Estudio no intervencionista de las alteraciones de la filtrabilidad sanguínea en el debut clínico de sorderas súbitas neurosensoriales
Non interventionist study about blood filterability changes in clinical onset of sensorineural sudden deafness
F.J. garcía callejo1, M.P. martínez beneyto, A. platero zamarreño, M. marco sanz, E.N. fernández julián, J. marco algarra
Servicio De Orl. Hospital ClÍNico Universitario. Valencia
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Martínez Ferreras, J.P. Rodrigo Tapia, M.V. González Meana, I. Álvarez Álvarez, E. Coto, C. Suárez Nieto" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Martínez Ferreras" ] 1 => array:2 [ "nombre" => "J.P." "apellidos" => "Rodrigo Tapia" ] 2 => array:2 [ "nombre" => "M.V." "apellidos" => "González Meana" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Álvarez Álvarez" ] 4 => array:2 [ "nombre" => "E." "apellidos" => "Coto" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Suárez Nieto" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001651901782490?idApp=UINPBA00004N" "url" => "/00016519/0000005200000007/v1_201304231335/S0001651901782490/v1_201304231335/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Estudio no intervencionista de las alteraciones de la filtrabilidad sanguínea en el debut clínico de sorderas súbitas neurosensoriales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "556" "paginaFinal" => "564" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F.J. garcía callejo, M.P. martínez beneyto, A. platero zamarreño, M. marco sanz, E.N. fernández julián, J. marco algarra" "autores" => array:6 [ 0 => array:3 [ "nombre" => "F.J." "apellidos" => "garcía callejo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.P." "apellidos" => "martínez beneyto" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "platero zamarreño" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "marco sanz" ] 4 => array:2 [ "nombre" => "E.N." "apellidos" => "fernández julián" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "marco algarra" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio De Orl. Hospital ClÍNico Universitario. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "F. J. García Callejo. Avenida Archiduque Carlos Nº 111 – 14. 46014 Valencia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Non interventionist study about blood filterability changes in clinical onset of sensorineural sudden deafness" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec79445" "palabras" => array:3 [ 0 => "sordera súbita" 1 => "filtrabilidad de la sangre" 2 => "viscosidad sanguínea" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec79446" "palabras" => array:3 [ 0 => "Sudden deafness" 1 => "Blood filterability" 2 => "Blood viscosity" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">en once pacientes que presentaron un cuadro de sordera súbita pudo efectuarse un estudio reológico de la filtrabilidad en sangre total (fst) de una forma seriada, incluso días antes del debut del trastorno. la evaluación de este hallazgo previo a la instauración de la hipoacusia es algo habitual en modelos experimentales, pero no en humanos. independientemente del contexto clínico en que cada paciente se desenvolvía (2 casos de diabetes mellitus, uno de colitis ulcerosa, lupus eritematoso sistémico, hipertensión arterial, postrasfundido, sepsis con coagulación intravascular diseminada, infección de vías respiratorias altas, postquirúrgico, y dos individuos sanos) en todos se detectó un descenso en la fst al aparecer la sordera (de 19,97±1,15 a 16,87±1,21 ?l/seg). este valor tendió a normalizarse a los 6 ó 7 días del debut en los individuos en que existió algún tipo de recuperación auditiva (18,83±1,01 ?l/seg, n=4), pero no lo hizo en los que no recuperaron ni siquiera a los 30 días (17,39±0,77 ?l/seg, n=7). existieron diferencias en la fst de los pacientes con y sin recuperación auditiva en las determinaciones a los siete y treinta días del debut. el descenso en esta prueba acompaña al trastorno auditivo y confirma la susceptibilidad de la microcirculación coclear al deterioro de las características viscoelásticas de la sangre</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Abstract</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">an hemorheological study on whole blood filterability (wbf) was done in eleven patients bearing of sudden deafness, in a continuous way, even before clinical onset. this evaluation is making usually in animal models, but not in humans. independently of clinical diagnosis of each patient (two cases of diabetes mellitus, one of ulcerative colitis, systemic lupus erythematosus, systemic hypertension, after blood transfusion, sepsis with disseminated intravascular coagulation, upper respiratory ways infection, after surgery, and two healthy individuals), all of them showed a decresed wbf when hearing loss appeared (from 19,97±1,15 ?l/sec to 16,87±1,21 ?l/sec). this value normalized at six or seven days from the onset in cases with some kind of hearing recovery (18,83±1,01 ?l/sec, n=4), but did not in those with no improvement even at thirty days (17,39±0,77 ?l/sec, n=7). there were differences in wbf values of patients with and without hearing recovery in determinations at seven and thirty days from onset. decrease in wbf accompanies this hearing disorder and confirms the cochlear microcirculation susceptibility to the impairment of blood viscoelastic properties</p>" ] ] "bibliografia" => array:2 [ "titulo" => "referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:57 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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