metricas
covid
Buscar en
Annals of Hepatology
Toda la web
Inicio Annals of Hepatology “CLIF-C ACLF mortality predictive utility in patients with acute liver failure...
Información de la revista
Vol. 19. Núm. S1.
Abstracts of the 2020 Annual meeting of the Mexican Association of Hepatology (AMH) – XV Congreso Nacional de Hepatología (23-25 de julio)
Páginas 12-13 (septiembre 2020)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 19. Núm. S1.
Abstracts of the 2020 Annual meeting of the Mexican Association of Hepatology (AMH) – XV Congreso Nacional de Hepatología (23-25 de julio)
Páginas 12-13 (septiembre 2020)
25
Open Access
“CLIF-C ACLF mortality predictive utility in patients with acute liver failure in chronic “ACLF” in the hospital Juarez de Mexico population
Visitas
716
J. Moreira-Alcívar, M. Mejía-Loza, C. Asencio-Barrientos, H. Citalan-Poroj, J. Hernández-Solís
Gastroenterology, Juárez Hospital of Mexico, Mexico City, Mexico
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo

Background and aim: ACLF is a condition associated with high mortality. The CANONIC trial developed a score that classifies the ACLF grade according to the number of extrahepatic organic failures. Useful to determine prognosis of mortality with 33% ACLF-1, 35% ACLF-2 and 74% ACLF-3. Furthermore, it was identified that a score >70 at admission is associated with a 90% mortality in 90 days. That is why we consider it relevant to objectify the risk of mortality associated with the degree of complication in our population. Aim: To determine ACLF grade and CLIF-C score that predicts 28-day mortality in patients with chronic acute liver failure at the Juárez hospital in Mexico.

Material and methods: Retrospective descriptive observational study of patients diagnosed with ACLF according to the criteria of European and American associations, 2019 records were reviewed, severity was classified according to CLIF-C, survival curves were assessed using the Kaplan-Meier method and Cox Regression with the SPSS statistical program.

Results: In our study, 58 patients who met ACLF criteria were collected, of these 36.2% (n 21) ACLF-1, 39.7% (n 23) ACLF-2, 24.1% (n 14) ACLF-3. Survival curves were performed using the Kaplan-Meier method, reporting a 28-day survival of 25%, 18%, and 7.7%, respectively. It was compared between these without showing statistical significance (p=0.25). It was decided to carry out a multivariate analysis using the Cox regression method, analyzing the degree of ACLF, CLIF-C score, age, sex, infection, gastrointestinal bleeding, acute kidney injury (AKI), resulting among these that AKI is the only variable with significant association in survival (p=0.017).

Conclusions: In our population, it was identified that there is no significant statistical impact on survival between ACLF grades, nor the number of organic failures (Clif-C score). The presence of LRA proved to be a better independent predictor of mortality.

Conflicts of interest: The authors have no conflicts of interest to declare.

Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos