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Annals of Hepatology
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Inicio Annals of Hepatology O-26 IMMUNE PROFILING PROVIDES A SET OF 5 CYTOKINES TO DETECT HEPATOCELLULAR CAR...
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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O-26 IMMUNE PROFILING PROVIDES A SET OF 5 CYTOKINES TO DETECT HEPATOCELLULAR CARCINOMA RELATED TO VIRAL HEPATITIS IN SOUTH AMERICAN PATIENTS
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Jose Debes1, Enrique Carrera Estupinan2, Melina Rocio Ferreiro3, Angelo Mattos4, Domingo Balderramo5, Maria Massotti6, Joe Koopmeiners7, Andre Boonstra8
1 Department of Medicine, University of Minnesota, Minneapolis, MN, USA
2 Department of Gastroenterology, Eugenio Espejo Hospital, Quito, Ecuador
3 Department of Gastroenterology, Clinic National Hospital, Buenos Aires, Argentina
4 Department of Gastroenterology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil
5 Department of Gastroenterology, University Private Hospital of Córdoba. University Institute of Biomedical Sciences of Córdoba, Argentina
6 Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA
7 Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA
8 Department of Gastroenterology, Erasmus MC, Rotterdam, the Netherlands
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Vol. 28. Núm S1

Abstracts of the 2022 Annual Meeting of the ALEH

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Introduction and Objectives

New peripheral markers are needed for the early detection of hepatocellular carcinoma (HCC). Currently, the only accepted biomarker is alpha-fetoprotein (AFP) which by itself is suboptimal for early HCC detection. We investigated peripheral immune markers to detect HCC in a large cohort of South American patients and a sub-group of viral hepatitis-related HCC.

Materials and Methods

Through the ESCALON network, we prospectively evaluated 127 individuals with HCC and 113 cirrhotic controls from 3 countries in South America (Argentina, Brazil and Ecuador). 42% of HCC cases were related to viral hepatitis B or C. Blood samples were analyzed for 37 unique interleukins, chemokines and growth factors using a multiplex Bio-Rad platform. We used leave-one-out cross-validation (LOOCV) to compute a ROC curve.

Results

Median age for HCC patients was 68 y/o and for controls 62 y/o. 70% of cases and 55% of controls were males. 55% of HCCs were under 5cm in diameter. The most common causes of HCC were viral hepatitis (42%) and NAFLD (23%). Twenty-two markers showed a significant difference between cases and controls. Three markers (IL-12p40, Beta-NGF and Gro-alpha) were exclusively dysregulated in viral hepatitis related HCC compared to other HCCs. From all causes of HCCs, we identified five cytokines (MIP-3a, MIG, CCL-25, MDC, and HGF) that were differentially regulated in HCCs compared to cirrhosis controls. ROC analysis of the top-5 markers in HCC cases exclusively related to viral hepatitis showed an AUROC of 0.816 (CI 0.783-0.886). The same panel applied to HCC <5cm related to viral hepatitis showed an AUROC of 0.751 (CI 0.671-0.832).

Conclusions

Our study identified a set of 5 cytokines in South American patients that can differentiate HCC from cirrhosis controls in patients with viral hepatitis. The 5 cytokines showed a lower prediction power for HCCs <5cm (likely due to the small size of this cohort).

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