Factores pronósticos en la supervivencia de los pacientes con carcinoma transicional de vejiga tratados con cistectomía radical
Prognostic factors for survival in patients with transitional baldder cancer treated with radical cystectomy
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"apellidos" => "Díez Cordero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ramiro" "apellidos" => "Cabello Benavente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Ángel" "apellidos" => "Silmi Moyano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Carlos" "apellidos" => "Hernández Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Hospital General Universitario Gregorio Marañón. Hospital Clínico San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Hospital Clínico San Carlos. Madrid. España" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. Juan I. Monzó Garnier Servicio Urología. Fundación Jiménez Díaz Avda. Reyes Católicos 2 - 28040 Madrid. Tel.: 915 504 800" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prognostic factors for survival in patients with transitional baldder cancer treated with radical cystectomy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-01" "fechaAceptado" => "2008-12-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras claves" "identificador" => "xpalclavsec88904" "palabras" => array:3 [ 0 => "Cáncer de vejiga" 1 => "Cistectomía radical" 2 => "Supervivencia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88903" "palabras" => array:3 [ 0 => "Bladder cancer" 1 => "Radical cystectomy" 2 => "Survival" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">conocer las variables clínicas y patológicas que influyen en la mortalidad cáncer-específica de los pacientes con carcinoma transicional de vejiga tratados mediante cistectomía radical (CR).</p> <span class="elsevierStyleSectionTitle">Material y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">análisis retrospectivo de 333 pacientes con cáncer transicional de vejiga tratados mediante CR. Se analizaron variables agrupadas en el período pre-cistectomía, peri-cistectomía y de seguimiento. Se definieron 4 grupos de riesgo en función del estadio patológico: a) Enfermedad localizada vesical sin afectación ganglionar (pT0-2, pN0); b) Enfermedad extravesical sin afectación ganglionar (pT3-4, pN0); c) Enfermedad con afectación ganglionar (pT0-4, pN+); d) Sin datos sobre la afectación ganglionar (pT0-4, pNx). Realizamos un análisis univariante y dos modelos de multivariante con y sin los grupos de riesgo descritos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La media de seguimiento de la serie fue de 52,6 ± 51 (2-221) meses con una mediana de 31 meses. Un 7,2% de los pacientes presentó estadio pT0, 12% pT1, 26,7% pT2, 34,5% pT3 y un 19,5% pT4. El 20,7% de los pacientes tenían metástasis ganglionares (pN+). La supervivencia cáncer específica a los 5 años fue del 57% y del 54% a los 10 años.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El estadio patológico, la afectación ganglionar y los grupos de riesgo se comportaron como factores predictivos independientes para la supervivencia cáncer-específica. La asociación por grupos de riesgo permite predecir de una forma más fiable el riesgo de fallecer por cáncer de vejiga e identificar a los pacientes en los que la cistectomía resulta un tratamiento insuficiente y que se podrían beneficiar de un tratamiento adyuvante.</p>" ] "en" => array:2 [ "titulo" => "Absctract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">to recognize clinical and pathological variables that influence in bladder cancer specific mortality in patients with transitional bladder cancer treated with radical cystectomy.</p> <span class="elsevierStyleSectionTitle">Matherial and Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">retrospective analysis of 333 patients with transitional bladder cancer treated with radical cystectomy. Variables included during pre-cystectomy, peri-cystectomy and post-cystectomy period were analyzed. Four groups were defined based on pathological state: a) Organ-confine bladder cancer without lymph node metastasis (pT0-2, pN0); b) Extravesical desease without lymph node metastasis (pT3-4, pN0); c) Bladder cancer with lymph node metastasis (pT0-4, pN+); d) No data of lymph node affection (pT0-4, pNx). Univariate analysis and two models of multivariate analysis were performed including the risk group as a variable in one the latest.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Mean follow up was 52.6 ± 51 (2-221) months with a median of 31 months. Pathological state pT0 was observed in 7.2% of the patients, 12% were pT1, 26.7% pT2, 34.5% pT3 and 10.5% pT4. Lymph node metastasis was detected in 20.7% of the patients. Lymph node metastasis increased according to pathological state rises. Five and 10 years specific survival was 57% and 54% respectively.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Local pathological state, lymph node status and risk groups were independent predictive factors for bladder cancer specific survival. Risk group association is a reliable method to predict bladder cancer specific survival and to identify the suitable patient group to get benefit from adjuvant therapy.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Globocan 2002. International Agency for research on Cancer. Acceso Junio de 2007. 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| año/Mes | Html | Total | |
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| 2024 Noviembre | 0 | 1 | 1 |
| 2024 Octubre | 0 | 8 | 8 |
| 2024 Septiembre | 0 | 7 | 7 |
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| 2024 Marzo | 0 | 27 | 27 |
| 2024 Febrero | 0 | 15 | 15 |
| 2024 Enero | 0 | 9 | 9 |
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| 2023 Noviembre | 0 | 33 | 33 |
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| 2023 Septiembre | 0 | 12 | 12 |
| 2023 Agosto | 0 | 32 | 32 |
| 2023 Julio | 0 | 61 | 61 |
| 2023 Junio | 0 | 19 | 19 |
| 2023 Mayo | 0 | 6 | 6 |
| 2023 Abril | 0 | 12 | 12 |
| 2023 Marzo | 0 | 22 | 22 |
| 2023 Febrero | 0 | 21 | 21 |
| 2023 Enero | 0 | 4 | 4 |
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| 2022 Noviembre | 0 | 13 | 13 |
| 2022 Octubre | 0 | 9 | 9 |
| 2022 Septiembre | 0 | 22 | 22 |
| 2022 Agosto | 0 | 8 | 8 |
| 2022 Julio | 0 | 4 | 4 |
| 2022 Junio | 0 | 11 | 11 |
| 2022 Mayo | 0 | 9 | 9 |
| 2022 Abril | 0 | 7 | 7 |
| 2022 Marzo | 0 | 4 | 4 |
| 2022 Febrero | 0 | 1 | 1 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 9 | 9 |
| 2021 Noviembre | 0 | 1 | 1 |
| 2021 Septiembre | 0 | 1 | 1 |
| 2021 Agosto | 0 | 4 | 4 |
| 2021 Julio | 0 | 2 | 2 |
| 2021 Junio | 0 | 3 | 3 |
| 2021 Mayo | 0 | 1 | 1 |
| 2021 Abril | 0 | 3 | 3 |
| 2021 Marzo | 0 | 4 | 4 |
| 2021 Febrero | 0 | 2 | 2 |
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| 2020 Noviembre | 0 | 1 | 1 |
| 2020 Octubre | 0 | 1 | 1 |
| 2020 Septiembre | 0 | 6 | 6 |
| 2020 Agosto | 0 | 5 | 5 |
| 2020 Julio | 0 | 4 | 4 |
| 2020 Junio | 0 | 1 | 1 |
| 2020 Mayo | 0 | 2 | 2 |
| 2020 Abril | 0 | 11 | 11 |
| 2020 Marzo | 0 | 4 | 4 |
| 2020 Febrero | 0 | 13 | 13 |
| 2020 Enero | 0 | 5 | 5 |
| 2019 Diciembre | 0 | 20 | 20 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 0 | 13 | 13 |
| 2019 Junio | 0 | 18 | 18 |
| 2019 Mayo | 0 | 51 | 51 |
| 2019 Abril | 0 | 43 | 43 |
| 2019 Marzo | 0 | 11 | 11 |
| 2019 Febrero | 0 | 13 | 13 |
| 2019 Enero | 0 | 4 | 4 |
| 2018 Diciembre | 0 | 6 | 6 |
| 2018 Noviembre | 0 | 14 | 14 |
| 2018 Octubre | 0 | 7 | 7 |
| 2018 Septiembre | 0 | 2 | 2 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Marzo | 1 | 1 | 2 |
| 2018 Febrero | 0 | 1 | 1 |
| 2018 Enero | 0 | 1 | 1 |
| 2017 Diciembre | 0 | 2 | 2 |
| 2017 Noviembre | 0 | 6 | 6 |
| 2017 Octubre | 4 | 3 | 7 |
| 2017 Septiembre | 4 | 5 | 9 |
| 2017 Agosto | 6 | 7 | 13 |
| 2017 Julio | 5 | 2 | 7 |
| 2017 Junio | 8 | 5 | 13 |
| 2017 Mayo | 12 | 2 | 14 |
| 2017 Abril | 4 | 2 | 6 |
| 2017 Marzo | 5 | 5 | 10 |
| 2017 Febrero | 6 | 1 | 7 |
| 2017 Enero | 2 | 2 | 4 |
| 2016 Diciembre | 20 | 3 | 23 |
| 2016 Noviembre | 24 | 10 | 34 |
| 2016 Octubre | 37 | 13 | 50 |
| 2016 Septiembre | 12 | 20 | 32 |
| 2016 Agosto | 10 | 2 | 12 |
| 2016 Julio | 9 | 14 | 23 |
| 2016 Junio | 14 | 15 | 29 |
| 2016 Mayo | 15 | 17 | 32 |
| 2016 Abril | 9 | 20 | 29 |
| 2016 Marzo | 12 | 25 | 37 |
| 2016 Febrero | 8 | 21 | 29 |
| 2016 Enero | 13 | 28 | 41 |
| 2015 Diciembre | 16 | 17 | 33 |
| 2015 Noviembre | 15 | 3 | 18 |
| 2015 Octubre | 22 | 10 | 32 |
| 2015 Septiembre | 7 | 4 | 11 |
| 2015 Agosto | 6 | 4 | 10 |
| 2015 Julio | 7 | 4 | 11 |
| 2015 Junio | 3 | 1 | 4 |
| 2015 Mayo | 7 | 4 | 11 |
| 2015 Abril | 10 | 9 | 19 |
| 2015 Marzo | 3 | 1 | 4 |
| 2015 Febrero | 9 | 8 | 17 |
| 2015 Enero | 7 | 6 | 13 |
| 2014 Diciembre | 10 | 15 | 25 |
| 2014 Noviembre | 4 | 1 | 5 |
| 2014 Octubre | 9 | 6 | 15 |
| 2014 Septiembre | 12 | 1 | 13 |
| 2014 Agosto | 9 | 2 | 11 |
| 2014 Julio | 12 | 2 | 14 |
| 2014 Junio | 5 | 6 | 11 |
| 2014 Mayo | 3 | 1 | 4 |
| 2014 Abril | 4 | 4 | 8 |
| 2014 Marzo | 6 | 3 | 9 |
| 2014 Febrero | 4 | 5 | 9 |
| 2014 Enero | 4 | 1 | 5 |
| 2013 Diciembre | 6 | 1 | 7 |
| 2013 Noviembre | 12 | 3 | 15 |
| 2013 Octubre | 3 | 2 | 5 |
| 2013 Septiembre | 7 | 2 | 9 |
| 2013 Agosto | 6 | 2 | 8 |
| 2013 Julio | 2 | 0 | 2 |
| 2009 Marzo | 324 | 0 | 324 |
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