P-6 PREVALENCE AND CLINICAL CHARACTERISTICS OF LEAN NON-ALCOHOLIC FATTY LIVER DISEASE IN MÉXICO

Introduction and Objectives

Non-alcoholic fatty liver disease (NAFLD) is one of the main etiologies of chronic liver disease and is mainly observed in people with obesity and type 2 diabetes mellitus; however it is estimated that 7%-20% of individuals with NAFLD have lean body habitus (BMI <25 kg/m2). In México, the prevalence of NAFLD ranges from 41.3% to 47%; however, there is no data on lean NAFLD. This study aimed to estimate the prevalence of lean NAFLD in México and determine the clinical and demographic characteristics of the studied population.

Materials and Methods

A cross-sectional study to estimate the prevalence of NAFLD in the adult population was carried out in 5 states in México. History of metabolic and cardiovascular diseases, alcohol and tobacco consumption were collected; in addition, weight and height were measured. Lean NAFLD was defined as the presence of hepatic steatosis (grade 1 or higher) and a BMI <25 kg/m2. To identify clinical and demographic characteristics associated with lean-NAFLD, the proportion of lean-NAFLD among subjects with NAFLD was compared between groups defined by each characteristic using a Pearson chi-square test.

Results

3554 patients were included, the mean age was 47 years (±12), and 60% were women. NAFLD was found in 52% of the participants, from which 5.5% (n=195) corresponded to lean NAFLD. 7.2% of patients with lean NAFLD had T2DM compared to 12% of patients with Non-lean NAFLD. Hypertension, 11% of patients with lean NAFLD presented it compared to 18% of patients with Non-lean NAFLD. Table 1 shows the characteristics of the study population.

Conclusions

The prevalence of LEAN NAFLD was 5.5%. We found that 1 of every 10 individuals with NAFLD corresponds to lean-NAFLD and that this relation is lower in those with hypertension and dyslipidemia but not in those with diabetes.