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Annals of Hepatology
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Inicio Annals of Hepatology P-7 LIVER INJURY AFTER COVID-19 VACCINATION COMPARED TO POST-INFLUENZA VACCINES:...
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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Vol. 28. Núm. S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(marzo 2023)
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P-7 LIVER INJURY AFTER COVID-19 VACCINATION COMPARED TO POST-INFLUENZA VACCINES: RETROSPECTIVE COHORT STUDY
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1064
Marlene Padilla Lopez1, Natalia Sobenko1, Valeria Ines Aliperti2, Vanina Cecilia Stanek3, Maria Florencia Grande Ratti4,5, Fernando Ezequiel Jabif6, Marcelo Gabriel Vallone6, Alejandra Villamil1
1 Hepatology Section, Buenos Aires Italian Hospital, Buenos Aires, Argentina
2 Epidemiology Section, Buenos Aires Italian Hospital, Buenos Aires, Argentina
3 Infectology Section, Buenos Aires Italian Hospital, Buenos Aires, Argentina
4 Internal Medicine Research Area, Buenos Aires Italian Hospital, Buenos Aires, Argentina
5 Conicet, Assistant Researcher, Buenos Aires, Argentina
6 Medical Clinic Service, Buenos Aires Italian Hospital, Buenos Aires, Argentina
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Vol. 28. Núm S1

Abstracts of the 2022 Annual Meeting of the ALEH

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Introduction and Objectives

Cases suggestive of immune-mediated acute hepatitis following SARS-CoV-2 vaccination have been reported. The risk of liver injury after Covid-19 vaccination is unknown. This study aimed to estimate the cumulative incidence of liver injury within 90 days after the Covid-19 vaccine, defined as the occurrence of AST and/or ALT increases at least two times the limit of normal or ALP increases at least x 2. To compare with an active comparator group (influenza vaccine).

Materials and Methods

Retrospective cohort study. We analyze a consecutive sample of adult patients vaccinated with Covid-19 vaccines (Sputnik, AstraZeneca/Oxford, Covishield, or Sinopharm) between January 1 and May 30, 2021, and a historical control group vaccinated with influenza between March 1 and July 30, 2019. Qualifying labs were collected as part of routine clinical care or the development of symptoms.

Results

From a total of 29,918 subjects who received the Covid-19 vaccine in 2021 and 24,753 who received the Influenza vaccine in 2019, 130 and 148 patients, respectively, were excluded because of previously altered liver function tests or known hepatic disease. Both groups were comparable in age (73 years old (IQR 65-80), p=0.125) and gender (67% were females). In the Influenza group were more dysmetabolic and immunosuppressed patients.

A total of 269 and 273 patients, respectively, presented altered liver function tests within 90 days post-vaccination. The cumulative incidence of liver injury was 4.6 per 1,000 (95% CI 3.9-5.5) for Covid-19 and 5.1 per 1,000 (95%CI 4.3-6.1) for Influenza (p=0.453). Although, two patients from the COVID group had a more severe injury, with hyperbilirubinemia, development of autoantibodies and requirement of steroids for disease control.

Conclusions

The occurrence of events was similar in subjects vaccinated with Covid-19 compared to the control group. Acute hepatitis characteristics arising after the COVID-19 vaccine needs to be further clarified.

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Figure 1. Flowchart diagram for study participants

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