Article information
Resumen
La artritis reumatoide (AR) es una enfermedad grave que conduce a la destrucción articular, a la pérdida de función y a la muerte prematura. Lograr la inducción de remisión es una meta terapéutica fundamental. El tratamiento con fármacos modificadores de enfermedad (FAME) convencionales en monoterapia raramente permite conseguir y mantener una adecuada respuesta terapéutica a lo largo del curso de la enfermedad. Este artículo revisa el papel de la terapia combinada con FAME convencionales en la AR de reciente comienzo y en la AR evolucionada refractaria. Asimismo, se comenta críticamente el lugar que deberían ocupar estas terapias combinadas en el actual arsenal terapéutico de la AR tras el advenimiento de los nuevos agentes biológicos.
Palabras clave:
Artritis reumatoide
Terapia combinada
Fármacos modificadores de enfermedad
Abstract
Rheumatoid arthritis (RA) is a severe disease that leads to joint destruction, loss of function and premature death. To achieve the induction of remission is a major therapeutic goal. The use of conventional disease-modifying anti-rheumatic drugs (DMARDs) as monotherapy rarely allows to achieve and maintain an adecuate clinical response over the course of the disease. This article reviews the role of the combination therapy with conventional DMARDs in the early-onset and refractory rheumatoid disease. In addition, the role that should play these combination therapies in the current therapeutic armamentarium of RA after the advent of the new biologic agents is critically discussed.
Key words:
Rheumatoid arthritis
Combination therapy
Disease-modifying antirheumatic drugs
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