Abstracts from XVII Mexican Congress of Hepatology
Más datosACLF is a syndrome characterized by acute decompensation of hepatic cirrhosis, organ failure(s) and high short-term mortality. The most used diagnostic criteria are those proposed by EASL-CLIF, according to the CANONIC study. This study aimed to compare severity scales and mortality according to ACLF grade.
Materials and MethodsRetrospective analysis of patients with hepatic cirrhosis admitted consecutively to the Gastroenterology Department of CMNO. ACLF diagnosis was made according to EASL-CLIF criteria; patients were followed for 28 days. As to statistical analysis, Anova or Kruskal Wallis was used for continuous variables and Chi-Square for categorical variables. Significance was set at p<0.05.
ResultsOf 268 admitted patients with hepatic cirrhosis, 87 (32.4%) met ACLF criteria, of which 45 (51.7%) were female, with a mean age of 61.7 years (10.4 SD). The most common cirrhosis etiology was alcoholic, followed by chronic HCV infection. As to ACLF grade, 40 patients (45.9%) were grade 1, 17 (19.5%) grade 2 and 30 (34.4%) grade 3. Statistically significant differences were found in Child-Pugh, CLIF-C and MELD-Na, as well as in 28 days mortality (p<.0001) and biochemical variables (Table 1).
DiscussionOur study found higher mortality than that reported in other series, probably due to the availability of liver transplants.
ConclusionACLF is an entity related to high short-term mortality.
FundingThe resources used in this study were from the hospital without any additional financing
Declaration of interestThe authors declare no potential conflicts of interest.
Table 1.- Patient characteristics according to ACLF grade. Variables are reported as mean and standard deviation (SD) or median and interquartile range according to their distribution.
