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MIP (A) de paciente con fiebre de origen desconocido y síndrome de Sjögren en tratamiento con rituximab. Cuadro clínico compatible con COVID-19 (fiebre y TC con afectación parenquimatosa pulmonar bilateral) desde el 25 de marzo de 2020 con 3 PCR de exudado nasofaríngeo negativas. PET/TC un mes después que muestra intensa captación pulmonar bilateral coincidente alteraciones radiológicas visibles en los cortes axiales de TC (B) y PET/TC (C) y probable reactivación medular. Se realizó un posterior broncoaspirado que confirma, mediante PCR, la infección persistente por SARS-CoV-2. Caso 2. MIP (A) de paciente con esclerosis múltiple en tratamiento con rituximab y fiebre post-COVID de dos meses evolución. Captación patológica de elevada intensidad en ambos parénquimas pulmonares coincidiendo con áreas de opacificación en el TC y PET/TC (B, C). Se realizó posterior biopsia transbronquial con el resultado de neumonitis linfocitaria T (D) y mediante tinción inmunohistoquímica en tejido pulmonar, se evidenció la persistencia del SARS-CoV-2 (E). Caso 3. MIP (A) de paciente joven sin antecedentes de interés con disnea post-COVID de ocho meses de evolución. Muestra múltiples captaciones nodulares en ambos pulmones y captación hiliomediastínica bilateral, coincidentes con áreas de opacificacion del parénquima y adenopatías no aumentadas de tamaño (B, C). El estudio histológico ganglionar obtenido por ecobroncoscopia (D) mostró inflamación granulomatosa no necrotizante de tipo sarcoide. La biopsia transbronquial posterior, demostró el mismo tipo de inflamación granulomatosa sin presencia de virus en la inmunotinción.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Rodríguez-Alfonso, S. Ruiz Solís, L. Silva-Hernández, I. Pintos Pascual, S. Aguado Ibáñez, C. 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"apellidos" => "Infante-de la Torre" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X20301426" "doi" => "10.1016/j.remn.2020.08.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X20301426?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808920301415?idApp=UINPBA00004N" "url" => "/22538089/0000004000000005/v1_202108210518/S2253808920301415/v1_202108210518/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808920300732" "issn" => "22538089" "doi" => "10.1016/j.remnie.2020.05.005" "estado" => "S300" "fechaPublicacion" => "2021-09-01" "aid" => "1178" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Med Nucl Imagen Mol. 2021;40:293-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Radiation exposure of the operators in the preparation and administration of yttrium-90 microspheres in the treatment of malignant hepatic lesions: What is the risk?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "293" "paginaFinal" => "298" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Exposición a la radiación de los operadores en la preparación y administración de microesferas de itrio-90 en el tratamiento de lesiones hepáticas malignas: ¿cuál es el riesgo?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1306 "Ancho" => 1750 "Tamanyo" => 226748 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Preparation of single dose of Sir-Sphere®.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Teresa Scotognella, Andrea Morasca, Luca Zagaria, Amedeo Capostosti, Roberto Iezzi, Luca Indovina, Alessandro Giordano, Germano Perotti" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Teresa" "apellidos" => "Scotognella" ] 1 => array:2 [ "nombre" => "Andrea" "apellidos" => "Morasca" ] 2 => array:2 [ "nombre" => "Luca" "apellidos" => "Zagaria" ] 3 => array:2 [ "nombre" => "Amedeo" "apellidos" => "Capostosti" ] 4 => array:2 [ "nombre" => "Roberto" "apellidos" => "Iezzi" ] 5 => array:2 [ "nombre" => "Luca" "apellidos" => "Indovina" ] 6 => array:2 [ "nombre" => "Alessandro" "apellidos" => "Giordano" ] 7 => array:2 [ "nombre" => "Germano" "apellidos" => "Perotti" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X2030086X" "doi" => "10.1016/j.remn.2020.05.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X2030086X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808920300732?idApp=UINPBA00004N" "url" => "/22538089/0000004000000005/v1_202108210518/S2253808920300732/v1_202108210518/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special collaboration</span>" "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG-PET/CT in SARS-CoV-2 infection and its sequelae" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "299" "paginaFinal" => "309" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "B. Rodríguez-Alfonso, S. Ruiz Solís, L. Silva-Hernández, I. Pintos Pascual, S. Aguado Ibáñez, C. Salas Antón" "autores" => array:6 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "Rodríguez-Alfonso" "email" => array:1 [ 0 => "brodrigueza@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Ruiz Solís" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Silva-Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Pintos Pascual" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Aguado Ibáñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Salas Antón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Nuclear del Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neurología del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Medicina Interna del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Neumología del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Anatomía Patológica del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG-PET/TC ante la infeccion por sars-cov-2 y sus secuelas" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2960 "Ancho" => 2508 "Tamanyo" => 1073550 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Case 1. MIP (A) of patient with fever of unknown origin and Sjögren syndrome receiving treatment with rituximab. Clinical picture compatible with COVID-19 (fever and CT with bilateral parenchymatous involvement) since March 25, 2020 with 3 PCR-negative nasopharyngeal exudates. PET/CT 1 month later showing intense bilateral pulmonary uptake coinciding with radiological alterations visible in the axial CT (B) and PET/CT slices (C) and probable medullary reactivation. A posterior bronchoaspirate was performed confirming persistent infection by SARS-CoV-2 in the PCR.</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Case 2. MIP (A) of patient with multiple sclerosis receiving treatment with rituximab and post-COVID fever of 2 months of evolution. Pathological uptake of elevated intensity is observed in both pulmonary parenchymas coinciding with areas of opacification in the CT and PET/CT (B,C). A transbronchial biopsy was later performed showing T lymphocyte pneumonitis (D), and immunohistochemical staining showed the persistence of SARS-CoV-2 in lung tissue. (E).</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Case 3. MIP (A) of young patient with no history of interest with post-COVID dsypnea of 8 months of evolution. Multiple nodular uptakes are shown in both lungs and bilateral hilar mediastinal uptake, coinciding with areas of opacification of the parenchyma and adenopathies which were not increased in size (B, C). The histological lymph node study obtained by echobronchoscopy (D) showed non necrotizing sarcoid type granulomatous inflammation. The posterior transbronchial biopsy showed the same type of granulomatous inflammation without the presence of virus in the immunostaining.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">On December 31, 2019, the Municipal Commission of Health of Wuhan (Hubei, China) notified an outbreak of 27 cases of pneumonia. After confirmation of almost 32,000 cases, on February 11, 2020, the World Health Organization established the term Coronavirus Disease 2019 (COVID-19) to refer to this new disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This new virus received this name due to the similarity with SARS in 2003, but it is recognized as a different entity. At the time of writing this work, the number of cases confirmed throughout the world was 169,597,415 (Spain 3,663,176) with a total of 3,530,582 deaths (Spain 79,888) and a global mortality of 2.1%, which may be as high as 37% among hospitalized patients<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Information on COVID-19 has increased exponentially, as has the number of cases and almost 100,000 articles have been published in one year, the equivalent to the number of articles on the human immunodeficiency virus published over 14 years<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>. Nevertheless, many aspects of this new disease remain unknown.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Pathogenesis</span><p id="par0015" class="elsevierStylePara elsevierViewall">The physiopathology of SARS-CoV-2 infection is not completely deciphered. It is an encapsulated single-stranded RNA virus that belongs to the β genera of the Coronaviridae family together with MERS and SARS<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. The main means of transmission is through liquid particles from the airway of infected persons. Once in contact with the host, SARS-CoV-2 penetrates into the cells by the binding of its Spike (S) glycoprotein to its principal receptor, angiotensin converting enzyme-2 (ACE-2). Encocytosis is facilitated by the transmembrane protein TMPRSS2<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>. The ACE-2 receptors are strongly expressed in ciliated epithelial cells of the respiratory tract, in type II pneumocytes and in the alveolar macrophages and are also present in other tissues such as the brain, kidney, intestine, heart, uterus, suprarenal glands, gastrointestinal system, corneas and vascular walls. Internalization of the virus activates the immune system, producing the release of proinflammatory cytokines which, in turn, activate natural immunity (monocytes, T lymphocytes and macrophages) producing a feedback of the inflammatory response. Inadequate immune response produces an excessive accumulation of inflammatory cells and overproduction of cytokines and consequent tissue damage and extension of the process to different territories of the organism. The B lymphocytes which produce neutralizing antibodies also contribute to extension of the virus<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>. In addition to this exaggerated inflammatory and immune response, SARS-CoV-2 infection is also associated with coagulopathy, which is probably multifactorial in origin and involves endothelitis, endothelial dysfunction, alteration of blood flow and the activation of platelets and coagulation factors<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>. Lastly, the binding of SARS-CoV-2 to the ACE-2 receptor leads to an increase in circulating angiotensin-2 and a reduction of angiotensins 1–7, favoring a proinflammatory, profibrotic and vasoconstrictor state<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Clinical manifestations</span><p id="par0020" class="elsevierStylePara elsevierViewall">Since the airway is the main entry point for SARS-CoV-2, COVID-19 mainly presents with symptoms of infection of the respiratory tract, the upper tract in mild cases and pneumonia in severe cases. However, it is a multisystemic process in which other acute cardiac, thromboembolic, gastrointestinal and neurological complications, among others, may appear<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–11</span></a>.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The percentage of asymptomatic infected individuals ranges from 15 to 45%, and may be higher in children<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>. Among symptomatic patients, the mean incubation period is 5 days, with the appearance of symptoms beyond 11.5 days after exposure to the virus being infrequent. Most patients present mild symptoms (81%) with headache, cough, fever and/or slight dyspnea, but 14% of patients may develop severe clinical manifestations with greater dyspnea and hypoxemia, and 5% may develop a critical status with respiratory insufficiency or distress, shock and/or multiorgan failure<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,12</span></a>. The risk factors associated with a higher mortality are age greater than 65 years, active smoking, arterial hypertension, diabetes and cardiovascular or chronic pulmonary disease. With regard to analytical parameters, elevated C-reactive protein (CRP), lactate dehydrogenase, ferritin, procalcitonin, D-dimers and cardiac enzymes have also shown to be related to a worse prognosis<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Real time reverse transcription polymerase chain reaction (RT-PCR) of respiratory samples is considered the diagnostic reference standard with a specificity of almost 100%. However, its sensitivity ranges between 60–97% due to failure of adequate sample collection, performance in different stages of the disease or due to a low viral load<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Simple radiography and chest computerized tomography (CT) play a fundamental role in the diagnosis of SARS-CoV-2 pneumonia and its complications. Radiography may be normal in the initial phases or in mild forms of the disease<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,13</span></a>. CT is more sensitive and can demonstrate alterations in up to 50–70% of asymptomatic individuals<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>. The most common findings are ground glass opacities in the lungs (50–98%) or a reticular radiological pattern (in up to 77% of the cases) with a bilateral distribution of peripheral and posterior predominance. Consolidations alone or overlapping the ground glass opacities may also be present (24.2–64%). Other findings such as a cobblestone pattern, pleural effusion or mediastinal adenopathies have been observed in a minority of cases<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>. The frequency of the findings depends on the time at which the exploration is made during the course of the disease. Ground glass opacities generally develop between days 0–4 after the onset of symptoms and achieve a maximum at 6–13 days. According to the course of the disease, the frequency of consolidation increases<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>. A recent meta-analysis demonstrated that determined findings are related to greater severity of the process, such as hilar mediastinal adenopathies, traction bronchiectasis, interlobar septal thickening, consolidations, cobblestone pattern, reticulation or pleural effusion<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Despite the elevated sensitivity of the radiological tests, in April 2020, the Fleischner Society declared an international consensus which, considering the limitation of resources, established that imaging studies are not indicated in asymptomatic patients or in those with mild symptoms because of the absence of the risk of worsening. This consensus also did not recommend serial studies in stable intubated patients. The indication of imaging studies was considered in patients with moderate or severe clinical manifestations independently of the PCR result or in patients diagnosed with COVID-19 with respiratory worsening or functional deterioration and/or hypoxemia following COVID-19<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Treatment</span><p id="par0045" class="elsevierStylePara elsevierViewall">Given the complexity of the physiopathology of COVID-19 and its clinical versatility, there is no standard treatment, and the response to therapy is variable.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Antiviral drugs and plasma antibodies of convalescent patients or hyperimmune immunoglobulins have been used in the treatment of SARS-CoV-2. Anti-inflammatory, immunomodulator, anticoagulant and antifibrotic treatments have been used in relation to host response<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>.</p><p id="par0055" class="elsevierStylePara elsevierViewall">More than 75% of hospitalized patients require supplementary oxygen support which may vary from nasal oxygenotherapy to invasive ventilation in severe cases. Dexamethasone has been associated with a reduction in the risk of mortality in patients with severe COVID-19, and its use is recommended in patients requiring oxygen (IA evidence), with no demonstrated benefits in patients in whom oxygen therapy is not indicated. Tocilizumab in combination with dexamethasone reduces the risk of progression to invasive mechanical ventilation and mortality<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a>.</p><p id="par0060" class="elsevierStylePara elsevierViewall">In the hospital setting wide spectrum antibiotherapy is often associated to cover possible fungal or bacterial infections.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Persistent symptoms or post-covid-19 status</span><p id="par0065" class="elsevierStylePara elsevierViewall">Increasingly more clinical and scientific evidence has been obtained regarding the subacute and long-term effects of COVID-19. Nonetheless, there is still no universally accepted definition, and these symptoms have not been classified as a disease or a clear syndrome. However, it has been proposed to differentiate at least 3 times of the disease<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a>:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall">acute COVID-19: symptoms and signs caused by SARS-CoV-2 which may last up to 4 weeks after the onset of the clinical manifestations.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">Sequelae of COVID-19: sequelae produced after acute SARS-CoV involvement which frequently occur in patients who required hospitalization, sometimes in the intensive care unit (ICU). These are the consequence of structural damage to different organs by the infection itself and/or associated complications. They include sequelae of the critical state itself and the possibility of secondary infections.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">persistent or “Long COVID”: symptomatology which persists 4–12 weeks after acute infection in patients diagnosed with COVID-19 in whom confirmation of COVID-19 by laboratory tests is not mandatory. Some authors have proposed calling this process subacute COVID to differentiate it from chronic or post-COVID syndrome COVID, which would involve symptoms which persist or appear beyond week 12<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>.</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">The pathogenesis of the post-COVID state remains unknown, but it seems that the persistence of a state of inflammation plays a fundamental role, with these patients presenting elevated CRP and interleukin-6 levels in blood. It is likely that other factors such as persistence of the virus in tissues causing latent or chronic infections, the possibility of reinfection, low ACE-2 receptor regulation and vascular dysfunction also contribute. Other factors that have been proposed include physical deconditioning due to prolonged inactivity, neuropsychological factors due to post-traumatic stress and dysregulation of the sympathetic nervous systems<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19–21</span></a>.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Persistent COVID has been described in up to 87% of patients requiring hospitalization in the acute phase of the disease, with the presence of at least 3 symptoms in 55% of the cases<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>. The clinical spectrum is very wide, and it is not accurately known why some persons take longer to recover. It can occur in not only patients who have presented an acute infection with a severe course but also in those who have had a milder form of the disease, and while it can affect people of any age or sex, it predominates in women between 36–50 years of age without previous comorbidities<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a>. In general, the symptoms fluctuate and are cyclic, alternating days in which they have practically disappeared with others in which they reappear. The most frequent symptom is fatigue, presented in 17–72% of the patients who have been hospitalized, followed by dyspnea, and joint, muscle and chest pain. However, many other symptoms may appear and affect practically any organ, with other sequelae or pulmonary (cough and reduction in diffusing capacity for carbon monoxide), cardiovascular (palpitations, arrhythmias, tachycardia, disautonomy and myocardial fibrosis), hematologic (thromboembolic phenomenon) neuropsychiatric (headache, disautonomy, parestesia, brain fog, anxiety, depression, sleep disorder, anosmia and dysgeusia), renal (reduction in glomerular filtration), endocrinological (poor control of diabetes, subacute thyroiditis, hypothyroididm, bone demineralization), digestive (diarrhea and abdominal pain, alteration of the intestinal microbiota), dermatological complications, pediatric multisystemic inflammatory syndrome and fever or low-grade fever<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20,21,23–25</span></a>. This symptomatology has been described in other coronaviruses (SARS, MERS) and in infection by the Ebstein–Barr virus and chikungunya, among others, resolving after several weeks or months.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Studies able to demonstrate this state are essential to plan treatments and the care of these patients and direct the focus of future lines of investigation. While there is still no evidence on the efficacy of pharmacological or non pharmacological measures versus this persistent symptomatology, multidisciplinary management is recommended<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22,26</span></a>.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">F-FDG PET/CT in SARS-CoV-2 infection</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Respiratory system</span><p id="par0100" class="elsevierStylePara elsevierViewall">As mentioned previously, viral pneumonia activates the inflammatory cells (neutrophils, monocytes and T-helper lymphocytes) and the local release of cytokines<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a>. Considering the avidity of inflammatory cells for glucose, it is to be expected that the disease can be evaluated by the fluorodeoxyglucose F 18 positron emission tomography/CT (<span class="elsevierStyleSup">18</span>F-FDG-PET/CT) technique that has shown to be useful in the study of infectious and inflammatory diseases in general and especially in the respiratory tract<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>. Previous studies have demonstrated that patients infected by MERS showed marked pulmonary uptake of <span class="elsevierStyleSup">18</span>F-FDG in progression to pneumonia<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a>. Likewise, pathological uptake of <span class="elsevierStyleSup">18</span>F-FDG has been described in mediastinal and axillary adenopathies in non human primates 5 days after having been infected by MERS, coinciding with monocytosis in peripheral blood with no changes in the CT images or in body temperature<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a>. Studies performed in camels and rabbits infected with MERS showed the presence of virus in the absence of clinical signs, speculating that subclinical infection could also occur in healthy immunocompetent humans, since the majority of patients presenting severe lower respiratory tract infection had underlying comorbidities<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a>. <span class="elsevierStyleSup">18</span>F-FDG-PET/CT has also demonstrated activation of the lymphoid tissue of axillary, cervical and mediastinal lymph nodes, which precedes fulminant replication of the virus, in macacos infected with the simian-human acute immunodeficiency virus<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>.</p><p id="par0105" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG-PET/CT can demonstrate characteristic and early radiological alterations of COVID-19 pneumonia despite using low-dose CT which, however, is also diagnostic<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>. Numerous studies have described incidental detection of metabolic alterations in the pulmonary parenchyma of often asymptomatic patients undergoing a <span class="elsevierStyleSup">18</span>F-FDG-PET/CT for any established clinical indication, in whom SARS-CoV-2 infection was later confirmed, with a frequency ranging from 4.1 to 9.2%<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34–37</span></a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. Case 1). The appearance of these alterations in asymptomatic patients may reflect early immune response to the infection similar to what was reported in the previously mentioned animal models.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">A recent systematic review described the findings observed in 52 patients with COVID-19 pneumonia incidentally detected following a PET/CT study with <span class="elsevierStyleSup">18</span>F-FDG in 48 cases, <span class="elsevierStyleSup">18</span>F-choline in 3 and with <span class="elsevierStyleSup">68</span>Ga-PSMA in 1 case. The most frequent findings were hypermetabolic bilateral ground glass opacities (75%), consolidations (34.6%), and interlobar septal thickening (7.6%). The range of the maximum standard uptake value (SUVmax) observed in studies with <span class="elsevierStyleSup">18</span>F-FDG was 2.2–18 (mean SUVmax 4.9 ± 2.3), between 3–4 in cases with <span class="elsevierStyleSup">18</span>F-choline, and in the only case with <span class="elsevierStyleSup">68</span>Ga-PSMA, the SUVmax was 3.2<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a>. It has been observed that pulmonary lesions with greater <span class="elsevierStyleSup">18</span>F-FDG uptake could be correlated with a greater globular sedimentation rate and with a greater time to curation, although cohort studies in a larger number of patients are needed to draw robust conclusions in this regard<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39,40</span></a>.</p><p id="par0115" class="elsevierStylePara elsevierViewall">Perhaps the most distinctive finding of the <span class="elsevierStyleSup">18</span>F-FDG-PET/CT studies performed in patients with COVID-19 pneumonia is the presence of mediastinal (27%) and hilar adenopathies (19.2%) with pathological uptake, which were infrequent in radiological studies published to date<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16,38</span></a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. Case 2).</p><p id="par0120" class="elsevierStylePara elsevierViewall">Despite the capacity of the technique to demonstrate pulmonary disease, in general, <span class="elsevierStyleSup">18</span>F-FDG-PET/CT is not recommended as a diagnostic procedure in COVID-19 pneumonia since it seems to provide little over chest radiography and CT<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>. In addition, although <span class="elsevierStyleSup">18</span>F-FDG-PET/CT reflects the inflammatory pulmonary process in the supposed peak of the acute phase of COVID-19, no correlation has been demonstrated between inflammatory status and the evolution of the radiological findings or short-term clinical outcomes<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a>. It should also be taken into account that this type of study increases the exposure time of professionals and other patients to the virus compared to CT or radiography which are more rapid techniques.</p><p id="par0125" class="elsevierStylePara elsevierViewall">The “normal” period of resolution of the pulmonary alterations in patients who have had pneumonia is not exactly known. The cohort with the longest follow-up after hospital discharge included 1733 patients, 353 of whom underwent CT study, finding persistent radiological alterations in approximately 50% of the cases, which, overall, were consistent with ground glass opacities.</p><p id="par0130" class="elsevierStylePara elsevierViewall">The uptake described in residual pulmonary lesions in patients recovering from COVID-19 pneumonia between the 2nd and 4th week after the establishment of symptoms was mild-moderate (SUVmax 3.4 ± 2.3) and was even lower after the first month (SUVmax 0.85–1.79)<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42,43</span></a>. Since the beginning of the pandemic we have studied 24 patients for persistence or worsening of systemic COVID-19 symptoms, with a time from symptom appearance or since hospital admission of at least one month. We detected elevated-moderate intensity of pulmonary uptake in 8 patients, coinciding with areas of parenchymatous alterations in CT consisting in ground glass infiltrates with different grades of consolidation. Six patients shared the common characteristic of having received immunosuppressive treatment for previous diseases and presented fever or persistently elevated low fever. Bronchoalveolar lavage performed after the PET/CT showed an elevated percentage of macrophages (45–81%) and a variable percentage of lymphocytes (4–51%). In one patient, the presence of SARS-CoV-2 was demonstrated by PCR of the bronchoaspirate, despite repeatedly negative nasopharyngeal samples (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. Case 1). In 3 other patients, immunohistochemistry of pulmonary tissue was performed in 2, showing positivity versus the S2 subunit of the surface Spike protein of SARS-CoV-2 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. Case 2). In the remaining cases immunohistochemistry was not performed since they occurred prior to the availability of the technique. These results warn of the possibility of the virus remaining beyond the acute phase in immunosuppressed patients.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">The other 2 patients with moderate-elevated pulmonary uptake did not have a history of immunosuppression. One case in which PET/CT was requested due to persistent high fever corresponded to bacterial superinfection, showing clearly dominant uptake in the left lung. In the second case, the PET/CT was carried out due to persistent low fever and significant dyspnea discordant with the radiological involvement. The study showed intense pulmonary uptake coinciding with nodular opacities of variable size as well as multiple hilar mediastinal lymph nodes which were not increased in size. Fine needle aspiration puncture of the subcarinal adenopathy was performed showing a sarcoid reaction for which high dose corticoid treatment was initiated (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>, Case 3).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">Based on our experience, within the framework of investigation of post-COVID status, elevated pulmonary uptake beyond the first month of the acute process with no evident cause constitutes a sign of alarm and justifies targeted studies.</p><p id="par0145" class="elsevierStylePara elsevierViewall">One of the most concerning sequelae is pulmonary fibrosis. According to a recent meta-analysis, approximately 30% of patients hospitalized for SARS-CoV-2 pneumonia demonstrate fibrotic changes which persist the first 12 months after discharge<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>. Given the time since the initiation of the pandemic, it is not known if this fibrosis will remain stable or whether, as with idiopathic pulmonary fibrosis (IPF) with which it shares common pathogenic pathways, it will have a progressive nature<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a>. In IPF, <span class="elsevierStyleSup">18</span>F-FDG PET/CT studies have shown a significant inverse association between the level of pulmonary uptake and survival, independently of age, sex and physiological variables, being maintained even in patients with good pulmonary function. Therefore, if the irreversible and progressive post-COVID nature of fibrosis is demonstrated, PET/CT could be useful as a prognostic biomarker and contribute to designing treatments<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a>.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Cardiovascular system</span><p id="par0150" class="elsevierStylePara elsevierViewall">Cardiovascular comorbidity has been associated with greater severity of COVID-19, with evidence of cardiac lesions in 7–28% of hospitalized patients, showing a substantially higher mortality rate<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">47,48</span></a>. In addition, there is increasingly greater evidence that acute respiratory disease is significantly associated with acute myocardial damage, which appears in up to 20–30% of patients<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a>, the mechanism of which has yet to be clarified. Autopsy series of patients with COVID-19 have found viral particles in the myocardium in 47% of cases, and more than 7.5% of the myocardial cells express ACE-2<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50,51</span></a>. It is likely that vascular and myocardial hyperinflammation mediated by cytokines, endothelial dysfunction, hypercoagulability and the effects of systemic infection on the heart are involved in this damage<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a>.</p><p id="par0155" class="elsevierStylePara elsevierViewall">In patients with a significant elevation of biomarkers of myocardial damage, imaging studies may be useful to clarify the origin, although the indication during the acute phase of the infection should be carefully weighed given the risk of exposure to the virus by personnel and patients. In hemodynamically stable patients with known coronary disease and chest pain of uncertain origin and acute coronary syndrome without ST elevation, perfusion SPECT or PET/CT studies with pharmacological stress are useful, but if there is low risk the study can be deferred until resolution of the acute phase<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a>.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Patients hospitalized for COVID-19 have a greater risk of associated fungal or bacterial infection, including endocarditis, in which <span class="elsevierStyleSup">18</span>F-FDG-PET/CT has shown an impact in 40% of the patients<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a>. This indication should, therefore, be taken into account even in patients with active infection.</p><p id="par0165" class="elsevierStylePara elsevierViewall">The prevalence of myocarditis associated with COVID-19 is unknown. A systematic review of autopsy studies has reported a prevalence of 1.5% of the cases<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a>, although other studies refer up to 7% of fulminant myocarditis in the acute phase of the disease. Follow-up studies of patients hospitalized for COVID-19 describe the presence of alterations in magnetic resonance (MR) studies in 75% of the cases, with a diagnosis of pericarditis in 3% of the patients, myopericarditis in 11% and myocarditis in 26%, being asymptomatic on many occasions<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a>. The detection of persistent inflammation is important since it may lead to the development of dilated myocardiopathy and potentially fatal arrhythmias. Delayed enhancement of gadolinium in MR, which is a sign of active inflammation in acute phases, loses specificity in the advanced phase due to greater difficulty in differentiating active inflammation from scarring or fibrosis. <span class="elsevierStyleSup">18</span>F-FDG-PET/CT provides additional information to the differential diagnosis, with a specificity of 97%<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">49,55</span></a> by demonstrating uptake in the lesions corresponding to inflammation. To date, no study has analyzed the utility of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in myocarditis by SARS-CoV-2, but it has already shown to be useful in the evaluation of ventricular dysfunction when other inflammatory myocardiopathies are suspected<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a>. The detection of myocardial inflammation and its response to corticoid treatment by <span class="elsevierStyleSup">18</span>F-FDG-PET/CT have been described in a pediatric patients with multisystemic inflammatory syndrome after infection by SARS-CoV-2<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a>.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Hopefully, the recently initiated CardiOvaScular Mechanisms In Covid-19 (COSMIC-19) study will clarify the presence and characteristics of cardiac lesions associated with SARS-CoV-2 infection and the utility of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT for its characterization<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a>. For now, and until more information is available, it may of interest to apply a protocol of preparation of myocardial suppression<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a> in <span class="elsevierStyleSup">18</span>F-FDG-PET/CT studies performed within the context of post-COVID-19 status taking into account the description of palpitations and chest pain 6 months after discharge in 9% and 5%, respectively of patients hospitalized for COVID-19<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> and the reported presence of alterations in MR even in asymptomatic patients.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Embolic phenomena have been described in up to 5% of patients after acute infection. The duration of the prothrombotic state is unknown. Preliminary studies indicated less than 5% of thromboembolic events after acute COVID-19. The predisposing risk factors identified include a elevation of D-dimer 2-fold above the normal values, intercurrent neoplasia, a body mass index greater than 30, age over 60 years, recent admission to an ICU or a previous thromboembolic episode<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a>. Some of these characteristics are present in patients referred for PET/CT study, and thus, we should be especially thorough in the review of pulmonary vascularization, especially in centers using a CT acquisition protocol with intravenous contrast.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Nervous system</span><p id="par0180" class="elsevierStylePara elsevierViewall">It is suspected that SARS-CoV-2 has neuroinvasive potential and viral particles have been demonstrated in endothelial cells of the frontal cortex in histological studies<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a>. In addition, ACE-2 receptors are expressed in vascular endothelium and in nerve cells in both neurons and glial cells, especially in the ventrolateral territory of the medulla, mesenchaphic black matter, medium temporal gyrus, posterior cingulate cortex and the olfactory bulb<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">61,62</span></a>. Several mechanisms of entry of the virus into the central nervous system have been considered, such as transynaptic retrograde dissemination from the olfactory bulb, direct vascular invasion by adhesion to endothelial cells passing the hematoencephalic barrier or as a Trojan horse in the interior of infected macrophages and lymphocytes<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a>. Apart from the direct damage caused by the virus, there are mechanisms of indirect damage mediated by cerebral hypoxia, activation of the microglia secondary to elevation of cytokine levels by the blockade of ionic receptors or canals by antibodies by activation of the hypothalamic-hypophyseal axis and by vascular and thrombotic phenomena<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A). Post-mortem series analyzing brain tissue have found the presence of the virus in 53% of the cases, with no relationship with the severity of neuropathological changes. The dominant findings were the presence of astrogliosis, activated microglia and cytotoxic T lymphocytes in the frontal cortex, cerebellum and basal lymph nodes as well as the presence of multiple areas of infarction<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a>.</p><p id="par0185" class="elsevierStylePara elsevierViewall">In the acute phase of the disease the majority of clinical series describe the appearance of neurological symptoms mainly in patients hospitalized due to the severity of the respiratory condition<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">62,66</span></a>. According to the largest series<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a>, up to 57.4% of the patients present unspecific neurological symptoms such as headache, reduction in the level of consciousness, agitation, alterations in smell and/or taste, myalgias and more specific conditions, such as cerebral infarction, encephalitis and white matter lesions in imaging studies<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a>.</p><p id="par0190" class="elsevierStylePara elsevierViewall">Although there is a lack of specific biomarkers of cognitive deterioration produced by SARS-CoV-2, some studies have shown that the inflammatory phenomenon related to infection could preferentially be directed at the frontal lobes and/or frontal neuronal networks in that behavioral and dysexecutive symptoms predominate, as well as frontotemporal hypoperfusion in MR, and deceleration of the electroencephalogram in the frontal regions and frontal hypometabolism in <span class="elsevierStyleSup">18</span>F-FDG-PET/CT studies is observed in not only patients with frontal syndrome but also in those without delirium but with anosmia or ageusia<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a>. Cases pf acute encephalopathy by COVID-19, encephalitis by SARS-CoV-2 or sensitive to steroids have frequently been reported in hospitalized patients with acute delirium and other neuropsychiatric symptoms. Early <span class="elsevierStyleSup">18</span>F-FDG-PET/CT studies in these patients show prefrontal or orbitofrontal hypometabolism of the anterior insular and cingulate cortex and in cerebellar, and less frequently, in caudate hemispheres. In the acute phase, hypermetabolism in the vermis and striates may also appear and is attributed to compensatory, electroconvulsive or inflammatory phenomena<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">69,70</span></a>. Sequential PET/CT studies performed 1 and 6 months after the basal image show the disappearance of hypermetabolic areas and less hypometabolism consistent with clinical improvement. This indicates that the metabolic alterations may be the neuronal substrate of the clinical manifestations of the patients which follow, overall, with a frontal syndrome, mood disorders and alteration of the perception of respiratory failure<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a>.</p><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG-PET/CT has also been used to study 2 patients with acute COVID-19 and cognitive-motor dissociation or covert consciousness, a condition which occurs in hospitalized patients due to severe brain lesions and who do not seem to respond to orders but preserve their cognitive capacity in contrast to real disorders of consciousness. Diffuse frontal hypometabolism with respect to the motor and premotor cortex has been observed but affecting associative areas responsible for the integration of motor initiation and coordination. These results demonstrate the utility of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in patients with severe COVID-19, normal MR, isolated motor deficit in the electromyography and absence of response, confirming the integrity of the structures responsible for voluntary movement<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a>.</p><p id="par0200" class="elsevierStylePara elsevierViewall">A case of acute anosmia with mild hypometabolism in the left orbitofrontal cortex has been published suggesting neuronal deterioration due to the direct action of SARS-CoV-2<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a>. However, a more recent study suggests that anosmia seems to be related to deaferentiation and functional reorganization processes due to a lack of olfactory stimulus leading to subtle metabolic changes in olfactory and associative cortical areas visible in <span class="elsevierStyleSup">18</span>F-FDG -PET/MR<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">73</span></a>.</p><p id="par0205" class="elsevierStylePara elsevierViewall">There is increasing evidence of the persistence of neurological symptoms following acute COVID-19, a process recently denominated Neuro-PACS (neurological manifestations of post-acute sequelae of SARS-CoV-2 infection)<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">74</span></a>. The incidence of this process is greater in patients requiring hospitalization, especially in the ICU or in those who develop encephalopathy. This symptomatology varies greatly. According to an electronic registry of the follow-up of 236,379 patients during the first 6 months after the diagnosis of COVID-19, neuoropsychiatric sequelae appeared in 34% of the cases, without including headache. The most common sequelae include mood disorders and anxiety and psychosis (24%), neuropathies (2.1%), ischemic infarctions (2.8%) and dementia (0.67%)<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a>. The possibility of developing Parkinsonism after COVID-19 is also of concern, considering the sequelae of previous pandemics such as the 1918 influenza pandemic. Involvement of the nigrostriatal system after infection by SARS-CoV-2 has been described in neuroimaging studies<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">76</span></a>. However, it not clear whether the risk of Parkinsonism is greater than that after other infections of the respiratory tract<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">75</span></a>.</p><p id="par0210" class="elsevierStylePara elsevierViewall">The most frequent symptoms in our setting are headache and cognitive complaints described in up to 68% and 81%, respectively, of patients with any neurological symptom beyond week 12 after the acute infection<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">77</span></a>. The cognitive complaint usually reported is a lack of concentration and lack attention or difficulty in task planning, which have been joined under the term of brain fog, although the neurocognitive profile has not yet been correctly described.</p><p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/CT studies performed in hospitalized patients with at least two neurological symptoms in the subacute phase of the disease show a reduction in metabolism with frontoparietal predominance correlated with alteration of the Montreal Cognitive Assessment with a profile of neocortical dysfunction<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">78</span></a>.</p><p id="par0220" class="elsevierStylePara elsevierViewall">It has been hypothesized that persistent functional complaints (fatigue, dyspnea, alteration of taste and/or smell, memory or cognitive decline, sleep disorder and pain, among others) after acute infection by SARS-CoV-2 may be related to central involvement which may be manifested by <span class="elsevierStyleSup">18</span>F-FDG PET/CT using this technique as a diagnostic biomarker and for follow-up. In this sense, retrospective analysis of brain metabolism in 35 patients with this symptomatology, compared with the control group, showed hypometabolism which fundamentally affected the orbital and rectal gyri of the right temporal lobe, with extension to the ipsilateral thalamus of the protuberance and the cerebellum. In addition, these hypometabolic areas were related to determined symptoms. Patients with a greater number of complaints showed greater involvement of the brain stem and the cerebellum. The greatest frontal hypometabolism was detected in patients with pain. Cognitive complaints were related to greater involvement of the cerebellar hemispheres<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a>.</p><p id="par0225" class="elsevierStylePara elsevierViewall">Another study in patients with persistent symptomatology beyond one month after the primary infection found a relationship between hyposmia/anosmic and a characteristic hypometabolism of the parahippocampal gyrus and bilateral orbitofrontal cortex and between fatigue and the right parahippocampal gyrus, the brain stem and the bilateral thalamus<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a>.</p><p id="par0230" class="elsevierStylePara elsevierViewall">According to our preliminary experience pending validation in 10 patients with brain fog of new appearance following COVID-19 presenting attention and dysexecutive deficit referred from the neuroCOVID consultation, metabolic involvement in the <span class="elsevierStyleSup">18</span>F-FDG-PET/CT showed mainly left inferior frontal predominance of the temporal territory also with left predominance, and of both cerebellar hemispheres. Similar to the study of Guedj et al.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a>, the patients with the greatest systemic functional involvement demonstrated greater alterations in the brain PET/CT study (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><p id="par0235" class="elsevierStylePara elsevierViewall">Astrocytes significantly contribute to cerebral uptake of <span class="elsevierStyleSup">18</span>F-FDG, and they are known to play a main role in defence against inflammatory aggression. Although the cellular substrate of the persistent cerebral hypometabolism with <span class="elsevierStyleSup">18</span>F-FDG-PET/CT has not yet been defined, the persistence of astrocytary alteration identified in post-mortem studies could be a main cause<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">81</span></a>.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">PET in post-COVID-19 state</span><p id="par0240" class="elsevierStylePara elsevierViewall">The tools for the diagnosis of the post-COVID state have yet to be established and possibly depend on the dominant symptoms. Considering their physiopathology, a technique such as <span class="elsevierStyleSup">18</span>F-FDG-PET/CT may offer advantages in these patients by its ability to demonstrate areas of inflammation and/or hypofunction as well as foci of active infection and provide a global evaluation of the organism. In addition, the sensitivity of this technique can be increased since the affinity of the glucose transporter receptors to <span class="elsevierStyleSup">18</span>F-FDG increases the presence of cytokines and growth factors<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a>. Nonetheless, we must be cautious since in daily practice it would be impossible to assume the total demand generated by patients in the post-COVID state. Therefore, it is necessary to evaluate the syndrome more in depth, maintaining fluid communication with the departments involved to establish a clinical framework of greater utility or diagnostic performance.</p><p id="par0245" class="elsevierStylePara elsevierViewall">In this article we have revised the utility or contribution of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in the complications or specific sequelae of COVID-19, but, to date, only one study has reported systemic findings of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT images in patients with unspecific symptoms beyond the first month, including dyspnea (69%), fatigue (62%), ageusia/anosmia (31%), joint pain (23%) and tachycardia (15%), among others. The results indicate that compared with the control group, in these patients there is greater multiorgan uptake, especially in the bone marrow, as well as vascular and in large joints, suggesting a state of persistent systemic inflammation, without being able to define a concrete metabolic pattern.</p><p id="par0250" class="elsevierStylePara elsevierViewall">In our setting, referral for a <span class="elsevierStyleSup">18</span>F-FDG-PET/CT study is mainly made due to persistent low fever/fever or significant constitutional syndrome with or without the remaining symptoms described. The objective of the <span class="elsevierStyleSup">18</span>F-FDG-PET/CT study is, overall, to rule out the presence of concomitant pathological processes.</p><p id="par0255" class="elsevierStylePara elsevierViewall">Of the 24 studies carried out, 8 showed significant pulmonary uptake (33%). In the remaining studies no reproducible pattern was found, except for diffuse uptake in the major salivary glands in 6 cases (25%) together with unspecific muscle uptake in one and thymic in another. Five patients (21%) showed physiological distribution of the radiotracer with no notable pathological findings. The fact of not having detected the multiorgan increase described by Sollini et al.<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a> is likely due to a greater time between acute infection and the imaging study. In 2 cases hypermetabolic hilar mediastinal adenopathies were detected and histologically confirmed as sarcoid reaction in one case (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. Case 3) and not investigated in the other. One papilar thyroid carcinoma was incidentally identified as well as 1 case of diffuse increased uptake corresponding to hypothyroidism. A prevalence of 5.2–5.6% of hypothyroidism has been reported in COVID-19 patients, but it remains unknown whether hypothyroidism was previously present in these cases or if it is a secondary phenomenon to the activation of the autoimmune process by the infection<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">82</span></a>. Lastly, one patient showed diffuse pathological uptake in the wall of the thoracic aorta. In this case, vasculitis was clinically suspected, with an initial study with <span class="elsevierStyleSup">18</span>F-FDG-PET/CT showing no findings of interest. Following COVID-19, the clinical manifestations worsened in consonance with the demonstration of pathological vascular uptake (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The possibility that the infection had acted as a phenomenon of activation of a previous autoimmune process was considered.</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0260" class="elsevierStylePara elsevierViewall">The main contribution of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in our patients post-COVID-19 with an unfavorable evolution has been to confirm or rule out other significant pathological processes that could justify the clinical manifestations.</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Changes in PET/CT imaging induced by vaccination against SARS-CoV-2</span><p id="par0265" class="elsevierStylePara elsevierViewall">Vaccination of the general population was initiated in December 2020 and on January 28, 2021 the first case of deltoid uptake in the <span class="elsevierStyleSup">18</span>F-FDG-PET/CT study was reported in relation to the injection site and reactive ipsilateral axillary adenopathies, warning of a potential artifact that massive immunization may have on the interpretation of imaging studies<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">83</span></a>. Later, an analysis of 728 patients revealed the presence of hypermetabolic adenopathies in 36.4% of the patients who had received a single dose of the Pfizer-BioNTech (BNT162b2) vaccine and in 53.9% of those who had completed the vaccine schedule. In the majority of the cases the lymph nodes were not pathological in size (86%) and were localized at axillary level I ipsilateral to the injection site (99%), although lymph nodes in axillary levels II and II and interpectoral, and less frequently, supraclavicular were also detected. Despite the experience in the reading of PET/CT studies, in up to 14.8% of the cases, the interpretation of these lymph nodes may not be conclusive<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">84</span></a>.</p><p id="par0270" class="elsevierStylePara elsevierViewall">To date, only one case of systemic inflammatory response has been described after having received the Moderna mRNA-1273 vaccine, visualizing uptake in the deltoid and ipsilateral axillary lymph node in the <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in addition to diffuse increase of glucidic metabolism in the spleen<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">85</span></a>.</p><p id="par0275" class="elsevierStylePara elsevierViewall">A proportional inverse relationship has been found between age and the presence of immunocompromise or hematological disease and the presence of these lymph nodes. Thus, the percentage of lymph node uptake in immunocompromised patients is reduced to 33%<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">86</span></a>. These factors cannot be acted upon, but an inverse relationship between the intensity of the lymph node uptake and the time since vaccination has been demonstrated. Therefore, to minimize the possibility of artifacts in lymph node interpretation, temporal windows have been proposed for the planning of imaging studies. A 5-day period after the first vaccine dose has been suggested in which the probability of lymph node uptake would be low, and 2–3 weeks after the first or second dose, being preferable at 4–6 weeks<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">84,87</span></a>. Nevertheless, persistence of lymph node uptake has been described in up to 29% of cases at 7–10 weeks post-vaccination<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">88</span></a>. In addition to the time factor, in oncological patients with tumors showing laterality (breast cancer, melanoma, sarcoma, head and neck tumors and lung, among others), it would obviously be beneficial to vaccinate in the arm contralateral to the theoretical territory of tumor drainage. And, of course, access to the information of the date and site of vaccination contributes to better interpretation of the findings. In cases in which uncertainty remains, an axillary ultrasound performed 4 weeks after the PET/CT study could contribute to lymph node characterization<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">89</span></a>. Lastly, not only PET/CT with <span class="elsevierStyleSup">18</span>F-FDG shows hypermetabolic axillary lymph nodes. Up to 50% of studies with <span class="elsevierStyleSup">68</span>Ga-DOTATATE are positive at the axillary level, with a much lower frequency with <span class="elsevierStyleSup">11</span>C-choline, <span class="elsevierStyleSup">18</span>F or <span class="elsevierStyleSup">68</span>Ga-PSMA and <span class="elsevierStyleSup">18</span>F-DOPA<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">86,90</span></a> (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0280" class="elsevierStylePara elsevierViewall">Infection by SARS-COV-2 is a systemic process which goes beyond involvement of the respiratory tract. The complications and sequelae of COVID-19 are very varied and increasingly more numerous, and patients require a multidisciplinary approach not only in the acute phase of the disease but also post-COVID.</p><p id="par0285" class="elsevierStylePara elsevierViewall">The role of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in the acute phase is limited by the risk of exposure to the virus during prolonged studies in patients with viral load. Nonetheless, this phase may provide fundamental information for the study of associated complications such as infectious endocarditis.</p><p id="par0290" class="elsevierStylePara elsevierViewall">In the post-COVID state it is too early to draw conclusions, but studies with <span class="elsevierStyleSup">18</span>F-FDG-PET/CT can be a useful tool to detect or rule out severe concomitant processes. Alterations of brain metabolism shown with this technique may be a marker of the systemic process.</p><p id="par0295" class="elsevierStylePara elsevierViewall">Lastly, during the next months we are going to live with local immunological response provoked by the vaccine, and therefore it will be fundamental to know the history of each patient with respect to the date and site of injection to adequately program and interpret <span class="elsevierStyleSup">18</span>F-FDG-PET-CT studies.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1562254" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1408891" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1562253" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1408892" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Introduction" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Pathogenesis" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Clinical manifestations" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Diagnosis" ] 3 => array:2 [ "identificador" => "sec0025" "titulo" => "Treatment" ] 4 => array:2 [ "identificador" => "sec0030" "titulo" => "Persistent symptoms or post-covid-19 status" ] ] ] 5 => array:3 [ "identificador" => "sec0035" "titulo" => "F-FDG PET/CT in SARS-CoV-2 infection" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Respiratory system" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Cardiovascular system" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Nervous system" ] 3 => array:2 [ "identificador" => "sec0055" "titulo" => "PET in post-COVID-19 state" ] ] ] 6 => array:2 [ "identificador" => "sec0060" "titulo" => "Changes in PET/CT imaging induced by vaccination against SARS-CoV-2" ] 7 => array:2 [ "identificador" => "sec0065" "titulo" => "Conclusions" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-07-06" "fechaAceptado" => "2021-07-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1408891" "palabras" => array:5 [ 0 => "<span class="elsevierStyleSup">18</span>F-FDG-PET/CT" 1 => "SARS-CoV-2" 2 => "Long COVID-19" 3 => "Inflammation" 4 => "Vaccine" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1408892" "palabras" => array:5 [ 0 => "<span class="elsevierStyleSup">18</span>F-FDG-PET/TC" 1 => "SARS-CoV-2" 2 => "COVID-19 persistente" 3 => "Inflamación" 4 => "Vacuna" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">In recent months, much of the scientific efforts have focused on research on SARSCoV-2 infection and its consequences in humans. Still, many aspects remain unknown. It is known that the damage caused by SARS-CoV-2 is multifactorial and that its extension goes beyond lung inflammation and the acute phase, with the appearance of numerous complications and sequelae. To date, knowledge about the usefulness of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in the acute phase has been limited to the incidental detection of SARS-CoV-2 unsuspected pneumonia. Recent studies have been appearing collecting the findings of <span class="elsevierStyleSup">18</span>F-FDG-PET/CT in long COVID-19 or persistent COVID-19 state as well as the alterations caused after mass vaccination of the population in the metabolic studies. This work aims to review the existing literature focusing on these three issues and to briefly present our own preliminary experience.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Durante los últimos meses gran parte de los esfuerzos científicos se han centrado en la investigación sobre el SARS-CoV-2 y las consecuencias de su infección en humanos. Aun así, muchos aspectos siguen siendo desconocidos. Se sabe que la afectación por SARS-CoV-2 es multifactorial y que su extensión va más allá del daño pulmonar y del momento agudo, con aparición de numerosas de complicaciones y secuelas. El conocimiento de la utilidad de la <span class="elsevierStyleSup">18</span>F-FDG-PET/TC en el momento agudo se ha limitado, hasta la fecha, a la detección incidental de afectación pulmonar por SARS-CoV-2. En los últimos meses han ido apareciendo trabajos que recogen los hallazgos de la <span class="elsevierStyleSup">18</span>F-FDG-PET/TC en el estado post-COVID, asícomo las alteraciones provocadas en la imagen metabólica tras la vacunación masiva de la población. Este trabajo pretende revisar la literatura existente sobre estas tres cuestiones y exponer de manera breve la experiencia preliminar propia.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Rodríguez-Alfonso B, Ruiz Solís S, Silva-Hernández L, Pintos Pascual I, Aguado Ibáñez S, Salas Antón C. <span class="elsevierStyleSup">18</span>F-FDG-PET/TC ante la infección por SARS-CoV-2 y sus secuelas. Rev Esp Med Nucl Imagen Mol. 2021;40:299–309.</p>" ] ] "multimedia" => array:5 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1776 "Ancho" => 2508 "Tamanyo" => 338306 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Acute infection by SARS-CoV-2 detected during an <span class="elsevierStyleSup">18</span>F-FDG-PET/CT study in 2 asymptomatic patients from a respiratory and infectious point of view, later confirmed by RT-PCR. Case 1. MIP (A) of a patient with diffuse large cell B lymphoma in complete metabolic response showing multiple pulmonary uptakes also visible in the axial PET slice (B) and corresponding to ground glass opacities in the axial CT (C) and PET/CT slices (D).</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Case 2. MIP (A) of patient followed for melanoma showing intense pulmonary and hilar mediastinal uptake corresponding to bilateral ground glass opacities of peripheral predominance and mediastinal and hilar adenopathies visible in the PET (B), CT (C) and PET/CT tomographic slices (D).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2960 "Ancho" => 2508 "Tamanyo" => 1073550 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Case 1. MIP (A) of patient with fever of unknown origin and Sjögren syndrome receiving treatment with rituximab. Clinical picture compatible with COVID-19 (fever and CT with bilateral parenchymatous involvement) since March 25, 2020 with 3 PCR-negative nasopharyngeal exudates. PET/CT 1 month later showing intense bilateral pulmonary uptake coinciding with radiological alterations visible in the axial CT (B) and PET/CT slices (C) and probable medullary reactivation. A posterior bronchoaspirate was performed confirming persistent infection by SARS-CoV-2 in the PCR.</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Case 2. MIP (A) of patient with multiple sclerosis receiving treatment with rituximab and post-COVID fever of 2 months of evolution. Pathological uptake of elevated intensity is observed in both pulmonary parenchymas coinciding with areas of opacification in the CT and PET/CT (B,C). A transbronchial biopsy was later performed showing T lymphocyte pneumonitis (D), and immunohistochemical staining showed the persistence of SARS-CoV-2 in lung tissue. (E).</p> <p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Case 3. MIP (A) of young patient with no history of interest with post-COVID dsypnea of 8 months of evolution. Multiple nodular uptakes are shown in both lungs and bilateral hilar mediastinal uptake, coinciding with areas of opacification of the parenchyma and adenopathies which were not increased in size (B, C). The histological lymph node study obtained by echobronchoscopy (D) showed non necrotizing sarcoid type granulomatous inflammation. The posterior transbronchial biopsy showed the same type of granulomatous inflammation without the presence of virus in the immunostaining.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1943 "Ancho" => 2508 "Tamanyo" => 526627 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Patient with autoimmune profile (history of sacroileitis, uveítis, sensitivity to gluten) and mild SARS-CoV-2 infection with progressive loss of short-term memory, attention deficit and important asthenia. The statistical brain surface maps obtained by automated analysis are shown (<span class="elsevierStyleItalic">Syngo.via Neurology; Siemens</span>). CT images showing normalization of the whole brain (A) and comparative analysis with the database adjusted for the age of the patient (B) showing frontal hypometabolism (fronto-orbital, rectal and inferior gyri) bilateral temporal bilateral (amygdalas and hippocampos), in both thalamuses and brain stem relative to both cerebellar hemispheres.</p>" ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1047 "Ancho" => 2508 "Tamanyo" => 221919 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patient with general malaise and weight loss and elevation in C-reactive protein following mild COVID-19. The patient was followed for a polymyalgic picture as the presentation of HLAB27+ enthesopathy. MIP (A) showing a diffuse increase of intestinal uptake attributed to oral antidiabetic treatment and slight bilateral hilar uptake and of the thoracic aorta. Axial (B) and sagittal slices (C) of CT and PET showing an increase of uptake in the aorta wall, not visible in a previous study performed for a rhematological picture (D, E).</p>" ] ] 4 => array:8 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 736 "Ancho" => 2508 "Tamanyo" => 202166 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">(A) <span class="elsevierStyleSup">18</span>F-FDG PET/CT study in a patient who had received the first dose of Vaxzevria 5 days previously. The MIP image shows focal uptake in the area of the injection site in the left arm and ipsilateral axillary adenopathies localized at levels I and II in the axial CT and PET/CT slices.</p> <p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">(B) <span class="elsevierStyleSup">68</span>Ga-edotreotide (Somakit-TOC) PET/CT study in a patient who had received the second dose of Vaxzevria 15 days previously. The MIP image shows uptake in the left axilla corresponding to adenopathies at the left axillary level I, visible in the axialCT and PET/CT slices.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:90 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard with Vaccination Data [Internet]. [cited 2021 May 31]. 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Special collaboration
18F-FDG-PET/CT in SARS-CoV-2 infection and its sequelae
18F-FDG-PET/TC ante la infeccion por sars-cov-2 y sus secuelas
B. Rodríguez-Alfonsoa,
, S. Ruiz Solísb, L. Silva-Hernándezc, I. Pintos Pascuald, S. Aguado Ibáñeze, C. Salas Antónf
Corresponding author
a Servicio de Medicina Nuclear del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
b Servicio de Medicina Nuclear del Hospital Universitario 12 de Octubre, Madrid, Spain
c Servicio de Neurología del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
d Servicio de Medicina Interna del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
e Servicio de Neumología del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
f Servicio de Anatomía Patológica del Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain