Article information
Resumen
Durante la última década el área de conocimiento relacionada con la patogénesis de infecciones odontogénicas y su posible asociación con enfermedades sistémicas ha sido de gran interés. Patógenos periodontal es que ingresan al torrente sanguíneo se encuentran implicados en efectos patológicos sistémicosy esto ha llevado al desarrollo de la Teoría de Infección Focal, que se basa en la correlación fisiopatológica entre periodontitis crónica y ciertas enfermedades autoinmunes.
La artritis reumatoide, como enfermedad inflamatoria, se caracteriza por sinovitis persistente, destrucción del cartílago y del hueso. Su etiología es incierta, pero ciertos microorganismos pueden jugar un papel importante en la pérdida de autotolerancia y desarrollo de autoinmunidad. P. gingivalis puede estar comprometida en la amplificación de la respuesta inmune en individuos susceptibles genéticamente. Surge, entonces, el concepto de medicina periodontal como una disciplina que integra dichas asociaciones.
Palabras clave:
infección focal
dental
periodontitis crónica
inflamación
artritis reumatoide
Summary
During the last decade the knowledge related to the pathogenesis of odontogenic infections and their possible association with systemic diseases has been of great interest. Periodontal pathogens that enter to bloodstream are involved in systemic pathological effects. The Focal Infection Theory is based on the pathophysiology correlation between chronic periodontitis and the development of certain autoimmune diseases.
Rheumatoid arthritis as inflammatory disease is characterized by persistent synovitis and destruction of cartilage and bone. The etiology is uncertain, but some microorganisms may play important role in the lack of self-tolerance and the consequent development of autoimmunity. P. gingivalis may be involved in amplifying the immune response and induction of the disease in individuáis with genetic susceptibility. Therefore, the concept of periodontal medicine as a discipline to intégrate these associations has emerged.
Key words:
focal infection
dental
periodontitis
inflammation
arthritis rheumatoid
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