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"apellidos" => "Rivas" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Parente" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Fanjul" ] 4 => array:2 [ "nombre" => "J.M." "apellidos" => "Angulo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Urología Infantil, Servicio de Cirugía Pediátrica, Hospital Materno Infantil Gregorio Marañón, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Es la inyección de toxina botulínica-A en el detrusor una alternativa a la ampliación vesical en niños" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-04-22" "fechaAceptado" => "2010-08-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85419" "palabras" => array:5 [ 0 => "Neurogenic bladder dysfunction" 1 => "Non-neurogenic bladder dysfunction" 2 => "Urinary incontinence" 3 => "Bladder augmentation" 4 => "Botulinum toxin" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85420" "palabras" => array:5 [ 0 => "Disfunción vesical neurógena" 1 => "Disfunción vesical no-neurógena" 2 => "Incontinencia urinaria" 3 => "Ampliación vesical" 4 => "Toxina botulínica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bladder dysfunction causes urinary incontinence and kidney damage in children. When treatment with anticholinergics and intermittent bladder catheterization fails, the alternative therapy is bladder augmentation.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Between 2005 and 2009, a prospective study was carried out with Botox<span class="elsevierStyleSup">®</span> injected into the detrusor of children suffering from high-pressure bladder despite anticholinergic treatment. We assessed their urodynamic, clinical and radiological evolution prior to and at 4 weeks, 6 months and 1 year after the injection (10<span class="elsevierStyleHsp" style=""></span>u/kg of weight up to 300<span class="elsevierStyleHsp" style=""></span>u). Reinjection was indicated in the event of clinical or urodynamic worsening. We employed the Wilcoxon test to statistically analyze the urodynamic parameters.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">12 patients were treated, 11 with neurogenic bladder (91.7%) and 1 with posterior urethral valves (8.4%). The mean age was 12.6 (4.3–17.8) years and follow-up took place after 40.8 (16.9–45–7) months. Bladder capacity, detrusor compliance and pressure improved after 4 weeks in all the patients except in 2 (16.7%). This improvement decreased after 6 months, although successive injections produced similar changes. One patient (8.3%) received 1 dose, six (50%) two doses and five (41.7%) received three. Clinical and urodynamic improvement in 8 patients (66.7%) prevented bladder augmentation.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Repeated botulinum toxin injection in the detrusor is a therapeutic instrument for high pressure and hypocompliant bladders in children. It could replace bladder augmentation in some cases, however further studies with long-term follow-up care are required to appropriately evaluate its safety and effectiveness.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La disfunción vesical causa incontinencia urinaria y daño renal en niños. Cuando el tratamiento con anticolinérgicos y cateterismo vesical intermitente fracasa, la alternativa terapéutica es la ampliación vesical.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Entre 2005 y 2009 se ha realizado un estudio prospectivo con Botox<span class="elsevierStyleSup">®</span> inyectado en el detrusor de niños por disfunción vesical con alta presión a pesar del tratamiento anticolinérgico. Se valora la evolución urodinámica, clínica y radiológica, antes y a las 4 semanas, 6 meses y 1 año tras la inyección (10<span class="elsevierStyleHsp" style=""></span>U/kg de peso hasta 300<span class="elsevierStyleHsp" style=""></span>U). La reinyección se indicó ante empeoramiento clínico o urodinámico. Se empleó test de Wilcoxon para el análisis estadístico de los parámetros urodinámicos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se trataron 12 pacientes, 11 de causa neurógena (91,7%) y 1 por válvulas de uretra posterior (8,4%). La mediana de edad fue 12,6 (4,3–17,8) años y el seguimiento 40,8 (16,9–45,7) meses. A las 4 semanas se produjo mejoría en capacidad vesical, acomodación y presión del detrusor en todos los pacientes salvo en 2 (16,7%). Esta mejoría fue disminuyendo a partir de 6 meses, aunque inyecciones sucesivas produjeron cambios similares. Un paciente (8,3%) recibió 1 dosis, seis (50%) 2 y cinco (41,7%) 3. En 8 pacientes (66,7%) la mejoría clínica y urodinámica permitió evitar ampliación vesical.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La inyección de toxina botulínica repetida en detrusor es una herramienta terapéutica frente a disfunciones vesicales con alta presión y baja acomodación en niños. Puede sustituir a la ampliación vesical en algunos casos, pero se necesitan estudios con largo seguimiento para evaluar apropiadamente su seguridad y eficacia.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Injection of botulinum toxin (BTX-A) in children with bladder dysfunction due to detrusor overactivity
Es la inyección de toxina botulínica-A en el detrusor una alternativa a la ampliación vesical en niños
R.M. Romero
, S. Rivas, A. Parente, M. Fanjul, J.M. Angulo
Autor para correspondencia
Sección de Urología Infantil, Servicio de Cirugía Pediátrica, Hospital Materno Infantil Gregorio Marañón, Madrid, Spain