array:23 [ "pii" => "S1699885519301102" "issn" => "16998855" "doi" => "10.1016/j.patol.2019.10.003" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "585" "copyright" => "Sociedad Española de Anatomía Patológica" "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2020;53:113-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "PDF" => 2 ] "itemSiguiente" => array:18 [ "pii" => "S169988551930025X" "issn" => "16998855" "doi" => "10.1016/j.patol.2019.02.002" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "536" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2020;53:117-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "PDF" => 2 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ARTÍCULO BREVE</span>" "titulo" => "Carcinoma secretor de mama multicéntrico: a propósito de un caso y revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "117" "paginaFinal" => "120" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multicentric secretory carcinoma of the breast: Case report and review of the literature" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 827 "Ancho" => 905 "Tamanyo" => 124196 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Marcadas con flechas, dos áreas de realce (de 7 y 11<span class="elsevierStyleHsp" style=""></span>mm) en plano medio y posterior de la mama izquierda, sin adenopatías axilares sospechosas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Almudena Sobrino Prados, Beatriz Eizaguirre Zarza, Esther Gimeno Esteras, Celia del Agua Arias-Camisón" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Almudena" "apellidos" => "Sobrino Prados" ] 1 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Eizaguirre Zarza" ] 2 => array:2 [ "nombre" => "Esther" "apellidos" => "Gimeno Esteras" ] 3 => array:2 [ "nombre" => "Celia" "apellidos" => "del Agua Arias-Camisón" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169988551930025X?idApp=UINPBA00004N" "url" => "/16998855/0000005300000002/v3_202003240609/S169988551930025X/v3_202003240609/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885519300066" "issn" => "16998855" "doi" => "10.1016/j.patol.2019.01.004" "estado" => "S300" "fechaPublicacion" => "2020-04-01" "aid" => "530" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Rev Esp Patol. 2020;53:100-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 14 "PDF" => 14 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">REVISIÓN</span>" "titulo" => "Citodiagnóstico del líquido sinovial" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "100" "paginaFinal" => "112" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Synovial fluid cytodiagnosis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 675 "Ancho" => 900 "Tamanyo" => 130971 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Intensa birrefringencia de los cristales de UM observados con luz polarizada (400x).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rafael Martínez Girón, Santiago Martínez Torre" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Rafael" "apellidos" => "Martínez Girón" ] 1 => array:2 [ "nombre" => "Santiago" "apellidos" => "Martínez Torre" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885519300066?idApp=UINPBA00004N" "url" => "/16998855/0000005300000002/v3_202003240609/S1699885519300066/v3_202003240609/es/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Basaloid squamous cell carcinoma of the breast" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "116" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Vicente Marco, Isabel T. Rubio, Felip García, Omar Clavero" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Vicente" "apellidos" => "Marco" "email" => array:1 [ 0 => "vmarcomolina@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Isabel T." "apellidos" => "Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Felip" "apellidos" => "García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Omar" "apellidos" => "Clavero" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Pathology, Hospital Quironsalud Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto Oncológico Baselga, Hospital Quironsalud Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Infections and Cancer Unit, Cancer Epidemiology Research Program, IDIBELL, Institut Català d’Oncologia (ICO)-IDIBELL, CIBERESP, L’Hospitalet de Llobregat, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma escamoso basaloide de mama" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 942 "Ancho" => 1255 "Tamanyo" => 343008 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical findings. (A) Diffuse nuclear p63 positivity. (B) Nuclear and cytoplasmic p16 positivity. (C) Focal nuclear Myb positivity. (D) High Ki 67 proliferative index.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma frequently described in the head and neck and less commonly in other organs, (e.g., anus, esophagus, uterine cervix and thymus).<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1–3</span></a> BSCC is considered an aggressive type of carcinoma and may be associated with papillomavirus (HPV) infection.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Histologically, BSCC is characterized by the presence of nests of basaloid cells with comedonecrosis and small foci of abrupt keratinization, surrounded by a densely fibrous stroma. Dense deposits of hyaline basement membrane-like material (HBMLM) around the epithelial nests and individual cells are also characteristic of these tumors.</p><p id="par0015" class="elsevierStylePara elsevierViewall">To date, no cases of BSCC of the breast have been reported although they are considered in the differential diagnosis of adenoid cystic carcinoma and basal-like tumors of the breast because of their basaloid appearance and the presence of HBMLM deposits.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a> The present study aims to describe the clinical, histological and prognostic features of a case of BSCC of the breast and discuss the differential diagnosis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Materials and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 44-year-old woman presented with dense area in the left breast, 4<span class="elsevierStyleHsp" style=""></span>mm in diameter. She underwent core needle biopsy from which a diagnosis of invasive carcinoma was made. Subsequently, she underwent breast conserving surgery and sentinel lymph node biopsy, after which the tumor was staged as pT1c, pN0(i-) (sn), M0. After postoperative radiation therapy and chemotherapy, she remains alive and free of disease at 48 months after surgery. The patient did not present other primary tumors at the time of presentation or during the follow-up.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Immunohistochemistry</span><p id="par0025" class="elsevierStylePara elsevierViewall">Four-micrometer-thick sections were cut from formalin-fixed, paraffin-embedded tissue blocks. The sections were subjected to immunohistochemistry using a Ventana Benchmark LT automated immunostainer (Ventana Medical Systems Inc., Tucson, AZ, USA) and different antibodies according to standard protocols.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The following primary antibodies were used: p63 (clone 4A4, Ventana Inc.); S100 (clone 4C4.9, Ventana Inc.); CK 5/6 (clone D5/16B4, Ventana Inc.); CK 14 (clone LL002, Ventana Inc.); CD 117 (clone 9.7, Ventana Inc.); Myb (clone EP769Y, Abcam, Cambridge, UK), p16 (Clone E6H4, Ventana Inc.), Retinoblastoma (Rb) (clone G3-245, Pharmingen, Germany), estrogen receptor (clone SP1, Ventana Inc.), progesterone receptor (clone PgR636, Ventana Inc, USA); HER2 (HER2 Pathway antibody, clone 4B5, Ventana Inc.); Ki-67 (clone 30.9, Ventana Inc.). HER2 staining was interpreted using the guidelines of the American Society of Clinical Oncology/College of American Pathologists (negative: 0/1+, equivocal: 2+, positive: 3+).<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">HPV-DNA detection and genotyping</span><p id="par0035" class="elsevierStylePara elsevierViewall">Total DNA was obtained from formalin fixed, paraffin-embedded tissue sections via treatment with proteinase K as described previously.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> The presence of HPV DNA in the biopsy was further determined using two different broad-papillomavirus PCR-based assays (SPF10-DEIA-LiPa and HSL-PCR/Luminex systems). Briefly, the SPF10 PCR and DNA enzyme immunoassay (DEIA) was used to detect a wide range of HPV types from the genera alpha: the reverse hybridization line probe assay LiPA25 was used to genotype the positive results (HPV6, 11, 16, 18, 31, 33, 34, 35, 39, 40, 42, 43, 44, 45, 51, 52, 53, 54, 58, 59, 56, 66, 68, 70 and 74).<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> The HSL-PCR/Luminex assay was used to detect HPV types from the genera alpha (HPV2, 3, 7, 10, 27, 28, 29, 40, 43, 57, 77, 91, and 94), gamma (HPVs 4, 65, 95, 48, 50, 60, and 88), mu (HPVs 1 and 63), and nu (HPV41). HSL-PCR amplification was followed by a xMAP Luminex technology bead-based genotyping assay with the capacity to identify 23 HPV genotypes.</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Microscopic findings</span><p id="par0040" class="elsevierStylePara elsevierViewall">The tumor showed a multinodular pattern with nests of basaloid cells embedded in a dense collagenous stroma (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Their nuclei showed dense chromatin but lacked prominent nucleoli and their cytoplasm was scanty. Extensive comedonecrosis and a high mitotic activity were observed. Focal abrupt keratinization was noted, in the form of small keratin pearls that often exhibited focal calcification. Abundant HBMLM was observed in the stroma surrounding the basaloid nests, as well as the intercellular matrix. There was no evidence of perineural or microvascular invasion. The tumor did not show any other associated histological types. Focal BSCC in situ was observed, accounting for approximately 10% of the tumor volume.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Immunohistochemistry findings</span><p id="par0045" class="elsevierStylePara elsevierViewall">The tumor was triple negative for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Diffuse nuclear p63 positivity, diffuse nuclear and cytoplasmic p16 positivity, focal cytoplasmic CD117 (c-kit) not related to ducts and Rb negativity was also observed (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Furthermore, moderate to intense nuclear Myb IHC positivity was detected in more than 80% of the tumor cells. Ki-67 proliferative index was high, with nuclear labeling in more than 50% of the cells. Other positive markers were for cytokeratins 5/6 and14, showing patchy cytoplasmic positivity, in approximately 70% and 30% of the tumor cells respectively. S100 was negative in the tumor cells.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">HPV genotyping results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The case was negative for HPV.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">BSCC of the breast has not been previously described. However, the present case meets the histological criteria described for their counterparts in the head and neck and in other organs, where BSCC is considered a high grade tumor with a poor prognosis.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1–4,9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Histologically, the tumor exhibited nests of basaloid cells with foci of comedonecrosis and abrupt keratinization, which were surrounded by abundant, collagenous stroma. The neoplasm also exhibited HBMLM, a characteristic feature also described in adenoid cystic carcinomas and other salivary gland tumors, including cylindromas.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">BSCCs of the head and neck predominantly occur in the oral cavity, particularly in the lingual and palatine tonsils.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4,9</span></a> A subset of these tumors are related to HPV. As positive p16 IHC staining is considered a surrogate marker of HPV infection in the head and neck, as well as the anogenital area, we screened for this marker in our case. However, despite positive p16 staining, we detected no evidence of HPV infection using genotyping; this could be due to Rb inactivation, which is considered responsible for p16 diffuse overexpression via a mechanism not related to HPV infection.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">BSCC of the breast exhibits a basaloid morphology with HBMLM and thus should be distinguished from the solid variant of adenoid cystic carcinomas (ACC) with basaloid features<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">10,11</span></a> and non-basaloid squamous cell carcinoma of the breast (SCCB).<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The differential diagnosis with solid variant ACC can be difficult, because in addition to basaloid features it may occasionally show necrosis and one incidence of squamous differentiation has been reported.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> However, intercalated ducts, small cysts and pseudoglandular structures characteristic of ACC are not features of BSCC.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> p63 immunohistochemistry is valuable in the differential diagnosis, because it is diffusely positive in BSCC while it tends to be patchy in ACC.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Lamovec et al.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> reported 9 cases of basaloid carcinoma of the breast, composed of basal-type neoplastic cells. They differ from BSCC as they lack stromal deposits of HBMLM, show no squamous differentiation and are p63 negative.</p><p id="par0085" class="elsevierStylePara elsevierViewall">We observed diffuse positivity for MYB, which is considered a characteristic marker of ACC.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> However, this finding was consistent with an earlier report by West et al.,<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> who described MYB expression in squamous cell carcinomas and in other non-ACC tumors.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">SCCBs also differ morphologically in that they are usually large and often exhibit cystic changes; their prognosis is also worse as they are associated with a high incidence of lymph node metastases.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a> According to Rosen's criteria, no primary squamous cell carcinoma in another location can be present for a correct diagnosis of SCCB.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">18,19</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">BSCC of the breast has not been specifically recognized as an entity in previous reports<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">19,20</span></a> and thus its biological characteristics and prognostic implications remain unknown.</p><p id="par0100" class="elsevierStylePara elsevierViewall">The tumor staging was favorable and the patient has remained free of disease after a follow-up of 48 months. Similar to the triple negative ACC, which has a good prognosis when presenting in the breast, our report suggests that BSCC of the breast, despite aggressive histological features such as high proliferative index, may have a favorable prognosis when compared with squamous cell carcinoma of the breast and BSCC of the head and neck. This possibility should be further explored in larger series.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1321001" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1218597" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1321002" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1218596" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Immunohistochemistry" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "HPV-DNA detection and genotyping" ] ] ] 6 => array:3 [ "identificador" => "sec0025" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Microscopic findings" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Immunohistochemistry findings" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "HPV genotyping results" ] ] ] 7 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of interest" ] 9 => array:2 [ "identificador" => "xack455494" "titulo" => "Acknowledgment" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-29" "fechaAceptado" => "2019-10-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1218597" "palabras" => array:4 [ 0 => "Basaloid squamous cell carcinoma" 1 => "Human papilloma virus" 2 => "Immunohistochemistry" 3 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1218596" "palabras" => array:4 [ 0 => "Carcinoma basaloide escamoso" 1 => "Virus del papiloma humano" 2 => "Inmunohistoquímica" 3 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma that characteristically occurs in the head and neck, may be related to HPV infection and is usually considered to be aggressive. We present the first description of BSCC of the breast. The tumor exhibited characteristic histologic features of BSCC, including nests of basaloid squamous cells with comedonecrosis, abrupt keratinization, and abundant hyaline basement membrane-like material deposition. The tumor showed immunohistochemical features of triple negativity, diffuse p63 positivity, p16 positivity, and Rb negativity. HPV immunogenotyping was negative.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The patient was free of disease after treatment with breast conserving surgery, chemotherapy and radiotherapy. BSCC of the breast should be distinguished from basaloid adenoid cystic carcinoma, triple-negative basal-like breast cancer and nonbasaloid squamous cell carcinoma of the breast based on histology and immunohistochemistry. The prognostic implications of BSCC of the breast should be further studied in larger series.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El carcinoma escamoso basaloide (CEB) es un subtipo de carcinoma escamoso que se origina normalmente en cabeza y cuello, que puede guardar relación con la infección por el virus del papiloma humano (VPH), y que normalmente se considera agresivo. Presentamos la primera descripción de CEB de la mama. El tumor mostró características histológicas de CEB, incluyendo los nidos de células escamosas basaloides con comedonecrosis, queratinización abrupta y abundante material de depósito tipo membrana basal hialina. El tumor mostró características inmunohistoquímicas de triple negatividad, positividad para p63 difusa, positividad para p16 y negatividad para Rb. La inmunofenotipificación para VPH fue negativa.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La paciente estaba libre de enfermedad tras el tratamiento con cirugía conservadora de mama, quimioterapia y radioterapia. El CEB de mama deberá distinguirse del carcinoma adenoide quístico basaloide, del cáncer de mama de tipo basal triple-negativo y del carcinoma no basaloide escamoso de mama, basado en histología e inmunohistoquímica. Además, las implicaciones pronósticas del CEB de mama deberán estudiarse en series adicionales de mayor tamaño.</p></span>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 986 "Ancho" => 1255 "Tamanyo" => 329970 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Basaloid squamous cell carcinoma of the breast. (A) Low-power view showing rounded nests of basaloid cells with comedonecrosis embedded in a dense fibrous stroma. (B) Rounded basaloid tumor cell nest with central comedo necrosis. (C) Abundant intercellular hyaline basement membrane-like material (HBMLM) in the tumor. (D) Foci of abrupt keratinization with some calcification in the basaloid cells.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 942 "Ancho" => 1255 "Tamanyo" => 343008 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemical findings. (A) Diffuse nuclear p63 positivity. (B) Nuclear and cytoplasmic p16 positivity. (C) Focal nuclear Myb positivity. 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Journal Information
Brief report
Basaloid squamous cell carcinoma of the breast
Carcinoma escamoso basaloide de mama
a Department of Pathology, Hospital Quironsalud Barcelona, Spain
b Instituto Oncológico Baselga, Hospital Quironsalud Barcelona, Spain
c Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain
d Infections and Cancer Unit, Cancer Epidemiology Research Program, IDIBELL, Institut Català d’Oncologia (ICO)-IDIBELL, CIBERESP, L’Hospitalet de Llobregat, Barcelona, Spain