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array:23 [ "pii" => "S0210480608739573" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73957-3" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73957" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:894-903" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1360 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 787 "PDF" => 566 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480608739585" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73958-5" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73958" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:904-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1560 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 878 "PDF" => 674 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Utilidad de la citología de orina para el diagnóstico del carcinoma vesical: estudio comparativo con biopsia" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "904" "paginaFinal" => "907" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Usefulness of Urine Cytology for Bladder Carcinoma Diagnosis: Comparative Study with Biopsy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.A. García Castro, E. Fernández Fernández, M.C. Martín Corriente, S. García Hernández, H. Álvarez-Argüelles Cabrera" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M.A." "apellidos" => "García Castro" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Fernández Fernández" ] 2 => array:2 [ "nombre" => "M.C." "apellidos" => "Martín Corriente" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "García Hernández" ] 4 => array:2 [ "nombre" => "H." "apellidos" => "Álvarez-Argüelles Cabrera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739585?idApp=UINPBA00004N" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739585/v1_201304251914/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480608739561" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73956-1" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73956" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:888-93" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1226 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 687 "PDF" => 532 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Serie inicial de prostatectomía radical laparoscópica en un hospital general: revisión y comparativa de series nacionales e internacionales." "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "888" "paginaFinal" => "893" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Initial Series Of Radical Prostatectomy In A General Hospital: Review And Comparative Of National And International Series" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Crego Tapias, P. Puig Duran, B. Juaneda Castell, J. Segura Forcada, C. Vallejo Gil, L.L. Cortadellas Angel" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Crego Tapias" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Puig Duran" ] 2 => array:2 [ "nombre" => "B." "apellidos" => "Juaneda Castell" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Segura Forcada" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Vallejo Gil" ] 5 => array:2 [ "nombre" => "L.L." "apellidos" => "Cortadellas Angel" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739561?idApp=UINPBA00004N" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739561/v1_201304251914/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Efecto terapéutico de Mitomicina C en el postoperatorio inmediato de pacientes con tumores vesicales no músculo invasores de riesgo intermedio" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "894" "paginaFinal" => "903" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Jalón Monzón, J.M. Fernández Gómez, S. Escaf Barmadah, M. Álvarez Múgica, J.L. Martín Benito, F.J. Regadera Sejas" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Jalón Monzón" "email" => array:1 [ 0 => "ajalonm@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Fernández Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Escaf Barmadah" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Álvarez Múgica" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "J.L." "apellidos" => "Martín Benito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "F.J." "apellidos" => "Regadera Sejas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital de Jove. Asturias. Actas Urol Esp. 2008;32(9):894-903" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología-1. Hospital Universitario Central de Asturias. Servicio de Urología. Hospital de Jove. Asturias. Actas Urol Esp. 2008;32(9):894-903" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. A. Jalón Monzón Servicio de Urología-I. Hospital Universitario Central de Asturias Celestino Villamil, s/n - 33006 Oviedo (Asturias) Tel.: 985 108 004" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Therapeutic Effect of Mitomycin C in the Immediate Postoperative Period in Patients with Intermediate-Risk Non-Muscle-Invasive Bladder Tumors." ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-02-29" "fechaAceptado" => "2008-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88722" "palabras" => array:5 [ 0 => "No músculo-invasor" 1 => "Cáncer vesical" 2 => "Terapia intravesical" 3 => "Quimioterapia" 4 => "Mitomicina C" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88721" "palabras" => array:5 [ 0 => "Non muscle-invasive" 1 => "Bladder cancer" 2 => "Intravesical therapy" 3 => "Chemotherapy" 4 => "Mitomycin C" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Aproximadamente del 70-85% de los carcinomas de células transicionales de vejiga no invaden la muscular propia. La recidiva después de la cirugía se cifra en un 60-90% de pacientes, siendo el periodo de alto riesgo los dos primeros años. La causa fundamental de recidiva en tumores de riesgo intermedio podría ser la inestabilidad del urotelio, por lo que la instilación única de un quimioterápico después de la RTU podría considerarse insuficiente, recomendándose un tratamiento diferido asociado con mantenimiento en algunos casos.</p> <span class="elsevierStyleSectionTitle">Pacientes y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, controlado y randomizado. Sólo se incluyeron pacientes con tumores vesicales no músculo-invasores de grado intermedio. Todos los pacientes fueron sometidos inicialmente a RTU y posteriormente randomizados para recibir Mitomicina C (MMC) postoperatoria en dosis única.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 105 pacientes. La media de seguimiento fue de 22,70±8,15 meses. Se administró MMC en 53 pacientes, de los cuales el 66% no recidivó y el 34% lo hicieron como tumor vesical no invasor. De los 52 pacientes que no recibieron MMC, el 53,8% no recidivaron, el 44,2% recidivaron como tumor no invasor y sólo un caso recurrió como tumor invasor. En cuanto al tiempo libre de enfermedad, no se encontraron diferencias significativas en los que se empleó MMC postoperatoria o tratamiento diferido. Sólo existió un caso de mielosupresión.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En tumores no músculo invasores de medio riesgo, diversos estudios sugieren que una instilación intravesical inmediata de un quimioterápico disminuye el riesgo de recidiva después de la RTU. No hemos logrado demostrar diferencias significativas al comparar la MMC postoperatoria frente a las instilaciones diferidas tradicionales.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Approximately 70-85% of transitional bladder cell carcinomas are non-muscle-invasive. After an initial surgery, around 60-90% will have a recurrence, being the highest risk period the first two years. Urothelium instability could be the main reason for recurrence in mid grade tumours, reason why a single dose of a chemotherapy after transurethral resection of the bladder (TURB) might be insufficient. That is why a deferred therapy in occasions associated with maintenance is recommended.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A prospective, controlled and randomized study was performed. We included non-muscle-invasive mid risk bladder tumours. All patients had initially a TURB performed and were randomized to receive a single dose of mitomycin C (MMC), in the immediate postoperative period.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 105 patients were included. Mean follow-up was 22, 70±8, 15 months. MMC was administered to 53 patients. Of these 66, 0% had no recurrence and 34,0% had a non-muscle-invasive recurrence. Of the 52 patients in the non MMC group, 53,8% had no recurrence and 44,2% had a non-muscle-invasive recurrence and only 1 patient had a muscleinvasive progression. We did not find significantly differences in time to recurrence in mid risk tumours when using immediate postoperative single dose of MMC or deferred therapy. There was only one case of myelosuppression.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In mid risk non-muscle-invasive tumors, some studies suggest that early intravesical instillation of chemotherapy reduces the risk of recurrence after TURB. 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