metricas
covid
Buscar en
Annals of Hepatology
Toda la web
Inicio Annals of Hepatology DIFFERENTIAL PROFILE OF PRO-INFLAMMATSORY / ANTI-INFLAMMATORY CYTOKINES AND MALO...
Información de la revista
Vol. 27. Núm. S2.
Oral presentations at the XVI National Congress of the Mexican Association of Hepatology
(enero 2021)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 27. Núm. S2.
Oral presentations at the XVI National Congress of the Mexican Association of Hepatology
(enero 2021)
Open Access
DIFFERENTIAL PROFILE OF PRO-INFLAMMATSORY / ANTI-INFLAMMATORY CYTOKINES AND MALONDIALDEHYDE IN PATIENTS WITH ALCOtHOL-INDUCED OR OBESITY OR MIXED INJURY
Visitas
409
L. Torres-González1, L.R. Aguilar Rivera2, D.P. Moreno-Peña1, O.H. Mendoza Hernández1, A.A. Lugo Rodriguez1, M.E. Posada Lerma2, L.E. Muñoz Espinosa1, H. Nañez Terreros2, P. Cordero-Pérez1
1 Unidad de Hígado, Universidad Autónoma de Nuevo León. Nuevo León, Monterrey, México
2 Departamento de Medicina Interna. Facultad de Medicina y Hospital Universitario “Dr. José E. González”, Monterrey, Nuevo León, México
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Resumen
Texto completo
Descargar PDF
Estadísticas
Figuras (1)
Suplemento especial
Este artículo forma parte de:
Vol. 27. Núm S2

Oral presentations at the XVI National Congress of the Mexican Association of Hepatology

Más datos
Introduction and Objectives

Dysregulation of pro-inflammatory/anti-inflammatory cytokines and oxidative stress markers has been reported in Non-Alcoholic Steatohepatitis (NASH) and alcoholic steatohepatitis (ASH); however, in the disease recently known, as Both Alcoholic and Non-Alcoholic SteatoHepatitis (BASH) that meets the criteria of ASH and NASH have not been described. The objective was to evaluate the influence of alcohol and obesity on a differential profile of cytokines and malondialdehyde (MDA) in patients with these etiologies.

Material and methods

Cross-sectional, prospective, observational study. Patients from the “Dr. José E. González” from March 2019-March 2020, with a diagnosis of ASH (alcohol consumption ≥ 5 years, 30 g/day for men and 20 g/day for women), NASH (demonstrated by ultrasound, FibroScan or FibroMax) and BASH (ASH and NASH criteria). The serum cytokines interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-10 (IL-10) and malondialdehyde (MDA) were determined. The protocol was approved by the ethics committee with registration MI19-000016.One-way analysis of variance was performed with Kruskal-Wallis and Dunn's post hoc. The results were expressed as median (interquartile range). The analysis was performed using Graph Pad Prism (v. 7.04, San Diego, CA, USA). A value of p<0.05 was considered significant.

Results

The patients were: 34 BASH, 43 NASH and 35 ASH. The severity of the patients with respect to clinical and biochemical parameters in increasing order was NASH p <0.0001), TNF-α (B; p=0.0014), IL-8 (C; p<0.0001), IL-10 (D; p<0.0001) and IL-1β (E; Not significant) in the different study groups.

Discussion

In ASH and NASH, common pathogenetic mechanisms mediated by pro-inflammatory.

The authors declare that there is no conflict of interest.

Texto completo

Figure. Serum levels of IL-6 (A; p <0.0001), TNF (B; p= 0.0014), IL-8 (C; p<0.0001), IL-10 (D; p<0.0001) and IL-1β (E; NS) in the different study groups. The values were expressed as median (interquartile range). NS: not significant.

Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.aohep.2020.08.021
No mostrar más