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Vol. 18. Issue 4.
Pages 271-284 (December 2011)
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Vol. 18. Issue 4.
Pages 271-284 (December 2011)
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Historia de la enfermedad de Devic
History of Devic's disease
Visits
18101
Antonio Iglesias Rodríguez1,
Corresponding author
, Diana Gil2, José Félix Restrepo3, Antonio Iglesias Gamarra3
1 Fellow de Neurología, Hospital San Ignacio de Loyola. Chicago. EUA
2 Reumatología. Unidad de Reumatología, Universidad Nacional de Colombia
3 Profesor titular de Medicina Interna y Reumatología, Facultad de Medicina, Universidad Nacional de Colombia
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Resumen

En este escrito hacemos una completa revisión de la enfermedad de Devic, desde sus primeras descripciones por Eugene Devic, hasta el concepto actual, donde es considerada una neuromielitis óptica. Exponemos las diferentes formas de presentación de la neuromielitis óptica así como los hallazgos clínicos y de laboratorio que permiten diferenciar esta entidad de la esclerosis múltiple, tarea que muchas veces no es fácil de realizar por la semejanza en la presentación clínica. Sin embargo es importante su diferenciación porque el tratamiento y el pronóstico difieren entre estas dos enfermedades. No obstante, el descubrimiento de los anticuerpos IgG anti NMO, dirigidos contra los canales de agua de acuaporina 4 fueron fundamentales en tal diferenciación. Realizamos una mención especial sobre la enfermedad de Devic y el lupus y finalmente hacemos unas notas sobre el tratamiento disponible para esta patología.

Palabras clave:
enfermedad de Devic
lupus eritematoso sistémico
neuromielitis óptica
esclerosis múltiple
Summary

In this paper we do a complete review of Devic's disease, from its first descriptions by Eugene Devic, to the current concept, which is considered a neuromyelitis optica (NMO). We present the different forms of presentation of NMO as well as clinical and laboratory findings that distinguish this entity from multiple sclerosis, a task that frequently is not easy to perform because of the similarity in clinical presentation. Its differentiation is important because the treatment and prognosis differ between these two diseases. However the discovery of NMO IgG antibodies directed against aquaporin-4 water channels was a critical step in such differentiation. We made special mention of Devic's disease and lupus, and finally make some notes on the available treatment for this pathology.

Key words:
Devic’disease
systemic lupus erythematosus
neuromyelitis optica
multiple sclerosis
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