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Inicio Revista Colombiana de Reumatología (English Edition) Interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM...
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Vol. 31. Issue 3.
Pages 399-411 (July - September 2024)
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Vol. 31. Issue 3.
Pages 399-411 (July - September 2024)
Review Article
Interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM-ILD): Definitions, epidemiology, pathophysiology, clinical manifestations, complications, risk, and mortality factors (narrative review)
Enfermedad pulmonar intersticial en pacientes con miopatía idiopática inflamatoria (EPI-MII): definiciones, epidemiología, fisiopatología, manifestaciones clínicas, complicaciones, factores de riesgo y mortalidad (revisión narrativa)
Andrés Hormaza-Jaramilloa,b,
Corresponding author
andres.hormaza@fvl.org.co

Corresponding author.
, Liliana Fernandez-Trujillob,c, Tatiana Delgado-Morad, Carlos Julio Vargas-Potesb,e
a Department of Internal Medicine, Rheumatology Service, Fundación Valle del Lili, Cali, Colombia
b Department of Internal Medicine, Faculty of Health Sciences, Universidad Icesi, Cali, Colombia
c Department of Internal Medicine, Pneumology Service, Fundación Valle del Lili, Cali, Colombia
d Clinical Research Center, Fundación Valle del Lili, Cali, Colombia
e Department of Internal Medicine, Internal Medicine Service, Fundación Valle del Lili, Cali, Colombia
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Table 1. Autoantibodies and their frequency in interstitial lung disease, myositis, mortality, clinical features and radiological patterns.
Abstract

Interstitial lung disease refers to a group of disorders generally characterized by progressive scarring of lung tissue due to a wide variety of causes and associated with a plethora of symptoms. Patients with this diagnosis can be asymptomatic or present severe symptoms that could lead to death. Its signs and symptoms are the same in patients with concomitant connective tissue disease and those without. Genetics and immunity play essential roles in patients with interstitial lung disease and idiopathic inflammatory myopathy. Alterations in genes and excessive production of specific cytokines can lead to the development of interstitial lung disease. Interstitial lung disease can have several complications, including chronic respiratory distress and infections, and can worsen the prognosis of patients with idiopathic inflammatory myopathy. Here, we present a narrative review describing the epidemiology, pathophysiology, clinical manifestations, risk factors, and complications of the population with interstitial lung disease and idiopathic inflammatory myopathy.

Keywords:
Interstitial lung disease
Idiopathic inflammatory myopathy
Autoantibodies
Epidemiology
Clinical manifestations
Mortality
Resumen

La enfermedad pulmonar intersticial se refiere a un grupo de trastornos generalmente caracterizados por cicatrización progresiva del tejido pulmonar, debidos a una amplia variedad de causas y asociados con múltiples síntomas. Los pacientes con este diagnóstico pueden estar asintomáticos o presentar síntomas severos que podrían conducir a la muerte. Los signos y los síntomas de esta enfermedad son iguales en pacientes que tienen una enfermedad del tejido conectivo concomitante y en aquellos que no la tienen. La genética y la inmunidad desempeñan papeles esenciales en pacientes con enfermedad pulmonar intersticial y miopatía idiopática inflamatoria. Las alteraciones en los genes y la producción excesiva de citoquinas específicas pueden conducir al desarrollo de la enfermedad. A su vez, la enfermedad pulmonar intersticial puede tener varias complicaciones, como dificultad respiratoria crónica e infecciones, y puede empeorar el pronóstico de los pacientes con miopatía idiopática inflamatoria. Presentamos una revisión narrativa que describe la epidemiología, la fisiopatología, las manifestaciones clínicas, los factores de riesgo y las complicaciones de la población con enfermedad pulmonar intersticial y miopatía idiopática inflamatoria.

Palabras clave:
Enfermedad pulmonar intersticial
Miopatía idiopática inflamatoria
Autoanticuerpos
Epidemiología
Manifestaciones clínicas
Mortalidad

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