Información de la revista
Vol. 28. Núm. 6.
Páginas 307-309 (octubre 2000)
Vol. 28. Núm. 6.
Páginas 307-309 (octubre 2000)
Acceso a texto completo
The inverse association between serum anti-streptolysin-O titers and the frequency of exacerbations of asthma in childhood
Visitas
2501
a Fellow. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
b Fellow. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
c Resident. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
d Doctor of Philosophy. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
e Associate Professor. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
f *****Professor of Pediatrics. Marmara University Hospital, Department of Pediatrics, Division of Pediatric Allergy/Immunology, Istanbul, Turkey.
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Background: the decline in infections in childhood may contribute to the rising severity and prevalence of atopic disorders in developed countries. Support for this hypothesis has been obtained from findings of an inverse association between tuberculin responses and atopy and from findings of high prevalence of asthma in certain islands with low prevalence of respiratory infections. With this regard, we investigated the association between serum antistreptolysin- O (ASO) titers and the frequency of exacerbations of asthma in childhood. Methods: thirty atopic asthmatic children who has no sign of upper respiratory tract infection at the time of presentation or during the previous two months were included in the study. Serum ASO titer was measured as an indicator of past streptococcal upper respiratory tract infections. ASO titer > or = 200 Todd units was accepted as positive. Results: a statistically significant association is found between high anti-streptolysin-O titers and decreased number of exacerbations in those children. Conclusions: our data suggests that streptococcal infections might be a factor attenuating asthma in childhood.
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