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Inicio Revista Española de Cirugía Ortopédica y Traumatología El cartílago de crecimiento: biología y biomecánica del desarrollo
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Vol. 49. Núm. 1.
Páginas 55-67 (enero 2004)
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Vol. 49. Núm. 1.
Páginas 55-67 (enero 2004)
Acceso a texto completo
El cartílago de crecimiento: biología y biomecánica del desarrollo
Growth cartilage: developmental biology and biomechanics
Visitas
20236
F. Shapiroa, F. Forriolb,
Autor para correspondencia
fforriol@unav.es

Correspondencia Departamento de Cirugía Ortopédica y Traumatología. Clinica Universitaria. Avda. Pío XII, 32. 31008 Pamplona. Navarra.
a Orthopaedic Research Laboratory. Department of Orthopaedic Surgery. Children's Hospital Boston. Harvard Medical School. Boston. MA. EE.UU
b Laboratorio de Ortopedia Experimental. Departamento de Cirugía Ortopédica y Traumatología. Universidad de Navarra. Pamplona
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Bibliografía
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Estadísticas
Introducción

El crecimiento óseo precisa de una intensa actividad anabólica que se centra, sobre todo, en la síntesis proteica. Cualquier alteración que afecte a la multiplicación celular y su diferenciación, la síntesis del colágeno o la formación de proteoglicanos puede producir un cambio patológico.

Revisión de la bibliografía

Los autores han llevado a cabo una profunda revisión bibliográfica referente al cartílago de crecimiento.

Conclusiones

Las hormonas actúan según diferentes patrones sobre el desarrollo esquelético, cambiando el grosor de las fisis y el índice y magnitud de su crecimiento. Hay factores locales en y alrededor de las epífisis unidos a los factores sistémicos (hormona de crecimiento, hormona tiroidea, estrógenos y andrógenos, glucocorticoides y vitamina D) que influyen sobre la función fisaria, sin olvidar que la modificación de los factores mecánicos puede producir importantes alteraciones en la magnitud del crecimiento y en su orientación.

Palabras clave:
cartílago crecimiento
hormonas
factores de crecimiento
biomecánica
Introduction

Bone growth requires intense anabolic activity centering mainly on protein synthesis. Any disturbance affecting cell multiplication and differentiation, collagen synthesis, or proteoglycan formation can produce a pathologic disorder.

Literature review

The literature on the growth cartilage has been reviewed in depth.

Conclusions

Hormones act in different ways on skeletal development, changing the thickness of the growth cartilage and the index and magnitude of growth. Local factors act in and around the growth cartilage, together with systemic factors (growth hormone, thyroid hormone, estrogens and androgens, glucocorticoids and vitamin D) that influence growth cartilage function. In addition, modifications in mechanical factors can produce important disturbances in the magnitude and direction of growth.

Key words:
growth cartilage
hormones
growth factors
biomechanics
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