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Clinical note
68Ga-DOTANOC PET/CT detection of multiple extracranial localizations in a patient with anaplastic meningioma
Uso de 68Ga-DOTANOC PET/TC en la detección de localizaciones extracraneales múltiples en un paciente con meningioma anaplásico
A. Golemia, A. Ambrosinib, P. Cecchic, A. Ruiud, S. Chondrogiannise, M. Farsada, D. Rubelloe,
Corresponding author
a Division of Nuclear Medicine, Central Hospital, Bolzano, Italy
b Division of Pathology, Central Hospital, Bolzano, Italy
c Division of Neurosurgery, Central Hospital, Bolzano, Italy
d Division of Radiology, Central Hospital, Bolzano, Italy
e Department of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Rovigo, Italy
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Intracranial meningiomas are slow-growing mostly benign neoplasms composed of neoplastic meningothelial tissue originating from the arachnoidal cap cells&#46; With its annual incidence of six cases on 100&#44;000 and its prevalence of 95 on 100&#46;000 they represent the most common benign tumours of the brain&#46; The WHO classification describes nine different histological benign variants and six histological variants associated with a greater risk&#44; WHO grade II &#40;atypical&#41; and WHO grade III &#40;anaplastic&#44; papillary and rhabdoid&#41;&#44; representing respectively 10&#37; and 2&#46;5&#37; of the overall tumours&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Malignant behaviour with distant metastatic localizations have been previously reported but therein not a common agreement about the effect of a multi-therapeutic approach&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> We report a case of a patient with intracranial meningioma and extracranial metastatic localizations and discuss the potentials of PET imaging with <span class="elsevierStyleSup">68</span>Ga-DOTA-Peptides in management of these patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 65-year-old male with a severe headache persisting for more than 1 month was admitted to our clinic&#46; His neurological examination was unremarkable&#46; Cranial computed tomography &#40;CT&#41; first and magnetic resonance imaging &#40;MRI&#41; next suspected meningioma&#46; At surgery the histological diagnosis was meningothelial meningioma WHO grade II&#46; About 8&#8211;9&#37; of the tumour cells were positive for Ki-67 antigen&#46; The patient was treated subsequently with radiation therapy&#46; He was admitted to our hospital for 2 years later with a 10-day history of blurred vision and progressive visual impairment&#46; MR imaging identified tumour recurrence on cerebellar tentorium&#44; cerebral falx and right parietal lobe&#46; He underwent a <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;CT scan for pre-therapeutic assessment of the somatostatin receptor status&#44; as a peptide receptor radionuclide therapy &#40;PRRT&#41; was proposed&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTANOC was produced in our radiopharmacy using standard synthesis techniques&#46; The patient was injected i&#46;v&#46; with about 185<span class="elsevierStyleHsp" style=""></span>MBq of the tracer&#59; the PET scanning was carried out 80&#8211;90<span class="elsevierStyleHsp" style=""></span>min after injection of <span class="elsevierStyleSup">68</span>Ga-DOTANOC&#44; using a dedicated tomograph &#40;PHILIPS GEMINI TF 16&#41;&#46; Emission scan was acquired for 4<span class="elsevierStyleHsp" style=""></span>min at every table positron&#44; PET images were evaluated by visual inspection and semi-quantitative analysis performed by two experienced readers&#46; Standardized uptake values &#40;SUV&#41; were available to the readers at the moment of reporting&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;TC revealed increased uptake in the cerebellar tentorium&#44; cerebral falx&#44; right parietal lobe&#44; both lungs and pleura and local lymph nodes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Only one of the pleural nodules was studied with a CT guided biopsy &#40;18 Gauge tru-cut biopsy needle&#41;&#58; histopathologic findings were consistent with an atypical meningioma&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">Meningiomas are frequently reported as primary intracranial neoplasms with a benign clinical course&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Distant localizations have been reported previously to be very rare and they occur not only in malignant tumours but&#44; to a lesser extent&#44; also in benign and intermediary tumours&#46; In a recent review Surov<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a> reported 115 cases of malignant meningiomas with a total of 164 metastatic extracranial lesions&#46; The most common extracranial localizations are the lung followed by liver&#44; lymph nodes&#44; and bones&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Surgical resection of meningiomas is the first treatment choice&#44; but is not always feasible&#46; As extracranial localizations of meningiomas are very rare&#44; there are no general guidelines regarding their treatment or staging&#46; Most distant lesions were either resected or treated in combination with local radiation&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">MRI with contrast administration is considered the gold standard imaging modality for detection and evaluation of disease extension of meningioma&#46; Whole-body imaging methods are not routinely performed&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">There are limited data about the use of Single Photon Emission Computed Tomography &#40;SPECT&#41; and Positron Emission Tomography &#40;PET&#41; with various tracers in different clinical settings of patients with meningioma&#46; Nuclear medicine techniques may provide complementary information to CT and MRI&#46; There are only few reports about the use of SPECT tracers&#44; especially Thalium-201 and <span class="elsevierStyleSup">99m</span>Tc-MIBI in meningioma patients&#44; providing information about the biological characteristics of tumour&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> PET imaging has become the preferred functional imaging method because of the better imaging properties compared to conventional nuclear medicine techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> The most commonly used PET tracer&#44; FDG&#44; showed however limited utility in management of patients with meningioma&#46; The FDG uptake of primary intracranial meningioma is typically low&#44; because glucose metabolism in meningioma is similar to that of surrounding tissue&#46; PET tracers beyond FDG&#44; Choline&#44; Methionine and Tyrosine&#44; have a more favourable tumour&#47;background ratio and allow easily the detection of intracranial meningioma&#46; These tracers were mainly used for radiation treatment planning or grading of meningiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Many studies have shown that somatostatin receptors &#40;SSTRs&#41; are expressed on the cell membrane of meningioma&#44; usually with a high SSTR2 density&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> Therefore some authors suggest the use of somatostatin receptor scintigraphy &#40;SRS&#41; and <span class="elsevierStyleSup">68</span>Ga-DOTATOC PET-CT for preoperative evaluation of meningioma in order to increase the accuracy of surgical resection and for delineation of the target volume for external beam radiation&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5&#44;6</span></a> Furthermore in meningioma patients who had relapsed after multiple surgery or radiotherapy&#44; or had non-operable lesions&#44; and in whom no further treatment options were available&#44; PRRT using <span class="elsevierStyleSup">90</span>Y-DOTA-Peptides or <span class="elsevierStyleSup">177</span>Lu-DOTA-Peptides were proposed&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Other authors confirmed the therapeutic potential of PRRT alone or in combination with radiation therapy in patients with meningioma and successful treatments has been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">8&#44;9</span></a> SRS and <span class="elsevierStyleSup">68</span>Ga-DOTA-Peptide PET-CT may be used as diagnostic method for selection of patients feasible for PPRT&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our case shows that malignant meningioma with extracranial locations may present high uptake of somatostatin receptor analogues&#46; Lanfranchi et al&#46; in a recent paper showed multiple pulmonary and hepatic metastases using SRS&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> To the best of our knowledge&#44; the current study is the only report of <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET-CT detecting multiple localizations of meningioma&#44; confirmed also by pathological examination&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In selected patients somatostatin receptor imaging may be useful for staging&#44; detection of recurrence&#44; evaluation of disease extension and patient selection for PPRT in patients with multiply relapsed or aggressive meningioma&#46; PET with <span class="elsevierStyleSup">68</span>Ga-DOTANOC had high affinity for human SSTR &#40;especially SSTR2&#44; SSTR3&#44; SSTR5&#41;&#44; presents several advantages over SRS and should be potentially the method of choice in this setting&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interest statement</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report herein a case of a 65-year-old male with intracranial recurrence of atypical meningioma initially treated with a combination of surgical resection and gamma knife radiotherapy&#46; Afterwards&#44; he underwent a <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;CT scan in order to evaluate the feasibility of peptide receptor radionuclide therapy &#40;PRRT&#41;&#46; The scan identified multiple pulmonary&#44; pleural and lymph node localizations&#46; Histological diagnosis was consistent with intracranial atypical meningioma with diffuse metastatic spread&#46; In our case&#44; we have shown that meningioma with extracranial locations may present high uptake of somatostatin receptor analogues&#46; Among other radionuclides&#44; we believe that <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;CT may be particularly useful for staging&#44; detection of recurrence&#44; evaluation of disease extension and alternative therapeutic approaches&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de un var&#243;n de 65 a&#241;os de edad&#44; con recurrencia intracraneal de meningioma at&#237;pico tratada inicialmente con una combinaci&#243;n de resecci&#243;n quir&#250;rgica y radioterapia bistur&#237; de rayos gamma&#46; Despu&#233;s se someti&#243; a una exploraci&#243;n <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;TC con el fin de evaluar la viabilidad de la terapia metab&#243;lica con el receptor del p&#233;ptido &#40;PRRT&#41;&#46; Se identificaron m&#250;ltiples localizaciones en pulm&#243;n&#44; pleura y ganglios linf&#225;ticos&#46; El diagn&#243;stico histol&#243;gico fue compatible con meningioma at&#237;pico intracraneal y diseminaci&#243;n metast&#225;sica difusa&#46; Se ha demostrado con nuestro caso que meningioma con localizaciones extracraneales puede presentar alta captaci&#243;n de an&#225;logos de los receptores de somatostatina&#46; Entre otros radiotrazadores creemos que <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET&#47;TC puede ser particularmente &#250;til en la estadificaci&#243;n&#44; detecci&#243;n de la recurrencia&#44; la evaluaci&#243;n de la extensi&#243;n de la enfermedad y los enfoques terap&#233;uticos alternativos&#46;</p></span>"
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