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Inicio Annals of Hepatology O-10 PRIMARY BILIARY CHOLANGITIS PATIENTS DIAGNOSED BY DIFFERENT COMBINATIONS OF...
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
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Vol. 24. Núm. S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(septiembre 2021)
Open Access
O-10 PRIMARY BILIARY CHOLANGITIS PATIENTS DIAGNOSED BY DIFFERENT COMBINATIONS OF THE DIAGNOSTIC CRITERIA PRESENT CLINICAL AND LABORATORY PECULIARITIES
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Guilherme G.L. Cançado1,2, Eduardo L.R. Cançado3, Maria L.G. Ferraz4, Cristiane A. Villela-Nogueira5, Debora R.B. Terrabuio3, Michelle H. Braga3, Mateus J. Nardelli1, Luciana C. Faria1, Nathalia M.F. GOMES4, ELZE M.G. Oliveira4, Vivian Rotman5, Maria Beatriz Oliveira6, Simone M.C.F. Cunha7, Daniel F. Mazo8, Liliana S.C. Mendes9, Claudia A.P. Ivantes10, Valéria Faborges11,12, Fabio H.L. Pace13, Mario G. Pessoa3, Izabelle V. Signorelli14..., Gabriela P. Coral15, Paulo L. Bittencourt16,17, Cynthia Levy18, Cláudia A. Couto1, Members of the Brazilian Cholestasis Study Group Consortium1Ver más
1 Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
2 Hospital da Polícia Militar de Minas Gerais, Belo Horizonte, Brazil
3 Departamento de Gastroenterologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
4 Disciplina de Gastroenterologia, Universidade Federal de São Paulo, São Paulo, Brazil
5 Hospital Universitário Clementino Fraga Filho e Departamento de Clínica Médica da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
6 Ambulatório Municipal de Hepatites Virais de São José dos Campos, São José dos Campos, Brazil
7 Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil
8 Divisão de Gastroenterologia (Gastrocentro), Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil
9 Hospital de Base do Distrito Federal, Brasília, Brazil
10 Serviço de Gastroenterologia, Hepatologia e Transplante Hepático, Hospital Nossa Senhora das Graças, Curitiba, Brazil
11 Instituto de Gastroenterologia, Endoscopia e Proctologia, Uberlândia, Brazil
12 Universidade Federal de Uberlândia, Uberlândia, Brazil
13 Serviço de Gastroenterologia e Hepatologia, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
14 Hospital Universitário Cassiano Antônio Moraes, Universidade Federal do Espírito Santo, Vitória, Brazil
15 Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil
16 Hospital Português, Salvador, Brazil
17 Escola Bahiana de Medicina e Saúde Pública
18 Division of Digestive Health and Liver Diseases, University of Miami Miller School of Medicine, Miami, Florida, United States of America
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Table. Comparison of PBC Features according to Different Combinations of Diagnostic Criteria
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Vol. 24. Núm S1

Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)

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Introduction

Primary biliary cholangitis (PBC) diagnosis is based on international criteria, which requires two of the following: (i) elevated alkaline phosphatase (AP), (ii) anti-mitochondrial antibody (AMA) and (iii) liver biopsy (BX) suggestive of PBC. It is still unclear if patients diagnosed by different criteria combinations present peculiarities, especially in highly-admixed populations.

Objectives

To investigate if patients diagnosed with PBC by different combinations of validated criteria present clinical or laboratory particularities.

Methods

The Brazilian Cholestasis Study Group database was reviewed to compare clinical, biochemical and histological characteristics of PBC between four groups diagnosed by: (1) AP ≥2x upper limit of normality (ULN) + presence of AMA, (2) AP ≥2x ULN + BX suggestive of PBC, (3) presence of AMA + BX suggestive of PBC and (4) all criteria.

Results

482 patients with PBC were included (Table 1). Group-1 presented with higher levels of IgG, lower frequency of arterial hypertension (AH) and lower response to ursodeoxycholic acid (UDCA), while Group-2 had lower: age at diagnosis and HDL-C levels. Group-3 had higher: age at diagnosis, frequency of neoplasms, AH and response to UDCA; and lower: frequency of pruritus and jaundice, levels of aminotransferases, GGT and bilirubin, advanced liver disease and esophageal varices. Group-4 showed higher frequency of symptoms at presentation, especially pruritus.

Conclusion

PBC patients diagnosed by different combinations of established criteria may present singular features that can possibly impact in disease presentation and progression.

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