metricas
covid
Buscar en
Acta Otorrinolaringológica Española
Toda la web
Inicio Acta Otorrinolaringológica Española Prognostic Capacity of the Lymph Node Ratio in Squamous Cell Carcinomas of the H...
Journal Information
Vol. 71. Issue 5.
Pages 265-274 (September - October 2020)
Share
Share
Download PDF
More article options
Visits
35
Vol. 71. Issue 5.
Pages 265-274 (September - October 2020)
Original article
Prognostic Capacity of the Lymph Node Ratio in Squamous Cell Carcinomas of the Head and Neck
Capacidad pronóstica de la densidad ganglionar en los carcinomas escamosos de cabeza y cuello
Visits
35
Xavier Leóna,b,
Corresponding author
xleon@santpau.cat

Corresponding author.
, Eduard Neumanna, Alfons Gutierreza, Jacinto Garcíaa, Miquel Quera, Montserrat Lópeza
a Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
b Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (4)
Table 1. Characteristics of the Patients Included in the Study.
Table 2. Mean LNR Values According to Primary Tumour Site and the Category of Regional Extension in the Pathological Study (pN).
Table 3. Specific Survival at 5 Years According to Primary Tumour Site and Category of Regional Extension in the Pathological Study (pN) According to the LNR.
Table 4. Results of the Multivariate Analysis.
Show moreShow less
Additional material (1)
Abstract
Introduction and objectives

Lymph node density or lymph node ratio (LNR), defined as the quotient between the total number of positive lymph nodes and the total number of dissected lymph nodes, has demonstrated a prognostic capacity in several tumour models, including patients with head and neck squamous cell carcinomas (HNSCC). The aim of the present study is to analyse the prognostic value of LNR in a wide cohort of patients with HNSCC.

Methods

We carried out a retrospective study of a cohort of 1311 patients with HNSCC treated with unilateral or bilateral neck dissections. Of the patients included in the study, 55.0% had lymph node metastases (pN +). We proceeded to calculate the value of the LNR, and its categorization through a recursive partition analysis considering specific survival as the dependent variable.

Results

Three categories were defined according to the value of the LNR with a cut-off point at the values < of .025 and .118. The 5-year specific survival for patients with an LNR less than .025 (n = 654, 49.8%) was 87.2%, for patients with a LNR .025–.118 (n = 394, 30.1%) it was 51.6%, and for patients with a LNR greater than .188 (n = 263, 20.1%) it was 27.3% (P = .0001). According to the results of a multivariate analysis, the LNR significantly related to specific survival.

Conclusion

The LNR can be a prognostic variable to be considered in the pathological staging of the lymph nodes.

Keywords:
Lymph node density
Lymph node ratio
Neck dissections
Pathological staging
Resumen
Introducción y objetivos

La densidad ganglionar o lymph node ratio (LNR), definido como el cociente entre el número total de ganglios positivos y el número total de ganglios disecados ha demostrado una capacidad pronóstica en diferentes modelos tumorales, incluidos los pacientes con carcinomas escamosos de cabeza y cuello (CECC). El objetivo del presente estudio es analizar el valor pronóstico del LNR en una serie amplia de pacientes con CECC.

Métodos

Se llevó a cabo un estudio retrospectivo de una cohorte de 1.311 pacientes con CECC tratados con vaciamientos cervicales uni o bilaterales. El 55,0% de los pacientes incluidos en el estudio contaron con la presencia de metástasis a nivel ganglionar (pN+). Se procedió a calcular el valor del LNR, y a su categorización mediante un análisis de partición recursiva considerando la supervivencia específica como la variable dependiente.

Resultados

Se definieron tres categorías en función del valor del LNR con unos puntos de corte en los valores de 0,025 y 0,118. La supervivencia específica a los 5 años para los pacientes con un LNR inferior a 0,025 (n = 654, 49,8%) fue del 87,2%, para los pacientes con un LNR 0,025–0,118 (n = 394, 30,1%) del 51,6%, y para los pacientes con LNR superior a 0,188 (n = 263, 20,1%) del 27,3% (P = 0,0001). De acuerdo con los resultados de un análisis multivariante, el LNR se relacionó de forma significativa con la supervivencia específica.

Conclusión

El LNR puede ser una variable pronóstica a considerar en la estadificación patológica de las áreas ganglionares.

Palabras clave:
Densidad ganglionar
Lymph node ratio
Vaciamientos cervicales
Estadificación patológica

Article

These are the options to access the full texts of the publication Acta Otorrinolaringológica Española
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Acta Otorrinolaringológica Española

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos