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Vol. 25. Issue 2.
Pages 239-253 (April - June 2024)
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Vol. 25. Issue 2.
Pages 239-253 (April - June 2024)
A review on non-small cell lung cancer
Revisión del cáncer de pulmón no microcítico
Sunil Kumar Vermaa, Minakshi Pandeyb, Renu Khareb, Devendra Singha,
Corresponding author
devendrasingh.ibst@srmu.ac.in

Corresponding author.
a Faculty of Biotechnology, Institute of Biosciences & Technology, Shri Ramswaroop Memorial University, Lucknow Deva Road, Barabanki-225003, Uttar Pradesh, India
b Faculty of Biosciences, Institute of Biosciences & Technology, Shri Ramswaroop Memorial University, Lucknow Deva Road, Barabanki-225003, Uttar Pradesh, India
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Abstract

Lung cancer is among the leading causes of death related to cancer globally, with NSCLC (non-small cell lung cancer) accounting for about 85% of all cases. NSCLC is characterized by a complex genetic landscape, with multiple driver mutations and epigenetic alterations that promote tumor progression and resistance to therapy. NSCLC is treated with immunotherapy, chemotherapy, radiation, surgery, or molecularly targeted therapy. However, a significant number of patients who had surgery are likely to experience local recurrence or distant metastases. Immunotherapy and targeted therapies have advanced rapidly in the last few years. Here, in this review, details related to NSCLC, its types, preventive measures, and risk factors, their symptoms, method of screening, diagnosis, and related treatment, and the latest updates related to NSCLC are discussed.

Keywords:
Cancer
Experimental drugs
Treatment
Diagnosis
Prevention
Resumen

El cáncer de pulmón se encuentra entre las principales causas de muerte relacionadas con el cáncer a nivel mundial, y el NSCLC (cáncer de pulmón de células no pequeñas) representa aproximadamente el 85 por ciento de todos los casos. El NSCLC se caracteriza por un panorama genético complejo, con múltiples mutaciones impulsoras y alteraciones epigenéticas que promueven la progresión del tumor y la resistencia a la terapia. El NSCLC se trata con inmunoterapia, quimioterapia, radiación, cirugía o terapia molecularmente dirigida. Sin embargo, es probable que un número significativo de pacientes sometidos a cirugía experimenten recurrencia local o metástasis a distancia. La inmunoterapia y las terapias dirigidas han avanzado rápidamente en los últimos años. Aquí, en esta revisión, se analizan los detalles relacionados con el NSCLC, sus tipos, medidas preventivas y factores de riesgo, sus síntomas, método de detección, diagnóstico y tratamiento relacionado, y las últimas actualizaciones relacionadas con el NSCLC.

Palabras clave:
Cáncer
fármacos experimentales
tratamiento
diagnóstico

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