Etiology and find in portal vein thrombosis at the Hospital de Especialidades del Centro Médico Nacional La Raza

Introduction and Objectives

To assess the reasons and forms of presentation and to correlate disease status to the degree of spread and outcome.

Materials and methods

Descriptive and retrospective study was performed on patients with DVT by review of clinical records. The patient was divided into non-cirrhotic, cirrhotic and cirrhotic with hepatocarcinoma; age, gender, a form of diagnosis, degree of spread of thrombosis and outcome were assessed. Qualitative variables were expressed as frequency and percentage, and numerical variables as means and standard deviation.

Results

We studied sixteen patients with a median age of 61 years. 3 (18.75%) were non-cirrhotic, 7 (43.75%) were cirrhotic and 6 (37.5%) were cirrhotic with hepatocarcinoma, 4 (30. 76%) due to HCV, 2 (15.38%) autoimmune, 1 (7.69%) due to alcohol, 1 (7.69%) MAFLD, mixed in 2 patients and 3 (23.07%) undetermined. Non-cirrhotic patients, 1 (33.33%) protein C deficiency, 1 (33.33%) antithrombin deficiency; 100% with abdominal pain, the cirrhosis without HCC, 2 (28.57%) were asymptomatic and 5 (71.4%) with decompensation, the patients with CH+HCC, 3 (50%) with encephalopathy. Complete DVT was onset in 14 (87.5%) and in 2 (12.5%), it was partially. It was located in the PV and/or its intrahepatic branches in 13 (81.2%) and in 3 (18.75%) extensions to the superior mesenteric vein and/or splenic vein. Patients without cirrhosis all received anticoagulant treatment; of patients with DVT with cirrhosis with or without HCC, 53% received treatment. They were mainly being treated with low-molecular weight heparin, and oral anticoagulants. In cirrhotic patients, 8 (61.52%) died as compared to non-cirrhotic patients who were discharged.

Conclusions

In our setting, DVT was more frequent in patients with cirrhosis, particularly those with late liver disease and HCC, with uncompensation as the main clinical manifestation in this group of patients.

Funding

The resources used in this study were from the hospital without any additional financing

Declaration of interest

The authors declare no potential conflicts of interest.