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Inicio Annals of Hepatology DIFFERENTIAL PROFILE OF PRO-INFLAMMATSORY / ANTI-INFLAMMATORY CYTOKINES AND MALO...
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Vol. 27. Núm. S2.
Oral presentations at the XVI National Congress of the Mexican Association of Hepatology
(enero 2021)
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Vol. 27. Núm. S2.
Oral presentations at the XVI National Congress of the Mexican Association of Hepatology
(enero 2021)
Open Access
DIFFERENTIAL PROFILE OF PRO-INFLAMMATSORY / ANTI-INFLAMMATORY CYTOKINES AND MALONDIALDEHYDE IN PATIENTS WITH ALCOtHOL-INDUCED OR OBESITY OR MIXED INJURY
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L. Torres-González1, L.R. Aguilar Rivera2, D.P. Moreno-Peña1, O.H. Mendoza Hernández1, A.A. Lugo Rodriguez1, M.E. Posada Lerma2, L.E. Muñoz Espinosa1, H. Nañez Terreros2, P. Cordero-Pérez1
1 Unidad de Hígado, Universidad Autónoma de Nuevo León. Nuevo León, Monterrey, México
2 Departamento de Medicina Interna. Facultad de Medicina y Hospital Universitario “Dr. José E. González”, Monterrey, Nuevo León, México
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Vol. 27. Núm S2

Oral presentations at the XVI National Congress of the Mexican Association of Hepatology

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Introduction and Objectives

Dysregulation of pro-inflammatory/anti-inflammatory cytokines and oxidative stress markers has been reported in Non-Alcoholic Steatohepatitis (NASH) and alcoholic steatohepatitis (ASH); however, in the disease recently known, as Both Alcoholic and Non-Alcoholic SteatoHepatitis (BASH) that meets the criteria of ASH and NASH have not been described. The objective was to evaluate the influence of alcohol and obesity on a differential profile of cytokines and malondialdehyde (MDA) in patients with these etiologies.

Material and methods

Cross-sectional, prospective, observational study. Patients from the “Dr. José E. González” from March 2019-March 2020, with a diagnosis of ASH (alcohol consumption ≥ 5 years, 30 g/day for men and 20 g/day for women), NASH (demonstrated by ultrasound, FibroScan or FibroMax) and BASH (ASH and NASH criteria). The serum cytokines interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-10 (IL-10) and malondialdehyde (MDA) were determined. The protocol was approved by the ethics committee with registration MI19-000016.One-way analysis of variance was performed with Kruskal-Wallis and Dunn's post hoc. The results were expressed as median (interquartile range). The analysis was performed using Graph Pad Prism (v. 7.04, San Diego, CA, USA). A value of p<0.05 was considered significant.

Results

The patients were: 34 BASH, 43 NASH and 35 ASH. The severity of the patients with respect to clinical and biochemical parameters in increasing order was NASH p <0.0001), TNF-α (B; p=0.0014), IL-8 (C; p<0.0001), IL-10 (D; p<0.0001) and IL-1β (E; Not significant) in the different study groups.

Discussion

In ASH and NASH, common pathogenetic mechanisms mediated by pro-inflammatory.

The authors declare that there is no conflict of interest.

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Figure. Serum levels of IL-6 (A; p <0.0001), TNF (B; p= 0.0014), IL-8 (C; p<0.0001), IL-10 (D; p<0.0001) and IL-1β (E; NS) in the different study groups. The values were expressed as median (interquartile range). NS: not significant.

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