Article information
Los factores de crecimiento desempeñan un papel clave en la consolidación de las fracturas, así como la regeneración ósea y cartilaginosa. El plasma rico en plaquetas es una forma actual de aplicar estos conocimientos para la mejora de la consolidación. En este artículo se revisan los conocimientos actuales sobre los factores de crecimiento, así como la experiencia de los autores en el plasma rico en plaquetas.
Palabras clave:
factores de crecimiento
consolidación de fracturas
plasma rico en plaquetas
Growth factors play a key factor in the healing of fractures, as well as in bone and cartilage regeneration. Platelet-rich plasma (PRP) treatment is a current way of using this knowledge to improve healing. In this article we review the state of the art on growth factors against the background of our own experience with platelet rich plasma.
Keywords:
growth factors
failure healing
platelet rich plasma
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Bibliografía
[1]
Le Roith D, Blakesley VA. Biology of growth factors. En: Canalis, director. Skeletal growth factors. Philadelphia: Lippincott W&W; 2000. p. 31-50..
[3]
Mac Kay B. Commercial approval of rhBMP-2 in spinal fusions; bringing the product to the market. En Sandell L, Grodzinsky AJ, directores. Tissue engineering in musculoskeletal practice. Rosemont, Illinois: American Academy of Orthopedic Surgeons; 2004. p. 61-71..
[4]
Rueger DC. Biochemistry of Bone Morphogenetgic Proteins. En: Vokicevic S, Sampath K, directores. Bone morphogenetic proteins: from laboratory to clinical practice. Basel: Brikhäuser Verlag; 2002..
[5]
Musgrave D.S., Fu F.H., Huard J..
Treapia génica e ingeniería tisular en cirugía ortopédica..
J Am Acad Orthop Surg (ed esp). , 2 (2000), pp. 72-81
[6]
Munuera L., Cordero J..
Ingeniería tisular..
Ingeniería tisular., (2001),
[7]
Einhorn TA. Tissue engineering in fracture repair. En: Sandell L, Grodzinsky AJ, directores Tissue engineering in musculoskeletal clinical pratice. Rosemont Illinois: American Academy of Orthopedic Surgeons; 2004. p.107-13..
[8]
Radomsky M.L., Thompson A.Y., Spiro R.C..
Potential role of FGF in enhancement of fracture healing..
Clin Orthop. , S355 (1998), pp. S283-S293
[9]
Alliston TN, Dorynk R. Transforming growth factor β in skeletal development and maintenance. En: Canalis E, director. Skeletal growth factors. Philadelphia: Lippincott W&W; 2000. p. 243-9..
[10]
Caplan A.L..
Mesenchymal stem cells..
J Orthop Res. , 9 (1991), pp. 641-650
[11]
Kabawata M, Mizayono K. Bone morphogenetic proteins en Skeletal growth factors. En: Canalis E, director. Philadelphia: Lippincott W&W; 2000. p. 269-90..
[12]
Boden SC. Clinical trials in bone tissue engineering: spine applications update. En: Sandell LJ, Grodzinsky AJ, directores. Tissue engineering in musculoskeletal clinical practice. Rosemont Illinois: American Academy of Orthopedic Surgeons; 2004. p. 141-50..
[13]
Watson J.T..
Platelet gels: pro-position. Commonly used enhancers of bone healing: do we really have evidence of efficacy?..
Platelet gels: pro-position. Commonly used enhancers of bone healing: do we really have evidence of efficacy?., pp. 348-349
[14]
Lane J.M..
Platelet gels: con-position. Commonly used enhancers of bone healing: do we really have evidence of efficacy?..
Platelet gels: con-position. Commonly used enhancers of bone healing: do we really have evidence of efficacy?., pp. 350
[15]
Friedlaender G.E., Perry C.R., Cole J.D., Cook S.D., Cierny G., Muschler G.F., et-al..
Osteogenic protein 1 (BMP-7) in the treatment of tibial non unions..
J Bone Joint Surg Am. , S83(A) (2001), pp. S151-S158
[16]
Vaccaro A.R., Anderson D.G., Toth C.A..
Recombinant human osteogenic protein (BMP-7) as an osteoinductive agent in spinal fusion..
Spine. , 27 (2002), pp. S59-S65
[17]
Einhorn T.A..
Biology of fracture repair and methods to enhance healing. Symposia: Basic research..
Biology of fracture repair and methods to enhance healing. Symposia: Basic research., pp. 114-122
[18]
Govender S., Csimma C., Gennant H.K., Valentin-Opran A., Amit Y., Arbel R., et-al, BESTT Study Group..
Recombinant bone morphogenetic protein-2 for the treatment of open tibial fractures..
J Bone Joint Surg Am. , 84(A) (2002), pp. 2123-2134
[19]
Caplan A.L., Goldberg V.M..
Principles of tissue engineered regeneration of skeletal tissues..
Clin Orthop. , S367 (1999), pp. S12-S16
[20]
van den Berg W., van den Kraan P.M., Scharstuhl A., van Beuningen H.M..
Growth factors in cartilage repair..
Clin Orthop Relat Res. , S391 (2001), pp. S244-S250
[21]
Hunziker E.B., Driesang I.M.K., Morris E.A..
Chondrogenesis in cartilage repair is induced by members of the TGF-β superfamily..
Clin Orthop. , S391 (2001), pp. S171-S181
[22]
Sittinger M. Engineering cartilage structures en Tissue engineering in musculoskeletal clinical practice. En: Sandell L, Grodzinsky AJ, directores. Rosemont, Illinois: AAOS; 2004. p. 175-82..
[23]
Thonar EJ, Sah RL, Masuda K. Manufacture of cartilage tissue in vitro en Tissue engineering in musculoskeletal clinical practice. En: Sandell L, Grodzinsky AJ, directores. Rosemont Illinois: AAOS; 2005. p. 211-7..
[24]
Hidaka Ch., Cunningham M.E., Rodeo S.A., Maher S.A., Zhu W..
Modern biologics used in orthopedic surgery..
Curr Opin Rheumatol. , 18 (2006), pp. 74-79
[25]
Anitua E., Sánchez M., Nurden A.T., Nurden P., Orive G., Andía I..
New insights and novel applications for platelet-rich fibrin therapies..
Trends in Biotechnology. , (2006),
[26]
Anitua E., Andia I., Ardanza B., Nurden P., Nurden A.T..
Autologous platelets as a source for healing and tissue regeneration..
Thromb Haemost. , 91 (2004), pp. 4-15
[27]
Fréchette J.P., Martineau I., Gagnon G..
Platelet-rich plasmas: growth factor content and roles in wound healing..
J Den Res. , 84 (2005), pp. 434-438
[28]
Bouletreau P.J..
Factors in the fracture microenvironment induce primary osteoblast angiogenic cytokine production..
Plast Reconstr Surg. , 110 (2002), pp. 139-148
[29]
Anitua E., Andia I., Sánchez M., Azofra J., Zalduendo M.M., de la Fuente M., et-al..
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture..
J Orthop Res. , 23 (2005), pp. 281-286
[30]
Anitua E, Sánchez M, Nurden AT, Zalduendo MM, de la Fuente M, Azofra J, et al. Reciprocal actions of platelet-secreted TGF-b1 on the production of VEGF and HGF by human tendon cells. Plastic Reconstr Surg. [En prensa]..
[31]
Werner S., Grose R..
Regulation of wound healing by growth factors and cytokines..
Physiol Rev. , 83 (2003), pp. 835-870
[32]
Dahlgren L.A., Mohammed H.O., Nixon A.J..
Temporal expression of growth factors and matrix molecules in healing tendon lesions..
J Orthop Res. , 23 (2005), pp. 84-92
[33]
Anitua E., Sánchez M., Nurden A.T., Zalduendo M., de la Fuente M., Azofra J., et-al..
Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities..
J Biomed Mater Res. , 76 (2006), pp. 000
[34]
Carano R.A., Filvaroff E.H..
Angiogenesis and bone repair DDT..
Drug Discov Today. , 8 (2003), pp. 980-988
[35]
Eppley B.L., Woodell J.E., Higgins B.S..
Platelet Quantification and growth factor analysis from platelet-rich plasma: implications for wound healing..
Plast Reconstr Surg. , 114 (2004), pp. 1502-1508
[36]
Weirbrich G., Kleis W.K.G..
Curasan PRP kit vs. PCCS PRP system collection efficiency and platelet counts of two different methods for the preparation of platelet-rich plasma..
Clin Oral Impl Res. , 13 (2002), pp. 437-443
[37]
Appel T.R., Pötzsch B., Müller J., Lindern J.-J., Bergé S.J., Reich R.H..
Comparison of three different preparations of platelet concentrates for growth factor enrichment..
Clin Oral Impl Res. , 13 (2002), pp. 522-528
[38]
Weirbrich G., Kleis W.K.G., Hafner G., Hitzler W.E., Wagner W..
Comparison of platelet, leukocyte and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified Curasan Kit, with preparations received from a local blood bank..
Clin Oral Impl Res. , 14 (2003), pp. 357-362
