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Inicio Annals of Hepatology P- 105 DETECTION OF HEPATITIS D VIRUS IN PATIENTS WITH CHRONIC HEPATITIS B FROM ...
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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P- 105 DETECTION OF HEPATITIS D VIRUS IN PATIENTS WITH CHRONIC HEPATITIS B FROM SOUTH AMERICA.
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María Belén Pisano1, Viviana E. Ré1, Enrique Carrera2, Domingo Balderramo3, Jhon Prieto4, Javier Díaz-Ferrer5, Marco Arrese6, Angelo Z. Mattos7, José D. Debes8,9, Andre Boonstra9
1 Institute of Virology "Dr. J. M. Vanella", Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina
2 Department of Gastroenterology and Hepatology, Eugenio Espejo Hospital, Quito, Ecuador
3 University Private Hospital of Córdoba. University Institute of Biomedical Sciences of Córdoba, Córdoba, Argentina
4 Cehyd, Bogotá, Colombia
5 San Martín de Porres University, Lima, Perú
6 Catholic University of Chile, Santiago de Chile, Chile
7 Federal University of Medical Sciences of Porto Alegre, Porto Alegre, Brazil
8 University of Minnesota, Minneapolis, USA
9 Erasmus University Hospital Rotterdam, Rotterdam, The Netherlands
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Vol. 28. Núm S1

Abstracts of the 2022 Annual Meeting of the ALEH

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Introduction and Objectives

Worldwide, there is incomplete information about the epidemiology of hepatitis D virus (HDV), a hepatotropic satellite pathogen with an RNA genome, which requires the hepatitis B virus (HBV) as a collaborating agent for its transmission and spread. HDV genotypes have a defined geographical distribution. Very few studies have been carried out in South America. This study aimed to study the circulation of HDV in subjects with chronic HBV from South America.

Materials and Methods

We studied 38 samples obtained between 2019 and 2021 from individuals chronically infected with HBV by assessing the ESCALON network (a cross-sectional and prospective study addressing hepatobiliary disease in South America). Samples were from Argentina (n=12), Peru (n=11), Colombia (n=4), Ecuador (n=4), Chile (n=4), and Brazil (n=3). Total anti-HDV antibody detection was performed using the Liaison XL Murex anti-HDV kit (DiaSorin). Positive samples were subjected to viral RNA detection by RT-PCR, and genotyped by Sanger sequencing.

Results

Median age was 59 years old (IQR 48.5-67.3); 75% of the individuals were males and 25% were females. Three samples were positive for anti-HDV antibody detection (8%). Two of them, from Colombia and Chile, belonged to individuals with cirrhosis, while the third one, from Ecuador, originated from an individual with hepatocellular carcinoma (HCC). This sample could be amplified by RT-PCR, corresponding to a 44 years-old male. The sequencing showed HDV genotype 3.

Conclusions

The results show circulation of HDV in South America, with a prevalence close to that estimated by the WHO (5%). The detections were performed in patients with severe liver disease, likely secondary to the presence of the two viral agents (HDV+HBV). Although our cohort is small, its strength lies in the geographical amplitude of the samples (6 countries). The study remains active and is expected to substantially increase the sample size over the coming year.

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