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Vol. 17. Issue 5.
Pages 195-200 (September - October 2010)
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Vol. 17. Issue 5.
Pages 195-200 (September - October 2010)
Open Access
Lecciones aprendidas de dos grandes estudios epidemiológicos de enfermedades cardio-cerebrovasculares en las que ha participado colombia
Lessons learned from two large epidemiological studies of cardiovascular and cerebrovascular diseases in which colombia took part
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Patricio López-Jaramillo1,2,
Corresponding author
jplopezj@hotmail.com
investigaciones@foscal.com.co

Correspondencia: Fundación Oftalmológica de Santander-Clínica Caros Ardila Lulle (FOSCAL), Torre Milton Salazar, primer piso, entrada Oftalmología y Farmacia. Calle 155A No. 23-09, Urbanización El Bosque, Floridablanca-Santander. Teléfonos. (57-7) 6384160 - 63860000 Ext. 2509-2510.
, José López-López3
1 Facultad de Medicina, Universidad de Santander, Bucaramanga, Colombia
2 Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle. Bucaramanga, Colombia
3 Facultad de Medicina, Universidad Autónoma de Bucaramanga. Bucaramanga, Colombia
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Resumen

Dos recientes estudios epidemiológicos de gran envergadura en los que participó Colombia, el INTERHEART y el INTERSTROKE, demostraron que en Latinoamérica en general y en Colombia en particular, el principal factor de riesgo para la presentación de infarto agudo del miocardio y accidente cerebro vascular isquémico y hemorrágico es la obesidad abdominal, a diferencia del resto del mundo donde el principal factor de riesgo fue el aumento en las concentraciones plasmáticas del colesterol total y del colesterol LDL, en el primer caso, y la hipertensión arterial, en el segundo. Estos datos dan soporte a la propuesta de que en Latinoamérica la transición rápida de los modelos económicos experimentados en los últimos años junto con la urbanización acelerada son la causa del explosivo aumento de la obesidad abdominal, la diabetes mellitus tipo 2 y las enfermedades cardio-cerebro-vasculares.

Palabras clave:
diferencias regionales
obesidad abdominal
inflamación de bajo grado
Abstract

Two recent large-scale epidemiological studies, INTERHEART and INTERSTROKE in which Colombia took part, demonstrated that in Latin America in general and particularly in Colombia, the main risk factor for the presentation of acute myocardial infarction and ischemic, and hemorrhagic stroke was the abdominal obesity in contrast to the rest of the world where the main risk factor was increase in plasma concentrations of total cholesterol and LDL-cholesterol for myocardial infarction, and hypertension for stroke. These data give support to the proposal that in Latin America the rapid transition in economic models experienced in the last years together with the fast urbanization has led to an explosive increase in abdominal obesity, diabetes mellitus type 2, and cardiovascular and cerebrovascular diseases.

Key words:
regional differences
abdominal obesity
low grade inflammation
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Bibliografía
[1.]
R. Sánchez, M. Ayala, H. Baglivio, C. Velásquez, G. Burlando, O. Kohlmann, J. Jiménez, On behalf of the Latin American Expert Group, et al.
Latin American guidelines of hypertension.
J Hypertens, 27 (2009), pp. 905-922
[2.]
P. López-Jaramillo, L.P. Pradilla, V. Castillo, V. Lahera.
Socioeconomical pathology as determinant of regional differences in the prevalence of metabolic syndrome and pregnancy-induced hypertension.
Rev Esp Cardiol, 60 (2007), pp. 168-178
[3.]
C. Rueda-Clausen, F. Silva, P. López-Jaramillo.
Epidemic of obesity and overweigh in Latin America and the Caribbean.
Int J Cardiol, (2008), pp. 111-112
[4.]
P. López-Jaramillo, S.Y. Silva, N. Rodríguez Salamanca, A. Durán, W. Mosquera, V. Castillo.
Are nutrition-induced epigenetic changes the link between socioeconomic pathology and cardiovascular diseases?.
Am J Therapeutics, 15 (2008), pp. 362-372
[5.]
P. López-Jaramillo, L.P. Pradilla, V. Lahera, F. Silva, C. Rueda-Clausen, G. Márquez.
A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglycemia and abdominal obesity.
ARAMIA Trials, 7 (2006), pp. 28
[6.]
I.A. Arenas, Y. Xu, P. López-Jaramillo, S.T. Davidge, I.I. Angiotensin.
induced MMP-2 release from endothelial cells is mediated by TNF alpha.
Am J Physiology Cell Physiology., 286 (2004), pp. C779-C784
[7.]
P. López-Jaramillo.
Cardiometabolic diseases in Latin America: the role of fetal programming in response to maternal malnutrition.
Rev Esp Cardiol, 62 (2009), pp. 670-676
[8.]
C.F. Rueda-Clausen, V. Lahera, J. Calderón, I.C. Bolívar, V.R. Castillo, M. Gutiérrez, et al.
The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors.
Int J Cardiol, 139 (2010), pp. 32-41
[9.]
P. López-Jaramillo, J. López-López.
Mecanismos epigenéticos implicados en la epidemia de diabetes mellitus tipo 2 en Latinoamérica: relevancia en el diagnóstico, prevención y tratamiento.
Actualizaciones en Medicina, 3 (2009), pp. 151-160
[10.]
P. López-Jaramillo, J.P. Casas, L. Bautista, N.C. Serrano, C.A. Morillo.
An integrated proposal to explain the epidemic of cardiovascular disease in a developing country: from socio-economic factors to free radicals.
Cardiology, 96 (2001), pp. 1-6
[11.]
S. Yusuf, S. Hawken, S. Ounpuu, et al.
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study.
[12.]
F. Lanas, A. Avezum, L.E. Bautista, et al.
INTERHEART Investigators in Latin America. Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study.
Circulation, 115 (2007), pp. 1067-1074
[13.]
M.J. O’Donnell, D. Xavier, Lisheng l, H. Zhang, S.L. Chin, P. Rao-Melacini, et al.
Risk factors for ischaemic and haemorrhagic stroke in 22 countries: results of the first phase of INTERSTROKE in 6,000 individuals.
[14.]
M. O’Donnell, D. Xavier, C. Diener, R. Sacco, L. Lisheng, H. Zhang, et al.
Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke.
Neuroepidemiology, 35 (2010), pp. 36-44
[15.]
R.G. García, M.Y. Rincón, W.D. Arenas, S.Y. Silva, L.M. Reyes, S.L. Ruiz, et al.
Hyperinsulinemia is a predictor of new cardiovascular events in Colombian patients with a first myocardial infarction.
[16.]
C. Rueda-Clausen, P. López-Jaramillo, C. Luengas, M.P. Oubiña, V. Cachofeiro, V. Lahera.
Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects.
Mediators of Inflammation, (2009),
[17.]
C.F. Rueda-Clausen, V. Lahera, J. Calderon, I.C. Bolivar, V.R. Castillo, M. Gutiérrez.
The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors.
Int J Cardiol, 139 (2010), pp. 32-41
[18.]
R.G. García, P. López-Jaramillo.
Cardiovascular prevention in high-risk patients with type 2 diabetes mellitus: when to start it?.
Eur Hearth J, 29 (2008), pp. 2058-2059
[19.]
P. López-Jaramillo, G. García, P.A. Camacho, E. Herrera, V. Castillo.
Interrelationship between body mass index.
C-reactive protein and blood pressure in a Hispanic pediatric population. Am J Hypertens., 21 (2008), pp. 527-532
[20.]
R.G. García, M. Pérez, R. Maas, E. Schwedhelm, R.H. Böger, P. López-Jaramillo.
Plasma Concentrations of Asymmetric Dimethylarginine (ADMA) in metabolic syndrome.
Int J Cardiol, 122 (2007), pp. 176-178
[21.]
C.F. Rueda–Clausen, F.A. Silva, M.A. Lindarte, C. Villa-Roel, E. Gómez, Cure-Cure, et al.
Olive, soybean and palm oils intake have a similar acute detrimental effect over the endothelial function in healthy young subjects.
Nutr Metabol Cardiovasc Dis, 17 (2007), pp. 50-57
[22.]
P. López-Jaramillo, C. Rueda-Clausen, F.A. Silva.
The utility of different definitions of metabolic syndrome in Andean population.
Int J Cardiol, 116 (2007), pp. 421-422
[23.]
R.G. García, A.E. Cifuentes, R.S. Caballero, L. Sánchez, P. López-Jaramillo.
A proposal for an apropiate central obesity diagnosis in Latin American population.
Int J Cardiol, 110 (2005), pp. 263-264
[24.]
M. Pérez, J.P. Casas, L.A. Cubillos, N.C. Serrano, F.A. Silva, C.A. Morillo, et al.
Using waist circumference as screening tool to identify colombian subjects at cardiovascular risk.
Eur J Cardiovasc Prev Rehab, 10 (2003), pp. 328-335
[25.]
P. López-Jaramillo, J.P. Casas, C.A. Morillo.
C - reactive protein and cardiovascular diseases in andean population.
Circulation, 105 (2002), pp. e10
[26.]
L. Bautista, P. López-Jaramillo, L.M. Vera, J.P. Casas, A.P. Otero, A.I. Guaracao.
Is C-reactive protein an independent risk factor for essential hypertension?.
J Hypertens, 19 (2001), pp. 857-861
[27.]
L. Accini, A. Sotomayor, F. Trujillo, J.G. Barrera, L. Bautista, P. López-Jaramillo.
Colombian Study to Assess the Use of Noninvasive Determination of Endothelium-Mediated Vasodilatation (CANDEV). Normal Values and Factors Associated.
Endothelium, 8 (2001), pp. 157-166
[28.]
P. López-Jaramillo.
Defining the research priorities to fight the burden of cardiovascular diseases in Latin America.
J Hypertens, 26 (2008), pp. 1886-1889
Copyright © 2010. Sociedad Colombiana de Cardiología y Cirugía Cardiovascular
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