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Resultados de la aplicación de mitomicina en la dacriocistorrinostomía endonasal y endocanalicular con láser diodo
Results the application of mitomicyn during endonasal and endocanalicular dacryocystorhinostomy by diode laser
M.A. Alañón Fernández1
Autor para correspondencia
miguelaaf@msn.com

Correspondencia: Miguel Ángel Alañón Fernández Plaza de los Jardinillos, 8-1ºD 23001 Jaén
, F.J. Alañón Fernández, A. Martínez Fernández, M. Cárdenas Lara
Instituto Internacional de Vías Nasolagrimales. Jaén
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar el beneficio&#44; efectos secundarios y seguridad de la aplicaci&#243;n de mitomicina C &#40;MMC&#41; de forma intraoperatoria&#44; durante la realizaci&#243;n de una dacriocistorrinostom&#237;a endonasal y endocanalicular con l&#225;ser diodo &#40;TLA-ELA DCR&#41;&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio prospectivo randomizado&#44; intervencional y doble ciego&#46; Se estudiaron 200 pacientes a 150 pacientes se les aplic&#243; MMC intraoperatoria &#40;0&#44;4 mg&#47;0&#44;2 ml&#41; durante un tiempo de 5 minutos&#44; mediante un ap&#243;sito de acetato de polivinilo que se coloca sobre la osteotom&#237;a&#46; En el resto de pacientes fueron revisados a las 24 horas&#44; 10 d&#237;as&#44; 1&#44; 3 y 6 meses postcirug&#237;a&#46; Se estudi&#243; el aspecto endosc&#243;pico y las posibles complicaciones&#46; Los resultados se comparan mediante el test de Chi-cuadrado con la correcci&#243;n de Yates&#46; Se estudi&#243; la presencia o ausencia de efectos secundarios por la aplicaci&#243;n de MMC&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El seguimiento medio fue 15&#44;25 meses &#40;rango&#61; 6-21 meses&#41;&#46; El porcentaje de alteraciones por cicatrizaci&#243;n excesiva fue del 21&#44;77&#37; y del 8&#44;03&#37;&#44; en los pacientes sin y con MMC respectivamente&#46; La diferencia fue estad&#237;sticamente significativa &#40;p&#61;0&#44;02&#41;&#46; No hubo efectos secundarios por la aplicaci&#243;n de MMC&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La aplicaci&#243;n de MMC intraoperatoria t&#243;pica durante TLA-ELA DCR disminuye los hallazgos patol&#243;gicos por cicatrizaci&#243;n del &#225;rea perif&#233;rica al nuevo drenaje sin producir efectos secundarios&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Aim of the study</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the effects&#44; secondary effects and security of the intrasurgical application of mitomicyn C during endonasal and endocanalicular dacryocystorhinostomy with diode laser &#40;TLA-ELA DCR&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We carried out a randomized&#44; prospective&#44; interventional and double blind study in 200 patients&#58; intrasurgical mitomicyn C was applied in 150 of then &#40;0&#46;4 mgr&#47;0&#46;2 ml&#41; for 5 minutes by means of a polivinil acetate dressing over the osteotomy&#46; In other 50 patients MMC was not used we followed up at 24 hours&#44; 10 days and 1&#44; 3 and 6 months after surgery&#46; Endoscopic aspects and possible complications were valued&#46; The results were compared using the Chi-squared test with the Yates correction&#46; We looked for the presence or abscense of secondary effects in the application of mitomicyn C&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The average follow up was 15&#46;25 months &#40;range 6 to 21 months&#41;&#46; The percentages of alterations for excesive scarring were 21&#46;77&#37; in patients without and MAC 8&#46;03&#37; in the ones MMC&#46; The difference was statisticaly significant &#40;p&#61; 0&#46;02&#41;&#46; We did not find secondary effects due to application of mitomcyn&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Intrasurgical application of topical MMC during TLA-ENL DCR reduces the number of pathological findings due to scarring of the surrouding area of the new drainage without secondary effects&#46;</p>"
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                        ]
                      ]
                    ]
                  ]
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                        "paginaInicial" => "611"
                        "paginaFinal" => "617"
                      ]
                    ]
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              "referencia" => array:1 [
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                        "tituloSerie" => "Curr Opin Ophthalmol"
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                        "paginaInicial" => "43"
                        "paginaFinal" => "47"
                        "link" => array:1 [
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                        "tituloSerie" => "Ophthalmic Surg Lasers"
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                        "paginaInicial" => "300"
                        "paginaFinal" => "304"
                        "link" => array:1 [
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Información del artículo
ISSN: 00016519
Idioma original: Español
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2024 Enero 1 3 4
2023 Diciembre 1 0 1
2023 Octubre 4 0 4
2023 Marzo 1 0 1
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2021 Febrero 0 1 1
2021 Enero 0 1 1
2020 Noviembre 0 2 2
2020 Octubre 0 1 1
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2020 Mayo 0 2 2
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2018 Diciembre 10 17 27
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2018 Octubre 28 34 62
2018 Mayo 0 1 1
2018 Abril 2 16 18
2018 Marzo 6 15 21
2018 Febrero 4 9 13
2018 Enero 12 19 31
2017 Diciembre 4 8 12
2017 Noviembre 7 16 23
2017 Octubre 3 14 17
2017 Septiembre 11 16 27
2017 Agosto 9 22 31
2017 Julio 4 22 26
2017 Junio 10 37 47
2017 Mayo 11 17 28
2017 Abril 9 27 36
2017 Marzo 9 20 29
2017 Febrero 7 13 20
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es en pt

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Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos