Abstracts of the 2022 Annual Meeting of the ALEH
Más datosDe-novo Autoimmune Hepatitis (De-novo AIH) after Liver Transplantation (LT) is an entity recently described and considered rare. Its importance relies on a severe clinical course, with graft loss in the short term, non-response to immunosuppressant therapies and requiring retransplantation even more than once. The Colombian population has a higher incidence of autoimmune liver diseases when compared to the literature, with a more aggressive clinical course and poorer response to classical immunosuppressive therapies requiring LT. This suggests a unique genetic component of the Colombian population that determines specific management and prognosis. The HLA (loci DR 3 * and DR 4 *) has been associated with De-novo AIH, especially in children, but no studies have been published in Hispanic Adults to date.
Materials and MethodsA retrospective observational study. The overall objective of this study was to determine the allelic frequencies of HLA (loci DR 3 * and DR 4 *) in donor livers of a Colombian population of patients with LT and its association with De-novo AIH.
ResultsOut of 260 adult patients with LT at Cardioinfantil Foundation, eight were identified with De-novo AIH, all with graft loss and indication for liver retransplantation, 2 of them with graft loss for the second time in less than one year. HLA DR 4 was identified in all donors of patients who developed De-novo AIH.
ConclusionsThe association between HLA DR-4 and De-novo AIH after LT establishes a precedent in the history of liver transplantation not only in Colombia but the world and requires immediate attention.