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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
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Vol. 27. Núm. S3.
Abstracts from XVII Mexican Congress of Hepatology
(diciembre 2022)
Open Access
MMP-7 is a non-invasive biomarker of chronic liver diseases
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D Montes de Oca-Angeles1, M Lemus-Peña1, A Hernandez-Barragan1, M Hernández-Santillán1, M Martinez-Castillo1, D Santana-Vargas2, Z Medina-Avila1, A Torre-Delgadillo2, JL Pérez-Hernández2, F Higuera-De la Tijera2, P Cordero-Pérez3, L Muñoz-Espinosa3, D Kershenobich4, G Gutiérrez-Reyes1
1 Liver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. Mexico
2 Department of Gastroenterology. General Hospital of Mexico “Dr. Eduardo Liceaga.” México City. México
3 Universitary Hospital “Dr. José Eluterio González”. School of Medicine. UANL. Nuevo Leon. México City. México
4 National Institute of Medical Sciences and Nutrition “Salvador Zubirán.” Mexico City. Mexico
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Vol. 27. Núm S3

Abstracts from XVII Mexican Congress of Hepatology

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Introduction and Objectives

This study aimed to evaluate serum concentrations of MMP-7 in different liver etiologies and according to fibrosis stage.

Materials and methods

A cross-sectional and multicenter study was carried out, including subjects with alcoholism (WHO criteria), without (OH) and with liver injury (cirrhosis, CiOH); diagnosed by clinical, biochemical data, non-alcoholic fatty liver (NAFLD) and chronic Hepatitis C (CHC). Transitional elastography (Fibroscan) was performed in NAFLD and CHC, considering mild fibrosis (MF: F0, F1, F2) and advanced fibrosis (AF: F3, F4). As controls, subjects without alcohol consumption (CT) were recruited. For the quantification of MMP-7, Multiplex-MERCK© was used. Statistical analysis was performed using SPSS V.22 using Mann Whitney U, p<0.05.

Results

It was included 99 subjects (OH); 45 (CiOH); 48 (CHC, FL); 54 (CHC, FA); 27 (NAFLD, FL); 36 (NAFLD, AF) and 131 CT. MMP-7 was found to be elevated in CHC (FL and FA), vs. CT; and decreased in OH, CiOH, NAFLD (FL and FA) vs. CT, plus there are significant differences between all etiologies, p<0.001.

Discussion

MMP-7 is a matrilysin that degrades extracellular matrix products (proteoglycans); it increases significantly in subjects with CHC compared to CT, while in other pathologies with stages, even in advanced fibrosis, the levels are decreased compared to CT.

Conclusion

The increased MMP-7 in serum of chronic Hepatitis C and decreased in alcoholism and non-alcoholic fatty liver patients suggests that, according to the etiology, the levels can be useful to make a differential diagnosis. It is a potential non-invasive biomarker.

Funding

This work was partially financed by CONACyT SALUD-2016-272579 and PAPIIT- UNAM TA200515.

Declaration of interest

The authors declare no potential conflicts of interest.

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