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array:24 [ "pii" => "S0210480609741361" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74136-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74136" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:235-41" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1692 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 979 "PDF" => 707 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741373" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74137-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74137" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:242-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1578 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 860 "PDF" => 708 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "242" "paginaFinal" => "248" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances on the influence of adipose tissue on prostate cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Constanza López Fontana, M. Eugenia Maselli Artola, M. Cristina Vanrell Rodríguez, Nicolás A. Di Milta Mónaco, Rafael Pérez Elizalde, José D. López Laur" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Constanza" "apellidos" => "López Fontana" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Eugenia Maselli Artola" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Cristina Vanrell Rodríguez" ] 3 => array:2 [ "nombre" => "Nicolás A." "apellidos" => "Di Milta Mónaco" ] 4 => array:2 [ "nombre" => "Rafael" "apellidos" => "Pérez Elizalde" ] 5 => array:2 [ "nombre" => "José D." "apellidos" => "López Laur" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741373?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741373/v1_201304251925/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S021048060974135X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74135-X" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74135" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:228-34" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1757 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 971 "PDF" => 779 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Controversias en la anatomía quirúrgica prostática. 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"apellidos" => "Juan Gardiner Monzó" ] 1 => array:2 [ "nombre" => "Felipe" "apellidos" => "Herranz Amo" ] 2 => array:2 [ "nombre" => "Ramiro" "apellidos" => "Cabello Benavente" ] 3 => array:2 [ "nombre" => "Maximiliano" "apellidos" => "Bun" ] 4 => array:2 [ "nombre" => "Jesús" "apellidos" => "Gómez Muñoz" ] 5 => array:2 [ "nombre" => "Carmen" "apellidos" => "González Enguita" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060974135X?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S021048060974135X/v1_201304251925/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "235" "paginaFinal" => "241" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Santiago Vilar Gónzalez, Francesc Montañá Puig, Mª Victoria Villas Sánchez, Mª del Mar Sevillano Capellán, Manuel Martos Aguayo, Sebastiá. Sabater Martí" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Santiago" "apellidos" => "Vilar Gónzalez" "email" => array:1 [ 0 => "santiagov06@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Francesc" "apellidos" => "Montañá Puig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mª" "apellidos" => "Victoria Villas Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Mª" "apellidos" => "del Mar Sevillano Capellán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Manuel" "apellidos" => "Martos Aguayo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Sebastiá." "apellidos" => "Sabater Martí" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Complejo Hospitalario Universitario de Albacete (CHUA)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Angelini-Farmacéutica. Barcelona, España" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. Santiago Vilar González Servicio de Radioterapia. Complejo Hospitalario Univ. de Albacete Hnos. Falco, s/n - 02006 Albacete. Tel.: 0034 96 75 97 523" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-10-01" "fechaAceptado" => "2008-11-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88894" "palabras" => array:3 [ 0 => "Carcinoma prostático" 1 => "Sofocos" 2 => "Deprivación hormonal" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88893" "palabras" => array:3 [ 0 => "Prostate carcinoma" 1 => "Hot flushes" 2 => "Hormone deprivation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los sofocos-sudores son problemas frecuentes durante el tratamiento con deprivación androgénica en pacientes afectos de carcinoma prostático. Estos efectos secundarios contribuyen en gran medida al deterioro de la calidad de vida.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han postulado diferentes hipótesis sobre los mecanismos fisiopatogénicos implicados, todos ellos de una alta complejidad debida básicamente a su multicausalidad.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El objetivo de esta revisión es aportar una visión meditada y actualizada de su génesis.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La retroalimentación negativa de las hormonas sexuales plasmáticas sobre la secreción hipotalámica de noradrenalina y serotonina serían la causa principal.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Asimismo la acción directa de estos mecanismos sobre el centro hipotalámico productor de LH-RH cercano al centro termorregulador, junto al acortamiento del intervalo termoneutral también estarían implicados.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La mejor comprensión de su mecanismo de producción nos puede hacer enfocar mas correctamente su tratamiento.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Hot flushes and perspiration are common problems during androgen deprivation therapy for prostate carcinoma, and largely contribute to worsen patient quality of life.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Different hypotheses have been proposed to explain the underlying physiopathological mechanisms, though all are very complex, basically because of the multiple causal factors involved.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The present review offers a pondered and updated perspective of the origin of hot flushes-perspiration in such patients.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Negative feedback of the plasma sexual hormones upon the hypothalamic secretion of noradrenalin and serotonin appears to be the main cause. Likewise, the direct action of such mechanisms upon the LH-RH producing hypothalamic center located close to the thermoregulatory center, together with shortening of the thermoneutral interval, would also play a role.</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Improved understanding of the causal mechanism may help improve the treatment of such symptoms.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. 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