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Camacho, M. Estorch, M. Marquié, A. Domènech, A. Flotats, A. Fernández, J. Duch, L.L. Geraldo, J. Deportos, C. Artigas, A. Lleó, I. Carrió" "autores" => array:12 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "Camacho" "email" => array:1 [ 0 => "mcamachom@santpau.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Estorch" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Marquié" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." 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"apellidos" => "Deportos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 9 => array:3 [ "nombre" => "C." "apellidos" => "Artigas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 10 => array:3 [ "nombre" => "A." "apellidos" => "Lleó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 11 => array:3 [ "nombre" => "I." "apellidos" => "Carrió" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Memoria, Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Utilidad de la imagen precoz de la gammagrafía de inervación miocárdica en el diagnóstico de la Demencia con Cuerpos de Lewy" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 763 "Ancho" => 2168 "Tamanyo" => 195958 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Patient diagnosed with Lewy body dementia. Both the early image (A) and the delayed image (B) show an important reduction in the myocardial uptake of <span class="elsevierStyleSup">123</span>I-MIBG. H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>min</span>: 1.20, H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>: 1.10.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Lewy body dementia (LBD) is the second cause of degenerative dementia in the elderly following Alzheimer dementia (AD), being observed in 10–15% of autopsies.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Definitive diagnosis of LBD is postmortem since the application of the International Consensus Criteria allows <span class="elsevierStyleItalic">in vivo</span> diagnosis with a high specificity but with limited sensitivity,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> thereby making differential diagnosis among dementias, especially AD, difficult. The importance of early diagnosis of LBD lays in its pharmacological management due to the good response to colinesterase inhibitors presented by these patients, albeit with secondary effects to the neuroleptics.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Metaiodobenzylguanidine (<span class="elsevierStyleSup">123</span>I-MIBG) is an analog of noradrenalin with which it shares the same mechanisms of uptake and storage. Myocardial innervation scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG allows non invasive evaluation of the sympathetic nervous system.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> This study consists in the acquisition of planar images of the thorax at 15<span class="elsevierStyleHsp" style=""></span>min (early image) and at 4<span class="elsevierStyleHsp" style=""></span>h (delayed image) after the administration of the tracer, with posterior semiquantification of myocardial uptake of the tracer using the heart/mediastinum (H/M) ratio. Early images reflect the integrity of the presynaptic nerve terminals while delayed images reflect the integrity of neuronal function.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> In LBD, Parkinson disease (PD) and pure autonomic failure, a reduction is observed in the cardiac uptake of <span class="elsevierStyleSup">123</span>I-MIBG in both the early and the delayed images secondary to the presence of Lewy bodies in the cardiac plexus.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,7</span></a> It has been demonstrated that delayed images in cardiac scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG allow differential diagnosis between LBD and other neurodegenerative diseases associated with dementia, especially AD.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–11</span></a> However, there is no evidence of the utility of early imaging for this diagnosis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Taking into account the short duration of the test as well as its comfortability compared to other functional tests, the aim of this study was to evaluate the utility of early imaging of cardiac scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG in the differential diagnosis between LBD and other neurodegenerative dementias.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">All the patients undergoing myocardial innervation scintigraphy for LBD from January 2003 to January 2008 were retrospectively evaluated. A total of 106 patients were included over these 5 years (51 men and 55 women) with a mean age of 78 years (range 61–89). The patients were visited by a neurologist with experience in neurodegenerative diseases in the Memory Unit of the Hospital de la Santa Creu i Sant Pau in Barcelona, Spain. Patients with diseases or taking medication known to interfere with the uptake of <span class="elsevierStyleSup">123</span>I-MIBG were excluded.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Myocardial innervation scintigraphy</span><p id="par0025" class="elsevierStylePara elsevierViewall">Thirty minutes after thyroid blockade with 500<span class="elsevierStyleHsp" style=""></span>mg of oral potassium perchlorate 370<span class="elsevierStyleHsp" style=""></span>MBq (10<span class="elsevierStyleHsp" style=""></span>mCi) of <span class="elsevierStyleSup">123</span>I-MIBG were endovenously administered. The scintigraphic studies were obtained at 15<span class="elsevierStyleHsp" style=""></span>min (early image) and at 4<span class="elsevierStyleHsp" style=""></span>h (delayed image) after the administration of the tracer. The acquisition of the studies was performed in a gamma camera (General Electric Millenium Hawkeye V3) equipped with parallel hole collimators for general purposes and centered in the photopeak of the <span class="elsevierStyleSup">123</span>I (159<span class="elsevierStyleHsp" style=""></span>keV) with an energy window of 20%. Planar images of the thorax were obtained in anterior projection and a 128<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>128 matrix. The early image was acquired for a fixed number of counts (1000<span class="elsevierStyleHsp" style=""></span>K) while the image at 4<span class="elsevierStyleHsp" style=""></span>h, or the delayed image, was acquired for the same time duration as the early image.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Myocardial uptake of <span class="elsevierStyleSup">123</span>I-MIBG was semiquantified using the H/M ratio at 15<span class="elsevierStyleHsp" style=""></span>min (H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>) and at 4<span class="elsevierStyleHsp" style=""></span>h (H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>). To obtain the H/M ratio, areas of interest were drawn over the cardiac area and the mediastium, the average counts/pixel of each of the regions drawn and the following formula was applied.<elsevierMultimedia ident="eq0005"></elsevierMultimedia></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0035" class="elsevierStylePara elsevierViewall">The “Statistical Package for Social Sciences” (SPSS) (v. 18) was used for statistical analysis. The H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> followed a normal distribution in the whole sample. The qualitative results are expressed as percentages and the quantitative results as means<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation. To determine the significance of the differences between the variables, analysis of variance (ANOVA) was performed. The differences between the means were calculated using the <span class="elsevierStyleItalic">T</span> test for independent samples. ROC (receiver operating curve) analysis was done to calculate the cut off of the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> to differentiate between LBD and other neurodegenerative diseases. Results with <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 were considered significant.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">At 4 years the final clinical diagnosis was made based on the International Clinical Consensus Criteria with 52 (4 with 52 (49.1%) patients with LBD, 31 (29.2%) with AD, 9 (8.5%) with Parkinson Plus (4 progressive supranuclear palsy, 4 multisystemic atrophy and 1 corticobasal degeneration), 6 (5.7%) with frontotemporal dementia, 5 (4.7%) with vascular dementia, 1 (0.9%) normotensive hydrocephalus and 2 (1.9%) with mild amnesic-type cognitive deterioration.</p><p id="par0045" class="elsevierStylePara elsevierViewall">No statistically significant differences were observed between the age and the sex among the different groups of dementias (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="par0050" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the H/<span class="elsevierStyleInf">M15<span class="elsevierStyleHsp" style=""></span>m</span> and H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> for each type of dementia.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">The H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> of the patients with LBD was significantly lower than that of those diagnosed with another type of dementia (1.27<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15 vs 1.76<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). Likewise, the same occurred with the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> (1.14<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.13 vs 1.68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.19, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01). All the patients with a reduction in the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> also presented a reduction in the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A cut off of the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> of 1.56 was obtained with the ROC analysis, with an area under the curve of 0.99 and with a sensitivity and specificity of 98% to differentiate between LBD and other types of neurodegenerative dementias.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">The initial diagnosis of LBD should take into account the specific symptoms such as visual hallucinations, falls and sleep alterations which these patients present and are generally not considered in other types of dementia. When the grade of dementia is similar, it has been observed that patients diagnosed with LBD have greater functional alteration and worse quality of life than those with AD.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Moreover, patients with LBD present good response to cholinesterase inhibitors but with elevated secondary effects to neuroleptic drugs.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> Therefore, a correct initial diagnosis helps not only the clinical management but also the evaluation of the prognosis of dementia in these patients.</p><p id="par0070" class="elsevierStylePara elsevierViewall">One of the histopathological characterisitcs which Lewy body diseases present, including LBD, PD and pure autonomic failure, is an alteration in cardiac sympathetic innervation because the presence of Lewy bodies produces a reduction in the cardiac uptake of <span class="elsevierStyleSup">123</span>I-MIBG.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,14</span></a> The last International Clinical Consensus Criteria considered an alteration in sympathetic innervation demonstrated with <span class="elsevierStyleSup">123</span>I-MIBG as clinical criteria supporting the disease.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> On the other hand, the 4th International Workshop of LBD and PD associated with dementia proposed the inclusion of an alteration in myocardial sympathetic innervation scintigraphy as criteria suggestive of LBD.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In the last International Clinical Consensus Criteria a reduction in basal lymph nodes observed by SPECT or PET appeared as suggestive criteria.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recently, our center studied the relationship between myocardial innervation scintigraphy and dopamine transporter SPECT in 28 patients diagnosed with LBD and found an reduction in the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> and an alteration in the cerebral SPECT in 23 of these patients, with a significant correlation between the two tests (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). We therefore concluded that both an alteration in cardiac sympathetic innervation and an alteration in the presynaptic nigrostriatal occur in parallel in patients with probable LBD.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Treglia et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> recently reviewed the utility of myocardial scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG in 8 studies including a total of 346 patients (152 diagnosed with LBD and 194 with other types of dementia). The results obtained indicated that the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> presented a sensitivity of 98% and a specificity of 94% (both with a confidence interval of 95%, 94–100%) to differentiate between LBD and other dementias and concluded that scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG allows precise differential diagnosis.</p><p id="par0085" class="elsevierStylePara elsevierViewall">To date, the studies undertaken to evaluate the utility of scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG in LBD are based on the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> as a specific marker for the assessment of myocardial sympathetic innervation.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9,18</span></a> To the contrary, the present study aimed to evaluate the utility of early imaging (H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>) in the differential diagnosis between degenerative dementias with the aim of reducingh the duration of the study and thereby increase the comfortability of the patients. The results obtained show a significant reduction in the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> in patients with LBD compared with those with other types of dementia, with a cut off of 1.56 providing a sensitivity and specificity of 98%.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Although the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> reflects the specific neuronal uptake of <span class="elsevierStyleSup">123</span>I-MIBG, the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>min</span> reflects the integrity of the myocardial sympathetic system and the distribution of the myocardial sympathetic neurones. No previous study has compared these two ratios, but similar to the H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>, it has been described<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,19</span></a> that the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> also presents statistically significant differences in patients with LBD compared to patients with other neurodegenerative dementias. Orimo et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> have histopathologically demonstrated a marked reduction in the myocardial sympathetic terminations in 11 patients with LBD independently of the age, sex, disease duration or the presence of orthostatic hypotension, with cardiac sympathetic denervation being a histopathological characteristic of Lewy body diseases. Thus, a reduction in the myocardial sympathetic terminations in patients with LBD may explain the alteration in cardiac sympathetic innervation observed in the early images, with a consequent reduction in the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>. Although further studies are necessary, the result obtained indicate the possibility of not performing the delayed images in patients presenting an important reduction in the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>, since in our study no patient with an H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> lower than 1.56 presented a normal H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>. Not undertaking the delayed images would shorten the study time, increasing the comfortability of both the patients and the care providers.</p><p id="par0095" class="elsevierStylePara elsevierViewall">The most important limitation of this study, as in most of the studies on neurological diseases, is the lack of histological confirmation of the disease since the gold pattern considered in this study is the clinical evolution. Another limitation may be the elderly age of the patients since the older the age the lower the myocardial uptake of <span class="elsevierStyleSup">123</span>I-MIBG. Nonetheless, this limitation has been obviated by the absence of statistically significant differences in the age of the patients in the two groups of dementias. Finally, the limitation related to possible false positives due to diseases and medications which may interfere with the cardiac uptake of <span class="elsevierStyleSup">123</span>I-MIBG was also obviated with the exclusion of these patients from the study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0100" class="elsevierStylePara elsevierViewall">Patients with LBD present a reduced H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> compared to those with another type of neurodegenerative dementia. Thus, early imaging of myocardial innervation scintigraphy with <span class="elsevierStyleSup">123</span>I-MIBG with obtention of the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> may be useful to differentiate between patients with LBD and those with other types of dementias and reduce the length of the study and increase the comfortability.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interests</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:2 [ "identificador" => "xres119605" "titulo" => array:4 [ 0 => "Abstract" 1 => "Material and methods" 2 => "Results" 3 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec106885" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres119606" "titulo" => array:4 [ 0 => "Resumen" 1 => "Material y métodos" 2 => "Resultados" 3 => "Conclusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec106886" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Myocardial innervation scintigraphy" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Conclusion" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-02-01" "fechaAceptado" => "2012-03-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec106885" "palabras" => array:4 [ 0 => "Cardiac MIBG scintigraphy" 1 => "<span class="elsevierStyleSup">123</span>I-MIBG" 2 => "Early imaging" 3 => "Dementia with Lewy bodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec106886" "palabras" => array:4 [ 0 => "Gammagrafía de inervación miocárdica" 1 => "<span class="elsevierStyleSup">123</span>I-MIBG" 2 => "Imagen precoz" 3 => "Demencia con Cuerpos de Lewy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The importance of accurate and early diagnosis of dementia with Lewy bodies (DLB) lies in its pharmacological management. Delayed imaging of cardiac <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy allows differentiation between DLB and other neurodegenerative diseases with cognitive impairment.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to assess the utility of early imaging of cardiac <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy for differentiating DLB from others neurodegenerative disease with cognitive impairment.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We assess retrospectively 106 patients (51 men, mean age 78 years) with cognitive impairment that underwent a cardiac <span class="elsevierStyleSup">123</span>I-MIBG study. Planar images were acquired in anterior view of the thorax 15<span class="elsevierStyleHsp" style=""></span>min (early) and 4<span class="elsevierStyleHsp" style=""></span>h (delayed) after tracer administration. The heart-to-mediastinum ratios (HMR) at 15<span class="elsevierStyleHsp" style=""></span>m (HMR<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>) and at 4<span class="elsevierStyleHsp" style=""></span>h (HMR<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>) were obtained.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">After four years, 52 patients were diagnosed of DLB.HMR<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> and HMR<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> were significantly inferior in DLB respect to the others neurodegenerative diseases (1.27<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15 vs 1.76<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) and (1.14<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.13 vs 1.68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.19, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01), respectively. The ROC analysis showed a HMR<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> cut off point of 1.56 to differentiated DLB from the other dementias with a sensitivity and a specificity of 98%.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Early imaging of cardiac <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy can help to differentiate DLB from other neurodegenerative diseases with cognitive impairment.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La realización de un correcto diagnóstico inicial ayuda al manejo clínico de los pacientes con Demencia con Cuerpos de Lewy (DCLw). La imagen tardía de la gammagrafía cardíaca con <span class="elsevierStyleSup">123</span>I-MIBG permite diferenciar entre DCLw y otro tipo de demencias.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El objetivo del estudio es valorar la utilidad de la imagen precoz de la gammagrafía cardíaca con <span class="elsevierStyleSup">123</span>I-MIBG para el diagnóstico diferencial entre DCLw y otras demencias neurodegenerativas.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de 106 pacientes (51 hombres, edad media 78 años) a los que se les realizó una gammagrafía de inervación miocárdica por estudio de demencia. Se obtuvieron imágenes planares en proyección anterior a los 15<span class="elsevierStyleHsp" style=""></span>min (precoz) y a las 4<span class="elsevierStyleHsp" style=""></span>h (tardía) de la administración del trazador. La captación miocárdica de <span class="elsevierStyleSup">123</span>I-MIBG se semicuantificó mediante la obtención del índice de captación corazón/mediastino (ICM) a los 15<span class="elsevierStyleHsp" style=""></span>min (ICM<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span>) y a las 4<span class="elsevierStyleHsp" style=""></span>h (ICM<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El diagnóstico clínico a los 4 años fue de 52 pacientes con DCLw. El ICM<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> para los pacientes con DCLw fue significativamente inferior al de los otros pacientes (1,27<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,15 vs 1,76<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,15, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,05), así como el ICM<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> (1,14<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,13 vs 1,68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,19, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,01). A partir del análisis ROC se obtuvo un punto de corte del ICM<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> de 1,56 con un área bajo la curva del 0,99, para poder diferenciar DCLw respecto a los otros tipos de demencia, con una sensibilidad y especificidad del 98%.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La imagen precoz de la gammagrafía de inervación miocárdica con <span class="elsevierStyleSup">123</span>I-MIBG, puede ser útil para diferenciar la DCLw de otro tipo de demencias neurodegenerativas.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: Camacho V, et al. Utilidad de la imagen precoz de la gammagrafía de inervación miocárdica en el diagnóstico de la Demencia con Cuerpos de Lewy. Rev Esp Med Nucl Imagen Mol. 2013;32:77–80.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 763 "Ancho" => 2168 "Tamanyo" => 195958 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Patient diagnosed with Lewy body dementia. Both the early image (A) and the delayed image (B) show an important reduction in the myocardial uptake of <span class="elsevierStyleSup">123</span>I-MIBG. H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>min</span>: 1.20, H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>: 1.10.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 755 "Ancho" => 2168 "Tamanyo" => 173086 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Patient diagnosed with Alzheimer dementia. The early image (A) and the delayed image (B) show correct myocardial uptake of <span class="elsevierStyleSup">123</span>I-MIBG. H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>min</span>: 1.75, H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span>: 1.64.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">LBD: Lewy body dementia; AD: Alzheimer dementia; FD: frontal dementia; Vascular D: vascular dementia; NT hydrocephalus: normotensive hydrocephalus; MACD: mild amnesic cognitive decline.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LBD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.26<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.14<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.66<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Parkinson Plus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.72<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.65<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.75<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.72<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vascular D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.77<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.74<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NT hydrocephalus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.73 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MACD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.81<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.17 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab207814.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Description of the H/M<span class="elsevierStyleInf">15<span class="elsevierStyleHsp" style=""></span>m</span> and H/M<span class="elsevierStyleInf">4<span class="elsevierStyleHsp" style=""></span>h</span> of each type of dementia.</p>" ] ] 3 => array:5 [ "identificador" => "eq0005" "tipo" => "MULTIMEDIAFORMULA" "mostrarFloat" => false "mostrarDisplay" => true "Formula" => array:5 [ "Matematica" => "H/M   ratio=(counts/pixel)heart(counts/pixel)mediastinum" "Fichero" => "si1.jpeg" "Tamanyo" => 3480 "Alto" => 39 "Ancho" => 253 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dementia with Lewy bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. McKeith" 1 => "J. Mintzer" 2 => "D. Aarsland" 3 => "D. Burn" 4 => "H. Chiu" 5 => "J. Cohen-Mansfield" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet Neurol" "fecha" => "2004" "volumen" => "3" "paginaInicial" => "19" "paginaFinal" => "28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14693108" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.G. McKeith" 1 => "D.W. Dickson" 2 => "J. Lowe" 3 => "M. Emre" 4 => "J.T. O’Brien" 5 => "H. Feldman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/01.wnl.0000187889.17253.b1" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2005" "volumen" => "65" "paginaInicial" => "1863" "paginaFinal" => "1872" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16237129" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroleptic sensitivity in dementia with Lewy bodies and Alzheimer's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Ballard" 1 => "J. Grace" 2 => "I. McKeith" 3 => "C. Holmes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "351" "paginaInicial" => "1032" "paginaFinal" => "1033" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9546516" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myocardial imaging in man with I-123 metaiodobenzylguanidine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.C. Kline" 1 => "D.P. Swanson" 2 => "D.M. Wieland" 3 => "J.H. Thrall" 4 => "M.D. Gross" 5 => "B. Pitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1981" "volumen" => "22" "paginaInicial" => "129" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7463156" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significance of <span class="elsevierStyleSup">123</span>I-MIBG scintigraphy as a pathophysiological indicator in the assessment of Parkinson's disease and related disorders: it can be a specific marker for Lewy body disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Taki" 1 => "M. Yoshita" 2 => "M. Yamada" 3 => "N. Tonami" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Nucl Med" "fecha" => "2004" "volumen" => "18" "paginaInicial" => "453" "paginaFinal" => "461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15515743" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic value of myocardial <span class="elsevierStyleSup">123</span>I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.J. Verberne" 1 => "L.M. Brewster" 2 => "G.A. Somsen" 3 => "B.L. Van Eck-Smit" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurheartj/ehn113" "Revista" => array:6 [ "tituloSerie" => "Eur Heart J" "fecha" => "2008" "volumen" => "29" "paginaInicial" => "1147" "paginaFinal" => "1159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18349024" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Orimo" 1 => "A. Takahashi" 2 => "T. Uchihara" 3 => "F. Mori" 4 => "A. Kakita" 5 => "K. Wakabayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1750-3639.2006.00032.x" "Revista" => array:6 [ "tituloSerie" => "Brain Pathol" "fecha" => "2007" "volumen" => "17" "paginaInicial" => "24" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17493034" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of <span class="elsevierStyleSup">123</span>I-MIBG radioactivity in the differential diagnosis of DLB from AD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Yoshita" 1 => "J. Taki" 2 => "K. Yokoyama" 3 => "M. Noguchi-Shinohara" 4 => "Y. Matsumoto" 5 => "K. Nakajima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1212/01.wnl.0000219640.59984.a7" "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "2006" "volumen" => "66" "paginaInicial" => "1850" "paginaFinal" => "1854" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16801649" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac (123)I-metaiodobenzylguanidine imaging allows early identification of dementia with Lewy bodies during life" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Estorch" 1 => "V. Camacho" 2 => "P. Paredes" 3 => "E. Rivera" 4 => "A. Rodriguez-Revuelto" 5 => "A. Flotats" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00259-008-0828-8" "Revista" => array:6 [ "tituloSerie" => "Eur J Nucl Med Mol Imaging" "fecha" => "2008" "volumen" => "35" "paginaInicial" => "1636" "paginaFinal" => "1641" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18509631" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological applications of the <span class="elsevierStyleSup">123</span>I-MIBG myocardial innervation scintigraphy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.M. Jimenez-Hoyuela Garcia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.remn.2011.02.001" "Revista" => array:6 [ "tituloSerie" => "Rev Esp Med Nucl" "fecha" => "2011" "volumen" => "30" "paginaInicial" => "197" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21439687" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dementia with Lewy bodies and Alzheimer's disease: differential diagnosis by cardiac sympathetic innervation MIBG imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Estorch" 1 => "V. Camacho" 2 => "J. Fuertes" 3 => "A. Rodriguez-Revuelto" 4 => "M.A. Hernandez" 5 => "A. Flotats" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Med Nucl" "fecha" => "2006" "volumen" => "25" "paginaInicial" => "229" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16827985" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EANM procedure guidelines for <span class="elsevierStyleSup">131</span>I-<span class="elsevierStyleItalic">meta</span>-iodobenzylguanidine (<span class="elsevierStyleSup">131</span>I MIBG) therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Giammarile" 1 => "A. Chiti" 2 => "M. Lassmann" 3 => "B. Brans" 4 => "G. Flux" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00259-008-0715-3" "Revista" => array:6 [ "tituloSerie" => "Eur J Nucl Med Mol Imaging" "fecha" => "2008" "volumen" => "35" "paginaInicial" => "1039" "paginaFinal" => "1047" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18274745" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Aarsland" 1 => "M. Kurz" 2 => "M. Beyer" 3 => "K. Bronnick" 4 => "S. Piepenstock Nore" 5 => "C. Ballard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000113417" "Revista" => array:6 [ "tituloSerie" => "Dement Geriatr Cogn Disord" "fecha" => "2008" "volumen" => "25" "paginaInicial" => "195" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204253" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Orimo" 1 => "T. Amino" 2 => "Y. Itoh" 3 => "A. Takahashi" 4 => "T. Kojo" 5 => "T. Uchihara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00401-005-0995-7" "Revista" => array:6 [ "tituloSerie" => "Acta Neuropathol" "fecha" => "2005" "volumen" => "109" "paginaInicial" => "583" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15933869" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging improves diagnosis of dementia with Lewy bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Tateno" 1 => "S. Kobayashi" 2 => "T. Saito" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Psychiatr Investig" "fecha" => "2009" "volumen" => "6" "paginaInicial" => "233" "paginaFinal" => "240" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiac sympathetic impairment parallels nigrostriatal degeneration in probable dementia with Lewy bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Camacho" 1 => "M. Marquie" 2 => "A. Lleo" 3 => "L. Alves" 4 => "C. Artigas" 5 => "A. Flotats" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Q J Nucl Med Mol Imaging" "fecha" => "2011" "volumen" => "55" "paginaInicial" => "476" "paginaFinal" => "483" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21150861" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic performance of myocardial innervation imaging using MIBG scintigraphy in differential diagnosis between dementia with Lewy bodies and other dementias: a systematic review and a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Treglia" 1 => "E. Cason" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1552-6569.2010.00532.x" "Revista" => array:6 [ "tituloSerie" => "J Neuroimaging" "fecha" => "2012" "volumen" => "22" "paginaInicial" => "111" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21091814" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usefulness of [<span class="elsevierStyleSup">123</span>I]metaiodobenzylguanidine ([<span class="elsevierStyleSup">123</span>I]MIBG) myocardial scintigraphy in differentiating between Alzheimer's disease and dementia with Lewy bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Oide" 1 => "T. Tokuda" 2 => "M. Momose" 3 => "K. Oguchi" 4 => "A. Nakamura" 5 => "S. Ohara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "686" "paginaFinal" => "690" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12924492" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A clinical role for [(123)I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer's-type and dementia with Lewy bodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Yoshita" 1 => "J. Taki" 2 => "M. Yamada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2001" "volumen" => "71" "paginaInicial" => "583" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11606666" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000003200000002/v1_201305061041/S2253808913000104/v1_201305061041/en/main.assets" "Apartado" => array:4 [ "identificador" => "7926" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000003200000002/v1_201305061041/S2253808913000104/v1_201305061041/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808913000104?idApp=UINPBA00004N" ]
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Original Article
Utility of early imaging of myocardial innervation scintigraphy in the diagnosis of Lewy body dementia
Utilidad de la imagen precoz de la gammagrafía de inervación miocárdica en el diagnóstico de la Demencia con Cuerpos de Lewy