metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Is a selective brain 18F-FDG PET/CT study profitable in patients with small cell...
Journal Information
Vol. 31. Issue 3.
Pages 124-129 (May - June 2012)
Share
Share
Download PDF
More article options
Visits
1468
Vol. 31. Issue 3.
Pages 124-129 (May - June 2012)
Original article
Is a selective brain 18F-FDG PET/CT study profitable in patients with small cell lung cancer?
¿Resulta rentable un estudio selectivo cerebral con 18F-FDG-PET/TAC en los pacientes con cáncer microcítico de pulmón?
Visits
1468
A. Palomar Muñoz
Corresponding author
azaharap@sescam.jccm.es

Corresponding author.
, A.M. García Vicente, M.E. Bellón Guardia, B. González García, M.P. Talavera Rubio, J.P. Pilkington Woll, A. Núñez García, V.M. Poblete García, J.M. Cordero García, A. Soriano Castrejón
Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (2)
Table 1. Epidemiologic and clinico-pathologic characteristics of the patients: age range (years).
Table 2. Characteristics and number of cerebral lesions in each of the patients in the selective cerebral PET/CT study and in the conventional imaging techniques performed posteriorly. CT with intravenous contrast and MRI in the case of patient number 5.
Show moreShow less
Abstract
Aim

To evaluate the diagnostic yield of a selective brain 18F-FDG PET/CT in neurologically asymptomatic patients with small cell lung cancer.

Material and methods

Twenty-one neurologically asymptomatic patients referred to our service between July 2008 and December 2009 for staging of small cell lung cancer were included in the study. All underwent a standard 18F-FDG PET/CT study followed by a selective brain PET/CT. The neurological findings were confirmed by CT scan with intravenous contrast, MRI or minimum clinical follow-up of 6 months.

The brain PET/CT was considered positive if any alteration was observed in the FDG distribution that was not related with previously known benign lesion in the CT image.

Results

Brain metastases were detected in 5 of the 21 patients (23.8%), these being correctly classified in 3 of them by the selective brain PET/CT. The stage was upgraded in one of them with the selective brain study. Only one patient showed a hypermetabolic lesion in the PET images in relationship to the lesions observed in the CT images. Sensitivity, specificity, positive predictive value and negative predictive value were 60, 100, 100 and 88.89%, respectively.

Conclusion

Hypometabolic areas in the cerebral parenchyma are frequently associated to metastatic lesions in patients with small cell lung cancer. The selective brain PET/CT in these patients allows correct staging and early treatment of unsuspected metastasis.

Keywords:
PET/CT
Small cell lung cancer
Brain metastases
Resumen
Objetivo

Evaluar la rentabilidad diagnóstica del estudio selectivo cerebral con 18F-FDG-PET/TAC en pacientes con cáncer microcítico de pulmón asintomáticos neurológicamente.

Material y métodos

Se incluyeron en el estudio 21 pacientes derivados a nuestro servicio entre julio de 2008 y diciembre de 2009, para estadificación, con histología de carcinoma microcítico de pulmón y asintomáticos neurológicamente. A todos ellos se les realizó un estudio 18F-FDG-PET/TAC estándar y a continuación un estudio selectivo cerebral, y se confirmaron los hallazgos neurológicos mediante TAC con contraste intravenoso, RM o seguimiento clínico mínimo de 6 meses. Un estudio cerebral PET fue considerado positivo si mostraba cualquier alteración en la distribución de la FDG no relacionada con lesiones benignas previas en la TAC cerebral.

Resultados

En 5 de los 21 pacientes (23,8%) se detectaron metástasis cerebrales, siendo correctamente diagnosticados mediante 18F-FDG-PET/TAC 3 de ellos. En uno de ellos la realización del estudio cerebral incrementó el estadio. Sólo uno de los pacientes mostró hipermetabolismo en la imagen PET en relación con las lesiones cerebrales evidenciadas en la imagen TAC. Se obtuvieron valores de sensibilidad, especificidad, valores predictivos positivo y negativo del 60, 100, 100 y 88,89%, respectivamente.

Conclusión

Las áreas hipometabólicas en el parénquima cerebral con frecuencia se asocian a lesiones metastásicas en pacientes con cáncer microcítico de pulmón. La realización de un estudio selectivo cerebral PET/TAC en estos pacientes permite una correcta estadificación y el tratamiento precoz de las metástasis no sospechadas.

Palabras clave:
PET/TAC
Cáncer de pulmón microcítico
Metástasis cerebrales

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos