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array:22 [ "pii" => "S0210480606735136" "issn" => "02104806" "doi" => "10.1016/S0210-4806(06)73513-6" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "73513" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2006;30:649-54" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1295 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 816 "PDF" => 474 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480606735148" "issn" => "02104806" "doi" => "10.1016/S0210-4806(06)73514-8" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "73514" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2006;30:655-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1393 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 714 "PDF" => 674 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Análisis de supervivencia de los carcinomas de células renales órgano-confinados. Valor pronóstico de la clasificación TNM 1997" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "660" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Survival analysis for localized renal cell carcinoma.prognostic value of 1997 tnm classification." ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "M. García Torrelles, M. Sánchez Sanchís, J.R. Beltrán Armada, J. Vidal Moreno, C. Sanjuán de Laorden" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "García Torrelles" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sánchez Sanchís" ] 2 => array:2 [ "nombre" => "J.R." "apellidos" => "Beltrán Armada" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Vidal Moreno" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Sanjuán de Laorden" ] ] ] 1 => array:2 [ "autoresLista" => "D. Bautista Rentero" "autores" => array:1 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Bautista Rentero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480606735148?idApp=UINPBA00004N" "url" => "/02104806/0000003000000007/v1_201304251821/S0210480606735148/v1_201304251821/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Características inmunofenotípicas y clínicas del carcinoma renal mucinoso tubular y de células fusiformes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "649" "paginaFinal" => "654" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L.F. Arias, j. Blanco, S. Hernández, G. Bocardo, L. González" "autores" => array:5 [ 0 => array:4 [ "nombre" => "L.F." "apellidos" => "Arias" "email" => array:1 [ 0 => "luisfer_uda@yahoo.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "j." "apellidos" => "Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "G." "apellidos" => "Bocardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "L." "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica." "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Urología, Hospital Clínico San Carlos, Madrid." "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Afiliación actual: Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia." "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. L.F. Arias Departamento de Patología. Facultad de Medicina Universidad de Antioquia, Carrera 51D, No. 62-29, Medellín, Colombia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-02-28" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec87951" "palabras" => array:6 [ 0 => "Mucinoso" 1 => "Células fusiformes" 2 => "Carcinoma de células renales" 3 => "Riñón" 4 => "Neoplasias" 5 => "Inmunohistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec87952" "palabras" => array:6 [ 0 => "Mucinous" 1 => "Spindle cell" 2 => "Renal cell carcinoma" 3 => "Kidney" 4 => "Neoplasms" 5 => "Immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Introducción: El carcinoma renal mucinoso y tubular de células fusiformes es una neoplasia recientemente incluida en la clasificación de tumores renales. Aún desconocemos aspectos moleculares y de su evolución. Nuestros objetivos son describir características inmunofenotípicas del tumor y aportar casos adicionales para un mejor conocimiento de la neoplasia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos inmunohistoquímica con un amplio panel de anticuerpos a 4 tumores (0,89% de carcinomas renales en nuestro centro). Correlacionamos con hallazgos clínicos y tratamos de determinar patrones de inmunotinción.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Todos los casos marcaron intensa y difusamente para citoqueratina (CK)7. La inmunotinción fue variable para antígeno de membrana epitelial, vimentina, S-100, antígeno Ulex europaeus, CK de alto peso molecular, CK8, CK18 y CK19. Los tumores fueron homogéneamente negativos para antígeno carcinoembriónico, CD15, CD10, CD34, desmina, actina, CK10, CK20 y HMB45. El índice proliferativo (Ki67) fue menor del 1% en todos los casos. La marcación fue similar en células cúbicas y fusiformes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Este tumor presenta un inmunofenotipo variable de acuerdo con diferentes trabajos y no se conoce con precisión su histogénesis o la célula hacia la cual se diferencian. La similitud en la expresión de marcadores en células cúbicas y fusiformes confirma un mismo origen y diferenciación.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We present the immunohistochemical (IHC) analyses of a series of four kidney tumors currently classified as mucinous tubular and spindle renal cell carcinoma (WHO), a tumor with uncertain histogenesis and differentiation. Our aims were to determine an immunoprofile and to add clinical and morphological information about this rare renal carcinoma.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The four tumors were found between 415 renal carcinomas at our center (0.89%). IHC was carried out with a panel of antibodies in these four cases. Morphogical and clinical information was collected and analyzed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All tumors were well circumscribed and confined to the kidney. Immunoreactivity for cytokeratin (CK)7 was intense and diffuse. Immunostaining was variable for EMA, vimentin, S-100, Ulex europaeus antigen, high-molecular-weight CK, CK 8, CK18, and CK 19. The tumors were homogeneously negative for CEA, CD15, CD10, CD34, desmin, actin, CK10, CK20, and HMB45. Proliferative index (Ki67) was < 1% en all cases. The immunoreactivity was similar in cuboidal and spindle cells. Conclusions: The present tumor shows a variable immunophenotype and there is not a precise cell type differentiation. The immunostaining in cuboidal and spindle cells suggests a similar differentiation and histogenesis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.N. Eble" 1 => "G. Sauter" 2 => "J.I. Epstein" 3 => "I.A. Sesterhenn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "IARC Press" "fecha" => "2004" "volumen" => "10" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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