Article information
Introducción
El crecimiento óseo precisa de una intensa actividad anabólica que se centra, sobre todo, en la síntesis proteica. Cualquier alteración que afecte a la multiplicación celular y su diferenciación, la síntesis del colágeno o la formación de proteoglicanos puede producir un cambio patológico.
Revisión de la bibliografíaLos autores han llevado a cabo una profunda revisión bibliográfica referente al cartílago de crecimiento.
ConclusionesLas hormonas actúan según diferentes patrones sobre el desarrollo esquelético, cambiando el grosor de las fisis y el índice y magnitud de su crecimiento. Hay factores locales en y alrededor de las epífisis unidos a los factores sistémicos (hormona de crecimiento, hormona tiroidea, estrógenos y andrógenos, glucocorticoides y vitamina D) que influyen sobre la función fisaria, sin olvidar que la modificación de los factores mecánicos puede producir importantes alteraciones en la magnitud del crecimiento y en su orientación.
Palabras clave:
cartílago crecimiento
hormonas
factores de crecimiento
biomecánica
Introduction
Bone growth requires intense anabolic activity centering mainly on protein synthesis. Any disturbance affecting cell multiplication and differentiation, collagen synthesis, or proteoglycan formation can produce a pathologic disorder.
Literature reviewThe literature on the growth cartilage has been reviewed in depth.
ConclusionsHormones act in different ways on skeletal development, changing the thickness of the growth cartilage and the index and magnitude of growth. Local factors act in and around the growth cartilage, together with systemic factors (growth hormone, thyroid hormone, estrogens and androgens, glucocorticoids and vitamin D) that influence growth cartilage function. In addition, modifications in mechanical factors can produce important disturbances in the magnitude and direction of growth.
Key words:
growth cartilage
hormones
growth factors
biomechanics
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