Guía de la eau para el cáncer de próstata(*)
EAU Guidelines on Prostate Cancer , Axel Heidenreich1,a, Gunna Ausb, Michel Bollac, Steven Joniaud, B. Matveev Vsevolode, Hans Peter Schmidf, Filliberto Zattonig
a aServicio de Urología, Hospital Universitario de Colonia, Colonia, Alemania.
b Servicio de Urología, Hospital Universitario de Sahlgrens, Göteborg, Suecia.
c Servicio de Radioterapia, C.H.U Grenoble, Grenoble, Francia.
d Servicio de Urología, Hospital Universitario de Gasthuisberg, Leuven, Bélgica.
e Servicio de Urología, Academia Rusa de Ciencias Médicas, Centro de Investigaciones Oncológicas, Moscú, Rusia.
f Servicio de Urología, Kantonspital St. Gallen, St. Gallen, Suiza.
g Servicio de Urología, Hospital Santa Maria Della Misericordia, Udine, Italia.
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"etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Autor para correspondencia: Dr. Axel Heidenreich Department of Urology, Division of Oncological Urology, University of Koln, Kerpener Strasse 62, 50924 Koln, Germany Tel.: +49 221 478 86577; Fax: +49 221 478 87901" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88834" "palabras" => array:10 [ 0 => "Bloqueo hormonal" 1 => "Quimioterapia" 2 => "Diagnostico" 3 => "Guias de la EAU" 4 => "Seguimiento" 5 => "Cancer de prostata" 6 => "Radioterapia" 7 => "Prostatectomia radical" 8 => "Revision" 9 => "Tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88833" "palabras" => array:10 [ 0 => "Androgen deprivation" 1 => "Chemotherapy" 2 => "Diagnosis" 3 => "EAU guidelines" 4 => "Follow-up" 5 => "Prostate cancer" 6 => "Radiation therapy" 7 => "Radical prostatectomy" 8 => "Review" 9 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentar un resumen de la version del 2007 de la guia de la Asociacion Europea de Urologia (EAU) para el cancer de prostata (CaP).</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realizo por un grupo de trabajo una revision de los nuevos datos presentes desde 2004 hasta 2007 en la literatura. Las guias han sido actualizadas y el nivel de evidencia/grado de recomendacion ha sido anadido al texto basandose en una revision sistematica de la literatura, que incluia una busqueda de las bases de datos online y revisiones bibliograficas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Una version completa esta disponible en la EAU Office o en <span class="elsevierStyleInterRef" href="http://www.uroweb.org">www.uroweb.org.</span> El metodo diagnostico de eleccion es la biopsia sistematizada de la prostata bajo control ecografico. El tratamiento activo es el recomendado en la mayoria de los pacientes con enfermedad localizada y una larga esperanza de vida, siendo la prostatectomia radical superior a la vigilancia (“watchful waiting”) en un ensayo randomizado prospectivo. La prostatectomia radical con preservacion de bandeletas es la tecnica de eleccion en la enfermedad organo-confinada; el bloqueo androgenico neoadyuvante no ha demostrado una mejoria en las variables de resultados. La radioterapia debe realizarse con al menos 72 Gy en el CaP de bajo riesgo y con 78 Gy en el de intermedio - alto riesgo. El bloqueo androgenico en monoterapia es el estandar del tratamiento en el CaP metastasico; el bloqueo androgenico intermitente podria ser un tratamiento alternativo en pacientes seleccionados. El seguimiento se basa principalmente en los niveles de PSA y en la anamnesis especifica de la enfermedad, estando las pruebas de imagen solo indicadas cuando aparecen los sintomas. La quimioterapia con docetaxel ha surgido como el tratamiento de referencia para el CaP metastasico hormonorefractario.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El conocimiento en el campo del CaP esta rapidamente cambiando. Estas guias de la EAU resumen los hallazgos mas recientes y los aplican a la practica clinica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To present a summary of the 2007 version of the European Association of Urology (EAU) guidelines on prostate cancer (PCa).</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A literature review of the new data emerging from 2004 to 2007 was performed by the working panel. The guidelines have been updated, and the level of evidence/grade of recommendation was added to the text based on a systematic review of the literature, which included a search of online databases and bibliographic reviews.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Afull version is available at the EAU Office or at <span class="elsevierStyleInterRef" href="http://www.uroweb.org">www.uroweb.org.</span> Systemic prostate biopsy under ultrasound guidance is the preferred diagnostic method. Active treatment is mostly recommended for patients with localized disease and a long life expectancy, with radical prostatectomy being shown to be superior to watchful waiting in a prospective randomized trial. Nerve-sparing radical prostatectomy represents the approach of choice in organ-confined disease; neoadjuvant androgen deprivation demonstrates no improvement of outcome variables. Radiation therapy should be performed with at least 72 and 78 Gy in low-risk and intermediate- to high-risk PCa, respectively. Monotherapeutic androgen deprivation is the standard of care in metastatic PCa; intermittent androgen deprivation might be an alternative treatment option for selected patients. Follow-up is largely based on prostate-specific antigen and a disease-specific history with imaging only indicated when symptoms occur. Cytotoxic therapy with docetaxel has emerged as the reference treatment for metastatic hormone-refractory PCa.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The knowledge in the field of PCa is rapidly changing. These EAU guidelines on PCa summarize the most recent findings and put them into clinical practice.Keywords: Androgen deprivation. Chemotherapy. Diagnosis. EAU guidelines. Follow-up. Prostate cancer. Radiation therapy. Radical prostatectomy. Review. Treatment.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "(*)" "nota" => "<p class="elsevierStyleNotepara">La traducción de este artículo se ha llevado a cabo con el permiso de la Asociación Europea de Urología.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EAU guidelines on prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Aus" 1 => "C.C. Abbou" 2 => "M. Bolla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Urol" "fecha" => "2005" "volumen" => "48" "paginaInicial" => "451" "paginaFinal" => "546" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "US Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research 1992, p. 115-27; <a class="elsevierStyleInterRef" href="http://www.ahcpr.gov/">http://www.ahcpr.gov/.</a>" ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimates of cancer incidence and mortality in Europe in 1995" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Bray" 1 => "R. Sankila" 2 => "J. Ferlay" 3 => "D.M. Parkin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "2002" "volumen" => "38" "paginaInicial" => "99" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11750846" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Black" 1 => "F. Bray" 2 => "J. Ferlay" 3 => "D.M. Parkin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "1997" "volumen" => "33" "paginaInicial" => "1075" "paginaFinal" => "1107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9376190" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial prostate cancer in Sweden: a nationwide register cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. Gronberg" 1 => "L. Damber" 2 => "J.E. Damber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1097-0142(19960101)77:1<138::AID-CNCR23>3.0.CO;2-5" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1996" "volumen" => "77" "paginaInicial" => "138" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8630920" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mendelian inheritance of familial prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B.S. Carter" 1 => "T.H. Beaty" 2 => "G.D. Steinberg" 3 => "B. Childs" 4 => "P.C. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA" "fecha" => "1992" "volumen" => "89" "paginaInicial" => "3367" "paginaFinal" => "3371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1565627" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TNM classification of malignant tumours. ed. 6" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.H. Sobin" 1 => "C. Wittekind" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:1 [ "serieFecha" => "2002" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.F. Gleason" 1 => "G.T. Mellinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1974" "volumen" => "111" "paginaInicial" => "58" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4813554" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer mortality reduction by screening: power and time frame with complete enrolment in the European Randomized Screening for Prostate Cancer (ERSPC) trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.J. De Koning" 1 => "M.K. Liem" 2 => "C.A. Baan" 3 => "R. Boer" 4 => "F.H. Schroder" 5 => "F.E. Alexander" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2002" "volumen" => "98" "paginaInicial" => "268" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11857418" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update on screening for prostate cancer with prostate specific antigen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.P. Schmid" 1 => "W. Riesen" 2 => "L. Prikler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.critrevonc.2003.11.001" "Revista" => array:6 [ "tituloSerie" => "Crit Rev Oncol Hematol" "fecha" => "2004" "volumen" => "50" "paginaInicial" => "71" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15094160" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer screening in the United States 2007: a review of current guidelines, practices, and prospects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.A. Smith" 1 => "V. Cokkinides" 2 => "H.J. Eyre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "90" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17392386" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cumulative prostate cancer risk assessment with the aid of the free-to-total prostate specific antigen ratio" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Aus" 1 => "C. Becker" 2 => "S. Franze´n" 3 => "H. Lilja" 4 => "P. Lodding" 5 => "J. Hugosson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2004" "volumen" => "45" "paginaInicial" => "160" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14734000" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of prostate cancer among men with a prostate-specific antigen level ?4.0 ng per milliliter" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I.M. Thompson" 1 => "D.K. Pauler" 2 => "P.J. Goodman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa031918" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "2239" "paginaFinal" => "2246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15163773" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Sun" 1 => "J.W. Moul" 2 => "J.M. Hotaling" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2006.06682.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2007" "volumen" => "99" "paginaInicial" => "753" "paginaFinal" => "757" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17244286" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Guichard" 1 => "S. Larre´" 2 => "A. Gallina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2007.02.062" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "430" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17412489" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of routine transition zone biopsies in patients undergoing ultrasound-guided sextant biopsies for the first time" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Morote" 1 => "M. Lopez" 2 => "G. Encabo" 3 => "I. de Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "19864" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "1999" "volumen" => "35" "paginaInicial" => "294" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10087391" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B. Djavan" 1 => "V. Ravery" 2 => "A. Zlotta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "166" "paginaInicial" => "1679" "paginaFinal" => "1683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11586201" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of conservativemanagement of clinically localized prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "G.W. Chodak" 1 => "R.A. Thisted" 2 => "G.S. Gerber" 3 => "J.E. Johansson" 4 => "J. Adolfsson" 5 => "G.W. Jones" 6 => "G.D. Chisholm" 7 => "B. Moskovitz" 8 => "P.M. Livne" 9 => "J. Warner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199401273300403" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1994" "volumen" => "330" "paginaInicial" => "242" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8272085" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Competing risk analysis of men aged 55 to 74 years at diagnosis managed conservatively for clinically localized prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.C. Albertsen" 1 => "J.A. Hanley" 2 => "D.F. Gleason" 3 => "M.J. Barry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1998" "volumen" => "280" "paginaInicial" => "975" "paginaFinal" => "980" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9749479" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Active surveillance for prostate cancer: for whom?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Klotz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.03.3134" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "8165" "paginaFinal" => "8169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16278468" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modeling prostate specific antigen kinetics in patients on active surveillance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Zhang" 1 => "A. Loblaw" 2 => "L. Klotz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.06.103" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2006" "volumen" => "176" "paginaInicial" => "1392" "paginaFinal" => "1397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16952640" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scandinavian Prostate Cancer Group study no. 4: radical prostatectomy versus watchful waiting in early prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Bill-Axelson" 1 => "L. Holmberg" 2 => "M. Ruutu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "1977" "paginaFinal" => "1984" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The discovery of the cavernous nerves and development of nerve sparing radical retropubic prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.C. Walsh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2007.01.012" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2007" "volumen" => "177" "paginaInicial" => "1632" "paginaFinal" => "1635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17437775" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomical extent of pelvic lymphadenectomy in patients undergoing radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Heidenreich" 1 => "C.H. Ohlmann" 2 => "S. Polyakov" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2007.04.020" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "29" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17448592" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pretreatment table for the prediction of final histopathology after radical prostatectomy in clinical unilateral T3a prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Joniau" 1 => "C.Y. Hsu" 2 => "E. Lerut" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.06.051" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2007" "volumen" => "51" "paginaInicial" => "388" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16901622" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical prostatectomy for clinically advanced (cT3) prostate cancer since the advent of prostate-specific antigen testing: 15- year outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.F. Ward" 1 => "J.M. Slezak" 2 => "M.L. Blute" 3 => "E.J. Bergstralh" 4 => "H. Zincke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2005.05394.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2005" "volumen" => "95" "paginaInicial" => "751" "paginaFinal" => "756" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15794776" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Kumar S, Shelley M, Harrison C, Coles B, Wilt TJ, Mason MD. Neo-adjuvant and adjuvant hormone therapy for localised and locally advanced prostate cancer. Cochrane Database Syst Rev 2006;CD006019" ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Casodex Early Prostate Cancer Trialists’Group. Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.G. McLeod" 1 => "P. Iversen" 2 => "W.A. See" 3 => "T. Morris" 4 => "J. Armstrong" 5 => "M.P. Wirth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2005.06051.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2006" "volumen" => "97" "paginaInicial" => "247" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16430622" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eastern Cooperative Oncology Group study EST 3886: immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.M. Messing" 1 => "J. Manola" 2 => "J. Yao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(06)70700-8" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "472" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16750497" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved biochemical relapse-free survival with increased external radiation doses in patients with localized prostate cancer: the combined experience of nine institutions in patients treated in 1994 and 1995" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Kupelian" 1 => "D. Kuban" 2 => "H. Thames" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijrobp.2004.05.018" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2005" "volumen" => "61" "paginaInicial" => "415" "paginaFinal" => "419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15667961" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Zelefsky" 1 => "S.A. Leibel" 2 => "P.B. Gaudin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "1998" "volumen" => "41" "paginaInicial" => "491" "paginaFinal" => "500" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9635694" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Pollack" 1 => "G.K. Zagars" 2 => "L.G. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2000.18.23.3904" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "3904" "paginaFinal" => "3911" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11099319" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Bolla" 1 => "L. Collette" 2 => "L. Blank" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2002" "volumen" => "360" "paginaInicial" => "103" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12126818" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Bolla" 1 => "D. Gonzalez" 2 => "P. Warde" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199707313370502" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1997" "volumen" => "337" "paginaInicial" => "295" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9233866" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESTRA/EAU Urological Brachytherapy Group, EORTC Radiotherapy Group. ESTRO/EAU/EORTC recommendations on permanent seed implantation for localized prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Ash" 1 => "A. Flynn" 2 => "J. Batterman" 3 => "T. de Reijke" 4 => "P. Lavagnini" 5 => "L. Blank" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Radiother Oncol" "fecha" => "2000" "volumen" => "57" "paginaInicial" => "315" "paginaFinal" => "321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11104892" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term results of interstitial brachytherapy (LDR-brachytherapy) in the treatment of patients with prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Machtens" 1 => "R. Baumann" 2 => "J. Hagemann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00345-006-0083-1" "Revista" => array:6 [ "tituloSerie" => "World J Urol" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "289" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16645877" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant radiotherapy after radical prostatectomy: indications, results and outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Bottke" 1 => "T. Wiegel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000099336" "Revista" => array:6 [ "tituloSerie" => "Urol Int" "fecha" => "2007" "volumen" => "78" "paginaInicial" => "193" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17406125" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current status of HIFU and cryotherapy in prostate cancer - a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Aus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.07.011" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "50" "paginaInicial" => "927" "paginaFinal" => "934" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16971038" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Single-therapy androgen suppression inmenwith advanced prostatecancer: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Seidenfeld" 1 => "D.J. Samson" 2 => "V. Hasselblad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2000" "volumen" => "132" "paginaInicial" => "566" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10744594" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Samson" 1 => "J. Seidenfeld" 2 => "B. Schmitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.10647" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2002" "volumen" => "95" "paginaInicial" => "361" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12124837" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Casodex (bicalutamide) 150-mg monotherapy compared with castration in patients with previously untreated nonmetastatic prostate cancer: results from two multicenter randomized trials at a median follow-up of 4 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Iversen" 1 => "C.J. Tyrell" 2 => "A.V. Kaisary" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1998" "volumen" => "51" "paginaInicial" => "389" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9510340" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.A. Loblaw" 1 => "K.S. Virgo" 2 => "R. Nam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.10.1949" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "1596" "paginaFinal" => "1605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17404365" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Absolute prostatespecific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer- data from Southwest Oncology Group Trial 9346 (INT- 0162" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Hussain" 1 => "C.M. Tangen" 2 => "C. Higano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.06.4246" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "3984" "paginaFinal" => "3990" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16921051" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.W. Moul" 1 => "H. Wu" 2 => "L. Sun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000113794.34810.d0" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "171" "paginaInicial" => "1141" "paginaFinal" => "1147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14767288" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for localized prostate cancer update panel report and recommendations for a standard in the reporting of surgical outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.S. Cookson" 1 => "G. Aus" 2 => "A.L. Burnett" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.10.097" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2007" "volumen" => "177" "paginaInicial" => "540" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17222629" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Roach III" 1 => "G. Hanks" 2 => "H. Thames Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijrobp.2006.04.029" "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2006" "volumen" => "65" "paginaInicial" => "965" "paginaFinal" => "974" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798415" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.J. Bubley" 1 => "M. Carducci" 2 => "W. Dahut" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1999.17.11.3461" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1999" "volumen" => "17" "paginaInicial" => "3461" "paginaFinal" => "3467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10550143" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of secondary hormonal therapy in the management of recurrent disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.J. Ryan" 1 => "E.J. Small" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2003" "volumen" => "62" "numero" => "Suppl 1" "paginaInicial" => "87" "paginaFinal" => "94" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14747046" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.P. Petrylak" 1 => "C.M. Tangen" 2 => "M.H. Hussain" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa041318" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "351" "paginaInicial" => "1513" "paginaFinal" => "1520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15470214" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TAX 327 Investigators. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I.F. Tannock" 1 => "R. de Wit" 2 => "W.R. Berry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa040720" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "351" "paginaInicial" => "1502" "paginaFinal" => "1512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15470213" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, placebocontrolled trial of zoledronic acid in patients with hormonerefractory metastatic prostate carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Saad" 1 => "D.M. Gleason" 2 => "R. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2002" "volumen" => "94" "paginaInicial" => "1458" "paginaFinal" => "1468" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12359855" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741105/v1_201304251922/es/main.assets" "Apartado" => array:4 [ "identificador" => "6502" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisión" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003300000002/v1_201304251922/S0210480609741105/v1_201304251922/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741105?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/02104806/addon/S0210480609741105/S300/en/292v33n02a13143322pdf001_2.pdf" "portada" => "292v33n02a13143322pdf001_2.png" ] ] ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 1 | 1 |
| 2024 Octubre | 0 | 11 | 11 |
| 2024 Septiembre | 0 | 7 | 7 |
| 2024 Agosto | 0 | 10 | 10 |
| 2024 Julio | 0 | 3 | 3 |
| 2024 Junio | 0 | 24 | 24 |
| 2024 Mayo | 0 | 9 | 9 |
| 2024 Abril | 0 | 3 | 3 |
| 2024 Marzo | 0 | 43 | 43 |
| 2024 Febrero | 0 | 11 | 11 |
| 2024 Enero | 0 | 38 | 38 |
| 2023 Diciembre | 0 | 14 | 14 |
| 2023 Noviembre | 0 | 24 | 24 |
| 2023 Octubre | 0 | 23 | 23 |
| 2023 Septiembre | 0 | 10 | 10 |
| 2023 Agosto | 0 | 22 | 22 |
| 2023 Julio | 0 | 55 | 55 |
| 2023 Junio | 0 | 6 | 6 |
| 2023 Mayo | 0 | 4 | 4 |
| 2023 Abril | 0 | 2 | 2 |
| 2023 Marzo | 0 | 8 | 8 |
| 2023 Febrero | 0 | 2 | 2 |
| 2023 Enero | 0 | 4 | 4 |
| 2022 Diciembre | 0 | 6 | 6 |
| 2022 Noviembre | 0 | 7 | 7 |
| 2022 Octubre | 0 | 9 | 9 |
| 2022 Septiembre | 0 | 8 | 8 |
| 2022 Agosto | 0 | 23 | 23 |
| 2022 Julio | 0 | 13 | 13 |
| 2022 Junio | 0 | 9 | 9 |
| 2022 Mayo | 0 | 4 | 4 |
| 2022 Abril | 0 | 6 | 6 |
| 2022 Marzo | 0 | 5 | 5 |
| 2021 Diciembre | 0 | 12 | 12 |
| 2021 Noviembre | 0 | 7 | 7 |
| 2021 Octubre | 0 | 11 | 11 |
| 2021 Septiembre | 0 | 5 | 5 |
| 2021 Agosto | 0 | 9 | 9 |
| 2021 Julio | 0 | 3 | 3 |
| 2021 Junio | 0 | 3 | 3 |
| 2021 Mayo | 0 | 4 | 4 |
| 2021 Abril | 0 | 2 | 2 |
| 2021 Marzo | 0 | 1 | 1 |
| 2021 Febrero | 0 | 3 | 3 |
| 2021 Enero | 0 | 4 | 4 |
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| 2020 Septiembre | 0 | 7 | 7 |
| 2020 Agosto | 0 | 8 | 8 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 12 | 12 |
| 2020 Mayo | 2 | 13 | 15 |
| 2020 Abril | 0 | 15 | 15 |
| 2020 Marzo | 0 | 8 | 8 |
| 2020 Febrero | 0 | 9 | 9 |
| 2020 Enero | 0 | 45 | 45 |
| 2019 Diciembre | 0 | 40 | 40 |
| 2019 Noviembre | 0 | 36 | 36 |
| 2019 Octubre | 0 | 35 | 35 |
| 2019 Septiembre | 0 | 38 | 38 |
| 2019 Agosto | 0 | 23 | 23 |
| 2019 Julio | 0 | 48 | 48 |
| 2019 Junio | 0 | 49 | 49 |
| 2019 Mayo | 0 | 88 | 88 |
| 2019 Abril | 0 | 55 | 55 |
| 2019 Marzo | 0 | 12 | 12 |
| 2019 Febrero | 0 | 23 | 23 |
| 2019 Enero | 0 | 3 | 3 |
| 2018 Diciembre | 0 | 16 | 16 |
| 2018 Noviembre | 0 | 10 | 10 |
| 2018 Octubre | 0 | 27 | 27 |
| 2018 Septiembre | 0 | 1 | 1 |
| 2018 Agosto | 0 | 16 | 16 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Junio | 0 | 3 | 3 |
| 2018 Mayo | 0 | 7 | 7 |
| 2018 Abril | 0 | 2 | 2 |
| 2018 Marzo | 0 | 7 | 7 |
| 2018 Febrero | 3 | 13 | 16 |
| 2018 Enero | 0 | 17 | 17 |
| 2017 Diciembre | 0 | 22 | 22 |
| 2017 Noviembre | 9 | 30 | 39 |
| 2017 Octubre | 10 | 42 | 52 |
| 2017 Septiembre | 9 | 51 | 60 |
| 2017 Agosto | 12 | 38 | 50 |
| 2017 Julio | 14 | 41 | 55 |
| 2017 Junio | 21 | 27 | 48 |
| 2017 Mayo | 14 | 14 | 28 |
| 2017 Abril | 14 | 7 | 21 |
| 2017 Marzo | 15 | 49 | 64 |
| 2017 Febrero | 24 | 11 | 35 |
| 2017 Enero | 10 | 8 | 18 |
| 2016 Diciembre | 27 | 20 | 47 |
| 2016 Noviembre | 34 | 18 | 52 |
| 2016 Octubre | 27 | 25 | 52 |
| 2016 Septiembre | 16 | 12 | 28 |
| 2016 Agosto | 12 | 5 | 17 |
| 2016 Julio | 18 | 1 | 19 |
| 2016 Junio | 26 | 27 | 53 |
| 2016 Mayo | 21 | 34 | 55 |
| 2016 Abril | 16 | 24 | 40 |
| 2016 Marzo | 21 | 17 | 38 |
| 2016 Febrero | 13 | 33 | 46 |
| 2016 Enero | 16 | 29 | 45 |
| 2015 Diciembre | 12 | 25 | 37 |
| 2015 Noviembre | 13 | 24 | 37 |
| 2015 Octubre | 19 | 33 | 52 |
| 2015 Septiembre | 17 | 10 | 27 |
| 2015 Agosto | 13 | 14 | 27 |
| 2015 Julio | 10 | 7 | 17 |
| 2015 Junio | 9 | 5 | 14 |
| 2015 Mayo | 14 | 17 | 31 |
| 2015 Abril | 16 | 28 | 44 |
| 2015 Marzo | 11 | 11 | 22 |
| 2015 Febrero | 7 | 11 | 18 |
| 2015 Enero | 12 | 7 | 19 |
| 2014 Diciembre | 10 | 12 | 22 |
| 2014 Noviembre | 3 | 6 | 9 |
| 2014 Octubre | 8 | 8 | 16 |
| 2014 Septiembre | 15 | 5 | 20 |
| 2014 Agosto | 13 | 0 | 13 |
| 2014 Julio | 15 | 4 | 19 |
| 2014 Junio | 10 | 5 | 15 |
| 2014 Mayo | 3 | 3 | 6 |
| 2014 Abril | 3 | 3 | 6 |
| 2014 Marzo | 2 | 3 | 5 |
| 2014 Febrero | 4 | 4 | 8 |
| 2014 Enero | 3 | 2 | 5 |
| 2013 Diciembre | 4 | 3 | 7 |
| 2013 Noviembre | 2 | 16 | 18 |
| 2013 Octubre | 9 | 19 | 28 |
| 2013 Septiembre | 7 | 10 | 17 |
| 2013 Agosto | 7 | 8 | 15 |
| 2013 Julio | 2 | 2 | 4 |
| 2009 Febrero | 572 | 0 | 572 |
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