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Are Mycoplasma pneumoniae coinfections frequent in COVID-19 patients? A systematic review
¿Son frecuentes las coinfecciones con Mycoplasma pneumoniae en pacientes con COVID-19? Una revisión sistemática
Jessica Mosmanna,1,
Corresponding author
jessica.mosmann@unc.edu.ar

Corresponding author.
, María Celia Frutosa,h,1, Javier Anibal Origliab, María Lucia Gallo Vauletc, Miriam Gabriela Garcíad, Gabriela Vilare, Celeste Péreze, María Julia Madariagag, Cecilia Cuffinia,h,2, María Estela Cadarioe,f,2
a Instituto de Virología, Dr. J.M. Vanella, Facultad de Ciencias Médicas – Universidad Nacional de Córdoba, Córdoba, Argentina
b Cátedra de Patología de Aves y Pilíferos, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina
c Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Bioquímica Clínica, Cátedra de Microbiología Clínica, Buenos Aires, Argentina
d Laboratorio de Virología y Biología Molecular, Hospital Interzonal General Agudos Pedro Fiorito, Buenos Aires, Argentina
e Departamento de Bacteriología, INEI-ANLIS Dr. Carlos G Malbrán, Ciudad Autónoma de Buenos Aires, Argentina
f Departamento de Virología, INEI-ANLIS Dr. Carlos G Malbrán, Ciudad Autónoma de Buenos Aires, Argentina
g Sección Serología y Pruebas Biológicas, Instituto de Zoonosis Luis Pasteur, Ciudad Autónoma de Buenos Aires, Argentina
h Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
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Airborne droplets containing <span class="elsevierStyleItalic">M&#46; pneumoniae</span> can be transmitted and spread among people through coughing and sneezing&#46; In most cases&#44; clinical symptoms are non-specific and cough is the main symptom&#44; which is usually paroxysmal and often persistent<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">43</span></a>&#46; Coinfection of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> has been identified in viral pneumonia<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">40</span></a>&#46; At present&#44; coronavirus disease 2019 &#40;COVID-19&#41; due to SARS-CoV-2 virus has spread to almost every part of the world&#46; The combination of SARS-CoV-2 infection and other respiratory pathogens is a challenge for health care systems in terms of diagnosis&#44; treatment&#44; and management&#46; Although viral infection and bacterial infection are essentially different in terms of pathogenesis&#44; the clinical manifestations of COVID-19 and CAP&#44; such as fever&#44; dry cough&#44; fatigue&#44; all-over ache and chest tightness<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">46</span></a>&#44; are similar&#46; Clinical practice indicates that reactive lymphocytes are frequently observed in COVID-19 infection&#44; while in <span class="elsevierStyleItalic">M&#46; pneumoniae</span> infection cold agglutination is common<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">20</span></a>&#46; There are only subtle differences in radiographic features between these two infections<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Several studies have reported a wide range of coinfection rates in SARS-CoV-2 patients&#44; with rates ranging from 3&#37; to more than 20&#37; being reported<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">24</span></a>&#46; Therefore&#44; studies that identify the pathogens coinfecting COVID-19 patients and the evaluation of their impact on the clinical outcome are crucial&#46; These data may guide clinicians to establish a directed antimicrobial therapy&#44; decrease the irrational use of antibiotics and improve the clinical outcome&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The objective was to assess the molecular prevalence of coinfection with this atypical bacterium in COVID-19 patients and describe the clinical features&#44; laboratory parameters&#44; complications&#44; clinical outcomes of such coinfections&#44; to determine the importance of detecting <span class="elsevierStyleItalic">M&#46; pneumoniae</span> in patients with COVID 19 and establishing an adequate treatment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Materials and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">A systematic review of the literature was performed focusing on the identification of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> coinfections in SARS-CoV-2 patients&#46; PubMed was searched using a combination of key terms such as COVID-19 and <span class="elsevierStyleItalic">M&#46; pneumoniae</span>&#44; SARS-COV-2 and <span class="elsevierStyleItalic">M&#46; pneumoniae&#44;</span> bacterial coinfections and COVID-19&#44; pneumonia and SARS-COV-2&#44; pneumonia and COVID-19&#46; We also used the same terms in Spanish and included articles written in English and Spanish &#40;the primary languages of the investigators&#41;&#46; We also reviewed the reference lists for the articles identified by our search&#44; as well as those of any included studies&#46; We only included those studies using molecular methods for <span class="elsevierStyleItalic">M&#46; pneumoniae</span> detection and excluded all studies employing culture or serology techniques for <span class="elsevierStyleItalic">M&#46; pneumoniae</span> identification&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Data abstraction</span><p id="par0025" class="elsevierStylePara elsevierViewall">Each abstract and the articles selected for full review were evaluated by all investigators&#46; For each included article&#44; the study characteristics and data regarding detection were abstracted by the authors&#46; For detection data&#44; defined cases were included and possible cases were excluded&#46; For each report&#44; the type of surveillance used&#44; number of cases reported and total population studies were documented&#46; This review was conducted and reported according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses &#40;PRISMA&#41; flow-charts &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Results and discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">The literature search yielded 103 studies&#46; After a first screening&#44; 64 were excluded because they were not related to the subject and 4 were duplicate&#46; After full text reading&#44; 14 studies were included &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Specifically&#44; four of the studies were retrospective and ten were prospective&#46; Most studies were from the USA&#44; Brazil&#44; China and France and the remaining ones from the United Kingdom&#44; Spain&#44; India&#44; Turkey&#44; Peru and Iran&#46; A total of 5855 COVID-19 patients were identified and included in our review &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Concerns regarding coinfections during viral pandemics&#44; specifically coinfections with respiratory bacterial pathogens&#44; are borne from the experience in H1N1 influenza A&#44; Severe Acute Respiratory Syndrome &#40;SARS&#41; and Middle East respiratory syndrome &#40;MERS&#41;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">1&#44;22&#44;33</span></a>&#46; In these outbreaks&#44; as in the COVID-19 pandemic&#44; much lower coinfection rates with <span class="elsevierStyleItalic">M&#46; pneumoniae</span> were reported<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">5&#44;11&#44;36&#44;39&#44;45</span></a>&#46; The prevalence of reported <span class="elsevierStyleItalic">M&#46; pneumoniae</span> infections in COVID-19 patients ranged from 0&#8211;33&#46;3&#37; in the retrospective studies and 0&#8211;28&#46;1&#37; in the prospective studies&#46; These differences in the proportion of coinfection may be attributable to the selection of case-patients &#40;adults or children&#41;&#44; geographic factors&#44; season and the clinical condition<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">9&#44;10&#44;25&#44;27</span></a>&#46; High prevalence of coinfection between <span class="elsevierStyleItalic">M&#46; pneumoniae</span> and SARS CoV-2 was described using serological methods<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">18&#44;28&#44;47</span></a>&#46; However&#44; these methods are not highly specific tests and may result in an overestimation of infections<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">37</span></a>&#46; In general&#44; the bacterium less frequently found in coinfection with SARS-COV-2 is <span class="elsevierStyleItalic">M&#46; pneumoniae</span><a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">13&#44;15&#44;16</span></a>&#46; Many of the most recent studies showed that coinfections appeared to be relatively rare&#46; However&#44; due to the variability between countries and the limited country&#47;region representation in the few studies published&#44; the results shown cannot be extrapolated to Latin America&#46; That is why it is important to generate local evidence to support decision-making&#46; In Argentina&#44; only one multicenter study reported the presence of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> in 12&#46;3&#37; &#40;24&#47;187&#41; of COVID-19 patients&#44; using nested-PCR<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In two studies &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; most patients who had contracted a bacterial respiratory infection did not test positive for COVID-19<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">3&#44;4&#44;24</span></a>&#46; The median age of COVID-19 patients studied for <span class="elsevierStyleItalic">M&#46; pneumoniae</span> was 48 years old &#40;range 1&#8211;107&#41;&#44; most of whom were male<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">2&#44;5&#44;8&#44;21&#44;23&#44;30&#44;34&#44;38</span></a>&#46; This observation is not consistent with the established literature that indicates that community-acquired viral coinfections are more common in younger populations<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">35</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common clinical symptoms in COVID-19 coinfected patients were fever&#44; cough and dyspnea<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">5&#44;6&#44;12&#44;21&#44;23&#44;30&#44;38</span></a>&#46; However&#44; these symptoms are similar among COVID-19 monoinfections and coinfections with other pathogens&#44; which made the clinical differentiation difficult&#46; Thus&#44; laboratory confirmation is required&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The clinical presentations of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> range from mild infections affecting the upper respiratory tract to pneumonia that needs hospital admission<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">43</span></a>&#46; It has been proposed that pathogens such as <span class="elsevierStyleItalic">M&#46; pneumoniae</span> can exacerbate clinical symptoms&#44; increase morbidity and prolong the stay in the intensive care unit &#40;ICU&#41; in COVID-19 patients<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">5&#44;13&#44;23&#44;30&#44;34</span></a>&#46; Boschiero et al&#46;&#44; 2022<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">3</span></a> did not find an association between coinfections and more severe COVID-19-related outcomes in Brazil&#44; while Perez-Lazo et al&#46;&#44; 2021<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">30</span></a> reported a high rate of mortality in Peru &#40;18&#46;1&#37;&#41;&#46; The authors described an elevated development of sepsis in the group with <span class="elsevierStyleItalic">M&#46; pneumoniae</span> coinfections &#40;37&#46;4&#37;&#41;&#59; however&#44; they found that mortality was similar among coinfected and monoinfected groups<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">30</span></a>&#46; In two studies included in this review a lower mortality rate was found<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">12&#44;23</span></a>&#44; whereas the remaining studies did not report any mortality rates<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">2&#44;3&#44;5&#44;21&#44;34&#44;38</span></a>&#46; Lower rates of comorbidities&#44; such as hypertension&#44; diabetes mellitus&#44; renal disease and obesity<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">5&#44;30</span></a> were described in coinfected patients&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Antibiotic use was reported in five studies<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">5&#44;12&#44;23&#44;30&#44;41</span></a>&#44; with &#62;50&#37; of patients receiving empirical antibiotics<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">30</span></a>&#46; This is particularly important in Latin America&#44; where the abuse of antibiotics in COVID-19 patients has reached alarming levels<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">7&#44;32</span></a>&#46; The finding that there was a low number of patients with bacterial infections&#44; such as <span class="elsevierStyleItalic">M&#46; pneumoniae</span>&#44; <span class="elsevierStyleItalic">Klebsiella pneumoniae</span>&#44; <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#44; <span class="elsevierStyleItalic">Haemophilus influenzae</span>&#44; highlights the fact that the empirical use of antibiotics in patients with COVID-19 should not be recommended<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">26&#44;29&#44;31&#44;44</span></a>&#46; The COVID-19 pandemic exacerbated the known challenges to optimal antibiotic administration&#44; representing a direct threat to patient safety and public health through antibiotic overprescription and promotion of bacterial resistance&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Unfortunately&#44; there were no specific data on clinical information and therapeutic interventions&#46; Due to the diversity of studies and the low number of patients with detected coinfection with <span class="elsevierStyleItalic">M&#46; pneumoniae</span>&#44; it was difficult to find symptoms indicating coinfection with <span class="elsevierStyleItalic">M&#46; pneumoniae</span> and SARS-CoV-2 in the studies included in our review&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Despite the fact that <span class="elsevierStyleItalic">M&#46; pneumoniae</span> coinfections were searched and infrequently documented in patients with COVID-19 pneumonia&#44; routine testing for respiratory pathogens should be advised&#44; since agents for which specific therapy can be prescribed may be detected and may have a beneficial impact on patient outcomes&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical approval</span><p id="par0070" class="elsevierStylePara elsevierViewall">Not required&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflict of interests</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Materials and methods"
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          "clase" => "keyword"
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            1 => "COVID-19"
            2 => "<span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>"
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            0 => "Infecci&#243;n por SARS-CoV-2"
            1 => "COVID-19"
            2 => "<span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>"
            3 => "Coinfecci&#243;n"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Understanding the proportion of SARS-CoV-2 patients with <span class="elsevierStyleItalic">Mycoplasma</span><span class="elsevierStyleItalic">pneumoniae</span> coinfection is crucial for treating patients suffering from coronavirus disease &#40;COVID-19&#41;&#44; help to ensure responsible use of antibiotics and minimize the negative consequences of overuse&#46; In addition&#44; this knowledge could have an impact on empirical antibiotic management guidelines for patients with COVID-19&#46; This systematic review aimed to identify the prevalence of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> in patients with coronavirus disease 2019 &#40;COVID-19&#41;&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A bibliographic search of studies published in Spanish or English was conducted using the PubMed search engine&#46; Fourteen articles from different continents &#40;America&#44; Asia and Europe&#41; were included&#44; involving a total of 5855 patients in these studies&#46; The mean age of COVID-19 patients with <span class="elsevierStyleItalic">M&#46; pneumoniae</span> was 48 years old &#40;range 1&#8211;107&#41;&#44; most of whom were male&#46; The detection of laboratory-confirmed <span class="elsevierStyleItalic">M&#46; pneumoniae</span> infection varied between 0 and 33&#46;3&#37;&#46; Most of patients referred fever&#44; cough&#44; and dyspnea&#44; and received empirical antibiotic treatment&#46; Bacterial coinfection was not associated with increased ICU admission and mortality&#46; The prevalence of coinfection showed extremely dissimilar figures according to the population studied and diagnostic criteria&#46; However&#44; it is important to develop Latin American studies&#44; given the heterogeneity observed in the studies conducted in different countries&#46; Standardized definitions should be developed in order to be able to assess the impact of coinfections in patients with a diagnosis of COVID-19&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Comprender la proporci&#243;n de coinfecci&#243;n por coronavirus &#40;COVID-19&#41; y <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span> es crucial para tratar a los pacientes con COVID-19&#44; garantizando el empleo responsable de antibi&#243;ticos y minimizando las consecuencias negativas del uso excesivo&#46; Adem&#225;s&#44; este conocimiento podr&#237;a tener un impacto en las pautas de manejo emp&#237;rico de antibi&#243;ticos en pacientes con COVID-19&#46; Esta revisi&#243;n sistem&#225;tica tuvo como objetivo identificar la prevalencia de <span class="elsevierStyleItalic">M&#46; pneumoniae</span> en pacientes con COVID-19&#46; Para ello se realiz&#243; una b&#250;squeda bibliogr&#225;fica de estudios publicados en espa&#241;ol o ingl&#233;s utilizando el buscador PubMed&#46; Se incluyeron 14 art&#237;culos de diferentes continentes &#40;Am&#233;rica&#44; Asia y Europa&#41;&#44; con un total de 5855 pacientes estudiados&#46; La media de edad de los pacientes COVID-19 con <span class="elsevierStyleItalic">M&#46; pneumoniae</span> fue de 48 a&#241;os &#40;intervalo&#58; 1 a 107 a&#241;os&#41; y la mayor&#237;a de ellos fueron varones&#46; La detecci&#243;n de <span class="elsevierStyleItalic">M&#46; pneumoniae</span> confirmada por laboratorio en pacientes con COVID-19 vari&#243; del 0 al 33&#44;3&#37;&#46; La mayor&#237;a de los pacientes refirieron fiebre&#44; tos y disnea&#44; y recibieron antibi&#243;ticos emp&#237;ricos&#46; La coinfecci&#243;n bacteriana no se asoci&#243; con un aumento de la admisi&#243;n en UCI ni de la mortalidad&#46; La prevalencia de coinfecci&#243;n fue muy dis&#237;mil seg&#250;n la poblaci&#243;n estudiada y los criterios diagn&#243;sticos empleados&#46; Dada la heterogeneidad de resultados en los diferentes pa&#237;ses&#44; es importante desarrollar estudios en Am&#233;rica Latina&#44; como as&#237; tambi&#233;n establecer definiciones estandarizadas para poder evaluar el impacto real de las coinfecciones en pacientes con COVID-19&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Grupo de Trabajo Bacterias At&#237;picas&#44; Sociedad Argentina de Bacteriolog&#237;a&#44; Micolog&#237;a y Parasitolog&#237;a Cl&#237;nicas &#40;SADEBAC&#41;&#44; Divisi&#243;n de la Asociaci&#243;n Argentina de Microbiolog&#237;a&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">These first authors contributed equally to this work&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">These authors contributed equally to this work&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Country&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Type of study&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Overall rate of coinfection &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">M&#46; pneumomiae</span>&#47;SARS-CoV-2 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnostic methods&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcomes of COVID19&#47;<span class="elsevierStyleItalic">M&#46; pneumoniae</span> patients &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Blasco et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">2</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Spain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;103 &#40;2&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Multiplex PCR assay&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Boschiero et al&#46;&#44; 2022<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#47;1503 &#40;5&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;84 &#40;2&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chaudry et al&#46;&#44; 2022<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">India&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#47;194 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;17 &#40;17&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;CARDS toxin gene&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Azithromycin&#44; or fluoroquinolones&#44; or doxycycline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chi et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">China&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;17 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Multiplex PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contou et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">8</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">France&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#47;92 &#40;28&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;26 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Easom et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">United Kingdom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#47;67 &#40;43&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;67 &#40;1&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Multiplex PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Doxycycline and monofloxacin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hazra et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">19</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#47;459 &#40;3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;459 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Husain et al&#46;&#44; 2022<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">21</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">France&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#47;784 &#40;2&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;22 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Multiplex PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Karaaslan et al&#46;&#44; 2021<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">23</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Turkey&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Retrospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#47;93 &#40;7&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;93 &#40;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Azithromycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kim et al&#46;&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#47;115 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;116 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">P&#233;rez-Lazo et al&#46;&#44; 2021<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">30</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peru&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154&#47;295 &#40;52&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#47;295 &#40;28&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Azithromycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;18&#46;1&#41; died&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Richardson et al&#46; 2020<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">34</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">USA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#47;1996 &#40;2&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;42 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Soltani et al&#46;&#44; 2021<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Iran&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#47;40 &#40;25&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#47;40 &#40;22&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PCR &#40;P1 adhesion gene&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Varela et al&#46;&#44; 2022<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">41</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prospective&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#47;97 &#40;31&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;31 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RT-PCR &#40;respiratory pathogen panel&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Azithromycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3657417.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Years &#40;mean&#41;&#46; NR&#58; not reported&#46; NA&#58; not applicable&#46; <span class="elsevierStyleItalic">M&#46; pneumoniae</span>&#58; <span class="elsevierStyleItalic">Mycoplasma</span><span class="elsevierStyleItalic">pneumonia</span>e&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Summary of studies reporting the incidence of <span class="elsevierStyleItalic">M&#46; pneumoniae</span> co- and secondary infection among COVID-19 patients&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:47 [
            0 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Critically ill patients with the middle East respiratory syndrome&#58; a multicenter retrospective cohort study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Saudi Critical Care Trial Group"
                          "etal" => false
                          "autores" => array:30 [
                            0 => "Y&#46;M&#46; Arabi"
                            1 => "A&#46; Al-Omari"
                            2 => "Y&#46; Mandourah"
                            3 => "F&#46; Al-Hameed"
                            4 => "A&#46;A&#46; Sindi"
                            5 => "B&#46; Alraddadi"
                            6 => "S&#46; Shalhoub"
                            7 => "A&#46; Almotairi"
                            8 => "K&#46; Al Khatib"
                            9 => "A&#46; Abdulmomen"
                            10 => "I&#46; Qushmaq"
                            11 => "A&#46; Mady"
                            12 => "O&#46; Solaiman"
                            13 => "A&#46;M&#46; Al-Aithan"
                            14 => "R&#46; Al-Raddadi"
                            15 => "A&#46; Ragab"
                            16 => "G&#46;A&#46; Al Mekhlafi"
                            17 => "A&#46; Al Harthy"
                            18 => "A&#46; Kharaba"
                            19 => "M&#46;A&#46; Ahmadi"
                            20 => "M&#46; Sadat"
                            21 => "H&#46;A&#46; Mutairi"
                            22 => "E&#46;A&#46; Qasim"
                            23 => "J&#46; Jose"
                            24 => "M&#46; Nasim"
                            25 => "A&#46; Al-Dawood"
                            26 => "L&#46; Merson"
                            27 => "R&#46; Fowler"
                            28 => "F&#46;G&#46; Hayden"
                            29 => "H&#46;H&#46; Balkhy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/CCM.0000000000002621"
                      "Revista" => array:6 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2017"
                        "volumen" => "45"
                        "paginaInicial" => "1683"
                        "paginaFinal" => "1695"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28787295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
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Original language: English
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es en pt

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