Papel de los polimorfismos del promotor del gen de la interleucina-10 en la génesis de los aneurismas de la aorta abdominal

Información del artículo

Resumen

Introducción

La interleucina-10 (IL-10) es una citocina antiinflamatoria que se ha implicado en la patogenia de los aneurismas de la aorta abdominal (AAA). Se han descrito variaciones en el promotor de su gen que pueden condicionar su producción, y alterar el equilibrio entre citocinas pro y antiinflamatorias.

Objetivo

Estudiar el genotipo de los microsatélites y polimorfismos del promotor de la IL-10 para valorar las posibles predisposiciones genéticas en la población española portadora de un AAA.

Sujetos y métodos

Se realizó el tipado de los microsatélites asociados (IL-10R e IL-10G) y de las tres posiciones polimórficas (-1082, -819, -592) del promotor de la IL-10 en un grupo de 72 pacientes con un AAA, y se comparó con una muestra control de 349 sujetos sanos.

Resultados

Microsatélites asociados: no se encontraron diferencias significativas al analizar el patrón fenotípico de los microsatélites IL-10G e IL-10R entre los pacientes con un AAA y el grupo control. Polimorfismos puntuales: no se encontraron diferencias significativas al analizar los diferentes haplotipos del promotor del gen de la IL-10 entre los pacientes con un AAA y el grupo control.

Conclusiones

A la vista de nuestros resultados, en la población española no existe una relación entre ninguno de los diferentes alelos de los microsatélites IL-10R e IL-10G asociados al promotor de la IL-10 y la presencia de un AAA en dicha población. Tampoco existe una relación entre los diferentes haplotipos del promotor de la IL-10 y esta enfermedad en nuestro medio.

Palabras clave:

Aneurismas de aorta abdominal

Autoinmunidad

Interleucina-10

Polimorfismos

Summary

Introduction

The anti-inflammatory cytokine interleukin-10 (IL-10) has been implicated in the pathogenesis of the abdominal aortic aneurysm (AAA). Changes in the promoter region of the IL-10 gene have been found to condition its production, altering the balance between pro- and anti-inflammatory cytokines.

Aim

Associated microsatellites and polymorphisms in the IL-10 promoter were typed in an attempt to identify a possible genetic predisposition for AAA in the Spanish population.

Subjects and methods

Associated microsatellites (IL-10R and IL-10G) and the three polymorphic loci (-1082, -819, -592) of the IL-10 promoter were determined in 72 patients with AAA and compared with those established in 349 healthy control subjects.

Results

No significant differences were observed between the AAA and control group in the phenotypic patterns shown by the microsatellites IL-10G and IL-10R nor in the different haplotypes of the IL-10 gene promoter.

Conclusions

Our findings suggest no relationship between the different alleles of the IL-10R and IL-10G microsatellites and AAA in the Spanish population. We were also unable to detect a clear association between the different IL-10 promoter haplotypes and this disease.

Key words:

Aortic abdominal aneurysm

Autoimmunity

Interleukin-10

Polimorphisms

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