array:23 [ "pii" => "S2173573507703654" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70365-4" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70365" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:347-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 436 "formatos" => array:3 [ "EPUB" => 23 "HTML" => 147 "PDF" => 266 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173573507703666" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70366-6" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70366" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:352-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 426 "formatos" => array:3 [ "EPUB" => 20 "HTML" => 158 "PDF" => 248 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Influence of Non-Neuronal Factors on Post-Thyroidectomy Dysphonia" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "352" "paginaFinal" => "357" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Influencia de factores no neuronales en la disfonía tras tiroidectomía" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gabriel Trinidad Ruiz, Alicia González Palomino, Carlos Pantoja Hernández, Elena Mora Santos, Eduardo Cruz de la Piedad, Antonio Blasco Huelva" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Gabriel" "apellidos" => "Trinidad Ruiz" ] 1 => array:2 [ "nombre" => "Alicia" "apellidos" => "González Palomino" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Pantoja Hernández" ] 3 => array:2 [ "nombre" => "Elena" "apellidos" => "Mora Santos" ] 4 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Cruz de la Piedad" ] 5 => array:2 [ "nombre" => "Antonio" "apellidos" => "Blasco Huelva" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573507703666?idApp=UINPBA00004N" "url" => "/21735735/0000005800000008/v1_201304231400/S2173573507703666/v1_201304231400/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173573507703642" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70364-2" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70364" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:341-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 397 "formatos" => array:3 [ "EPUB" => 15 "HTML" => 100 "PDF" => 282 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Is Microvascular Density an Independent Prognostic Factor in Squamous Cell Carcinoma of the Tongue?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "341" "paginaFinal" => "346" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿La densidad microvascular es un factor pronóstico independiente en el carcinoma epidermoide de lengua?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mario M. Fernández, Álvaro García-Rozado, Pablo L. Parente" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mario M." "apellidos" => "Fernández" ] 1 => array:2 [ "nombre" => "Álvaro" "apellidos" => "García-Rozado" ] 2 => array:2 [ "nombre" => "Pablo L." "apellidos" => "Parente" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573507703642?idApp=UINPBA00004N" "url" => "/21735735/0000005800000008/v1_201304231400/S2173573507703642/v1_201304231400/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Relationship Between FAK and P53 Expression in Squamous Cell Carcinomas of the Larynx" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "347" "paginaFinal" => "351" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan Pablo Rodrigo, Rubén Cabanillas, Pablo Secades, Marta Canel, María Dolores Chiara, Carlos Suárez" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Juan Pablo" "apellidos" => "Rodrigo" "email" => array:1 [ 0 => "juanpablo.rodrigo@sespa.princast.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Rubén" "apellidos" => "Cabanillas" ] 2 => array:2 [ "nombre" => "Pablo" "apellidos" => "Secades" ] 3 => array:2 [ "nombre" => "Marta" "apellidos" => "Canel" ] 4 => array:2 [ "nombre" => "María Dolores" "apellidos" => "Chiara" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Suárez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Otorrinolaringología. Hospital Universitario Central de Asturias. IUOPA. Universidad de Oviedo. Oviedo. Asturias. Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Otorrinolaringología. Hospital Universitario Central de Asturias. Celestino Villamil, s/n. 33006 Oviedo. Asturias. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Relación entre la expresión de FAK y p53 en los carcinomas epidermoides de laringe" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-06-20" "fechaAceptado" => "2007-06-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec80089" "palabras" => array:4 [ 0 => "Squamous cell carcinoma" 1 => "Larynx" 2 => "FAK" 3 => "p53" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec80090" "palabras" => array:4 [ 0 => "Carcinoma epidermoide" 1 => "Laringe" 2 => "FAK" 3 => "p53" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">FAK expression is frequently elevated in human cancers, including head and neck squamous cell carcinomas. However, the regulation of FAK expression is poorly understood. The aim of this study is to establish the possible role of the p53 tumour suppressor gene in the regulation of FAK expression in squamous cell carcinomas of the larynx.</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The expression of FAK and p53 proteins were studied using immunohistochemistry in 102 samples from surgically-treated squamous cell carcinomas of the supraglottic larynx (with postoperative radiotherapy in 49 cases).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">All the cases showed some degree of FAK expression, which was moderate to intense in 60 cases (59%). Also 60 cases showed positive p53 expression (>10% of tumour cells with nuclear staining). No relationship was observed between p53 positivity and FAK expression (<span class="elsevierStyleItalic">P</span>=.54). In addition, none of these proteins presented association with the prognosis of the patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Our results suggests that p53 activity does not correlate with FAK expression in squamous cell carcinomas of the larynx.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La expresión de la proteína FAK frecuentemente se encuentra elevada en múltiples tipos de cánceres, como los carcinomas epidermoides de cabeza y cuello. Sin embargo, los mecanismos que regulan la expresión de dicha proteína son poco conocidos. Nuestro objetivo es analizar si el supresor tumoral p53 está implicado en la regulación de la expresión de FAK en los carcinomas epidermoides de laringe.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudia mediante inmunohistoquímica la expresión de las proteínas FAK y p53 en una muestra de 102 carcinomas epidermoides de laringe supraglótica tratados quirúrgicamente (con radioterapia postoperatoria en 49 casos).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Todos los tumores presentaban algún grado de expresión de FAK, que era moderada o intensa en 60 (59%) de los casos. También en 60 casos hubo positividad de p53 (> 10% de las células tumorales con tinción nuclear). No se halló relación entre la positividad de p53 y la expresión de FAK (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,54). La expresión de cualquiera de las dos proteínas no mostró relación con el pronóstico de los pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nuestros resultados indican que la actividad de p53 no se relaciona con la expresión de FAK en los carcinomas epidermoides de laringe.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Paper financed with the assistance of FISPI041537 research project and the Social Fund of the Cajastur savings bank.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Relationship Between FAK and P53 Expression in Squamous Cell Carcinomas of the Larynx
Relación entre la expresión de FAK y p53 en los carcinomas epidermoides de laringe
Juan Pablo Rodrigo
, Rubén Cabanillas, Pablo Secades, Marta Canel, María Dolores Chiara, Carlos Suárez
Autor para correspondencia
juanpablo.rodrigo@sespa.princast.es
Correspondence: Servicio de Otorrinolaringología. Hospital Universitario Central de Asturias. Celestino Villamil, s/n. 33006 Oviedo. Asturias. Spain.
Correspondence: Servicio de Otorrinolaringología. Hospital Universitario Central de Asturias. Celestino Villamil, s/n. 33006 Oviedo. Asturias. Spain.
Servicio de Otorrinolaringología. Hospital Universitario Central de Asturias. IUOPA. Universidad de Oviedo. Oviedo. Asturias. Spain