Sclerosing Polycystic Adenosis of the Submandibular Gland

Beato Martínez, Ainhoa; Moreno Juara, Angel; Candia Fernández, Antonio

doi:10.1016/j.otoeng.2013.02.005

array:24 ["pii" => "S2173573513000070" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2013.02.005" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "329" "copyright" => "Elsevier España, S.L.. All rights reserved" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2013;64:78-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2590 "formatos" => array:3 [ "EPUB" => 30 "HTML" => 2004 "PDF" => 556 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S000165191100207X" "issn" => "00016519" "doi" => "10.1016/j.otorri.2011.09.005" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "329" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2013;64:78-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3516 "formatos" => array:3 [ "EPUB" => 38 "HTML" => 2908 "PDF" => 570 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Caso clínico" "titulo" => "Adenosis poliquística esclerosante de la glándula submaxilar" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "78" "paginaFinal" => "80" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Sclerosing polycystic adenosis of the submandibular gland" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 715 "Ancho" => 950 "Tamanyo" => 293069 ] ] "descripcion" => array:1 [ "es" => "Adenosis poliquística esclerosante (×10) (tinciónH-E) Proliferación de acines y conductos, algunos dilatados, en un estroma esclerótico y con un ligero infiltrado inflamatorio crónico." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ainhoa Beato Martínez, Angel Moreno Juara, Antonio Candia Fernández" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ainhoa" "apellidos" => "Beato Martínez" ] 1 => array:2 [ "nombre" => "Angel" "apellidos" => "Moreno Juara" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "Candia Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173573513000070" "doi" => "10.1016/j.otoeng.2013.02.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573513000070?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000165191100207X?idApp=UINPBA00004N" "url" => "/00016519/0000006400000001/v1_201304231456/S000165191100207X/v1_201304231456/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173573513000033" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2013.02.001" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "312" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2013;64:81-2" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1302 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 903 "PDF" => 364 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Images in Otorhinolaryngology" "titulo" => "Internal Carotid Artery Parallel to the Skull Base" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "82" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Arteria carótida interna paralela a la base del cráneo" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 960 "Ancho" => 952 "Tamanyo" => 92721 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Andrés Coca-Pelaz, Ángela Meilán-Martínez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Andrés" "apellidos" => "Coca-Pelaz" ] 1 => array:2 [ "nombre" => "Ángela" "apellidos" => "Meilán-Martínez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651911001634" "doi" => "10.1016/j.otorri.2011.06.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651911001634?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573513000033?idApp=UINPBA00004N" "url" => "/21735735/0000006400000001/v1_201304231504/S2173573513000033/v1_201304231504/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173573513000069" "issn" => "21735735" "doi" => "10.1016/j.otoeng.2013.02.004" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "324" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Acta Otorrinolaringol Esp. 2013;64:75-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4461 "formatos" => array:3 [ "EPUB" => 65 "HTML" => 3350 "PDF" => 1046 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Case study" "titulo" => "Lemierre Syndrome: Thrombosis of the Cavernous Sinus and Internal Carotid Artery Occlusion Secondary to Acute Sphenoid Sinusitis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "75" "paginaFinal" => "77" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Lemierre: trombosis de seno cavernoso y oclusión de arteria carótida interna secundarios a sinusitis esfenoidal aguda" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1020 "Ancho" => 1499 "Tamanyo" => 200988 ] ] "descripcion" => array:1 [ "en" => "CT scan showing: (a) the persistence of thrombosis in the right cavernous sinus and absence in the homolateral internal carotid artery compared with the contralateral, (b) maximum intensity projection reconstructions, and (c) volume rendering of the angiography study of the supra-aortic trunks showing a graphic image of the occlusion of the internal carotid artery (arrows)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luciana Rudski Ricondo, Manuel J. Ramos Gómez, Juan Aguilar Cantador, Francisco A. Bravo-Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luciana" "apellidos" => "Rudski Ricondo" ] 1 => array:2 [ "nombre" => "Manuel J." "apellidos" => "Ramos Gómez" ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Aguilar Cantador" ] 3 => array:2 [ "nombre" => "Francisco A." "apellidos" => "Bravo-Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001651911001877" "doi" => "10.1016/j.otorri.2011.08.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651911001877?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573513000069?idApp=UINPBA00004N" "url" => "/21735735/0000006400000001/v1_201304231504/S2173573513000069/v1_201304231504/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Case study" "titulo" => "Sclerosing Polycystic Adenosis of the Submandibular Gland" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "78" "paginaFinal" => "80" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ainhoa Beato Martínez, Angel Moreno Juara, Antonio Candia Fernández" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Ainhoa" "apellidos" => "Beato Martínez" "email" => array:1 [ 0 => "ainhoilla@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Angel" "apellidos" => "Moreno Juara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Antonio" "apellidos" => "Candia Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Otorrinolaringología, Hospital Moncloa, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario de Guadalajara, Guadalajara, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Adenosis poliquística esclerosante de la glándula submaxilar" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 715 "Ancho" => 951 "Tamanyo" => 289691 ] ] "descripcion" => array:1 [ "en" => "Sclerosing polycystic adenosis (×10) (H-E staining). Proliferation of acini and ducts, some of them dilated, in a sclerotic stroma with a slight, chronic, inflammatory infiltrate." ] ] ] "textoCompleto" => "IntroductionSclerosing polycystic adenosis (SPA) is a rare entity which was first described in 1996. Its anatomopathological appearance is similar to that of fibrocystic breast disease. A total of 51 cases have been described in the literature. Its aetiology is unknown, although it is clonal and, therefore, neoplastic nature has been reported. Most cases appear in the major salivary glands, especially in the parotid gland.It is important to carry out the differential diagnosis with other salivary gland tumours, mainly acinar cell carcinoma.Case ReportWe present the case of a 63-year-old female who attended consultation due to a left cervical tumour of a few months evolution. The patient was a smoker.Examination revealed a normal oropharynx, with reddening of the drainage orifice of the left Wharton duct. Fibroscopy was normal, whilst bimanual and cervical palpation noticed an enlarged, left submandibular gland, with a posterior adenopathy to a mobile and rolling gland of about 2cm in diameter.A cervical computed tomography (CT) scan revealed a solid nodule of 16mm in the left submandibular gland, with an adenopathy of 6mm adjacent to the submaxillary gland.Ultrasound-guided fine needle aspiration reported a well-differentiated acinar cell carcinoma (low grade).Given these findings, we performed a left submaxillectomy with neck dissection of group I.The pathological anatomy of the surgical specimen reported an irregular, whitish tumour of firm consistency, measuring 1.7cm in its greatest dimension, occupying 30% of the gland, without extension into the rest of the gland and without vascular or perineural invasion.Microscopically, we observed dilated ducts with intraluminal, epithelial hyperplasia and cellular atypia, surrounded by a stroma with abundant sclerosis. The lymph nodes were negative for malignancy. The final diagnosis was SPA (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>Two years after surgery, the patient remains asymptomatic and has not suffered recurrence or distant metastasis.DiscussionSPA was first described in 1996 by Smith et al.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> At present, there are about 50 cases reported in the literature.It mainly affects the major salivary glands, especially the parotid gland, although it may exceptionally affect the minor salivary glands.<a class="elsevierStyleCrossRefs" href="#bib0010">2,3</a> It appears in middle-aged subjects (40–50 years) with no clear gender prevalence. The tumours measure between 0.5 and 7cm in diameter.It is characterised by a slow growth, which is usually asymptomatic, nodular and similar in many respects to fibrocystic breast disease.<a class="elsevierStyleCrossRef" href="#bib0020">4</a>The pathological anatomy reveals circumscribed, but not encapsulated nodules, with dilated ducts and epithelial hyperplasia, surrounded by a very fibrous stroma and with chronic inflammation.<a class="elsevierStyleCrossRef" href="#bib0025">5</a>The aetiology of this condition is currently unknown, although some recent articles have reported conducting trials with human androgen-receptor gene (HUMARA),<a class="elsevierStyleCrossRef" href="#bib0030">6</a> and demonstrated its clonal and, therefore, neoplastic nature. Furthermore, immunohistochemistry techniques have detected positivity for oestrogen and progesterone receptors which may play a role in its pathogenesis. Moreover, some studies have pointed to the role of Epstein–Barr virus (EBV) in SPA.<a class="elsevierStyleCrossRef" href="#bib0035">7</a>Its treatment is surgery with disease-free margins, given that 30% of cases have reported recurrences. There have been no reports of distant metastases or mortality in this condition.In many cases, fine-needle aspiration (FNA) techniques<a class="elsevierStyleCrossRef" href="#bib0040">8</a> may confuse the tumours with other types of salivary gland tumours, such as acinar cell carcinoma or mucoepidermoid carcinoma. Therefore, we must always consider this entity when conducting the differential diagnosis, since, while still remaining a neoplasm, treatment and prognosis of this disease are different from those of other malignant tumours of the salivary glands.Conflict of InterestsThe authors have no conflict of interests to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xres94868" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec82018" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres94869" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec82019" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case Report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of Interests" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-02-27" "fechaAceptado" => "2011-04-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec82018" "palabras" => array:3 [ 0 => "Sclerosing polycystic adenosis" 1 => "Submandibular gland" 2 => "Salivary glands tumours" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec82019" "palabras" => array:3 [ 0 => "Adenosis poliquística esclerosante" 1 => "Glándula submaxilar" 2 => "Tumores glándulas salivales" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Sclerosing polycystic adenosis (SPA) is a rare, newly reported lesion of the salivary glands. Most cases occurred within major salivary glands and were frequently confused with other salivary gland carcinomas such as acinar cell carcinoma. We report a case of sclerosing polycystic adenosis within the submandibular gland in a 63-year-old woman." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La Adenosis Poliquística Esclerosante (APE) es una entidad poco frecuente descrita hace poco tiempo que afecta a las glándulas salivales, principalmente mayores, y que frecuentemente se ha confundido con otros carcinomas de glándula salival como el carcinoma de células acinares. Presentamos un caso de adenosis poliquística esclerosante en la glándula submaxilar de una mujer de 63 años." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Beato Martínez A, et al. Adenosis poliquística esclerosante de la glándula submaxilar. Acta Otorrinolaringol Esp. 2013;64:78–80." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 714 "Ancho" => 951 "Tamanyo" => 214162 ] ] "descripcion" => array:1 [ "en" => "Sclerosing polycystic adenosis (×2) (H-E staining). Circumscribed, partially encapsulated lesion consisting of a proliferation of ducts and acini, with a lobar pattern and without atypia. By comparison, the adjacent gland is not affected and presents no fibrosis, inflammatory infiltrates or atrophy." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 715 "Ancho" => 951 "Tamanyo" => 289691 ] ] "descripcion" => array:1 [ "en" => "Sclerosing polycystic adenosis (×10) (H-E staining). Proliferation of acini and ducts, some of them dilated, in a sclerotic stroma with a slight, chronic, inflammatory infiltrate." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sclerosing polycystic adenosis of major salivary glands. A clinicopathologic analysis of nine cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.C. Smith" 1 => "G.L. Ellis" 2 => "L.J. Slater" 3 => "R.D. Foss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1996" "volumen" => "20" "paginaInicial" => "161" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8554105" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sclerosing polycystic adenosis of the minor salivary gland: case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.A. Silva Gurgel" 1 => "V. Souza Freitas" 2 => "E.A. Goncalves Ramos" 3 => "J. Nunes dos Santos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Braz J Otorhinolaryngol" "fecha" => "2010" "volumen" => "76" "paginaInicial" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20549092" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sclerosing polycystic adenosis of the buccal mucosa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Meer" 1 => "M. Altini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hed Neck Pathol" "fecha" => "2008" "volumen" => "2" "paginaInicial" => "31" "paginaFinal" => "35" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenosis poliquística esclerosante de la glándula parótida" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Mercado" 1 => "J. Mercado" 2 => "S. García" 3 => "J.P. Loyola" 4 => "F. Heller" 5 => "H. Vallejos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Otorrinolaringol Cir Cabeza Cuello" "fecha" => "2009" "volumen" => "69" "paginaInicial" => "41" "paginaFinal" => "44" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What's new in the AFIP fascicle on salivary gland tumors: a few highlights from the fourth series atlas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.L. Ellis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12105-009-0128-z" "Revista" => array:6 [ "tituloSerie" => "Head Neck Pathol" "fecha" => "2009" "volumen" => "3" "paginaInicial" => "225" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20596976" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Skálová" 1 => "D.R. Gnepp" 2 => "R.H. Simpson" 3 => "J.E. Lewis" 4 => "D. Janssen" 5 => "R. Sima" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2006" "volumen" => "30" "paginaInicial" => "939" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16861963" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathogenic role of Epstein-Barr virus (EBV) in sclerosing polycistic adenosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.M. Swelam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.prp.2010.03.003" "Revista" => array:6 [ "tituloSerie" => "Pathol Res Pract" "fecha" => "2010" "volumen" => "206" "paginaInicial" => "565" "paginaFinal" => "571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20400234" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Fulciniti" 1 => "N.S. Losito" 2 => "F. Ionna" 3 => "F. Longo" 4 => "C. Aversa" 5 => "G. Botti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/dc.21228" "Revista" => array:6 [ "tituloSerie" => "Diagn Cytopathol" "fecha" => "2010" "volumen" => "38" "paginaInicial" => "368" "paginaFinal" => "373" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19937766" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735735/0000006400000001/v1_201304231504/S2173573513000070/v1_201304231504/en/main.assets" "Apartado" => array:4 [ "identificador" => "5881" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Studies" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735735/0000006400000001/v1_201304231504/S2173573513000070/v1_201304231504/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573513000070?idApp=UINPBA00004N"]

ISSN: 2173-5735

Acta Otorrinolaringológica Española, the official publication of the Spanish Society of Otolaryngology and Head and Neck Surgery and the Ibero-American Society of Otorhinolaryngology, is the most important journal in Spanish dedicated to Otorhinolaryngology, which reflects the continuous scientific and technical progress of the specialty. It has become an important tool to be kept up to date. The Journal publishes Original Articles (articles on basic research and clinical investigation), reviews, brief communications, case studies and images, which are subjected to a rigorous peer review process.

See more Open Access Option

Acta Otorrinolaringológica Española has received its first journal Impact Factor (JCR) in 2023. Instructions for authors - Submit an article

Indexed in:

Web of Science, MedLine/PubMed, Scopus, Emerging Science Citation Index (ESCI/WoS), EMBASE/Excerpta Medica, Concerlit, Aidsline, Bibliomed, Biosis, Healfnstar, IBECS

Subscribe:

Impact factor

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.

© Clarivate Analytics, Journal Citation Reports 2022

Impact factor 2023

0.9

Citescore

CiteScore measures average citations received per document published.

Citescore 2023

1.4

SJR

SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

SJR 2023

0.326

SNIP

SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

SNIP 2023

0.54

View more metrics

Journal Information

Previous article | Next article

Vol. 64. Issue 1.