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Vol. 38. Issue 7.
Pages 459-464 (September 2014)
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Vol. 38. Issue 7.
Pages 459-464 (September 2014)
Original article
Angiogenesis inhibition impairs testicular morphology in experimental left varicocele rat model
La inhibición de la angiogénesis deteriora la morfología testicular en modelo de rata con varicocele izquierdo experimental
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M. Gökhan-Kösea,
Corresponding author
vensyou@gmail.com

Corresponding author.
, Ş.R. Erdemb, Ç.L. Peşkircioğlua, B. Çaylakc
a Baskent University School of Medicine, Department of Urology, Ankara, Turkey
b Baskent University School of Medicine, Department of Pharmacology, Ankara, Turkey
c Baskent University School of Medicine, Department of Pathology, Ankara, Turkey
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Abstract
Introduction

It has been reported that varicocele might promote angiogenesis. However, it is not clearly identified how angiogenesis affect testicular morphology or spermatogenic activity. The objective of the study is to investigate the effect of spironolactone, as an angiogenesis inhibitor, on the ipsilateral testis morphology in left varicocele-induced rats.

Materials and methods

Twenty-four adult (12–14 mo), male Wistar albino rats were randomly assigned to four groups (n=6, for each): 1. Control group, 2. Sham-operated group, 3. Experimental left varicocele group and, 4. Spironolactone (20mg/kg/day)-treated experimental left varicocele group. Histopathological findings in rat testis were investigated.

Results

Microvessel density increased in varicocele group and spironolactone inhibited angiogenesis neither by antimineralocorticoid, nor by antiandrogenic effect. However, spermatogenesis impaired in spironolactone treated varicocele group.

Conclusion

Angiogenesis seems to be a protective process in varicocele. Spironolactone treatment, probably by inhibiting angiogenesis, impairs testicular morphology.

Keywords:
Angiogenesis
Experimental left varicocele
Rat
Spironolactone
Varicocele
Vascular endothelial growth factor
Resumen
Introducción

Se ha señalado que el varicocele podría favorecer la angiogénesis. Sin embargo, no se ha identificado claramente cómo la angiogénesis afecta a la morfología testicular o a la actividad espermatogénica. El objetivo de este estudio es investigar los efectos de la espironolactona, como inhibidor de la angiogénesis, en la morfología del testículo ipsilateral en ratas con varicocele inducido en el lado izquierdo.

Materiales y métodos

Veinticuatro ratas albinas Wistar, adultas (12–14 meses) y de sexo masculino, fueron asignadas aleatoriamente a 4 grupos (n=6, para cada uno): 1) grupo de control; 2) grupo con operación simulada; 3) grupo experimental con varicocele izquierdo; y 4) grupo experimental con varicocele izquierdo tratado con espironolactona (20mg/kg/día). Se investigaron los resultados histopatológicos en testículos de rata.

Resultados

La densidad microvascular aumentó en el grupo con varicocele y la espironolactona no inhibió la angiogénesis ni por efecto antimineralcorticoide ni por efecto antiandrogénico. No obstante, la espermatogénesis se vio afectada en el grupo con varicocele tratado con espironolactona.

Conclusión

La angiogénesis parece ser un proceso protector en el varicocele. El tratamiento con espironolactona, probablemente al inhibir la angiogénesis, afecta a la morfología testicular.

Palabras clave:
Angiogénesis
Varicocele izquierdo experimental
Rata
Espironolactona
Varicocele
Factor de crecimiento endotelial vascular

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