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Influence of the physiological medium on the mechanical properties of bone cement: Can current studies be extrapolated?
Influencia del medio fisiológico sobre las propiedades mecánicas del cemento óseo. ¿Son los estudios actuales extrapolables?
P. Sanz-Ruiza,
Corresponding author
pablo.sanzruiz@gmail.com

Corresponding author.
, E. Pazb, J. Abenojarc, J.C. del Realb, F. Forriold, J. Vaqueroa
a Servicio de Cirugía Ortopédica y Traumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Instituto para la investigación tecnológica, Departamento de ingeniería mecánica, Universidad Pontificia Comillas, Madrid, Spain
c Grupo desarrollo materiales, Departamento de ingeniería y ciencia de materiales, Universidad Carlos III, Madrid, Spain
d Facultad de Medicina, Universidad San Pablo CEU, Madrid, Spain
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achieving high local concentrations with very few systemic effects&#46; This is particularly important&#44; given that an increase of nearly 50&#37; in the rate of prosthesis review caused by infection is projected by 2030&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The usefulness of PMMA as a method of fixation&#44; as well as growing interest in its use in the treatment and prophylaxis of prosthetic infection&#44; has made it into one of the most frequently studied materials in our environment&#59; this in turn has led to the appearance of multiple commercial preparations and the publication of minimum requirements by international agencies such as the ISO and the ASTM&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> Given that the great majority of studies performed to date have been under experimental conditions of dry medium&#44; it is difficult to extrapolate these results correctly to clinical practice&#46; This difficulty undoubtedly is of special interest when studying PMMA used with antibiotics&#44; whose elution in liquid medium inevitably affects the mechanical characteristics of PMMA&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The objective of this study was to assess the influence of a liquid medium such as saline solution on the resistance and wear of bone cement mixed with an antibiotic&#44; and whether such influence varied over time&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We performed an experimental study to assess the effect on liquid medium on bone cement&#46; The PMMA used was bone cement that was quick setting&#44; of high viscosity and preloaded with 0&#46;5<span class="elsevierStyleHsp" style=""></span>g of gentamicin Palacos<span class="elsevierStyleSup">&#174;</span> R&#43;G &#40;Heraeus Medical GmbH&#44; Wehrheim&#44; Germany&#41;&#44; because of its wide use and its good survival data in various series&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> To each commercial preparation of cement&#44; we added a vial of 1<span class="elsevierStyleHsp" style=""></span>g of powdered vancomycin &#40;Normon EFG&#44; Tres Cantos&#44; Madrid&#44; Spain&#41; manually to reproduce the treatment conditions of an infected arthroplasty&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two types of samples were prepared&#58; circular and rectangular&#46; Before sample preparation the cement had been stored at controlled temperature and relative humidity&#46; The components were not cooled beforehand&#59; they were mixed in a tray manually&#46; We added vancomycin independently&#44; following the method of Frommelt and K&#252;hn<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> for manual addition of antibiotics&#44; previously adding the same amount of powdered antibiotic as of polymer in a tray for a minute until we achieved a homogeneous mixture of the powder&#46; Room temperature at the time of mixing was 23<span class="elsevierStyleHsp" style=""></span>&#176;<span class="elsevierStyleSmallCaps">C</span>&#44; with a relative humidity of 55&#8211;60&#37;&#46; The mixing process was carried out following the recommendation of the manufacturer and ASTM F451-99<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and ISO 5833&#58;2002<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> regulations&#46; Each 20-ml vial of monomer was mixed with a 40-g sachet of polymer&#44; added in that order in a reusable plastic tray&#46; The mixture was prepared by stirring in a clock-wise direction in homogeneous frequency for a timed period of 30<span class="elsevierStyleHsp" style=""></span>s&#46; Once the paste was achieved&#44; it was left to set until it was shown that the mixture would not stick &#40;2<span class="elsevierStyleHsp" style=""></span>min at work temperature&#41;&#44; then beginning the preparation of the samples&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To prepare the samples we used a predesigned mold made of silicone &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#44; with circular samples 30<span class="elsevierStyleHsp" style=""></span>mm in diameter and 4<span class="elsevierStyleHsp" style=""></span>mm thick &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41; and rectangular samples 79<span class="elsevierStyleHsp" style=""></span>mm long&#44; 10<span class="elsevierStyleHsp" style=""></span>mm wide and 4&#46;5<span class="elsevierStyleHsp" style=""></span>mm high &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; The process of preparing these was similar&#44; using cement in ductile phase to fill the molds&#44; leaving them to set under a continuous weight of 10<span class="elsevierStyleHsp" style=""></span>kg to become compact and to obtain homogeneous samples&#46; Following a hardening period &#40;10&#8211;12<span class="elsevierStyleHsp" style=""></span>min&#41; we removed the samples from the molds&#46; Each bag of cement yielded enough for the preparation of 6 samples in 1 of the molds&#46; The circular samples were used to study wear&#44; while the rectangular ones were used to study resistance to fracture&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">We defined various groups based on the conditioning process to which they were submitted&#44; yielding 4 groups for the circular samples and 2 groups for the rectangular samples &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The conditioning process consisted of immersing the samples in isotonic saline solution &#40;B&#46; Braun&#44; Melsungen&#44; Germany&#41; during the appropriate time for each group&#44; maintaining the samples at a constant temperature of 37<span class="elsevierStyleHsp" style=""></span>&#176;C by incubation with a heater&#46; These conditions attempted to replicate a medium similar to that which exists in a joint&#46; Three homogeneous samples were prepared for each study group&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">For the determination of wear and of the coefficient of friction&#44; we performed mechanical testing following Standard ASTM G99-05&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> For the production of a wear track&#44; we used a PIN-ON-DISK tribometer &#40;Microtest&#44; Madrid&#44; Spain&#41;&#44; with a 304 stainless steel ball 6<span class="elsevierStyleHsp" style=""></span>mm in diameter&#46; The test conditions used were with a normal load applied of 15<span class="elsevierStyleHsp" style=""></span>N&#44; a described path of 1000<span class="elsevierStyleHsp" style=""></span>m&#44; and a frequency of 120<span class="elsevierStyleHsp" style=""></span>rpm &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B and D&#41;&#46; For the tests performed with the samples submerged in saline solution&#44; a recipient was attached to the tribometer plate&#44; where the samples covered in saline solution were introduced&#46; The measurement of the wear track and its width was done with a <span class="elsevierStyleSmallCaps">V</span>-20A Nikon Profile Projector &#40;Nikon instrument INT&#44; NY&#44; USA&#41;&#46; The use of a trigonometric model let us measure the wear obtained&#44; defining the volume lost in mm<span class="elsevierStyleSup">3</span>&#47;Nm &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; All of the samples tested were observed using a scanning electron microscope&#44; with a previous requisite gold dust coated by sputtering&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">To assess the resistance of the samples at a moment of flexion&#44; we carried out testing using the international standard ISO 178&#58;1993 and its Spanish modification UNE-EN-ISO 178&#46; We used a universal testing machine &#40;IB-MU4&#44; IBERTEST&#44; Ibertest group&#44; Madrid&#44; Spain&#41; with 3-point flexion testing jaws&#44; placing each sample over the lower points and applying a central force over the upper face of the sample&#46; The distance between both lower supports was 64<span class="elsevierStyleHsp" style=""></span>mm&#44; applying the force in the central point at a speed of 1<span class="elsevierStyleHsp" style=""></span>mm&#47;min &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and C&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">For the statistical analysis&#44; we used the SPSS<span class="elsevierStyleSup">&#174;</span> version 15&#46;0 computer package for MS-Windows &#40;SPSS Inc&#46;&#44; Chicago&#44; USA&#41;&#46; The ANOVA test was used for the comparison of the variables studied among the various groups for the wear tests&#44; and Student&#39;s <span class="elsevierStyleItalic">t</span>-test for independent samples in the mechanical resistance studies&#46; Statistically significant differences were defined as those having <span class="elsevierStyleItalic">P</span> values lower than 5&#37; &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>05&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the results obtained in the wear testing&#46; In the samples tested in dry medium there were wear and coefficient of friction values significantly greater than those tested in liquid medium&#44; whatever the process of conditioning &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>05&#41;&#46; The medium of study also conditioned how wear was produced&#44; in that continuous wear was observed in the samples in dry medium in comparison to exponential wear in samples studied in liquid medium &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The decrease in wear observed was more than 60&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; The performance of a previous process of conditioning &#40;Groups 3&#8211;4&#41; diminished both wear and the coefficient of friction obtained in comparison to the samples that presented a lack of conditioning &#40;Group 2&#41;&#44; although there was no statistically significant difference&#46; Increasing the time of conditioning from 1 week &#40;Group 3&#41; to 1 month &#40;Group 4&#41; produced a significantly greater decrease in the values of wear and coefficient of friction &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#46;</span>04&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Scanning electron microscopy &#40;SEM&#41; showed a smaller size of the wear tracks tested in dry medium&#46; The wear was of the abrasive type&#44; changing to mainly adhesive when testing the samples in liquid medium &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The results obtained in the flexion testing are summarized in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; Samples tested in liquid medium presented lower resistance to breaking&#44; bearing forces of lesser magnitude and suffering deformation to a lesser degree&#44; than the samples studied in dry medium&#46; The stress registered in the samples studied in liquid medium was also lower than that obtained in dry medium&#46; No variations in the model of elasticity were observed&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">The results of our study were influenced by the choices of bone cement&#44; environmental conditions&#44; and antibiotic&#46; For this study we used Palacos<span class="elsevierStyleSup">&#174;</span> R&#43;G &#40;Heraeus Medical GmbH&#44; Wehrheim&#44; Germany&#41; as it is one of the most widely used commercial cements that had the best long-term results&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> The environmental conditions selected were defined attempting to imitate the normal conditions existing in operating rooms where bone cement is used&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> The industrial addition of a small amount of an antibiotic like gentamicin has not been shown to affect the mechanical properties in previous studies&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The choice of vancomycin as the antibiotic was based on its wide distribution&#44; its use as treatment of prosthesis infection associated to PMMA&#44; and its reduced price&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;17</span></a> All samples were mixed manually&#46; This method increases porosity in PMMA&#44; which leads to reducing the mechanical resistance and increasing the elution of PMMA&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;18&#8211;20</span></a> This has been called into question by McLaren et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The effect of immersing PMMA in a liquid medium has been studied previously&#46; Schmitt et al&#46; described an increase in cement mass when it was submerged in saline solution&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Other authors observed a decrease in the model of elasticity as water was absorbed&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> with PMMA even becoming saturated at 3 months without any observable changes in its properties although the water acted as an initiator of fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> The plasticizing effect of the water and its influence on the mechanical properties of the bone cement have been described in detail&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;24&#44;25</span></a> with it being due to the absorption of water by the PMMA&#44; a process described in other polymers&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> being cyclic&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In our study we did not find statistical significance in the changes observed in the mechanical properties of PMMA studied in dry medium as compared to that studied in liquid medium&#46; However&#44; there was a clear tendency to a decrease in these properties when we introduced the PMMA in a medium with liquid&#46; These results are the same as those found in the literature&#46; Nottrott<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> studied the behavior of Palacos<span class="elsevierStyleSup">&#174;</span> R&#43;G and CMW 3 Genta<span class="elsevierStyleSup">&#174;</span> stored for 5 years in a dry medium against for 3 weeks in a medium with water&#59; they found an increase in resistance to stress and in the model of elasticity in the samples that had been stored dry&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The wear observed in our study was low compared to the coefficients of friction obtained&#44; with significantly lower wear in the samples studied in liquid medium&#46; This could be due to the lubricating effect of water&#44; the modification of the wear pattern from an abrasive behavior to an adhesive one&#44; and to the deposit itself of substances in the wear track of the samples tested in liquid &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>A&#8211;F&#41;&#44; although the authors have no knowledge of any prior descriptions of this phenomenon&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Bone cement is not a static component&#59; its mechanical properties vary over time&#46; Cizmecioglu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> described the influence of PMMA &#8220;aging&#8221; on its elasticity&#44; determined by the amount of residual monomer&#44; which has a damaging effect on PMMA resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In our study&#44; we obtained less wear in the samples that had undergone a process of conditioning&#44; observing an influence of period of adaptation in this decrease&#59; the samples submitted to a month of conditioning presented significantly less wear than the samples submitted to a week&#46; To the best of our knowledge&#44; there is no previous study that evaluates the time of aging in a liquid medium on PMMA resistance to wear&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In contrast to previous studies in the literature&#44; in our study we used PMMA wear as another variable to measure the influence of the liquid medium on mechanical properties&#46; An increase in wear could be prejudicial to implant fixation&#59; Saleh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> and Goodman<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> described how the particles of bone cement wear could be involved in periprosthetic osteolysis&#44; although excessive wear could be useful in other situations because of the increase in elution of antibiotic present on the surface of articulating spacers&#46; This study is an initial step in attempting to understand what happens on the surface of these spacers&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In our study we wanted to imitate the environmental conditions in a joint&#46; To this end&#44; we used a medium of study with saline solution&#44; but we must accept certain limitations&#46; A healthy joint contains&#44; in addition to synovial liquid&#44; various substances such as proteins&#44; cells&#44; glucose and so on that give it different rheological properties from those of saline solution&#46; Using a watertight medium for producing the conditioning and wear also differs from the normal behavior of a joint&#44; where there is a flux between absorption&#47;production&#44; in addition to movement&#44; which can have an effect on the particles of wear being deposited on the cement itself and can consequently change the wear values obtained&#46; We feel that it is important to keep these considerations in mind when interpreting the results&#46; We do not believe that the limited number of samples represents a limitation for the results of this study&#44; although it could indeed have limited the obtaining of statistical significance in specific groups&#46; Other publication of special relevance in biomaterials have used similar sample sizes&#59; examples are Unemori et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> who utilized 3 samples to observe the absorption of water in modified PMMA&#44; and Bridgens et al&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> who used 2 samples to study the elution and mechanical resistance of various cements mixed with PMMA&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In conclusion&#44; the results obtained in this study show the damaging effect of the liquid medium on PMMA&#44; which brings into question the use of the data obtained in previous studies carried out in dry medium extrapolated to clinical practice&#46; Nevertheless&#44; further studies that back this up are required&#44; as well as additional studies to evaluate if the decrease in PMMA resistance and wear with vancomycin observed in this study continues in other PMMA isolated or in combination with other antibiotics&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Level of evidence</span><p id="par0110" class="elsevierStylePara elsevierViewall">Level of evidence 1&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical responsibilities</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Protection of persons and animals</span><p id="par0115" class="elsevierStylePara elsevierViewall">The authors declare that no experiments on human beings or animals were performed for this research&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Data confidentiality</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Right to privacy and informed consent</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The use of bone cement is widespread in orthopedic surgery&#46; Most of the mechanical tests are performed in dry medium&#44; making it difficult to extrapolate the results&#46; The objective of this study is to assess if the mechanical properties of polymethylmethacrylate &#40;PMMA&#41;&#44; obtained in previous reports&#44; are still present in a liquid medium&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An experimental study was designed with antibiotic &#40;vancomycin&#41; loaded PMMA&#46; Four groups were defined according to the medium &#40;dry or liquid&#41; and the pre-conditioning in liquid medium &#40;one week or one month&#41;&#46; Wear and flexural strength tests were performed according to ASTM and ISO standards&#46; Volumetric wear&#44; friction coefficient&#44; tensile strength&#44; and Young&#39;s modulus were analyzed&#46; All samples were examined by scanning electron microscopy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The samples tested in liquid medium showed lower wear and flexural strength values &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; The kind of wear was modified from abrasive to adhesive in those samples studied in liquid medium&#46; The samples with a pre-conditioning time showed lower values of wear &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Caution is recommended when extrapolating the results of previous PMMA results&#46; The different mechanical strength of the cement in a liquid medium&#44; observed in saline medium&#44; is much closer to the clinical situation&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El uso del cemento &#243;seo esta muy extendido en COT&#44; existiendo multitud de estudios experimentales que lo avalan&#46; La mayor&#237;a de los ensayos mec&#225;nicos est&#225;n realizados en seco&#44; lo que cuestiona la extrapolaci&#243;n de los resultados a la cl&#237;nica&#46; El objetivo de este estudio es evaluar si las propiedades mec&#225;nicas del polimetilmetacrilato &#40;PMMA&#41; obtenidas en series previas en seco&#44; se mantienen en un medio fisiol&#243;gico&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se ha dise&#241;ado un estudio experimental para evaluar este aspecto&#44; utilizando PMMA con antibi&#243;tico &#40;vancomicina&#41;&#46; Cuatro grupos fueron definidos en funci&#243;n del medio estudiado &#40;seco o l&#237;quido&#41; y de la realizaci&#243;n de un acondicionamiento previo en suero fisiol&#243;gico &#40;una semana o un mes&#41;&#46; Se hicieron estudios de desgaste y resistencia a flexi&#243;n seg&#250;n las normativas ISO y ASTM&#44; valorando el desgaste&#44; el coeficiente de fricci&#243;n&#44; la resistencia a la rotura y el modulo de Young&#46; Las muestras fueron analizadas mediante microscop&#237;a electr&#243;nica&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Las muestras ensayadas en medio l&#237;quido presentaron menores valores de desgaste&#44; as&#237; como menor resistencia a flexi&#243;n&#44; obteni&#233;ndose significaci&#243;n en el desgaste&#46; El tipo de desgaste se modific&#243; de un desgaste abrasivo a uno adhesivo en aquellas muestras estudiadas en medio l&#237;quido&#46; El tiempo de acondicionamiento proporcion&#243; menores valores de desgaste &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se recomienda precauci&#243;n a la hora de extrapolar los resultados de los estudios sobre PMMA en seco dado el diferente comportamiento mec&#225;nico del cemento en un medio l&#237;quido mucho m&#225;s cercano a la situaci&#243;n cl&#237;nica real&#44; como es el suero fisiol&#243;gico&#46;</p>"
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sanz-Ruiz P&#44; Paz E&#44; Abenojar J&#44; del Real JC&#44; Forriol F&#44; Vaquero J&#46; Influencia del medio fisiol&#243;gico sobre las propiedades mec&#225;nicas del cemento &#243;seo&#46; &#191;Son los estudios actuales extrapolables&#63;&#46; Rev Esp Cir Ortop Traumatol&#46; 2014&#59;58&#58;3&#8211;10&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">This study received the 2013 SECOT Award for Basic Research in Orthopedic Surgery and Traumatology&#46;</p>"
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 970
            "Ancho" => 1301
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Molds used to prepare the samples of wear &#40;A&#41; and flexion &#40;B&#41;&#46; Samples before their testing&#44; once removed from the mold &#40;C and D&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2015
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            "Tamanyo" => 371669
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        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Instruments used to carry out the testing and the conditions applied&#46; Universal testing machine &#40;A&#41; and tribometer &#40;B&#41;&#46; Illustration of the study conditions for flexion &#40;C&#41; and wear &#40;D&#41; testing&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1446
            "Ancho" => 2152
            "Tamanyo" => 107046
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Trigonometric model used to calculate wear&#59; <span class="elsevierStyleItalic">d</span> &#40;distance covered<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1000<span class="elsevierStyleHsp" style=""></span>m&#41;&#44; <span class="elsevierStyleItalic">F</span> &#40;force applied<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>N&#41;&#44; <span class="elsevierStyleItalic">V</span><span class="elsevierStyleInf">lost</span> &#40;volume lost due to wear&#41;&#44; <span class="elsevierStyleItalic">V</span><span class="elsevierStyleInf">torus</span> &#40;volume of the rotation torus&#41;&#44; <span class="elsevierStyleItalic">R</span><span class="elsevierStyleInf">spin</span> &#40;radius of the wear track&#41;&#44; <span class="elsevierStyleItalic">R</span><span class="elsevierStyleInf">ball</span> &#40;radius of the wear ball<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; <span class="elsevierStyleItalic">D</span><span class="elsevierStyleInf">external</span> &#40;external diameter of the wear track&#41;&#44; <span class="elsevierStyleItalic">B</span> &#40;width of the track&#41;&#44; <span class="elsevierStyleItalic">A</span> &#40;area&#41;&#44; and <span class="elsevierStyleItalic">h</span> &#40;height&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1662
            "Ancho" => 1579
            "Tamanyo" => 191847
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Evolution of the coefficient of friction in liquid medium &#40;upper figure&#41; and in dry medium &#40;lower figure&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 897
            "Ancho" => 1800
            "Tamanyo" => 354412
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Images of the wear tracks obtained by electron microscope&#46; In the upper images &#40;A&#8211;C&#41; abrasive wear can be seen in contrast to that obtained in the lower images &#40;D&#8211;F&#41;&#46; Note the particles adhered to the surface in E and &#40;in a larger scale&#41; in Image F&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Circular samples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Rectangular samples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No conditioning&#46; Samples tested in dry medium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No conditioning&#46; Samples tested in dry medium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Samples tested in liquid medium without prior conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Samples tested in liquid medium after a week of conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Samples tested in liquid medium after a month of conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Samples tested in liquid medium after a month of conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab455480.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Definition of the 4 groups based on conditioning process&#46;</p>"
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      ]
      6 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Group 1Dry medium without conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Group 2Liquid medium without conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Group 3Liquid medium 1 week of conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Group 4Liquid medium 1 month of conditioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wear track width&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wear track diameter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;8<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;94<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;9<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;1<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;70<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;1<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Wear&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;09<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#47;Nm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;003<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#47;Nm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;003<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#47;Nm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;001<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>&#47;Nm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;4</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coefficient of friction&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;72<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;07&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Dry medium &#40;no conditioning&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;3<span class="elsevierStyleHsp" style=""></span>MPa&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;005<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Young model&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1814&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>71&#46;3&nbsp;\t\t\t\t\t\t\n
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:32 [
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              "referencia" => array:1 [
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                  "host" => array:1 [
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            1 => array:3 [
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            3 => array:3 [
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                        "fecha" => "2007"
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                      "autores" => array:1 [
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Article information
ISSN: 19888856
Original language: English
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2022 May 29 9 38
2022 April 23 13 36
2022 March 23 8 31
2022 February 8 9 17
2022 January 6 11 17
2021 December 10 11 21
2021 November 5 13 18
2021 October 6 13 19
2021 September 10 6 16
2021 August 11 7 18
2021 July 9 11 20
2021 June 12 17 29
2021 May 10 3 13
2021 April 15 12 27
2021 March 9 11 20
2021 February 8 3 11
2021 January 6 4 10
2018 February 7 1 8
2018 January 3 0 3
2017 December 5 0 5
2017 November 6 1 7
2017 October 8 0 8
2017 September 4 8 12
2017 August 17 1 18
2017 July 6 3 9
2017 June 33 3 36
2017 May 13 5 18
2017 April 10 6 16
2017 March 12 30 42
2017 February 12 3 15
2017 January 13 2 15
2016 December 16 3 19
2016 November 11 2 13
2016 October 22 5 27
2016 September 20 5 25
2016 August 15 1 16
2016 July 21 3 24
2016 June 17 5 22
2016 May 15 20 35
2016 April 11 11 22
2016 March 19 18 37
2016 February 14 13 27
2016 January 14 16 30
2015 December 0 8 8
2015 November 0 8 8
2015 October 0 7 7
2015 September 0 1 1
2015 August 0 1 1
2014 October 0 1 1
2014 September 0 1 1
2014 August 0 1 1
2014 July 0 1 1
2014 May 0 1 1
2014 March 1 0 1
2014 February 1 1 2
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos