023;55:272-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0325754123000214" "issn" => "03257541" "doi" => "10.1016/j.ram.2023.01.006" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "535" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2023;55:278-88" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>" "titulo" => "Statin and aspirin use in parasitic infections as a potential therapeutic strategy: A narrative review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "278" "paginaFinal" => "288" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Uso de estatinas y aspirina en infecciones parasitarias como potencial estrategia terapéutica: Una revisión narrativa" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Valentina Burgess, Juan D. Maya" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Valentina" "apellidos" => "Burgess" ] 1 => array:2 [ "nombre" => "Juan D." "apellidos" => "Maya" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall">Aspirin or statins through pro-resolving lipids may improve inflammation in parasitosis.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">Statins in cerebral malaria reduce mortality in murine models of infection.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">In toxoplasmosis, statin use is controversial, although it decreases cytokines.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0020" class="elsevierStylePara elsevierViewall">In leishmaniasis, statins decrease local inflammation.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">•</span><p id="par0025" class="elsevierStylePara elsevierViewall">In Chagas disease, aspirin or statins decrease cardiac inflammation in murine models.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754123000214?idApp=UINPBA00004N" "url" => "/03257541/0000005500000003/v1_202309280755/S0325754123000214/v1_202309280755/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0325754123000226" "issn" => "03257541" "doi" => "10.1016/j.ram.2023.01.007" "estado" => "S300" "fechaPublicacion" => "2023-07-01" "aid" => "536" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2023;55:262-71" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Enterotoxigenic profiles and submerged and interface biofilms in <span class="elsevierStyleItalic">Bacillus cereus</span> group isolates from foods" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "262" "paginaFinal" => "271" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Perfiles enterotoxigénicos y biopelículas de superficie y sumergidas en aislados del grupo <span class="elsevierStyleItalic">Bacillus cereus</span> de alimentos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 910 "Ancho" => 1675 "Tamanyo" => 119615 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Biofilm production in different materials and by source isolation at 37<span class="elsevierStyleHsp" style=""></span>°C with O<span class="elsevierStyleInf">2</span>. (a) Biofilm production of <span class="elsevierStyleItalic">B cereus</span> group strains in different materials and (b) from source isolation: light blue circles, powered infant formula; gray squares, surfaces; orange triangles, infant food; purple triangles, eggshell. *<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>0.05, ****<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>≤<span class="elsevierStyleHsp" style=""></span>0.0001. In the <span class="elsevierStyleItalic">X</span> axis are the materials and, in the <span class="elsevierStyleItalic">Y</span>, the specific biofilm formation (SBF). Top Kruskal–Wallis post hoc Dunn's. Lower ANOVA.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Itzel-Maralhi Cruz-Facundo, Roberto Adame-Gómez, Natividad Castro-Alarcón, Jeiry Toribio-Jiménez, Yaneth Castro-Coronel, María-Cristina Santiago-Dionisio, Marco-Antonio Leyva-Vázquez, David Tafolla-Venegas, Arturo Ramírez-Peralta" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Itzel-Maralhi" "apellidos" => "Cruz-Facundo" ] 1 => array:2 [ "nombre" => "Roberto" "apellidos" => "Adame-Gómez" ] 2 => array:2 [ "nombre" => "Natividad" "apellidos" => "Castro-Alarcón" ] 3 => array:2 [ "nombre" => "Jeiry" "apellidos" => "Toribio-Jiménez" ] 4 => array:2 [ "nombre" => "Yaneth" "apellidos" => "Castro-Coronel" ] 5 => array:2 [ "nombre" => "María-Cristina" "apellidos" => "Santiago-Dionisio" ] 6 => array:2 [ "nombre" => "Marco-Antonio" "apellidos" => "Leyva-Vázquez" ] 7 => array:2 [ "nombre" => "David" "apellidos" => "Tafolla-Venegas" ] 8 => array:2 [ "nombre" => "Arturo" "apellidos" => "Ramírez-Peralta" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Highlights" "clase" => "author-highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall">We observe in the strains from foods a higher production of biofilms in PVC.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall">In the BHI broth, no submerged biofilms were found.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">The enterotoxin profile most common includes genes for the three enterotoxins.</p></li></ul></p></span>" ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754123000226?idApp=UINPBA00004N" "url" => "/03257541/0000005500000003/v1_202309280755/S0325754123000226/v1_202309280755/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "<span class="elsevierStyleItalic">Ureaplasma diversum</span>–<span class="elsevierStyleItalic">Ureaplasma</span> sp. alone or concomitantly with <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> in pig lungs with and without pneumonia: A descriptive exploratory study in abattoirs" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "272" "paginaFinal" => "277" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jimena Seitz, Claudina Vissio, Judith Bertone, Lucas Marques, Julián Parada, Alicia Carranza, Gabriel Di Cola, Roberto Ambrogi, Pablo Tamiozzo" "autores" => array:9 [ 0 => array:3 [ "nombre" => "Jimena" "apellidos" => "Seitz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Claudina" "apellidos" => "Vissio" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Judith" "apellidos" => "Bertone" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Lucas" "apellidos" => "Marques" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Julián" "apellidos" => "Parada" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Alicia" "apellidos" => "Carranza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Gabriel" "apellidos" => "Di Cola" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 7 => array:3 [ "nombre" => "Roberto" "apellidos" => "Ambrogi" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 8 => array:4 [ "nombre" => "Pablo" "apellidos" => "Tamiozzo" "email" => array:1 [ 0 => "ptamiozzo@ayv.unrc.edu.ar" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Departamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Córdoba, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto para el Desarrollo Agroindustrial y de Salud (IDAS), CONICET-Universidad Nacional de Río Cuarto, Córdoba, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Multidisciplinary Institute of Health, Universidade Federal da Bahia, Vitória da Conquista, Brazil" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Instituto Ciencias Veterinarias (INCIVET), CONICET-Universidad Nacional de Río Cuarto, Córdoba, Argentina" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Presencia de <span class="elsevierStyleItalic">Ureaplasma diversum</span>-<span class="elsevierStyleItalic">Ureaplasma</span> sp. solo o junto con <span class="elsevierStyleItalic">Mycoplasma</span> <span class="elsevierStyleItalic">hyopneumoniae</span> en pulmones de cerdos con y sin neumonía: un estudio exploratorio descriptivo en frigorífico" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma diversum</span> (<span class="elsevierStyleItalic">U. diversum</span>) is considered one of the most important members of the family <span class="elsevierStyleItalic">Mycoplasmataceae</span> causing reproductive failure in cattle. <span class="elsevierStyleItalic">U. diversum</span> has also been detected in pneumonic cattle<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a>. In pigs, it was first detected in animals with and without pneumonia<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,2</span></a> and recently in nasal swabs of live pigs<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a>. However, there is a lack of information on this microorganism with regard to its distribution and participation in the multifactorial porcine respiratory disease complex (PRDC). While <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> (<span class="elsevierStyleItalic">M. hyopneumoniae</span>) is the primary agent of the PRDC, co-infections with other pathogens such as viruses and bacteria are frequent<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a>. Although the concomitant presence of <span class="elsevierStyleItalic">M. hyopneumoniae</span> with other <span class="elsevierStyleItalic">Mycoplasma</span> species, including <span class="elsevierStyleItalic">Mycoplasma hyorhinis</span> (<span class="elsevierStyleItalic">M. hyorhinis</span>) and <span class="elsevierStyleItalic">Mycoplasma flocculare</span> has been reported<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5,7</span></a>, there has been scant confirmatory evidence of the important role of these <span class="elsevierStyleItalic">Mollicutes</span> in <span class="elsevierStyleItalic">M. hyopneumoniae</span> infections. Furthermore, recent swine lung microbiome studies have demonstrated that members of the family <span class="elsevierStyleItalic">Mycoplasmataceae</span> are one of the most common microbial families in pig lungs with and without pneumonia<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a>. Although other <span class="elsevierStyleItalic">Ureaplasma</span> species, such as <span class="elsevierStyleItalic">Ureaplasma parvum</span> and <span class="elsevierStyleItalic">Ureaplasma urealyticum</span>, have been detected in pig lungs<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a>, there are only limited reports of the presence of <span class="elsevierStyleItalic">U. diversum</span> with other <span class="elsevierStyleItalic">Mollicutes</span> in pneumonic pig lungs<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,2</span></a>. The objectives of this study were: (i) to detect <span class="elsevierStyleItalic">U. diversum</span> in abattoir-collected pig lungs at the individual and herd level and (ii) to determine the concomitant presence of <span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A cross-sectional study was conducted in five abattoirs involving eight Argentinian herds (1–8) from three provinces (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The main characteristics of the herds, such as type of system, size (number of sows) and main aspects of health management are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Lung samples were collected using systematic random selection procedures where the first unit is randomly selected followed by selection at equal intervals. The herd sample size was set in 20, 40 and 60 lungs for herds with less than 500 sows, between 500 and 1000 sows, and more than 1000 sows, respectively. Each lung was grossly inspected for enzootic pneumonia (EP)-like lesions. Briefly, looking for purple to grey areas of pulmonary consolidation, located in the apical, intermediate, accessory and cranial parts of the diaphragmatic lobes<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a>. Then, the type of pneumonia was determined by histopathological examination. For each inspected lung two specimens were collected using the following criteria: if the lung showed any macroscopic lesion compatible with EP-like pneumonia, a BAL sample (for PCR) and a piece of lung (for histopathological examination, in 10% buffered formalin) were collected for the affected lobe. Each BAL specimen was collected by a cut made in the affected lobe and a sterile 3<span class="elsevierStyleHsp" style=""></span>ml plastic pipette with sterile saline was introduced into the secondary or tertiary bronchi adjacent to the lesion. In case no gross lesions were detected, the specimens were collected from the right middle lobe. For the histopathological analysis, lung tissues were formalin-fixed, paraffin wax embedded and haematoxylin and eosin (H–E) stained. To determine EP-compatible lesions, each sample was graded from 0 to 4, according to the criteria described by Calsamiglia et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a>. Lesions scoring 1–2 were considered nonspecific pneumonias and 3–4 were considered to be compatible with EP. DNA from 280 BAL samples was extracted using the commercial Puri-Prep S kit (Inbio-Highway, Argentina) according to the manufacturer's instructions. For both, <span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span> detection, species-specific nested PCRs were performed under the conditions reported by Cardoso et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> and Calsamiglia et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a>, respectively. Considering that Cardoso et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> reported a specificity of 73.1% using this PCR in bovine samples and in order to verify the specificity of this reaction within pig lung samples, two <span class="elsevierStyleItalic">U. diversum</span> PCR positive samples from each herd were randomly selected for sequencing. The 18 PCR products obtained were purified (Puriprep-GP Kit, Inbio Highway), quantified and sequenced (ABI 3130xl; Applied Biosystems) using the inner primers described by the authors<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a>. The sequences were curated using the BioEdit software<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> and aligned using Clustal Omega software to obtain a consensus sequence (along with other sequences obtained from nasal swabs specimens from pigs)<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a>. Then, the consensus sequence was aligned against the database using nucleotide BLAST (<a href="http://www.ncbi.nlm.nih.gov/blast">http://www.ncbi.nlm.nih.gov/blast</a>) excluding environmental sample sequences. The proportion of positive pigs was based on the number of PCR-positive specimens for <span class="elsevierStyleItalic">M. hyopneumoniae</span>, <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> or both, among the number of analyzed samples. Herds were classified as positive if at least one specimen rendered a positive result, and negative if all specimens were negative. The proportion of positive herds was based on the number of positive results among the total number of analyzed herds. The positive pig distribution among the type of microscopic lung was described. A contingency table and a test of independence based on a chi-square distribution was used with the level of significance set at 0.05.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M. hyopneumoniae</span> and <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> were detected in 29.3% (95% CI 24.0–34.6) and 17.1% (95% CI 12.7–21.6) of the analyzed BAL specimens, respectively. The concomitant presence of both microorganisms was detected in 12.5% (95% CI 8.6–16.4) of pig lungs. All herds were positive for at least one of the evaluated specimens; in all herds <span class="elsevierStyleItalic">M. hyopneumoniae</span> was detected alone or in combination with <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span>, while <span class="elsevierStyleItalic">U. diversum</span> was detected in 7 out of the 8 herds. The proportion of positive pigs in each herd ranged between 40% and 90%. <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the proportions of PCR positives for <span class="elsevierStyleItalic">M. hyopneumoniae</span> alone, <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> alone or mixed detection and the proportion of macroscopic and microscopic lung lesions. The 16S ribosomal RNA consensus sequence obtained – 173 pb – (GenBank accession number ON059750) showed 100% similarity with the same region of <span class="elsevierStyleItalic">U. diversum</span> strains ATCC 49782 (<a href="ncbi-n:CP009770.1">CP009770.1</a>: <a href="ncbi-n:GU227397.1">GU227397.1</a>), T95 (<a href="ncbi-n:JN935894.1">JN935894.1</a>), ATCC 49783 (<a href="ncbi-n:GU227398.1">GU227398.1</a>) and A417 (NR_025878.1), and <span class="elsevierStyleItalic">Ureaplasma</span> sp. strains USP45 (<a href="ncbi-n:GU227392.1">GU227392.1</a>), USP4 (<a href="ncbi-n:GU227390.1">GU227390.1</a>), USP3012 (<a href="ncbi-n:GU227389.1">GU227389.1</a>) and USP47 (<a href="ncbi-n:GU227388.1">GU227388.1</a>). Among the 280 lungs examined, 125 (44.6%) and 110 (39.3%) had no macroscopic and microscopic lesions of pneumonia respectively. Of the 170 lungs with microscopic lesions, 66 (38.8%; 95% CI 31.2–46.4) were diagnosed as EP-like lesions (scored as 3–4) and 104 (61.2%; 95% CI 53.6–68.8) as nonspecific pneumonias, scored as 1–2 (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the proportion of each type of pneumonia diagnosed by histopathological examination for all PCR results from the BAL specimens; from the data, there is sufficient evidence to conclude that the histopathological diagnosis and PCR results are dependent on each other. Among the lungs diagnosed as EP-like lesions, an overlap of the confidence intervals was observed, indicating that there were no differences between the proportion of diagnoses by PCR, while among the lungs diagnosed as nonspecific lesions the proportion of PCR positives for <span class="elsevierStyleItalic">M. hyopneumoniae</span> alone was higher than for <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> alone or mixed detection.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The nested PCR used in this study for <span class="elsevierStyleItalic">U. diversum</span> detection was developed and originally tested in clinical specimens from bovines with a specificity of about 73%<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a>. The obtained sequencing and alignment results showed that their specificity was not enough for the identification of <span class="elsevierStyleItalic">U. diversum</span>, since other close-related <span class="elsevierStyleItalic">Ureaplasma</span> species could be detected. Other specific molecular techniques should be used in future studies for specific <span class="elsevierStyleItalic">U. diversum</span> detection. Despite this fact, there are no antecedents in the literature about the detection of <span class="elsevierStyleItalic">U. diversum</span> and other close-related species in pig lungs at herd level. Given the low sensitivity of culture and the availability of PCR in our laboratory, we did not attempt a culture of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> in this study but relied on molecular diagnostics to confirm their presence in the BAL samples. <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> were detected in BAL fluid from lungs of approximately 17% of finisher pigs of slaughter age, a proportion greater than that previously reported in pigs from Cuba and Canada, with 6.6% and 3.85%, respectively<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,2</span></a>. It is important to note here that the positive proportion of both, <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span>, might be overestimated, considering that the scalding tank has been highlighted as a critical point of cross contamination during the slaughtering process<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a>. However, we recently estimated a prevalence of 16.5% of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> in nasal swabs specimens from 6–8 and 15–22 weeks-old pigs<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a>. These results might indicate, that a similar proportion of pigs carry <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> at different sites in the respiratory tract and at different ages. Further studies are needed to understand this phenomenon. On the one hand, the evaluation of lung lesions in abattoirs is limited because it only identifies chronic (or recent) lung lesions at the end of the production period and does not provide any information regarding the evolution of respiratory diseases in younger pigs<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a>. On the other hand, a limitation of gross lung lesion evaluation in abattoirs is that other agents may also cause macroscopic lesions similar to those induced by mycoplasmas<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10,12</span></a>. Thus, a histological examination is important in lesion characterization. With regard to microscopic lesions, BALT hyperplasia has so far been associated with <span class="elsevierStyleItalic">M. hyopneumoniae</span> and <span class="elsevierStyleItalic">M. hyorhinis</span><a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7,12</span></a> in spite of the fact that the role of <span class="elsevierStyleItalic">M. hyorhinis</span> in the PRDC is still controversial<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5,7</span></a>. In this case, only <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> were detected in 27.3% of EP-like lesions (scored as 3–4). Furthermore, negative PCR results were obtained in 25.8% of EP-like lesions. Not having searched for <span class="elsevierStyleItalic">M. hyorhinis</span> is a limitation of this study. However, a putative relationship between the presence of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> with lung lesions cannot be strictly ruled out, especially considering previous findings in which <span class="elsevierStyleItalic">U. diversum</span> has been detected in lungs with EP-like lesions<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a>. Experimental studies should be conducted to confirm if <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> can produce chronic lung inflammation, resulting in BALT hyperplasia. Our second objective, to determine the concomitant presence of <span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span>, resulted in evidence of mixed infection in almost 13% of BAL samples. This is an important finding since there are scarce antecedents about the presence of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> together with other <span class="elsevierStyleItalic">Mollicutes</span><a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a>. However, this type of mixed infection would not be rare, mainly due to the abundance of <span class="elsevierStyleItalic">Ureaplasma</span> and other <span class="elsevierStyleItalic">Mollicute</span> species within the pig lungs<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5,7,13</span></a>. While pathogenic mechanisms of <span class="elsevierStyleItalic">U. diversum</span> in pigs remain unknown, there are already antecedents of the presence of the agent associated with lung lesions in other species. Human <span class="elsevierStyleItalic">Ureaplasma</span> sp. closely related to <span class="elsevierStyleItalic">U. diversum</span> are capable of causing pneumonia<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a>, and <span class="elsevierStyleItalic">U. diversum</span> has been detected in pneumonic calves<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a>. In pigs with pneumonia, not only <span class="elsevierStyleItalic">U. diversum</span> but also other species of the genus <span class="elsevierStyleItalic">Ureaplasma</span> have been detected<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,13</span></a>. The identification of surface molecules and capsular material involved in the interaction of <span class="elsevierStyleItalic">U. diversum</span> with the host, and virulence factors including the <span class="elsevierStyleItalic">Mycoplasma</span> immunoglobulin binding/<span class="elsevierStyleItalic">Mycoplasma</span> immunoglobulin protease (MIB-MIP) system<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a>, most of them also present in <span class="elsevierStyleItalic">M. hyopneumoniae</span>, suggest that this organism has a pathogenic potential. This descriptive exploratory study provides information that can be used to design experimental and field-based studies to better define the pathogenic role of this organism within the PRDC.</p><p id="par0040" class="elsevierStylePara elsevierViewall">This study represents a comprehensive investigation of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> presence in pig lungs at the individual and herd level. The concomitant presence of <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> with <span class="elsevierStyleItalic">M. hyopneumoniae</span> was demonstrated in BAL, being the first study to investigate such an association on a large field-based scale.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None reported.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres1976950" "titulo" => "Highlights" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:3 [ "identificador" => "xres1976951" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec1700522" "titulo" => "Keywords" ] 3 => array:3 [ "identificador" => "xres1976952" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0015" ] ] ] 4 => array:2 [ "identificador" => "xpalclavsec1700523" "titulo" => "Palabras clave" ] 5 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 6 => array:2 [ "identificador" => "xack692871" "titulo" => "Acknowledgements" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-03-29" "fechaAceptado" => "2023-02-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1700522" "palabras" => array:5 [ 0 => "Pigs" 1 => "Porcine respiratory disease complex" 2 => "Enzootic pneumonia-like lesion" 3 => "<span class="elsevierStyleItalic">Ureaplasma</span> sp." 4 => "<span class="elsevierStyleItalic">Ureaplasma diversum</span>: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1700523" "palabras" => array:6 [ 0 => "Cerdos" 1 => "Complejo de enfermedad respiratoria porcina" 2 => "Lesión compatible con neumonía enzoótica" 3 => "<span class="elsevierStyleItalic">Ureaplasma</span> sp." 4 => "<span class="elsevierStyleItalic">Ureaplasma diversum</span>" 5 => "<span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>" ] ] ] ] "tieneResumen" => true "highlights" => array:2 [ "titulo" => "Highlights" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">Ureaplasma diversum</span> were detected in 17.1% of pig lungs.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span> were detected in 12.5% of lungs.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0015" class="elsevierStylePara elsevierViewall">In the 27.3% of EP-like lesions <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">Ureaplasma diversum</span> were detected.</p></li></ul></p></span>" ] "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Occurrence of <span class="elsevierStyleItalic">Ureaplasma diversum</span> (<span class="elsevierStyleItalic">U. diversum</span>) has been associated with reproductive failures in cattle and detected in pigs with and without pneumonia. However, its role in the porcine respiratory disease complex (PRDC) is unclear. A cross-sectional study was conducted in abattoirs, inspecting 280 pig lungs from eight herds. All the lungs were inspected, processed and classified according to the histopathological analysis. Moreover, bronchoalveolar lavage (BAL) specimens were collected and processed by PCR for detection of <span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> (<span class="elsevierStyleItalic">M. hyopneumoniae</span>). <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span> were detected in 17.1% and 29.3% of the analyzed BAL specimens, respectively. The concomitant presence of both microorganisms was detected in 12.5% of the inspected lungs. Both agents were found in lungs with and without pneumonia. <span class="elsevierStyleItalic">M. hyopneumoniae</span> was detected in 31.8% of pig lungs with enzootic pneumonia-like lesions, while <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> was detected in 27.5% of lungs with these lesions. This descriptive exploratory study provides information for future experimental and field-based studies to better define the pathogenic role of this organism within the PRDC.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La presencia de <span class="elsevierStyleItalic">Ureaplasma diversum</span> se ha asociado a fallas reproductivas en el ganado bovino y se ha detectado en cerdos con y sin neumonía. Sin embargo, su participación en el complejo de enfermedades respiratorias porcinas (CERP) no es clara. Se llevó a cabo un estudio transversal en matadero, inspeccionando 280 pulmones de cerdo provenientes de ocho piaras. Todos los pulmones fueron inspeccionados, procesados y clasificados según el análisis histopatológico. También se colectaron muestras de lavado broncoalveolar (LBA) y se procesaron mediante PCR para la detección de <span class="elsevierStyleItalic">U. diversum</span> y <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>. <span class="elsevierStyleItalic">Ureaplasma</span> sp.-<span class="elsevierStyleItalic">U. diversum</span> y <span class="elsevierStyleItalic">M. hyopneumoniae</span> se detectaron en el 17,1% y en el 29,3% de los LBA analizados, respectivamente. La presencia concomitante de ambos microorganismos se detectó en el 12,5% de los pulmones inspeccionados. Ambos agentes se encontraron en pulmones con y sin neumonía. <span class="elsevierStyleItalic">M. hyopneumoniae</span> se detectó en el 31,8% de los pulmones con lesiones compatibles con neumonía enzoótica, mientras que <span class="elsevierStyleItalic">Ureaplasma</span> sp.-<span class="elsevierStyleItalic">U. diversum</span> se detectó en el 27,5% de los pulmones con estas lesiones. Este estudio exploratorio descriptivo proporciona información para futuros estudios experimentales y de campo tendentes a definir mejor el papel patógeno de este organismo dentro del CERP.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Vaccination schedules and antibiotic treatments of piglets are described in greater detail. For sows, only the vaccines used are described.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">PCV2: Porcine Circovirus type 2; wks old: weeks old.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Herd \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Size and characteristics \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Location (province) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Main health and management aspects \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, two-site, 2900-sow, commercial herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">San Luis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: Parvovirus-leptospirosis-<span class="elsevierStyleItalic">Erysipelothrix rhusopathiae</span>, <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>, atrophic rhinitis and Glässer's disease.Pig vaccination: PCV2 at 3 wks old.Free of Aujeszky's disease, brucellosis, influenza and <span class="elsevierStyleItalic">A. pleuropneumoniae</span>.<span class="elsevierStyleItalic">Pasteurella multocida</span> and <span class="elsevierStyleItalic">Streptococcus suis</span> endemic.In growers, strategic in-feed medication with 100<span class="elsevierStyleHsp" style=""></span>ppm tiamulin (Denagard® 80% premix, Elanco, Argentina) and 300<span class="elsevierStyleHsp" style=""></span>ppm chlortetracycline (Diclortet® 15% premix, Elanco, Argentina) for two weeks at 6 wks old \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, three-site, 1100-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Córdoba \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: Parvovirus-leptospirosis-<span class="elsevierStyleItalic">Erysipelothrix rhusopathiae</span>, atrophic rhinitis, <span class="elsevierStyleItalic">A. pleuropneumoniae</span> and Glässer's disease.Pig vaccination: PCV2 and <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 wks old; <span class="elsevierStyleItalic">A. pleuropneumoniae</span> at 6 and 9 wks old.Free of Aujeszky's disease and brucellosis.<span class="elsevierStyleItalic">Pasteurella multocida</span> and <span class="elsevierStyleItalic">Streptococcus suis</span> endemic.In growers, strategic in-feed medication with generic antibiotics at 12–16 wks old (100<span class="elsevierStyleHsp" style=""></span>ppm tiamulin and 300<span class="elsevierStyleHsp" style=""></span>ppm chlortetracycline) and at 16–20 wks old (50<span class="elsevierStyleHsp" style=""></span>ppm tylosin) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one site, 550 sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Córdoba \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: Parvovirus-leptospirosis-<span class="elsevierStyleItalic">Erysipelothrix rhusopathiae</span>Pig vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 and 6 wks old.Free of Aujeszky's disease and brucellosis<span class="elsevierStyleItalic">Pasteurella multocida</span>, <span class="elsevierStyleItalic">Streptococcus suis</span> and PCV2 diagnosedIn growers, strategic in-feed medication at 3–5, 11–13, and 14–16 wks old (100<span class="elsevierStyleHsp" style=""></span>ppm tiamulin, Denagard® 80% premix, Elanco, Argentina and 50<span class="elsevierStyleHsp" style=""></span>ppm tylvalosin, Aivlosin®, 62.5% premix ECO Animal Health) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one-site, 500-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Córdoba \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: Parvovirus-leptospirosis-<span class="elsevierStyleItalic">Erysipelothrix rhusopathiae</span>Pig vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 wks oldFree of Aujeszky's disease and brucellosis<span class="elsevierStyleItalic">Pasteurella multocida</span>, <span class="elsevierStyleItalic">Streptococcus suis</span> and PCV2 diagnosedIn growers, strategic in-feed medication at 3–5, 11–13 and 14–16 wks old (100<span class="elsevierStyleHsp" style=""></span>ppm tiamulin, Denagard® 80% premix, Elanco, Argentina and 50<span class="elsevierStyleHsp" style=""></span>ppm tylvalosin – Aivlosin®, 62.5% premix ECO Animal Health) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one-site, 120-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mendoza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>Pig vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 wks old.Free of Aujeszky's disease and brucellosis<span class="elsevierStyleItalic">Pasteurella multocida</span> and <span class="elsevierStyleItalic">Streptococcus suis</span> endemic.In growers, strategic in-feed medication with generic antibiotics at 7–9 wks old (300<span class="elsevierStyleHsp" style=""></span>ppm chlortetracycline) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one-site, 110-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mendoza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sow vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>Pig vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 wks old.Free of Aujeszky's disease and brucellosis<span class="elsevierStyleItalic">Pasteurella multocida</span> and <span class="elsevierStyleItalic">Streptococcus suis</span> endemic.In growers, strategic in-feed medication with generic antibiotics at 11–13 wks old (300<span class="elsevierStyleHsp" style=""></span>ppm chlortetracycline) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one-site, 100-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mendoza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Free of Aujeszky's disease and brucellosis<span class="elsevierStyleItalic">Pasteurella multocida</span> diagnosed.No vaccinationIn growers, strategic in-feed medication with generic antibiotic at 6–8 wks old (100<span class="elsevierStyleHsp" style=""></span>ppm of tiamulin) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Indoor, one-site, 300-sow, commercial farrow-to-finish herd \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mendoza \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pig vaccination: <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> at 3 wks and 6 wks oldFree of Aujeszky's disease, brucellosisNo antibiotic treatment \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3290893.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Description of study herds, showing production type, number of sows, location and main health and management aspects.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Herd \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lung pathology (%; 95% CI)</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PCR positive (%; 95% CI)</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Macroscopic EP-like lesions \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Microscopic lesions (scored 1–4) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">M. hyopneumoniae</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">U. diversum–Ureaplasma</span> spp. \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">U. diversum–Ureaplasma</span> spp. and <span class="elsevierStyleItalic">M. hyopneumoniae</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38/60(63.3; 50.3–76.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41/60(68.3; 55.7–80.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19/60(31.7; 19.9–43.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/60(1.7; −1.6–4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9/60(15; 6–24) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21/60(35; 22–47.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23/60(38.3; 25.2–51.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/60(21.7; 11.2–32.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/60(10; 2.4–17.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/60(8.3; 1.3–15.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17/40(42.5; 25.9–59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19/40(47.5; 30.7–64.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/40(2.5; −2.3–7.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20/40(50; 34.5–65.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/40(37.5; 22.5–52.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/40(70; 54.5–85.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28/40(70; 54.5–85.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/40(37.5; 22.5–52.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/40(0; 0–0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/40(2.5; −2.3–7.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/20(65; 40.7–84.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/20(75; 50.9–91.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/20(20; 2.5–37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/20(30; 9.9–50.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/20(15; −0.6–30.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10/20(50; 25.6–74.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/20(65; 40.7–84.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18/20(90; 76.9–103.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/20(0; 0–0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/20(0; 0–0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/20(65; 40.7–84.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13/20(65; 40.7–84.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/20(0; 0–0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14/20(70; 49.9–90.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/20(5; −4.6–14.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15/20(75; 50.9–91.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18/20(90; 68.3–98.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/20(60; 38.5–81.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/20(5; −4.6–14.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/20(5; −4.6–14.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">155/280(55.3; 49.3–61.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">170/280(60.7; 54.8–66.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82/280(29.3; 23.7–34.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48/280(17.1; 12.5–21.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35/280(12.5; 8.4–16.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3290894.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Proportion (percentage and 95% confidence interval) of BAL PCR-positive specimens for <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and/or <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> and lungs with macroscopic and microscopic lung lesions, according to the herds.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">PCR results \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lung pathology (%; 95% CI)</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Total \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No lesion \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Nonspecific lesions(scored as 1–2) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">EP-like lesions(scored as 3–4) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">M. hyopneumoniae</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18/110(16.4; 9.5, 23.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43/104(41.3; 31.9, 50.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21/66(31.8; 20.6, 43.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82/280(29.2%: 23.7–34.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/100(14.5; 8, 21.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14/104(13.5; 6.9, 20) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18/66(27.3; 16.5, 38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48/280(17.1%: 12.5–21.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and <span class="elsevierStyleItalic">M. hyopneumoniae</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17/110(15.5; 8.7, 22.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/104(7.7; 2.6, 12.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10/66(15.2; 6.5, 23.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35/280(12.5%; 8.4–16.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59/110(53.6; 44.3, 63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39/104(37.5; 28.2, 46.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17/66(25.8; 15.2, 36.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">115/280(41%: 35.1–47) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3290892.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Proportion (percentage and confidence interval 95%) of BAL PCR-positive or negative specimens for <span class="elsevierStyleItalic">Ureaplasma</span> sp.–<span class="elsevierStyleItalic">U. diversum</span> and/or <span class="elsevierStyleItalic">M. hyopneumoniae</span> according to the type of lesion diagnosed by histopathological examination in 280 lungs.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Canada: first report of <span class="elsevierStyleItalic">Ureaplasma diversum</span>, a bovine pathogen, in the respiratory tract of swine in Canada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Y. Burgher" 1 => "M. Koszegi" 2 => "V.G. St-Sauveur" 3 => "D. Fournier" 4 => "C. Lafond-Lambert" 5 => "C. Provost" 6 => "C.A. Gagnon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Can Vet J" "fecha" => "2018" "volumen" => "59" "paginaInicial" => "1333" "paginaFinal" => "1337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30532293" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0085" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Ureaplasma diversum</span> in pneumonic lungs of swine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "Y. Burgher" 1 => "L. Miranda" 2 => "R. Rodriguez-Roche" 3 => "A.C. de Almeida Campos" 4 => "E. Lobo" 5 => "T. Neves" 6 => "O. Martínez" 7 => "J. Timenetsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.meegid.2013.07.003" "Revista" => array:6 [ "tituloSerie" => "Infect Genet Evol" "fecha" => "2014" "volumen" => "21" "paginaInicial" => "486" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23851111" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0090" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Application of a nested polymerase chain reaction assay to detect <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> from nasal swabs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Calsamiglia" 1 => "C. Pijoan" 2 => "A. Trigo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/104063879901100307" "Revista" => array:6 [ "tituloSerie" => "J Vet Diagn Invest" "fecha" => "1999" "volumen" => "11" "paginaInicial" => "246" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10353356" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0095" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of <span class="elsevierStyleItalic">Ureaplasma diversum</span> in cattle using a newly developed PCR-based detection assay" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.V. Cardoso" 1 => "A. Blanchard" 2 => "S. Ferris" 3 => "R. Verlengia" 4 => "J. Timenetsky" 5 => "R.A. Florio Da Cunha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0378-1135(99)00203-5" "Revista" => array:6 [ "tituloSerie" => "Vet Microbiol" "fecha" => "2000" "volumen" => "72" "paginaInicial" => "241" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10727834" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0100" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new multiplex real-time TaqMan® PCR for quantification of <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span>, <span class="elsevierStyleItalic">M. hyorhinis</span> and <span class="elsevierStyleItalic">M. flocculare</span>: exploratory epidemiological investigations to research mycoplasmal association in enzootic pneumonia-like lesions in slaughtered pigs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "S. Fourour" 1 => "C. Fablet" 2 => "V. Tocqueville" 3 => "V. Dorenlor" 4 => "F. Eono" 5 => "E. Eveno" 6 => "I. Kempf" 7 => "C. Marois-Créhan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jam.13770" "Revista" => array:6 [ "tituloSerie" => "J Appl Microbiol" "fecha" => "2018" "volumen" => "125" "paginaInicial" => "345" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29603531" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0105" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BioEdit: a user-friendly biological sequence alignment editor and analysis program for windows 95/98/NT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Hall" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nucl Ac Symp Series" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "95" "paginaFinal" => "98" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0110" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence of <span class="elsevierStyleItalic">Mycoplasma hyorhinis</span> infections in fattening pigs and association with clinical signs and pathological lesions of enzootic pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Luehrs" 1 => "S. Siegenthaler" 2 => "N. Grützner" 3 => "E. Grosse Beilage" 4 => "P. Kuhnert" 5 => "H. Nathues" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vetmic.2017.02.001" "Revista" => array:6 [ "tituloSerie" => "Vet Microbiol" "fecha" => "2017" "volumen" => "203" "paginaInicial" => "1" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28619130" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0115" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transmission of pathogenic respiratory bacteria to specific pathogen free pigs at slaughter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Marois" 1 => "R. Cariolet" 2 => "H. Morvan" 3 => "M. Kobisch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vetmic.2007.11.030" "Revista" => array:6 [ "tituloSerie" => "Vet Microbiol" "fecha" => "2008" "volumen" => "129" "paginaInicial" => "325" "paginaFinal" => "332" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18242013" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0120" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Ureaplasma diversum</span> genome provides new insights about the interaction of the surface molecules of this bacterium with the host" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:19 [ 0 => "L.M. Marques" 1 => "I.S. Rezende" 2 => "M.S. Barbosa" 3 => "A.M. Guimarães" 4 => "H.B. Martins" 5 => "G.B. Campos" 6 => "N. do Nascimento" 7 => "A.P. Dos Santos" 8 => "A. Amorim" 9 => "V. Santos" 10 => "S. Farias" 11 => "F. Barrence" 12 => "L. de Souza" 13 => "M. Buzinhani" 14 => "V. Arana-Chavez" 15 => "M. Zenteno" 16 => "G. Amarante-Mendes" 17 => "J. Messick" 18 => "J. Timenetsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "PLoS One" "fecha" => "2016" "volumen" => "11" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0125" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycoplasmal diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Pieters" 1 => "D. Maes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "J.J.Zimmerman, S.D’Allaire, D.J.Taylor" "titulo" => "Diseases of swine" "paginaInicial" => "701" "paginaFinal" => "717" "edicion" => "9th ed." "serieFecha" => "2019" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0130" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Ureaplasma diversum</span> and <span class="elsevierStyleItalic">Ureaplasma</span> sp. in nasal cavity of pigs: distribution among herds and individual frequency based on pooled samples" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "J. Seitz" 1 => "G. Vicharelli" 2 => "V. García" 3 => "C. Vissio" 4 => "A. Estanguet" 5 => "J. Parada" 6 => "A. Carranza" 7 => "G. Di Cola" 8 => "P. Tamiozzo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ram.2020.11.002" "Revista" => array:6 [ "tituloSerie" => "Rev Argent Microbiol" "fecha" => "2021" "volumen" => "53" "paginaInicial" => "141" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33386175" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0135" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current perspectives on the diagnosis and epidemiology of <span class="elsevierStyleItalic">Mycoplasma hyopneumoniae</span> infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Sibila" 1 => "M. Pieters" 2 => "T. Molitor" 3 => "D. Maes" 4 => "F. Haesebrouck" 5 => "J. Segalés" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tvjl.2008.02.020" "Revista" => array:6 [ "tituloSerie" => "Vet J" "fecha" => "2009" "volumen" => "181" "paginaInicial" => "221" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18396428" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0140" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microbiome overview in swine lungs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "F.M. Siqueira" 1 => "E. Pérez-Wohlfeil" 2 => "F.M. Carvalho" 3 => "O. Trelles" 4 => "I.S. Schrank" 5 => "A. Vasconcelos" 6 => "A. Zaha" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "PLoS One" "fecha" => "2017" "volumen" => "2" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0145" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isolation of mycoplasma species from the lower respiratory tract of healthy cattle and cattle with respiratory disease in Belgium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "A. Thomas" 1 => "H. Ball" 2 => "I. Dizier" 3 => "A. Trolin" 4 => "C. Bell" 5 => "J. Mainil" 6 => "A. Linden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/vr.151.16.472" "Revista" => array:6 [ "tituloSerie" => "Vet Rec" "fecha" => "2002" "volumen" => "151" "paginaInicial" => "472" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12418530" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0150" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Mycoplasmas</span> and <span class="elsevierStyleItalic">Ureaplasmas</span> as neonatal pathogens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.B. Waites" 1 => "B. Katz" 2 => "R.L. Schelonka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CMR.18.4.757-789.2005" "Revista" => array:6 [ "tituloSerie" => "Clin Microbiol Rev" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "757" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16223956" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack692871" "titulo" => "Acknowledgements" "texto" => "<p id="par0050" class="elsevierStylePara elsevierViewall">This study was financially supported in part by <span class="elsevierStyleGrantSponsor" id="gs1">FONCyT-ANPCyT-MinCyT</span>, República Argentina [<span class="elsevierStyleGrantNumber" refid="gs1">PICT 02148/2018</span>]; and <span class="elsevierStyleGrantSponsor" id="gs2">SeCyT-UNRC</span>, República Argentina [<span class="elsevierStyleGrantNumber" refid="gs2">PPI 2020-2022</span>]. J.S. was holder of an “Ayudantía de Investigación” scholarship during the development of this study (UNRC).</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03257541/0000005500000003/v1_202309280755/S0325754123000251/v1_202309280755/en/main.assets" "Apartado" => array:4 [ "identificador" => "41740" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Microbiología de alimentos" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03257541/0000005500000003/v1_202309280755/S0325754123000251/v1_202309280755/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754123000251?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 2 | 0 | 2 |
2024 October | 26 | 1 | 27 |
2024 September | 25 | 8 | 33 |
2024 August | 27 | 12 | 39 |
2024 July | 31 | 3 | 34 |
2024 June | 34 | 6 | 40 |
2024 May | 39 | 5 | 44 |
2024 April | 28 | 3 | 31 |
2024 March | 52 | 9 | 61 |
2024 February | 29 | 9 | 38 |
2024 January | 26 | 5 | 31 |
2023 December | 18 | 7 | 25 |
2023 November | 14 | 8 | 22 |
2023 October | 41 | 8 | 49 |
2023 September | 26 | 2 | 28 |
2023 August | 13 | 3 | 16 |
2023 July | 11 | 1 | 12 |
2023 June | 28 | 4 | 32 |
2023 May | 32 | 214 | 246 |
2023 April | 15 | 8 | 23 |