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Inicio Annals of Hepatology O-20 EFFECTS OF ISOCALORIC AND NEGATIVE CALORIE BALANCE EXERCISE ON SERUM LEVELS...
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Vol. 29. Núm. S1.
Abstracts of the 2023 Annual Meeting of the ALEH
(febrero 2024)
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Vol. 29. Núm. S1.
Abstracts of the 2023 Annual Meeting of the ALEH
(febrero 2024)
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O-20 EFFECTS OF ISOCALORIC AND NEGATIVE CALORIE BALANCE EXERCISE ON SERUM LEVELS OF INSULIN-LIKE GROWTH FACTOR TYPE 1 IN SUBJECTS WITH INITIAL AND ADVANCED FATTY LIVER
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María Jesús Fuenzalida1, Francisco Barrera1, Hermann Mies1, Valeria Correa1, Francisca Allendes1, Nancy Solis1, Vanessa Oyarzún1, Luis Antonio Díaz1, Marco Arrese1, Juan Pablo Arab1, Daniel Cabrera1, Felipe Contreras1, Santiago Riquelme1, Catterina Ferreccio1, Laura Andrea Huidobro1, María De Los Ángeles Spencer1, Macarena Garrido1, Jennifer Loyola1, Paola Correa1, Felipe Sobarzo1..., Paula Silva1, Cristian Herrera2, Franco Godoy1Ver más
1 Gastroenterología, Pontificia Universidad Católica de Chile, Santiago, Chile
2 Centro Avanzado para Enfermedades Crónicas, Pontificia Universidad Católica del Maule, Santiago, Chile
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Vol. 29. Núm S1

Abstracts of the 2023 Annual Meeting of the ALEH

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Introduction and Objectives

Insulin-like growth factor 1 (IGF-1) is a hepatokine that has a protective effect on fatty liver. Previous studies in healthy subjects suggest that isocaloric exercise (with neutral caloric balance) would increase serum levels of IGF-1. This study aimed to evaluate the effect of moderate isocaloric exercise (ICBE) and negative caloric balance exercise (NCBE) on serum levels of IGF-1 in subjects with initial and advanced (F3-4) MAFLD (Metabolic Associated Fatty Liver Disease).

Materials and Methods

Prospective trial in postmenopausal women undergoing supervised and standardized exercise at moderate intensity (1 hour, 3 times per week). The study includes subjects with initial MAFLD (F0-2 Fibroscan <8 kPa) and advanced MAFLD (F3-4, Fibroscan >8 kPa). The protocol consisted of an initial two-week period of ICBE (with nutritional supplement) followed by two weeks of NCBE (without supplement). Using the t-student test for paired samples, the change was analyzed pre vs. post-protocol, and the comparison between groups used the analysis for unpaired samples.

Results

We recruited 27 subjects (20 non-advanced MAFLD and 7 advanced MAFLD). We demonstrated that: (1) Exercise did not significantly increase IGF-1 levels in MAFLD; (2) There was a tendency for subjects with initial MAFLD to have higher IGF-1 levels than subjects with advanced MAFLD before and after exercise, which became significant after 2 weeks of exercise (F0-2 67.9 + 6.4 (ng/mL) versus F3-4 41.2 + 5.3 (ng/mL), p 0.047); and (3) There were no significant differences in IGF-1 levels between ICBE and NCBE (figure 1).

Conclusions

Subjects with advanced MAFLD tend to have lower IGF-1 levels than subjects with initial MAFLD, which becomes significant after 2 weeks of exercise. This suggests that the response to exercise in terms of changes in hepatokines (IGF-1) varies depending on the stage of the disease.

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