array:24 [ "pii" => "S021048060974207X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74207-X" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74207" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:681-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1992 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1203 "PDF" => 781 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609742081" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74208-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74208" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2009;33:686-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1843 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 961 "PDF" => 876 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Linfoma prostático y revisión de la literatura" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "686" "paginaFinal" => "690" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prostatic Lymphoma and review of the literature" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge Rioja Zuazu, Rebeca Iglesias, David Rosell Costa, Anibal Rincón Mayans, Xavier Brugarolas i Roselló, Ángel Panizo Santos, José Mª Berián Polo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Rioja Zuazu" ] 1 => array:2 [ "nombre" => "Rebeca" "apellidos" => "Iglesias" ] 2 => array:2 [ "nombre" => "David" "apellidos" => "Rosell Costa" ] 3 => array:2 [ "nombre" => "Anibal" "apellidos" => "Rincón Mayans" ] 4 => array:2 [ "nombre" => "Xavier" "apellidos" => "Brugarolas i Roselló" ] 5 => array:2 [ "nombre" => "Ángel" "apellidos" => "Panizo Santos" ] 6 => array:2 [ "nombre" => "José Mª" "apellidos" => "Berián Polo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742081?idApp=UINPBA00004N" "url" => "/02104806/0000003300000006/v1_201304251934/S0210480609742081/v1_201304251934/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609742068" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74206-8" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74206" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:670-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1959 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 934 "PDF" => 1020 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Complicaciones en cirugía laparoscópica renal en la edad pediátrica: análisis de nuestra experiencia y revisión de la literatura" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "670" "paginaFinal" => "680" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Complications in laparoscopy renal surgery in pediatric age: Analysis of our experience and literature review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alberto Pérez-Lanzac de Lorca, Andrés Gómez Fraile, Adolfo Aransay Bramtot, Daniel Cabezalí Brabancho, Francisco López Vázquez, Jesús Castiñeiras Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Alberto" "apellidos" => "Pérez-Lanzac de Lorca" ] 1 => array:2 [ "nombre" => "Andrés" "apellidos" => "Gómez Fraile" ] 2 => array:2 [ "nombre" => "Adolfo" "apellidos" => "Aransay Bramtot" ] 3 => array:2 [ "nombre" => "Daniel" "apellidos" => "Cabezalí Brabancho" ] 4 => array:2 [ "nombre" => "Francisco" "apellidos" => "López Vázquez" ] 5 => array:2 [ "nombre" => "Jesús" "apellidos" => "Castiñeiras Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742068?idApp=UINPBA00004N" "url" => "/02104806/0000003300000006/v1_201304251934/S0210480609742068/v1_201304251934/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Alternativa terapéutica para el dolor pélvico crónico de origen vesical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "681" "paginaFinal" => "685" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Pedro A. López González, Jesús I. Tornero Ruiz, Pedro López Cubillana, Gloria Doñate Iñiguez, Jose C. Ruíz Morcillo, Mariano Pérez Albacete" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Pedro" "apellidos" => "A. López González" "email" => array:1 [ 0 => "peterangel@ono.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Jesús" "apellidos" => "I. Tornero Ruiz" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "López Cubillana" ] 3 => array:2 [ "nombre" => "Gloria" "apellidos" => "Doñate Iñiguez" ] 4 => array:2 [ "nombre" => "Jose" "apellidos" => "C. Ruíz Morcillo" ] 5 => array:2 [ "nombre" => "Mariano" "apellidos" => "Pérez Albacete" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología. Hospital Universitario Virgen de la Arrixaca. El Palmar. Murcia. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "New approach in treatment of pelvic chronic pain syndrome (CPPS)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-01-01" "fechaAceptado" => "2009-02-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec89001" "palabras" => array:3 [ 0 => "Dolor pélvico crónico" 1 => "Cistitis intersticial" 2 => "Tratamiento médico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec89002" "palabras" => array:3 [ 0 => "Pelvic pain" 1 => "Interstitial cystitis" 2 => "Treatment outcome" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El dolor pélvico crónico (DPC) es un problema complejo e importante tanto por su frecuencia como por su morbilidad. Cuando se presenta asociado con síntomas miccionales deberemos pensar en un origen vesical.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar la respuesta a un tratamiento intravesical, al que denominamos Formula Sedante, en pacientes con dolor pélvico crónico de origen vesical, refractarios a otros tratamientos.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Entre junio 2005 y septiembre de 2008, 14 pacientes (edad media de 59 años), 12 mujeres y 2 hombres, con DPC de origen vesical siguieron un tratamiento intravesical con “Formula Sedante”, como terapia de segunda línea. Su composición es Dexametasona, Nitrofurantoína, Lidocaína y Suero salino. Evaluamos el dolor (escala 0-10), la frecuencia miccional y la mejoría subjetiva del paciente.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El dolor global medio fue de 6’4 de base, al mes y a los 6 meses fue de 4’7 y 3’5 respectivamente. El 75% de los pacientes mostró una disminución de los valores en la escala de dolor. La frecuencia miccional diurna mejoró un 28% al mes del tratamiento y un 40% a los 6 meses. Un 70 % de los pacientes refirió sentir mejoría tras la pauta de instilaciones, de los cuales en torno a un 80% la evaluó como “moderadamente mejor” o “mucho mejor”, tanto al mes como a los 6 meses del tratamiento. Ninguno de los pacientes presento efectos secundarios reseñables.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Consideramos el tratamiento de instilación intravesical con “Formula Sedante” una opción útil y segura, como segunda línea de tratamiento, para el dolor pélvico crónico de origen vesical.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Chronic pelvic pain syndrome (CPPS) is a complex problem that is a major cause of morbidity and disability.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To evaluate the feasibility, safety and efficacy of intravesical instillation of a new therapeutic tool in patients suffering from CPPS.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Between june 2005 and september 2008 we recruited 14 patients (mean age 59) who had been diagnosed with CPPS, and refractory to previous treatments. The intravesical solution consisted of steroids, local anaesthetic, antibiotic and saline solution. Was evaluated the intensity of pain; voiding frequency and subjective improvement (with patient global improvement impression PGI-I).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Global pain at baseline was 6,4, at 1 month and 6 months 4,7 and 3,5. 75% of the patients showed improvement in the reduction of pain. Voiding frequency at baseline was 22’5 daily. At one and six months, voiding frequency was 16,2 and 13,5 respectively. According to the PGI-I test 30% of patients were much better, 30% moderate improvement, 10% slight improvement and 30% with no changes at 1 month. At 6 months, 15% of patients were much better, 40% moderated improvement, 15% slight improvement and 30% with no changes. None of the patients felt worse than before treatment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Therapeutic results of our intravesical solution traduces in an improvement of pain and voiding frequency reduction with no side-effects. Patients benefit of this improvement in the PGI-I test that reflects an improvement in quality of life. We consider this treatment a second-line approach for CPPS in which gold standard management is still a challenge.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blinded, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.C. Nickel" 1 => "J. Barkin" 2 => "J. Forrest" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "165" "numero" => "5 suppl" "paginaInicial" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11125366" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of prednisone for severe refractory ulcerative interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Soucy" 1 => "M. 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Alternativa terapéutica para el dolor pélvico crónico de origen vesical
New approach in treatment of pelvic chronic pain syndrome (CPPS)
Pedro A. López González1
, Jesús I. Tornero Ruiz, Pedro López Cubillana, Gloria Doñate Iñiguez, Jose C. Ruíz Morcillo, Mariano Pérez Albacete
Autor para correspondencia
peterangel@ono.com
Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500
Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500
Servicio de Urología. Hospital Universitario Virgen de la Arrixaca. El Palmar. Murcia. España