Expresión de las anexinas a1 y a2 en la mucosa del tracto aerodigestivo superior
Expression of annexins a1 and a2 in the mucosa of the upper aerodigestive tract
J.P. Rodrigo Tapia1,2,a
, J.M. García Pedrero2, E. Pena Alonso2, M.P. Fernández3, R. Owen Morgan3, C. Suárez Nieto1,2, A. Herrero Zapatero4
Autor para correspondencia
juanpablo.rodrigo@sespa.princast.es
J. P. Rodrigo Tapia. C/ Fernández Ladreda, 32-A - 4º B. 33011 Oviedo. Fecha de recepción: 6-5-2004 Fecha de aceptación: 1-6-2004
J. P. Rodrigo Tapia. C/ Fernández Ladreda, 32-A - 4º B. 33011 Oviedo. Fecha de recepción: 6-5-2004 Fecha de aceptación: 1-6-2004
1 Servicio de otorrinolaringología. hospital universitario central de asturias
2 Instituto universitario de oncología. universidad de oviedo
3 Departamento de bioquímica y biología molecular. universidad de oviedo
4 Servicio de anatomía patológica. hospital universitario central de asturias. oviedo. asturias
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"apellidos" => "Rodrigo Tapia" "email" => array:1 [ 0 => "juanpablo.rodrigo@sespa.princast.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "García Pedrero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Pena Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.P." 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"apellidos" => "Herrero Zapatero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de otorrinolaringología. hospital universitario central de asturias" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto universitario de oncología. universidad de oviedo" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de bioquímica y biología molecular. universidad de oviedo" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de anatomía patológica. hospital universitario central de asturias. oviedo. asturias" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "a" "correspondencia" => "J. P. Rodrigo Tapia. C/ Fernández Ladreda, 32-A - 4º B. 33011 Oviedo. Fecha de recepción: 6-5-2004 Fecha de aceptación: 1-6-2004" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Expression of annexins a1 and a2 in the mucosa of the upper aerodigestive tract" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-06" "fechaAceptado" => "2004-06-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec80817" "palabras" => array:4 [ 0 => "Anexinas" 1 => "Epitelio" 2 => "Tracto aerodigestivo" 3 => "Función" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec80818" "palabras" => array:4 [ 0 => "Annexins" 1 => "Epithelium" 2 => "Aerodigestive tract" 3 => "Function" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las anexinas A1 y A2 se han relacionado con el mantenimiento de la integridad tisular. Han sido identificadas en varios tejidos humanos pero su expresión en el tracto aerodigestivo superior es poco conocida. El objetivo de este trabajo es estudiar la expresión de estas proteínas en la mucosa del tracto aerodigestivo superior</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudian muestras de mucosa respiratoria (nasal y laríngea) y digestiva (de cavidad oral y faringe) de pacientes intervenidos de cirugía no oncológica. La expresión de las anexinas A1 y A2 se estudia por inmunohistoquímica</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Ambas anexinas se expresan tanto en el epitelio ciliado pseudoestratificado como en el plano poliestratificado no queratinizado, pero con un patrón diferente; la anexina A1 se expresa en las células más diferenciadas, mientras que la A2 lo hace en las menos diferenciadas (con la excepción de los cilios de las células ciliadas)</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Aunque las anexinas A1 y A2 están estructural y filogenéticamente relacionadas, su diferente expresión en la mucosa del tracto aerodigestivo superior sugiere que participan en funciones claramente diferenciadas</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Annexins A1 and A2 have been related with the maintenance of tissue integrity. They have been identified in a wide variety of tissues, but little is known regarding their expression in upper the aerodigestive tract. The aim of this work is to describe the expression of these proteins in the mucosa of the upper aerodigestive tract</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Tissue samples from respiratory (nasal and laryngeal) and digestive (oral and pharyngeal) mucosa from non-oncological patients were studied. Annexin A1 and A2 expression was determined by immunohistochemistry</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Both annexins were expressed in the ciliated and in the stratified non-keratinized epithelia, but with a different pattern; ANXA1 was expressed in the more differentiated cells whereas ANXA2 was expressed in the less differentiated ones (with the exception of the cilia of ciliated cells)</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Although annexins A1 and A2 are structurally and philogenetically related its expression pattern in the upper aerodigestive tract suggests that they have different functions</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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