Correspondencia autor: Dr. John Slof Departamento de Economía de la Empresa. Universidad Autónoma de Barcelona. Campus de la UAB 08193 Bellaterra (Barcelona). Tel.: 935 814 399; Fax.: 935 812 555
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Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. John Slof Departamento de Economía de la Empresa. Universidad Autónoma de Barcelona. Campus de la UAB 08193 Bellaterra (Barcelona). Tel.: 935 814 399; Fax.: 935 812 555" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Economic Evaluation Of Medical Treatment Of Benign Prostatic Hyperplasia (Bph) In The Specialised Care Setting In Spain. Application To The Cost-Effectiveness Of Two Drugs Frequently Used In Its Treatment" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-31" "fechaAceptado" => "2008-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88724" "palabras" => array:6 [ 0 => "Análisis coste-efectividad" 1 => "Hiperplasia benigna de próstata" 2 => "Tratamiento médico" 3 => "Gestión de recursos" 4 => "Serenoa repens" 5 => "Tamsulosina" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88723" "palabras" => array:6 [ 0 => "Benign prostatic hyperplasia" 1 => "Cost effectiveness analysis" 2 => "Drug therapy" 3 => "Healthcare resources" 4 => "Serenoa repens" 5 => "Tamsulosin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Llevar a cabo un estudio farmacoeconómico para conocer el coste medio del diagnóstico y seguimiento de la HBP en España en el ámbito de la atención especializada desde la perspectiva del sistema público de salud, considerando dos fármacos frecuentemente utilizados en el entorno sanitario español, un alfabloqueante (tamsulosina) y el extracto lipidoesterólico de Serenoa repens (Permixón®).</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se determinaron los costes sanitarios directos del diagnóstico y tratamiento de la HBP para cada presentación clínica según el valor del International Prostate Symptom Score (IPSS): leve, moderada y grave. Los datos sobre el consumo y los costes unitarios de los recursos sanitarios se recogieron mediante una encuesta semi-estructurada a expertos clínicos. La eficacia clínica del tratamiento médico fue obtenida del estudio clínico PERMAL, en el que se observó equivalencia terapéutica entre ambos fármacos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El coste medio anual de pruebas diagnósticas y visitas médicas de la HBP sintomática según fuese leve, moderada o grave fueron, respectivamente, 124, 207 y 286 para pacientes tratados en atención especializada. El coste medio anual del tratamiento médico, incluyendo la atención de los efectos adversos fue de 211 para Permixón® y 346 para tamsulosina.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El coste de la atención médica de la HBP es proporcional a la intensidad de la sintomatología. El tratamiento farmacológico constituye una parte significativa del coste de la enfermedad. En base al modelo utilizado, el tratamiento con Permixón® es sensiblemente más coste-efectivo que el tratamiento con tamsulosina, representando un ahorro medio de 135 por paciente y año.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To develop a pharmacoeconomic study in order to know the average cost of BPH diagnosis and follow-up in Spain in the Urology Department setting from the perspective of the public health system, considering two frequently used drugs in the Spanish Healthcare environment, an alpha-blocker (tamsulosin) and the lipido-sterolic extract of Serenoa repens (Permixon®).</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Direct healthcare costs of BPH diagnosis and treatment were determined for each clinical stage according to the International Prostate Symptom Score (IPSS): mild, moderate and severe. Data on the usage and unit costs of healthcare resources were obtained from a semi-structured interview with clinical experts. The clinical efficacy of the medical treatments was obtained from the PERMAL clinical study, where therapeutic equivalence between the two studied drugs was observed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">For patients treated in the Urology Department setting, the average annual cost of diagnostic tests and medical visits related to mild, moderate or severe BPH symptoms were, respectively, 124, 207, and 286. The average annual cost of the drugs, including adverse effects treatment, was 211 for Permixon® and 346 for tamsulosin.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Costs of medical care of BPH increases with symptom intensity. Pharmacological treatment makes up a significant part of the disease’s cost. According to the model used, treatment with Permixon® is considerably more cost-effective than with tamsulosin, offering average yearly savings of 135 per patient.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and natural history of benign prostatic hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.A. Guess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Clin North Am" "fecha" => "1995" "volumen" => "22" "numero" => "2" "paginaInicial" => "247" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7539173" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of urinary symptoms and other urological conditions in Spanish men 50 years old or older" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Hunter" 1 => "A. Berra-Unamuno" 2 => "A. Martin-Gordo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1996" "volumen" => "155" "numero" => "6" "paginaInicial" => "1975" "paginaFinal" => "1976" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8618300" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of benign prostatic hyperplasia in Spanish men 40 years old or older" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Chicharro-Molero" 1 => "R. Burgos-Rodriguez" 2 => "J.J. Sanchez-Cruz" 3 => "J.M. del Rosal-Samaniego" 4 => "P. Rodero-Carcia" 5 => "J.M. Rodriguez-Vallejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1998" "volumen" => "159" "numero" => "3" "paginaInicial" => "878" "paginaFinal" => "882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9474174" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abordaje de la hiperplasia benigna de próstata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Blasco Valle" 1 => "A. Timón García" 2 => "V. Lázaro Muñoz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actuación Aten Primaria" "fecha" => "2003" "volumen" => "13" "numero" => "3" "paginaInicial" => "133" "paginaFinal" => "142" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is Europe ready for STD screening?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Jiménez Cruz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "HBP 2001. Hiperplasia Benigna de Próstata" "paginaInicial" => "V" "serieFecha" => "2001" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hipertrofia benigna de próstata" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.M. Muñoz Rodríguez" 1 => "J.R. Toribio Onieva" 2 => "M.I. Moreno Moreno" 3 => "R. Luque Vargas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Guías Clínicas" "fecha" => "2002" "volumen" => "2" "numero" => "2" "paginaInicial" => "1" "paginaFinal" => "5" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aproximación al coste del tratamiento médico de la hiperplasia benigna de próstata en la Comunidad Foral de Navarra" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V. Grasa Lanau" 1 => "J.A. Cuesta Alcalá" 2 => "A. Ipiens Aznar" 3 => "I. Ansa Erice" 4 => "J. Aldave Villanueva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2004" "volumen" => "28" "numero" => "4" "paginaInicial" => "255" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15248396" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Sacristán del Castillo" 1 => "X. Badía Llach" 2 => "J. Rovira Foros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1995" "editorial" => "Editores Médicos" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomised international study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "F. Debruyne" 1 => "G. Koch" 2 => "P. Boyle" 3 => "Silva FC Da" 4 => "J.G. Gillenwater" 5 => "F.C. Hamdy" 6 => "P. Perrin" 7 => "P. Teillac" 8 => "R. Vela-Navarrete" 9 => "J.P. Raynaud" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2002" "volumen" => "41" "numero" => "5" "paginaInicial" => "497" "paginaFinal" => "506" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12074791" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symptoms evaluation, quality of life and sexuality. IPSS. The 2nd international consultation on benign prostatic hyperplasia proceedings. En: Cockett AT, Aso Y, Chatelain C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Bosch" 1 => "J. Donovan" 2 => "K. Okada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "SCI" "fecha" => "1993" "paginaInicial" => "131" "paginaFinal" => "143" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validación cultural y lingüística, en castellano del baremo internacional de síntomas prostáticos (I-PSS" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Vela Navarrete" 1 => "J.M. Martín Moreno" 2 => "F.J. Calahorra" 3 => "J. Damián Moreno" 4 => "A. Hernández Coronado" 5 => "P. Boyle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "1994" "volumen" => "18" "numero" => "8" "paginaInicial" => "841" "paginaFinal" => "847" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7527993" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of sociodemographic and health status variables on the American Urological Association symptom scores in patients with lower urinary tract symptoms" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "ESECI-98 Group" "etal" => false "autores" => array:7 [ 0 => "X. Badia" 1 => "F. Rodríguez" 2 => "J. Carballido" 3 => "M. García Losa" 4 => "M. Unda" 5 => "R. Dal-Ré" 6 => "M. Roset" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2001" "volumen" => "57" "numero" => "1" "paginaInicial" => "71" "paginaFinal" => "77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11164147" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Madersbacher" 1 => "G. Alivizatos" 2 => "J. Nordling" 3 => "C.R. Sanz" 4 => "M. Emberton" 5 => "J.J. de la Rosette" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2004.07.016" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2004" "volumen" => "46" "numero" => "5" "paginaInicial" => "547" "paginaFinal" => "554" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15474261" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Catálogo de Especialidades Farmacéuticas" "fecha" => "2006" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Análisis coste-efectividad del tratamiento de la hiperplasia prostática benigna de grado moderado" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.M. Meseguer Barros" 1 => "M.L. Fidalgo García" 2 => "S. Rubio Cebrían" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aten Primaria" "fecha" => "2000" "volumen" => "25" "numero" => "8" "paginaInicial" => "546" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10876947" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Características sociosanitarias y diagnósticas del paciente prostático en España a finales del siglo XX" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Grupo ESECI-98" "etal" => false "autores" => array:6 [ 0 => "M. Unda Urzaiz" 1 => "F. Rodríguez Alcántara" 2 => "X. Badia" 3 => "M. García Losa" 4 => "J. Carballido Rodríguez" 5 => "R. Dal-Ré Saavedra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2001" "volumen" => "25" "numero" => "3" "paginaInicial" => "200" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11402533" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TRIUMPH Pan-European Expert Panel. Medical consumption and costs during a one-year follow-up of patients with LUTS suggestive of BPH in six european countries: report of the TRIUMPH study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.J. Van Exel" 1 => "M.A. Koopmanschap" 2 => "J. McDonnell" 3 => "C.R. Chapple" 4 => "R. Berges" 5 => "F.F. Rutten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2005.09.016" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "49" "numero" => "1" "paginaInicial" => "92" "paginaFinal" => "102" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16314039" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics of patients presenting with LUTS/BPH in six European Countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Hutchison" 1 => "R. Farmer" 2 => "C. Chapple" 3 => "R. Berges" 4 => "L. Pientka" 5 => "P. Teillac" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.05.001" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "50" "numero" => "3" "paginaInicial" => "555" "paginaFinal" => "556" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16782265" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Morote Robles J, Alcaraz Asensio A, Jiménez Verdejo J. Estudio de los hábitos en España sobre métodos diagnósticos y de seguimiento de la hiperplasia benigna de próstata (HBP). En: Libro de abstracts del LXX Congreso Nacional de Urología. San Sebastián, 4-7 junio, 2005; (resumen C-34). Disponible en (<a class="elsevierStyleInterRef" href="http://www.aeu.es">www.aeu.es</a>" ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Five-year experience in treating patients with prostatic hyperplasia patients with permixone (Serenoa repens “Pierre Fabre Medicament" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "IuG Aliaev" 1 => "A.Z. Vinarov" 2 => "K.L. Lokshin" 3 => "L.G. Spivak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Urologia" "fecha" => "2002" "volumen" => "1" "paginaInicial" => "23" "paginaFinal" => "25" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term clinical and biological effects of the lipidosterolic extract of Serenoa repens in patients with symptomatic benign prostatic hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y.A. Pytel" 1 => "A. Vinarov" 2 => "N. Lopatkin" 3 => "A. Sivkov" 4 => "L. Gorilovsky" 5 => "J.P. Raynaud" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Adv Ther" "fecha" => "2002" "volumen" => "19" "numero" => "6" "paginaInicial" => "297" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12665050" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the clinical benefit of permixon and tamsulosin in severe BPH patients-PERMAL study subset analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "F. Debruyne" 1 => "P. Boyle" 2 => "F. Calais Da Silva" 3 => "J.G. Gillenwater" 4 => "F.C. Hamdy" 5 => "P. Perrin" 6 => "P. Teillac" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2004.01.015" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2004" "volumen" => "45" "numero" => "6" "paginaInicial" => "773" "paginaFinal" => "779" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15149751" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Hizli" 1 => "M.C. Uygur" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11255-006-9106-5" "Revista" => array:7 [ "tituloSerie" => "Int Urol Nephrol" "fecha" => "2007" "volumen" => "39" "numero" => "3" "paginaInicial" => "879" "paginaFinal" => "886" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17203353" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739603/v1_201304251914/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003200000009/v1_201304251914/S0210480608739603/v1_201304251914/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739603?idApp=UINPBA00004N" ]
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2024 Noviembre | 0 | 1 | 1 |
2024 Octubre | 0 | 6 | 6 |
2024 Septiembre | 0 | 6 | 6 |
2024 Agosto | 0 | 2 | 2 |
2024 Julio | 0 | 11 | 11 |
2024 Junio | 0 | 12 | 12 |
2024 Mayo | 0 | 5 | 5 |
2024 Abril | 0 | 13 | 13 |
2024 Marzo | 0 | 20 | 20 |
2024 Febrero | 0 | 9 | 9 |
2024 Enero | 0 | 6 | 6 |
2023 Diciembre | 0 | 15 | 15 |
2023 Noviembre | 0 | 8 | 8 |
2023 Octubre | 0 | 27 | 27 |
2023 Septiembre | 0 | 5 | 5 |
2023 Agosto | 0 | 18 | 18 |
2023 Julio | 0 | 45 | 45 |
2023 Junio | 0 | 7 | 7 |
2023 Mayo | 0 | 2 | 2 |
2023 Abril | 0 | 4 | 4 |
2023 Marzo | 0 | 4 | 4 |
2023 Febrero | 0 | 8 | 8 |
2023 Enero | 0 | 6 | 6 |
2022 Diciembre | 0 | 4 | 4 |
2022 Noviembre | 0 | 16 | 16 |
2022 Octubre | 0 | 16 | 16 |
2022 Septiembre | 0 | 15 | 15 |
2022 Agosto | 0 | 5 | 5 |
2022 Julio | 0 | 2 | 2 |
2022 Junio | 0 | 4 | 4 |
2022 Mayo | 0 | 5 | 5 |
2022 Abril | 0 | 8 | 8 |
2022 Marzo | 0 | 1 | 1 |
2022 Febrero | 0 | 1 | 1 |
2022 Enero | 0 | 7 | 7 |
2021 Diciembre | 0 | 8 | 8 |
2021 Noviembre | 0 | 6 | 6 |
2021 Octubre | 0 | 6 | 6 |
2021 Agosto | 0 | 1 | 1 |
2021 Julio | 0 | 4 | 4 |
2021 Junio | 0 | 3 | 3 |
2021 Mayo | 0 | 3 | 3 |
2021 Abril | 0 | 10 | 10 |
2021 Marzo | 0 | 1 | 1 |
2021 Febrero | 0 | 2 | 2 |
2021 Enero | 0 | 16 | 16 |
2020 Diciembre | 0 | 8 | 8 |
2020 Noviembre | 0 | 4 | 4 |
2020 Octubre | 0 | 1 | 1 |
2020 Septiembre | 0 | 4 | 4 |
2020 Agosto | 0 | 6 | 6 |
2020 Julio | 0 | 3 | 3 |
2020 Junio | 0 | 3 | 3 |
2020 Mayo | 0 | 6 | 6 |
2020 Abril | 0 | 5 | 5 |
2020 Marzo | 0 | 5 | 5 |
2020 Febrero | 0 | 9 | 9 |
2020 Enero | 0 | 9 | 9 |
2019 Diciembre | 0 | 20 | 20 |
2019 Noviembre | 0 | 7 | 7 |
2019 Octubre | 0 | 12 | 12 |
2019 Septiembre | 0 | 5 | 5 |
2019 Agosto | 0 | 5 | 5 |
2019 Julio | 0 | 10 | 10 |
2019 Junio | 0 | 11 | 11 |
2019 Mayo | 0 | 52 | 52 |
2019 Abril | 0 | 25 | 25 |
2019 Marzo | 0 | 3 | 3 |
2019 Febrero | 0 | 7 | 7 |
2019 Enero | 0 | 3 | 3 |
2018 Diciembre | 0 | 6 | 6 |
2018 Noviembre | 0 | 10 | 10 |
2018 Octubre | 0 | 15 | 15 |
2018 Febrero | 3 | 3 | 6 |
2018 Enero | 2 | 3 | 5 |
2017 Diciembre | 3 | 0 | 3 |
2017 Noviembre | 6 | 5 | 11 |
2017 Octubre | 4 | 2 | 6 |
2017 Septiembre | 2 | 19 | 21 |
2017 Agosto | 5 | 3 | 8 |
2017 Julio | 4 | 0 | 4 |
2017 Junio | 12 | 8 | 20 |
2017 Mayo | 16 | 8 | 24 |
2017 Abril | 10 | 1 | 11 |
2017 Marzo | 16 | 30 | 46 |
2017 Febrero | 7 | 4 | 11 |
2017 Enero | 2 | 1 | 3 |
2016 Diciembre | 14 | 1 | 15 |
2016 Noviembre | 22 | 3 | 25 |
2016 Octubre | 27 | 5 | 32 |
2016 Septiembre | 19 | 4 | 23 |
2016 Agosto | 10 | 4 | 14 |
2016 Julio | 16 | 1 | 17 |
2016 Junio | 12 | 8 | 20 |
2016 Mayo | 14 | 15 | 29 |
2016 Abril | 7 | 14 | 21 |
2016 Marzo | 10 | 6 | 16 |
2016 Febrero | 6 | 8 | 14 |
2016 Enero | 9 | 18 | 27 |
2015 Diciembre | 5 | 7 | 12 |
2015 Noviembre | 12 | 2 | 14 |
2015 Octubre | 15 | 4 | 19 |
2015 Septiembre | 9 | 3 | 12 |
2015 Agosto | 8 | 1 | 9 |
2015 Julio | 9 | 3 | 12 |
2015 Junio | 2 | 1 | 3 |
2015 Mayo | 16 | 1 | 17 |
2015 Abril | 5 | 6 | 11 |
2015 Marzo | 2 | 1 | 3 |
2015 Febrero | 2 | 2 | 4 |
2015 Enero | 7 | 4 | 11 |
2014 Diciembre | 13 | 6 | 19 |
2014 Noviembre | 7 | 2 | 9 |
2014 Octubre | 20 | 3 | 23 |
2014 Septiembre | 17 | 1 | 18 |
2014 Agosto | 4 | 1 | 5 |
2014 Julio | 11 | 1 | 12 |
2014 Junio | 21 | 2 | 23 |
2014 Mayo | 5 | 2 | 7 |
2014 Abril | 4 | 1 | 5 |
2014 Marzo | 7 | 1 | 8 |
2014 Febrero | 3 | 3 | 6 |
2014 Enero | 6 | 2 | 8 |
2013 Diciembre | 6 | 4 | 10 |
2013 Noviembre | 8 | 8 | 16 |
2013 Octubre | 2 | 24 | 26 |
2013 Septiembre | 5 | 9 | 14 |
2013 Agosto | 3 | 4 | 7 |
2013 Julio | 1 | 1 | 2 |
2008 Septiembre | 317 | 0 | 317 |