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B) Patrón de crecimiento infiltrativo con afectación de ganglios linfáticos, actividad mitótica notable y necrosis masiva de tipo comedo (HE, X200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nese Torun, Emine Tuba Canbolat" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Nese" "apellidos" => "Torun" ] 1 => array:2 [ "nombre" => "Emine Tuba" "apellidos" => "Canbolat" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808918300600" "doi" => "10.1016/j.remnie.2018.07.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300600?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18301197?idApp=UINPBA00004N" "url" => "/2253654X/0000003800000004/v1_201906280916/S2253654X18301197/v1_201906280916/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2253808918300727" "issn" => "22538089" "doi" => "10.1016/j.remnie.2018.10.002" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "1026" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:256-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3 "HTML" => 3 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "An unusual metastasis of prostate cancer detected with <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT imaging: Corpus spongiosum of the radix penis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "256" "paginaFinal" => "257" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis inusual de cáncer de próstata en el cuerpo esponjoso del pene detectada mediante PET/TC con <span class="elsevierStyleSup">68</span>Ga-PSMA" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2263 "Ancho" => 2500 "Tamanyo" => 263755 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Whole body Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography maximum projection image shows uptake in the primary prostate lesion, multiple pelvic lymph nodes, right ischium, and penis. (a) In addition, tracer uptake was noted in two lesions in the corpus spongiosum of the radix penis as seen in the sagittal PET (b), fused sagittal PET/CT (c), and sagittal CT (d) images. The same penile lesions are also easily seen in the axial images of PET (e), fused axial PET/CT (f), and axial CT (g).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Hanife Asli Ayan, Murat Zor, Birol Yildiz, Selahattin Bedir" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Hanife Asli" "apellidos" => "Ayan" ] 1 => array:2 [ "nombre" => "Murat" "apellidos" => "Zor" ] 2 => array:2 [ "nombre" => "Birol" "apellidos" => "Yildiz" ] 3 => array:2 [ "nombre" => "Selahattin" "apellidos" => "Bedir" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X18301690" "doi" => "10.1016/j.remn.2018.09.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18301690?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300727?idApp=UINPBA00004N" "url" => "/22538089/0000003800000004/v1_201907020628/S2253808918300727/v1_201907020628/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808918300363" "issn" => "22538089" "doi" => "10.1016/j.remnie.2018.06.002" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "990" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:252-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 5 "formatos" => array:2 [ "HTML" => 1 "PDF" => 4 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG PET/CT “superscan” in a patient with immunoblastic lymphoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "252" "paginaFinal" => "253" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleSup">18</span>F-FDG PET/TC “superscan” en paciente con linfoma inmunoblástico" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1012 "Ancho" => 1400 "Tamanyo" => 124419 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/CT study shows an intense and symmetrical uptake of bone marrow that produces an absence of physiological uptake in renal and brain parenchyma, whereas low uptake is observed in soft tissues, liver, spleen and also in supra and infra-diaphragmatic pathological lymph nodes.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Irene Acevedo-Báñez, Álvaro De-Bonilla-Damiá, Rosa Fernández-López" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Irene" "apellidos" => "Acevedo-Báñez" ] 1 => array:2 [ "nombre" => "Álvaro" "apellidos" => "De-Bonilla-Damiá" ] 2 => array:2 [ "nombre" => "Rosa" "apellidos" => "Fernández-López" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X18300556" "doi" => "10.1016/j.remn.2018.04.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18300556?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300363?idApp=UINPBA00004N" "url" => "/22538089/0000003800000004/v1_201907020628/S2253808918300363/v1_201907020628/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "Aggressive metastatic malignant pilomatrixoma followed by <span class="elsevierStyleSup">18</span>F-FDG PET/CT" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "254" "paginaFinal" => "255" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Nese Torun, Emine Tuba Canbolat" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Nese" "apellidos" => "Torun" "email" => array:1 [ 0 => "ntoruntorun@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Emine Tuba" "apellidos" => "Canbolat" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Nuclear Medicine, Baskent University Faculty of Medicine, Adana Dr. TurgutNoyan Teaching and Medical Research Center, Adana, Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Pathology, Baskent University Faculty of Medicine, Adana Dr. TurgutNoyan Teaching and Medical Research Center, Adana, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Seguimiento de Pilomatrixoma maligno metastásico agresivo mediante PET/TC con <span class="elsevierStyleSup">18</span>F-FDG" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 474 "Ancho" => 1255 "Tamanyo" => 237586 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Basal cell tumor with significant infiltrative growth patterns including mitotic activity, comedo-type necrosis, and some markedly focalized ghost cell changes, H.EX200. (B) Infiltrative growth pattern involving the lymph nodes, remarkable mitotic activity and massive comedo-type necrosis, H.EX200.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sixty one year old female referred to our clinic with the complaint of swelling in the neck; FNAB suggested squamous cell carcinoma. The patient was evaluated for staging by means of F-18 fluoro-2-deoxyglucose (<span class="elsevierStyleSup">18</span>F-FDG) positron emission tomography and computed tomography (PET/CT). PET/CT showed hypermetabolic giant mass lesions (SUVmax: 17.56), of which the largest was 120<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>145<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>85<span class="elsevierStyleHsp" style=""></span>mm in size, filling the right supraclavicular area and posterior triangle of the neck as well as hypermetabolic lymph nodes in the bilateral cervical chain and under the skin of the right chest wall (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A, B). SUVmax values of the lesions supported malignancy. The patient received chemotherapy as the results of histopathological examination of the surgical excision material were consistent with malignant pilomatrixoma (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). PET/CT after chemotherapy revealed hypermetabolic lesions suggestive of residue/relapse (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C, D), whereas PET/CT after radiotherapy revealed progression (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>E, F). Hypermetabolic lesions detected on PET/CT after chemotherapy and radiotherapy were histopathologically consistent with malignant pilomatrixoma, thus the diagnosis was confirmed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">While PET/CT is widely used in head and neck cancers, there is limited number of studies reporting the use of <span class="elsevierStyleSup">18</span>F-FDG PET/CT in pilomatrixoma and malignant pilomatrixoma, which is quite uncommon. The diagnosis of pilomatrixoma and discrimination between benign and malignant lesions are made histopathologically. <span class="elsevierStyleSup">18</span>F-FDG is not specific for malignant pathologies as <span class="elsevierStyleSup">18</span>F-FDG uptake is also seen in benign pathologies. For this reason, it may not be reasonable to use <span class="elsevierStyleSup">18</span>F-FDG PET/CT in making the diagnosis of pilomatrixoma as well as in making discrimination between benign and malignant lesions. However, <span class="elsevierStyleSup">18</span>F-FDG PET/CT plays a critical role in determining the biopsy site, in staging, and in detecting relapse/residual disease. Contribution of <span class="elsevierStyleSup">18</span>F-FDG PET/CT to the staging, patient follow-up and determination of biopsy site in the cases with suspicious relapse/residual disease has been demonstrated in cases with malignant pilomatrixoma, which is an uncommon condition and whose aggressive forms have been reported as in the present case, in contrast to pilomatrixoma not showing local recurrence after total excision.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Pilomatrixoma is an uncommon, superficial tumor of the skin arising from the hair follicle matrix. It is also called as calcified epithelioma of Malherbe. It may either be benign or malignant.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Malignant pilomatrixoma is a very rare condition but may be fatal.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> Malignant pilomatrixoma as well as pilomatrixoma is localized in the head and neck region particularly in the posterior triangle of the neck, upper back and preauricular area. It displays tendency to grow through the deep planes, aggressive progression and local recurrence. Local recurrence may be seen after excision despite negative surgical border.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> The present case is an example of an aggressive malignant pilomatrixoma followed by PET/CT.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Torun N, Canbolat ET. Seguimiento de Pilomatrixoma maligno metastásico agresivo mediante <span class="elsevierStyleSup">18</span>F-DG PET/TC. Rev Esp Med Nucl Imagen Mol. 2019;38:254–255.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 927 "Ancho" => 1255 "Tamanyo" => 98157 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A, B) Hypermetabolic giant mass lesions (SUVmax: 17.56) and lymph nodes (SUVmax: 8.39) filling the right supraclavicular area, chest wall and posterior triangle of the neck on <span class="elsevierStyleSup">18</span>F-FDG PET/CT performed for staging. (C, D) Hypermetabolic lesions (SUVmax: 12.1) consistent with residual disease/relapse on the <span class="elsevierStyleSup">18</span>F-FDG PET/CT of the patient that underwent surgery and received chemotherapy. (E, F) Progression (SUVmax: 15.74) on <span class="elsevierStyleSup">18</span>F-FDG PET/CT performed after radiotherapy in the patient followed for three years.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 474 "Ancho" => 1255 "Tamanyo" => 237586 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Basal cell tumor with significant infiltrative growth patterns including mitotic activity, comedo-type necrosis, and some markedly focalized ghost cell changes, H.EX200. (B) Infiltrative growth pattern involving the lymph nodes, remarkable mitotic activity and massive comedo-type necrosis, H.EX200.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pilomatrix carcinoma: 12-year experience and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Jones" 1 => "M. Twoon" 2 => "W. Ho" 3 => "M. Portelli" 4 => "B.F. Robertson" 5 => "W. 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Ravi Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RLU.0b013e3182443cbe" "Revista" => array:6 [ "tituloSerie" => "Clin Nucl Med" "fecha" => "2012" "volumen" => "37" "paginaInicial" => "684" "paginaFinal" => "686" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22691514" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Hardisson" 1 => "M.D. Linares" 2 => "J. Cuevas-Santos" 3 => "C. Felix" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "2001" "volumen" => "23" "paginaInicial" => "394" "paginaFinal" => "401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11801770" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000003800000004/v1_201907020628/S2253808918300600/v1_201907020628/en/main.assets" "Apartado" => array:4 [ "identificador" => "47121" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting image" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000003800000004/v1_201907020628/S2253808918300600/v1_201907020628/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300600?idApp=UINPBA00004N" ]