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Resumen
Este trabajo revisa varios «puntos conflictivos» de la gerontología actual, como la búsqueda de los genes de la longevidad, el papel en el envejecimiento del estrés oxidativo y el de las vías de señalización de insulina IGF-1, la participación en el envejecimiento celular y el cáncer de los telómeros y las telomerasas, y la función de la glándula pineal en el proceso de envejecimiento y el cáncer. Se ha publicado en los últimos años una gran cantidad de artículos y excelentes documentos de investigación sobre estos temas. Creemos que el entusiasmo que han provocado los nuevos descubrimientos debe ser compensado por un sano escepticismo, como indica el sofisma de Sócrates: cuando aumenta nuestro conocimiento, obligatoriamente aumenta nuestro desconocimiento.
Palabras clave:
Gerontología actual
Genes de la longevidad
Envejecimiento del estrés oxidativo
Abstract
The present study reviews several controversial areas of current gerontology, such as the search for longevity genes, the role of oxidative stress in ageing and that of insulin/insulin-like growth factor-1 (IGF-1) signalling pathways, the contribution of telomeres and telomerases in cellular ageing and cancer, and the function of the pineal gland in the process of ageing and cancer. In the last few years, a large number of articles and high-quality research studies have been published on these subjects. We believe that theenthusiasm stimulated by these new findings should be counterbalanced by healthy scepticism, as expressed by Socrates' sophism: as our knowledge increases, so necessarily does our lack of knowledge.
Key words:
Current gerontology
Longevity genes
Oxidative stress ageing
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