Article
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
array:23 [ "pii" => "S2253808921000823" "issn" => "22538089" "doi" => "10.1016/j.remnie.2021.04.011" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "1289" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41 Supl 1:S26-S28" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S2253654X21000664" "issn" => "2253654X" "doi" => "10.1016/j.remn.2021.03.008" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "1289" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41 Supl 1:S26-S28" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imágenes de interés</span>" "titulo" => "Carcinoma primario de células pequeñas de próstata: implicación prometedora de la imagen PET con doble radiotrazador utilizando PSMA y análogos de receptores de somatostatina (SSTR)" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S26" "paginaFinal" => "S28" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Primary small cell carcinoma of the prostate: Promising implication for double tracer PET-imaging using PSMA and SSTR-ligands" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1584 "Ancho" => 2007 "Tamanyo" => 279020 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cortes axiales de fusión de la PET/TC con [<span class="elsevierStyleSup">68</span>Ga]Ga-PSMA-11 (A, D, G) y la PET/TC con [<span class="elsevierStyleSup">68</span>Ga]Ga-DOTA-TOC (B, E y H), así como las correspondientes imágenes de TC con contraste (C, F, I). En la PET/TC con [<span class="elsevierStyleSup">68</span>Ga]Ga-PSMA-11, se evidencia una elevada captación en las metástasis óseas (A), captación ausente en la extensa afectación hepática (D) y captación heterogénea y parcialmente ausente o baja en las adenopatías metastásicas (G). Con el [<span class="elsevierStyleSup">68</span>Ga]Ga-DOTA-TOC se documentan metástasis óseas múltiples, con captación heterogénea, parcialmente ausente o leve (B), metástasis hepáticas con captación parcialmente ausente o baja (E) y captación intensa en las metástasis linfáticas ganglionares (H).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Hanna Svirydenka, Christian Uprimny, Bernhard Nilica, Elisabeth von Guggenberg, Lisa-Maria Rossetti, Irene Virgolini" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Hanna" "apellidos" => "Svirydenka" ] 1 => array:2 [ "nombre" => "Christian" "apellidos" => "Uprimny" ] 2 => array:2 [ "nombre" => "Bernhard" "apellidos" => "Nilica" ] 3 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "von Guggenberg" ] 4 => array:2 [ "nombre" => "Lisa-Maria" "apellidos" => "Rossetti" ] 5 => array:2 [ "nombre" => "Irene" "apellidos" => "Virgolini" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808921000823" "doi" => "10.1016/j.remnie.2021.04.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921000823?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X21000664?idApp=UINPBA00004N" "url" => "/2253654X/00000041000000S1/v1_202207160644/S2253654X21000664/v1_202207160644/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S225380892100104X" "issn" => "22538089" "doi" => "10.1016/j.remnie.2021.05.003" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "1292" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41 Supl 1:S29-S30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "Neoplasia neuroendocrina metastásica de origen desconocido: de la incertidumbre en el diagnóstico por imagen a la precisión de la cirugía radioguiada laparoscópica" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S29" "paginaFinal" => "S30" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metastatic neuroendocrine neoplasia of unknown origin: From uncertainty in diagnostic imaging to the accuracy of radioguided laparoscopic surgery" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2398 "Ancho" => 1874 "Tamanyo" => 530072 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Intraoperative localization of the tumor with a laparoscopic probe.</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A/B/C/D—Small intestine. E—Maximum uptake in liver metastases. F—The increase in activity detected by the laparoscopic probe allowed us to identify a small lesion at the level of the serosa of a jejunal loop that in other circumstances could have been considered irrelevant. G—Ex vivo detection in the surgical specimen.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Sanz Viedma, J. Alors Ruiz, J. Roldán de la Rua, S. Ortega Lozano, D. Osorio Fernández, M. Angel Suárez Muñoz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Sanz Viedma" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Alors Ruiz" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Roldán de la Rua" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Ortega Lozano" ] 4 => array:2 [ "nombre" => "D." "apellidos" => "Osorio Fernández" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Angel Suárez Muñoz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X2100069X" "doi" => "10.1016/j.remn.2021.02.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X2100069X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S225380892100104X?idApp=UINPBA00004N" "url" => "/22538089/00000041000000S1/v1_202207210552/S225380892100104X/v1_202207210552/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808921000811" "issn" => "22538089" "doi" => "10.1016/j.remnie.2021.04.010" "estado" => "S300" "fechaPublicacion" => "2022-01-01" "aid" => "1288" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" 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Uprimny, Bernhard Nilica, Elisabeth von Guggenberg, Lisa-Maria Rossetti, Irene Virgolini" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Hanna" "apellidos" => "Svirydenka" "email" => array:1 [ 0 => "hanna.svirydenka@tirol-kliniken.at" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Christian" "apellidos" => "Uprimny" ] 2 => array:2 [ "nombre" => "Bernhard" "apellidos" => "Nilica" ] 3 => array:2 [ "nombre" => "Elisabeth" "apellidos" => "von Guggenberg" ] 4 => array:2 [ "nombre" => "Lisa-Maria" "apellidos" => "Rossetti" ] 5 => array:2 [ "nombre" => "Irene" "apellidos" => "Virgolini" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Medical University Innsbruck, Department of Nuclear Medicine, Austria" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma primario de próstata de células pequeñas: implicación prometedora de la imagen PET de doble trazador utilizando PSMA y análogos de la somatostatina (SSTR) radiomarcados" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2301 "Ancho" => 2925 "Tamanyo" => 562316 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Axial fused <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT (A, D, G) and <span class="elsevierStyleSup">68</span>Ga-DOTATOC PET/CT (B, E and H) and corresponding contrast enhanced CT images (C, F, I). On <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT was the evidence of high uptake in bone metastases (A) absent uptake in extended liver metastases (D) and heterogeneous, partially absent until low uptake in lymph node metastases (G). On <span class="elsevierStyleSup">68</span>Ga-DOTATOC was the documentation of multiple bone metastases with heterogeneous partially absent until mild uptake (B), partially absent until low uptake in liver metastases (E) and intense uptake in lymph node metastases (H).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">One year ago a 51-year-old man was diagnosed with a metastatic poorly differentiated invasive and partially neuroendocrine differentiated prostate adenocarcinoma, Gleason score 9 (4<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>5), UICC2017: Grad 3, L1, Pn1, with high initial prostate-specific antigen (PSA) level (152<span class="elsevierStyleHsp" style=""></span>ng/ml).</p><p id="par0010" class="elsevierStylePara elsevierViewall">Conventional pre-therapeutic staging showed extensive, histologically confirmed, bone involvement. Based on the diagnosis palliative therapeutic lines were employed: docetaxel 6 cycles 75<span class="elsevierStyleHsp" style=""></span>mg/m<span class="elsevierStyleSup">2</span>, androgen-deprivation therapy with 22,5<span class="elsevierStyleHsp" style=""></span>mg eligard and 120<span class="elsevierStyleHsp" style=""></span>mg denosumab.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Ten months later the patient presented with a good clinical response, having a significant reduction of PSA level (PSA 2,3<span class="elsevierStyleHsp" style=""></span>ng/ml) as well as stable disease according RECIST 1.1.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Unfortunately, another four months later, the patient had new laboratory tumor onset (PSA 3,6<span class="elsevierStyleHsp" style=""></span>ng/ml) and was scheduled for restaging with the <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) which demonstrated extensive metastatic lymph node, visceral and bone spread (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A, D, and G). It also showed absent uptake in extended liver metastases and a heterogeneous, partially absent to low uptake in lymph node metastases. Therefore, the patient was addressed to further investigations.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">A histopathological examination of liver biopsy specimen (segment IV) demonstrated Ki-67-LI 90%, cromogranin –, Islet 1+, CdX2. Synaptophysin and thyroid transcription factor (TTF 1) were both positive and PSA negative. These findings could possibly point in the direction of a neuroendocrine differentiated pulmonary or extrapulmonary tumour.</p><p id="par0030" class="elsevierStylePara elsevierViewall">To exclude primary neuroendocrine differentiated cancer and to show the extend of somatostatin receptor (SSTR) avid lesions, the patient was scheduled for a SSTR PET/CT using the <span class="elsevierStyleSup">68</span>Ga-DOTATOC ligand (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B).</p><p id="par0035" class="elsevierStylePara elsevierViewall">Two weeks later the SSTR scan was performed and the absence of pulmonary lesions was confirmed. Moreover, no other SSTR positive primary tumor was revealed. It did however, reveal multiple extended SSTR avid lesions (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B, E, H), proving a clear PSMA/SSTR mismatch pattern. Based on these findings, evidence of advanced-stage SCPCa (small cell prostate cancer) has to be considered.</p><p id="par0040" class="elsevierStylePara elsevierViewall">SCPCa is however, less than 2% of the de novo prostate cancer. In some cases, neuroendocrine differentiation occurs sequentially.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Histologically, SCPCa is a part of a spectrum of anaplastic tumors of the prostate and similar to small cell cancer of the lungs.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The most common immunohistochemical markers used to diagnose SCPCa are neurospecific enolase, chromogranin, synaptophysin and TTF1.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although TTF-1 is a relatively specific marker for thyroid and lung cancers, it might be expressed in some SCPCa. Studies have demonstrated TTF1 expression in over 50% of SCPCa. The majority of SCPCa are negative for PSA. The histological origin of SCPCa remains controversial.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Metastatic disease occurs frequently with visceral and bone metastases and disproportionally low or absent PSA level. These tumors are highly aggressive, with median survival of 9–10 months.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Much of the therapeutic management of SCPCa are extrapolated from small case series or single-arm trial, prospective trials are lacking.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In view of a growing number of novel drug regimens for therapy of aggressive prostate cancer or prostate cancer of aberrant histology the employment of additional 18F-FDG PET/CT study may be possible in such peculiar context.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Unfortunately, the execution of 18F-FDG PET and the targeted combined radionuclide therapy with 177Lu-PSMA and 177Lu-DOTATATE as intended therapeutic challenging modalities could not be applied in our case: one month after performance the <span class="elsevierStyleSup">68</span>Ga-DOTATOC PET/CT the severe clinical course of metastatic disease has resulted with the <span class="elsevierStyleItalic">exitus</span> of the patient.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Double tracer PET-imaging using PSMA and SSTR-ligand provides the advantages for mapping the extent of this rare disease, which may offer the way toward new frontiers in therapeutic dilemma, particularly the implementation of reasonable novel radionuclide targets for the treatment of the aggressive subtype of prostate cancer.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support and disclaimer</span><p id="par0075" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support and disclaimer" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Svirydenka H, Uprimny C, Nilica B, von Guggenberg E, Rossetti L-M, Virgolini I. Carcinoma primario de células pequeñas de la próstata: implicación prometedora de la imagen PET de doble trazador utilizando PSMA y ligandos SSTR. Rev Esp Med Nucl Imagen Mol. 2022;41:S26–S28.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1220 "Ancho" => 1305 "Tamanyo" => 103352 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Maximum intensity projection (MIP) of <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT (A) vs.</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTANOC PET/CT (B). Different PSMA/SSTR-positive metastases were evidenced.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2301 "Ancho" => 2925 "Tamanyo" => 562316 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Axial fused <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT (A, D, G) and <span class="elsevierStyleSup">68</span>Ga-DOTATOC PET/CT (B, E and H) and corresponding contrast enhanced CT images (C, F, I). On <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT was the evidence of high uptake in bone metastases (A) absent uptake in extended liver metastases (D) and heterogeneous, partially absent until low uptake in lymph node metastases (G). On <span class="elsevierStyleSup">68</span>Ga-DOTATOC was the documentation of multiple bone metastases with heterogeneous partially absent until mild uptake (B), partially absent until low uptake in liver metastases (E) and intense uptake in lymph node metastases (H).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostatic oat cell carcinoma, and marked hypernatremia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.E. Wenk" 1 => "B.S. Bhagavan" 2 => "R. Levy" 3 => "D. Miller" 4 => "W. Weisburger" 5 => "A.C.T.H. Ectopic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1097-0142(197708)40:2<773::aid-cncr2820400226>3.0.co;2-i" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "1977" "volumen" => "40" "numero" => "2" "paginaInicial" => "773" "paginaFinal" => "778" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/196743" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of the prostate: an immunohistochemical study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Yao" 1 => "R. Madeb" 2 => "P. Bourne" 3 => "J. Lei" 4 => "X. Yang" 5 => "S. Tickoo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00000478-200606000-00005" "Revista" => array:7 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2006" "volumen" => "30" "numero" => "6" "paginaInicial" => "705" "paginaFinal" => "712" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16723847" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small cell carcinoma of the prostate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Nadal" 1 => "M. Schweizer" 2 => "O.N. Kryvenko" 3 => "J.I. Epstein" 4 => "M.A. Eisenberger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrurol.2014.21" "Revista" => array:8 [ "tituloSerie" => "Nat Rev Urol" "fecha" => "2014" "volumen" => "11" "numero" => "4" "paginaInicial" => "213" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24535589" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0300893210000667" "estado" => "S300" "issn" => "03008932" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/00000041000000S1/v1_202207210552/S2253808921000823/v1_202207210552/en/main.assets" "Apartado" => array:4 [ "identificador" => "7927" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/00000041000000S1/v1_202207210552/S2253808921000823/v1_202207210552/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921000823?idApp=UINPBA00004N" ]
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The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.
Science Citation Index Expander, Medline, IME, Bibliomed, EMBASE/Excerpta Medica, Healthstar, Cancerlit, Toxine, Inside Conferences, Scopus
See moreThe Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.
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SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
See moreSNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.
See moreRevista Española de Medicina Nuclear e Imagen Molecular (English Edition)
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